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List of works by Heather R Christofk

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

scientific article

A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen

scientific article

A metabolic metamorphosis

scientific article published in Nature

A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia

scientific article published on 17 December 2021

Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication

scientific article

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

scientific article published on 25 February 2013

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

scientific article published on 29 April 2016

Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

scientific article published on 26 March 2019

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

scientific article published on 8 May 2015

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

scientific article

Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway

scientific article

Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer

scientific article published on 18 January 2014

Doxycycline alters metabolism and proliferation of human cell lines

scientific article

EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer

scientific article published on 23 May 2013

Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.

scientific article published on 4 May 2016

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression

scientific article

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

scientific article

Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system

scientific article

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State

scientific article published on 3 September 2016

Histone acetylation regulates intracellular pH.

scientific article

Identification of small molecule inhibitors of pyruvate kinase M2

scientific article

In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification

scientific article published on January 2006

In-gel stable isotope labeling for relative quantification using mass spectrometry

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

scientific article published on 09 January 2019

Lactate dehydrogenase activity drives hair follicle stem cell activation.

scientific article

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

scientific article published on 10 February 2016

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

scientific article

Metabolic state of glioma stem cells and nontumorigenic cells

scientific article

Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment

scientific article

New aspects of the Warburg effect in cancer cell biology

scientific article published on 08 March 2012

Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition

scientific article published on 12 February 2013

Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life

scientific article

Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries

scientific article published on 2 August 2011

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Pyruvate kinase M2 is a phosphotyrosine-binding protein

scientific article

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.

scientific article published on 15 February 2017

Rethinking glutamine addiction

scientific article published in November 2015

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

scientific article published on January 2017

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

scientific article (publication date: 13 March 2008)

The metabolic milieu of metastases

scientific article published in January 2015

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

scientific article

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