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List of works by Harmit Singh Malik

A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function

scientific article published on 01 March 2020

A Diversified Portfolio

scientific article published on 01 September 2016

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

scientific article published on 30 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing ⬇️

journal article from 'bioRxiv' published in 2020

A balancing act between primate lentiviruses and their receptor

scientific article

A burst of genetic innovation in actin-related proteins (Arps) for testis-specific function in a Drosophila lineage

scientific article

A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli

scientific journal article

A hitchhiker's guide to survival finally makes CENs

scientific article

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

scientific article

A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae

scientific article published on 16 October 2020

A natural variant of the essential host geneMMS21restricts the parasitic 2-micron plasmid inSaccharomyces cerevisiae

scientific article

A rapidly evolving actin mediates fertility and developmental tradeoffs in Drosophila

scientific article

A rapidly evolving genomic toolkit for Drosophila heterochromatin

scientific article

A surrogate approach to study the evolution of noncoding DNA elements that organize eukaryotic genomes

scientific article

A unified phylogeny-based nomenclature for histone variants

scientific article

Absence of positive selection on centromeric histones in Tetrahymena suggests unsuppressed centromere: drive in lineages lacking male meiosis

scientific article

Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa

scientific article (publication date: December 2009)

AcrIIA22 is a novel anti-CRISPR that impairs SpyCas9 activity by relieving DNA torsion of target plasmids

scientific article

Adaptive Evolution of Centromeric Proteins

Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H.

scientific article

Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species

scientific article

An essential cell cycle regulation gene causes hybrid inviability in Drosophila

scientific article

An evolutionary perspective on the broad antiviral specificity of MxA ⬇️

scientific article published on May 28, 2013

An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family

scientific article (publication date: 2013)

An expanded clade of rodent Trim5 genes

scientific article published on 15 January 2009

Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses.

scientific article

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

scientific article

Ancient co-retention of paralogs of Cid centromeric histones and Cal1 chaperones in mosquito species

scientific article published on 03 March 2020

Ancient lineages of non-LTR retrotransposons in the primitive eukaryote, Giardia lamblia

scientific article published on May 2002

Antiretroelement activity of APOBEC3H was lost twice in recent human evolution

scientific article

Are retrotransposons long-term hitchhikers?

scientific article published in March 1998

BIOSAFETY. Safeguarding gene drive experiments in the laboratory

scientific article

Biparental contributions of the H2A.B histone variant control embryonic development in mice

scientific article published on 23 December 2020

Birth, death, and replacement of karyopherins in Drosophila

scientific article published on 10 December 2011

Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes

scientific article (publication date: 12 February 2013)

Centromeres.

scientific article published in June 2016

Centromeres: selfish drivers

scientific article published in May 2002

Chromosome segregation: human female meiosis breaks all the rules.

scientific article published in August 2015

Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins

scientific article published on 01 October 2019

Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins

scientific article

Conflict begets complexity: the evolution of centromeres

scientific article

Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution

scientific article published on 6 April 2016

Convergent evolution of escape from hepaciviral antagonism in primates

scientific article (publication date: 2012)

Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin

scientific article published on April 2017

Culture shock

article

Density-dependent resistance protects from its own antimicrobial metabolite, HGA

scientific article published on 28 May 2019

Density-dependent resistance protectsLegionella pneumophilafrom its own antimicrobial metabolite, HGA

scientific article

Determining the evolutionary potential of a gene ⬇️

scientific article published on August 1, 1998

Diamonds and rust: how transposable elements influence mammalian genomes. Conference on Mobile Elements in Mammalian Genomes

scientific article (publication date: December 2009)

Did a Single Amino Acid Change Make Ebola Virus More Virulent?

scientific article published on November 2016

Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals

scientific article

Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces.

scientific article

Dual recognition–incision enzymes might be involved in mismatch repair and meiosis

scientific article published on 01 September 2000

Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes

scientific article published on 20 February 2020

Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes

scientific article

EvoChromo: towards a synthesis of chromatin biology and evolution

scientific article published on 26 September 2019

Evolution of TRIM antiviral genes in primate genomes.

scientific article

Evolution of a transcriptional regulator from a transmembrane nucleoporin

scientific article published on 19 May 2016

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

scientific article

Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.

scientific article published on October 2012

Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction

scientific article

Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus?

scientific article published on 11 February 2016

Evolutionary cell biology: two origins, one objective

scientific article

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals

scientific article published on 16 March 2018

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals

Evolutionary specialization of the nuclear targeting apparatus

scientific journal article

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

scientific article

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

scientific article published on 10 September 2019

Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

scientific article

Gametic specialization of centromeric histone paralogs in Drosophila virilis

scientific article

Genes get diabolical

article

Genetic conflicts during meiosis and the evolutionary origins of centromere complexity

scientific article published in August 2006

Genetic conflicts: stronger centromeres win tug-of-war in female meiosis.

scientific article published in October 2014

Genetic conflicts: the usual suspects and beyond

scientific article published on January 2017

Genetics: Master Regulator or Master of Disguise?

scientific article published in September 2017

Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast

scientific article

Guidelines for naming nonprimate APOBEC3 genes and proteins

scientific article

Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline

scientific article published on 25 January 2016

High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans

scientific article published on January 2006

Host gene evolution traces the evolutionary history of ancient primate lentiviruses ⬇️

scientific article (publication date: 19 September 2013)

