List of works - Stefan Gründer

A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).

scientific article published on 27 September 2016

A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication.

scientific article published on 16 February 2004

A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel

scientific article

A new subunit of the epithelial Na+ channel identifies regions involved in Na+ self-inhibition

scientific article published on 21 May 2003

A peptide-gated ion channel from the freshwater polyp Hydra

scientific article

A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC)

scientific journal article

A single conserved proline residue determines the membrane topology of stomatin.

scientific article published in March 2009

ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease.

scientific article

Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry

scientific article

Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia

scientific article

Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression

scientific article

Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).

scientific article published on 26 August 2002

An acid-sensing ion channel from shark (Squalus acanthias) mediates transient and sustained responses to protons

scientific article published on 11 January 2010

BASIC--a bile acid-sensitive ion channel highly expressed in bile ducts

scientific article

Back to the Basics: Cnidarians Start to Fire

scientific article published on 29 December 2016

Bile acids are potent inhibitors of rat P2X2 receptors

scientific article published on 17 May 2019

Bile acids increase the activity of the epithelial Na+ channel

scientific article published on 30 November 2013

Biophysical properties of acid-sensing ion channels (ASICs).

scientific article

Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.

scientific article published on November 2007

Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat.

scientific article published in February 2001

Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b

scientific article

Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).

scientific article

Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis.

scientific article published on 24 April 2018

Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea

scientific journal article

Functional and evolutionary insights from the genomes of three parasitoid Nasonia species

scientific article

Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.

scientific article published on 9 June 2016

Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3.

scientific article

High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra

scientific article published on October 2012

Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain.

scientific article published on 10 April 2017

Identification of a highly conserved sequence at the N-terminus of the epithelial Na+ channel alpha subunit involved in gating

scientific article published on October 1999

Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating

scientific article

Inactivation of muscle chloride channel by transposon insertion in myotonic mice

scientific article

Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit

scientific article

Inhalational anesthetics accelerate desensitization of acid-sensing ion channels

scientific article published on 05 April 2018

Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality

scientific article

Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations

scientific article published on 01 March 2018

New techniques, applications and perspectives in neuropeptide research.

scientific article published on 8 February 2018

Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities

scientific article

Peptide-gated ion channels and the simple nervous system of Hydra

scientific article

Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a.

scientific article published on 4 January 2007

Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).

scientific article published on 11 July 2013

Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension

scientific article published in February 1997

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

scientific article published on December 1992

Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators

scientific article published in Scientific Reports

Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid

scientific article published on 12 October 2012

Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium

scientific article published on 20 March 2006

The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand–Sensing Domain

scientific article published on 16 July 2018

The P2X(7) receptor from Xenopus laevis: formation of a large pore in Xenopus oocytes

scientific article

The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment

scientific article

The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC

scientific article published on 23 December 2013

The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission

scientific article

The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1.

scientific article

The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K+ channel Kv1.1 through protein kinase C delta

scientific article published on 15 October 2020

The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates

scientific article published on 9 August 2011

Three homologous subunits form a high affinity peptide-gated ion channel in Hydra

scientific article

Toxin binding reveals two open state structures for one acid-sensing ion channel

scientific article published on 18 September 2012

Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand protein peflin

scientific article published on 15 November 2012

Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells

scientific article

Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+.

scientific article

List of works by Stefan Gründer

A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).

A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication.

A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel

A new subunit of the epithelial Na+ channel identifies regions involved in Na+ self-inhibition

A peptide-gated ion channel from the freshwater polyp Hydra

A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC)

A single conserved proline residue determines the membrane topology of stomatin.

ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease.

Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry

Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia

Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression

Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).

An acid-sensing ion channel from shark (Squalus acanthias) mediates transient and sustained responses to protons

BASIC--a bile acid-sensitive ion channel highly expressed in bile ducts

Back to the Basics: Cnidarians Start to Fire

Bile acids are potent inhibitors of rat P2X2 receptors

Bile acids increase the activity of the epithelial Na+ channel

Biophysical properties of acid-sensing ion channels (ASICs).

Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.

Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat.

Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b

Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).

Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis.

Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea

Functional and evolutionary insights from the genomes of three parasitoid Nasonia species

Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.

Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3.

High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra

Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain.

Identification of a highly conserved sequence at the N-terminus of the epithelial Na+ channel alpha subunit involved in gating

Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating

Inactivation of muscle chloride channel by transposon insertion in myotonic mice

Inflammatory mediators potentiate ATP-gated channels through the P2X(3) subunit

Inhalational anesthetics accelerate desensitization of acid-sensing ion channels

Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality

Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations

New techniques, applications and perspectives in neuropeptide research.

Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities

Peptide-gated ion channels and the simple nervous system of Hydra

Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a.

Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).

Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators

Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid

Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium

The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand–Sensing Domain

The P2X(7) receptor from Xenopus laevis: formation of a large pore in Xenopus oocytes

The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment

The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC

The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission

The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1.

The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K+ channel Kv1.1 through protein kinase C delta

The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates

Three homologous subunits form a high affinity peptide-gated ion channel in Hydra

Toxin binding reveals two open state structures for one acid-sensing ion channel

Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand protein peflin

Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells

Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+.