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List of works by Irmgard Tegeder

"Disease modifying nutricals" for multiple sclerosis

scientific article

ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers

scientific article published on 18 March 2022

Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier

scientific article

Acetaminophen Inhibits Spinal Prostaglandin E2 Release after Peripheral Noxious Stimulation

scientific article published on 01 July 1999

Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers

scientific article published on 20 May 2003

Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia

scientific article published on 16 September 2009

Anandamide deficiency and heightened neuropathic pain in aged mice

scientific article published on 15 April 2013

Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test

scientific article published on May 2000

Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration

scientific article

Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders

Author's reply to Kapoor S. GTP cyclohydrolase and cancer pain ⬇️

scientific article published on October 17, 2012

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

scientific article published on 01 August 2011

COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib

scientific article

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

scientific article

Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?

scientific article

Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB.

scientific article

Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer

scientific article published on 01 May 2003

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

scientific article published on 26 April 2008

Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models

scientific article published in June 2005

Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state

scientific article published on 01 May 1999

Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice

scientific article

Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen

scientific article

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo

scientific article

Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation

scientific article published on 7 December 2013

Contribution of genetic variants to pain susceptibility in Parkinson disease

scientific article published on 4 April 2012

Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders

scientific article published on 02 January 2019

Cream psoralen plus ultraviolet A therapy for granuloma annulare

scientific article published in May 2001

Current evidence for a modulation of low back pain by human genetic variants

scientific article published on 17 February 2009

Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain

scientific article published in January 2004

Cyclooxygenase-independent actions of cyclooxygenase inhibitors

scientific article (publication date: October 2001)

Cysteine-Rich Protein 2, a Novel Downstream Effector of cGMP/cGMP-Dependent Protein Kinase I-Mediated Persistent Inflammatory Pain

scientific article published on 01 February 2008

Data file of a deep proteome analysis of the prefrontal cortex in aged mice with progranulin deficiency or neuronal overexpression of progranulin

scientific article

Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and rapamycin treatment

Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry

scientific article

Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry.

scientific article

Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia

scientific article published on 30 April 2013

Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.

scientific article

Drug interactions with patient-controlled analgesia

scientific article

Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats

scientific article published in October 2002

Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.

scientific article

Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord

scientific article published in November 2001

Effects of selective and unselective cyclooxygenase inhibitors on prostanoid release from various rat organs

scientific article published on 01 March 2000

Einsatz von Opioiden bei Leber- oder Niereninsuffizienz

Elevated serum cyclophilin levels in patients with severe sepsis

scientific article published on 01 September 1997

Emerging country pharmacology: a 10-year perspective from Naunyn-Schmiedeberg's Archives of Pharmacology

scientific article

Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord

scientific article

Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans

scientific article published in October 2013

Expression and regulation of redoxins at nociceptive signaling sites after sciatic nerve injury in mice

scientific article published on 10 November 2015

Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics

scientific article

G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation

scientific article

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function

scientific article published on July 2008

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

scientific journal article

Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn

scientific article published on 12 August 2008

Genetic modulation of the pharmacological treatment of pain

scientific article published on 15 July 2009

Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol

scientific article

Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

scientific article

High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease

scientific article published on 11 July 2020

Hypoxia-Inducible Factor 1 Regulates Heat and Cold Pain Sensitivity and Persistence

scientific article published on 30 January 2014

Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting

scientific article

Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein

scientific article published in October 2002

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages.

scientific article

Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine

scientific article published on 17 June 2012

Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

scientific article

Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation

scientific article published in March 2003

Inhibition of noxious stimulus-induced spinal prostaglandin E2 release by flurbiprofen enantiomers: a microdialysis study

scientific article published on May 2000

Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury

scientific article published in May 2012

Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity

scientific article published in October 2009

Inter-strain differences of serotonergic inhibitory pain control in inbred mice

scientific article

Kinetics and dose-response of photosensitivity in cream psoralen plus ultraviolet A photochemotherapy: comparative in vivo studies after topical application of three standard preparations

scientific article

Learning and memory with neuropathic pain: impact of old age and progranulin deficiency

scientific article

Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord

scientific article published on 01 January 2000

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats

scientific article published on 22 January 2008

Mast cell tetrahydrobiopterin contributes to itch in mice.

scientific article published on 18 November 2018

Modulation of spinal nociceptive processing through the glutamate transporter GLT-1.

scientific article published in January 2003

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain

scientific article

Nitric oxide mediated redox regulation of protein homeostasis

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing

scientific article published on 04 May 2009

Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications

scientific article published in September 2004

Opioid‐mediated drug actions cannot be concluded from naloxone induced reversal of anti‐nociceptive effects in behavioural tests only ⬇️

scientific article published on November 1, 2010

Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation

scientific article published in March 2003

Pathophysiology and treatment of pain in joint disease

scientific article

Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain

scientific article

Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice

scientific article published on 7 March 2011

Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord

scientific article published on 26 September 2012

Peripheral opioid analgesia in experimental human pain models

scientific article

Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration.

scientific article published in December 1997

Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration

scientific article published on January 1999

Pharmacokinetics of opioids in liver disease

scientific article

Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice

scientific article published in 2022

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity

scientific article

Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

scientific article published on 28 May 2020

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice

scientific article published on April 2012

Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice

scientific article published on 29 August 2019

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

scientific article published on 22 October 2016

Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve

scientific article published on 14 May 2012

Protein associated with Myc (PAM) is involved in spinal nociceptive processing.

scientific article published on February 2004

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice

scientific article

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids

scientific article (publication date: 2010)

Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and rapamycin treatment

Reduced exploratory behavior in neuronal nucleoredoxin knockout mice

scientific article published on 23 June 2021

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype

scientific article published on 18 April 2008

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.

scholarly article

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

scientific article published on June 2015

Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation

scientific article published on 01 August 2000

Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans

scientific article

Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation

scientific article published in May 2001

Reliable Screening for a Pain-Protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms

article

Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals

scientific article

Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats

scientific article

Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia

scientific article published in February 2001

SNO-ing at the nociceptive synapse?

scientific article published on 24 March 2011

Sensory neuropathy and nociception in rodent models of Parkinson's disease

scientific article published on 27 June 2019

Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate

scientific article

Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration

scientific article published on November 2002

Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.

scientific article published in February 2004

Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test

scientific article published on 01 May 1997

Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders

scholarly article by Carine Thalman published in August 2018

The Partial 5-Hydroxytryptamine1A Receptor Agonist Buspirone does not Antagonize Morphine-induced Respiratory Depression in Humans

scientific article published on 01 January 2007

The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia

scientific article

The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception

scientific article published on 06 August 2007

The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats

scientific article published in August 2002

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia

scientific article

Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen

scientific article published in March 2002

Tissue distribution of imipenem in critically ill patients

scientific article

Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population

scientific article published on November 2002

When lipid homeostasis runs havoc: lipotoxicity links lysosomal dysfunction to autophagy

scientific article published on 05 December 2020

When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping

scientific article published on 16 March 2021

Yeast-2-Hybrid data file showing progranulin interactions in human fetal brain and bone marrow libraries

scientific article

[Pain management in general practice. Therapy with nonsteroidal anti-inflammatory drugs]

scientific article published on 01 March 2000

[Therapy with opioids in liver or renal failure]

scientific article published on 01 June 1999

cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.

scientific article

cGMP-dependent signaling pathways in spinal pain processing

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