How a virus blocks a cellular emergency access lane to the nucleus, STAT!

scientific article

Hybridization promotes asexual reproduction in Caenorhabditis nematodes

scientific article published on 16 December 2019

Hybridization promotes asexual reproduction in Caenorhabditis nematodes

scientific article

Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes

scientific article published on 11 July 2013

Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements

scientific article

Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.

scientific article

Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

scientific article published on 10 November 2020

Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes inDrosophila

scientific article

Kindr Motors Drive in Meiosis

scientific article published on 01 May 2018

LINE-1 Retroelements Get ZAPped!

scientific article published on 16 July 2015

Learning to protect your genome on the fly

scientific article published on December 2011

Major evolutionary transitions in centromere complexity.

scientific article published in September 2009

Meiosis: How Gambling Chromosomes Beat the Rules

scientific article published on 01 December 2019

Microbial Genomics: The Expanding Universe of Bacterial Defense Systems

scientific article published on 01 April 2018

Mimulus finds centromeres in the driver's seat

scientific article published in April 2005

Mitotic fidelity requires transgenerational action of a testis-restricted HP1.

scientific article published on 7 July 2015

Mobile DNA: an evolving field

scientific article published on 5 June 2014

Modular evolution of the integrase domain in the Ty3/Gypsy class of LTR retrotransposons

scientific article published on June 1999

Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes

scientific article published on 20 March 2014

Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins

scientific article published on May 2007

Multiple roles for heterochromatin protein 1 genes in Drosophila.

scientific article published on January 2009

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

scientific article published on 15 September 2020

Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline

scientific article published in 2022

Origins and Evolution of Retrotransposons

Paleovirology - ghosts and gifts of viruses past

scientific article (publication date: October 2011)

Paleovirology--modern consequences of ancient viruses

scientific article published in February 2010

Phylogenetic Analysis of Ribonuclease H Domains Suggests a Late, Chimeric Origin of LTR Retrotransposable Elements and Retroviruses

article

Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family

scientific article

Phylogenomics of the nucleosome

scientific article published on November 2003

Poised for contagion: evolutionary origins of the infectious abilities of invertebrate retroviruses

scientific article published on September 2000

Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein

scientific article

Positive selection and multiple losses of the LINE-1-derived L1TD1 gene in mammals suggest a dual role in genome defense and pluripotency.

scientific article

Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila

scientific article

Positive selection of Iris, a retroviral envelope-derived host gene in Drosophila melanogaster

scientific article

Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain

scientific article (publication date: 22 February 2005)

Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis

scholarly article

Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses

scientific article (publication date: 17 August 2012)

Protein kinase R reveals an evolutionary model for defeating viral mimicry

scientific article

Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans

scientific article

Putting the brakes on centromere drive in Mimulus

scientific article

R2d2 and Hyperdrive Mechanisms (in Mouse Meiosis).

scientific article

Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts

scientific article

Rapid evolution of centromeres and centromeric/kinetochore proteins

article published in 2012

Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila

scientific article published in September 2017

Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila

scientific article published on 14 March 2016

Recurrent Gene Duplication Leads to Diverse Repertoires of Centromeric Histones in Drosophila Species.

scientific article

Recurrent evolution of DNA-binding motifs in the Drosophila centromeric histone

scientific article

Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects

scientific article

Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein

scientific article

Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

scientific article published on 01 June 2020

Retroviruses push the envelope for mammalian placentation ⬇️

scientific article published on January 26, 2012

Ribonuclease H evolution in retrotransposable elements

scientific article

Rules of engagement: molecular insights from host-virus arms races

scientific article published on January 2012

Speciation via Autoimmunity: A Dangerous Mix

article

Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila

scholarly article

Stepwise evolution of essential centromere function in a Drosophila neogene

scientific article

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

scientific article published on 16 December 2020

Ten-kilodalton domain in Ty3 Gag3-Pol3p between PR and RT is dispensable for Ty3 transposition

scientific article

The CNA1 histone of the ciliate Tetrahymena thermophila is essential for chromosome segregation in the germline micronucleus

scientific article

The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months

scientific article published on 27 February 2019

The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.

scientific article published on 26 January 2012

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions

scientific article

The breadth of antiviral activity of Apobec3DE in chimpanzees has been driven by positive selection ⬇️

scientific article published on 10 August 2011

The cellular mechanisms and consequences of centromere drive.

scientific article published on 14 February 2018

The centromere paradox: stable inheritance with rapidly evolving DNA.

scientific article

The centromere-drive hypothesis: a simple basis for centromere complexity

scientific article published on January 2009

The evolutionary conundrum of pathogen mimicry

scientific article published on 06 October 2009

The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses

scientific article

The gene drive bubble: New realities

scientific article

The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity

scientific article published on 13 October 2021

The piggyBac transposon-derived genes TPB1 and TPB6 mediate essential transposon-like excision during the developmental rearrangement of key genes in Tetrahymena thermophila

scientific article

Transferred interbacterial antagonism genes augment eukaryotic innate immune function

scientific article

Waddington Redux: De Novo Mutations Underlie the Genetic Assimilation of Stress-Induced Phenocopies in Drosophila melanogaster

scientific article published in September 2017

wtf genes are prolific dual poison-antidote meiotic drivers

scientific article published on 20 June 2017

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