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List of works by Kai Kaarniranta

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

scientific article

5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration.

scientific article published on 18 October 2011

A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).

scientific article published on 20 March 2006

A novel proteotoxic stress associated mechanism for macular corneal dystrophy.

scientific article published on 19 January 2015

A prospective study on postoperative pain after cataract surgery

scientific article published on 15 July 2013

A randomized phase I clinical study of cis-urocanic acid eye drops in healthy adult subjects

scientific article published on 21 January 2015

A rat experimental model of glaucoma incorporating rapid-onset elevation of intraocular pressure

scientific article published on August 2014

ADAMTS9locus associates with increased risk of wet AMD

scientific article published on 16 January 2014

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

scientific article published on 15 December 2011

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

scientific article published on 23 March 2011

AMP-activated protein kinase: a potential player in Alzheimer's disease

scientific article published on 24 June 2011

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

scientific article published on 3 June 2016

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

scientific article published on 20 March 2016

Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis

scientific article

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

scientific article published on 20 September 2007

Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population

article

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

scientific article published on 6 April 2016

Age-related macular degeneration (AMD): Alzheimer's disease in the eye?

scientific article published on January 2011

Age-related macular degeneration--a difficult problem for the patient and for the ophthalmologist

scientific article

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors

scientific article

Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment

scientific article published on 02 April 2015

All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress

scientific article published on 14 June 2016

Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.

scientific article published in April 2007

Altered calcium signaling in an experimental model of glaucoma

scientific article

Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

scientific article published on 13 September 2008

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

scientific article

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

scientific article

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

scientific article published on 07 June 2011

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells

scientific article

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

scientific article

Autophagy in DNA damage response

scientific article

Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration.

scientific article published on November 2012

Autophagy--hot topic in AMD.

scientific article published on 26 March 2010

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process

scientific article published on 07 December 2012

Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials

scientific article published on 15 March 2016

Best-corrected visual acuity and retinal thickness are associated with improved cortical visual processing in treated wet AMD patients

scientific article

Biocompatibility of different poly(lactide-coglycolide) polymers implanted into the subconjunctival space in rats

scientific article published on 11 January 2011

Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures

scientific article published on 22 January 2014

Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells

scientific article published on 7 June 2011

Celastrol: Molecular targets of Thunder God Vine

scientific article published on 10 March 2010

Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization.

scientific article published on 17 April 2013

Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration

scientific article published on 27 February 2013

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

scientific article

Climatic droplet keratopathy: an old disease in new clothes.

scientific article

Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea.

scientific article published on 4 February 2014

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process

scientific article

Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging

scientific article published on 16 October 2010

Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops

scientific article published on March 2007

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

scientific article published on 6 November 2008

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

scientific article published on 11 February 2013

Cytoskeleton and Proteoglycan Synthesis in Chondrocytes Under Hydrostatic Pressure

Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells

scientific article published on 28 September 2014

Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.

scientific article published on 3 September 2015

ER stress and hormetic regulation of the aging process

scientific article published on 21 April 2010

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

scientific article

Efflux protein expression in human retinal pigment epithelium cell lines.

scientific article published on 21 April 2009

Efflux protein expression in human stem cell-derived retinal pigment epithelial cells

scientific article

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).

scientific article published on 11 December 2011

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

scientific article

Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization

scientific article published on 27 July 2010

Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function

scientific article

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

scientific article published on 03 April 2007

Estrogen signalling in the pathogenesis of age-related macular degeneration.

scientific article

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

scientific article published on 27 September 2016

Filter-cultured ARPE-19 cells as outer blood-retinal barrier model

scientific article published on 10 April 2010

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.

scientific article

Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells

scientific article

Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells

scientific article

Genetic variability in DNA repair proteins in age-related macular degeneration

scientific article

Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process

scientific article

Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process

scientific article published on July 2010

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY

Health-related quality of life after cataract surgery with the phacoemulsification technique and intraocular lens implantation

scientific article published on 14 May 2015

Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD).

scientific article published on April 2009

Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells

scientific article published on September 2014

High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis

scientific article published on January 2002

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

scientific article published on 14 June 2014

Histopathology of the three implanted degradable biopolymers in rabbit eye.

scientific article

Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells

scientific article published on 28 May 2022

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation

scientific article published in March 1998

Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure

scientific article

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

scientific article

Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation

scientific article published on 20 February 2019

Hydrostatic pressure-induced changes in cellular protein synthesis.

scientific article published in January 2004

Hypoxic conditions stimulate the release of B-type natriuretic peptide from human retinal pigment epithelium cell culture.

scientific article published on 16 April 2014

Imiquimod in the treatment of eyelid basal cell carcinoma

scientific article

Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids.

scientific article published on November 2006

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

scientific article published on July 2013

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

scientific article published on 19 May 2015

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: direct contact studies

scientific article published on November 2007

In vitro biocompatibility of degradable biopolymers in cell line cultures from various ocular tissues: extraction studies

scientific article

Increased IL-6 levels are not related to NF-κB or HIF-1α transcription factors activity in the vitreous of proliferative diabetic retinopathy.

scientific article published on 2 August 2011

Inflammation and its role in age-related macular degeneration

scientific article

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

scientific article published on February 2009

Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells

scientific article published on 24 October 2010

Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19).

scientific article published on 21 May 2010

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

scientific article published on 19 April 2016

Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes.

scientific article published on 17 February 2016

Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90.

scientific article published on February 2008

Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling

scientific article published on 25 October 2009

Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1.

scientific article published on April 2008

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process

scientific article published on 02 April 2014

Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process

scientific article

Leucine 7−proline 7 polymorphism in the signal peptide of neuropeptide Y is not a risk factor for exudative age-related macular degeneration

scientific article published on 01 March 2007

Long-term topical application of preservative-free prostaglandin analogues evokes macrophage infiltration in the ocular adnexa.

scientific article published on 8 June 2016

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium

scientific article

Maturation of autophagosomes and endosomes: a key role for Rab7.

scientific article published on 05 December 2012

Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration

scientific article

Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration

scientific article

Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

scientific article published on 25 March 2012

Mitomycin C in revision endoscopic dacryocystorhinostomy: a prospective randomized study

scientific article

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.

scientific article

Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration

scientific article

NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?

scientific article

NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD).

scientific article published on 12 September 2009

NF-kappaB signaling in the aging process

scientific article

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress.

scientific article published on 24 October 2014

Neuronal cells show regulatory differences in the hsp70 gene response

scientific article published in May 2002

Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells

scientific article published on 11 May 2016

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD).

scientific article

Oxidative stress protection by exogenous delivery of rhHsp70 chaperone to the retinal pigment epithelium (RPE), a possible therapeutic strategy against RPE degeneration.

scientific article

Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration.

scientific article published on 23 February 2014

Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015% and Timolol 0.5% in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies.

scientific article published in April 2016

Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers

scientific article published in January 2008

Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process

scientific article published on January 2012

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

scientific article (publication date: 2015)

Postoperative pain after cataract surgery

scientific article published on May 2013

Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response

article

Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature

scientific article published on 01 June 2000

Protein-oxidized phospholipid interactions in cellular signaling for cell death: from biophysics to clinical correlations

scientific article published on 19 April 2012

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

scientific article published on 4 February 2015

ROCK, PAK, and Toll of synapses in Alzheimer's disease

scientific article published on 06 May 2008

Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells

scientific article

Recovery after cataract surgery

scientific article published on April 2016

Recovery and patient satisfaction after cataract surgery. A one-year prospective follow-up study

scientific article

Regression of necrotizing scleritis in Wegener’s granulomatosis after infliximab treatment

scientific article published on 16 September 2009

Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90.

scientific article

Regulation of the aging process by autophagy

scientific article published on 18 April 2009

Regulatory role of HIF-1alpha in the pathogenesis of age-related macular degeneration (AMD).

scientific article published on 07 July 2009

Relation of biometric eye profile with intraocular pressure corrections in healthy myopes

scientific article published on 06 March 2012

Reperfusion but Not Acute Ischemia in Pig Small Intestine Induces Transcriptionally Mediated Heat Shock Response in situ

scientific article published on 01 November 2002

Retinal arterial macroaneurysms

scientific article published on 25 June 2013

Retinal haemorrhages in shaken baby syndrome

scientific article published on 8 July 2008

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)

scientific article published on 14 May 2019

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

scientific article published on 22 September 2013

Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases

article

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

article

SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree

scientific article

SIRT1: regulation of longevity via autophagy

scientific article published on 26 February 2009

Siglec receptors and hiding plaques in Alzheimer's disease

scientific article published on 24 April 2009

Specific induction of heat shock protein 90beta by high hydrostatic pressure

scientific article published on January 2003

Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium.

scientific article published in April 1998

Stress responses of mammalian cells to high hydrostatic pressure.

scientific article published on January 2003

Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating

scientific article published on 20 January 2014

Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication

scientific article published in May 2010

Symptom score questionnaire for nasolacrimal duct obstruction in adults--a novel tool to assess the outcome after endoscopic dacryocystorhinostomy

scientific article published on 01 December 2010

Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential

scientific article published on October 2008

The Aging Stress Response and Its Implication for AMD Pathogenesis

scientific article published on 22 November 2020

The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells

scientific article published on 21 May 2007

The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model

scientific article

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

scientific article

The role of vision-related problems in fatal road accidents in Finland

scientific article published on 09 September 2020

Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy.

scientific article

Visual recovery of the amblyopic eye in an adult patient after loss of the dominant eye

scientific article published on 01 October 2003

Zinc and Autophagy in Age-Related Macular Degeneration ⬇️

scientific article published on 15 July 2020

cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure

scientific article published on August 2002

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