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List of works by Juan Carlos Espín

4-Hydroxyanisole: The Most Suitable Monophenolic Substrate for Determining Spectrophotometrically the Monophenolase Activity of Polyphenol Oxidase from Fruits and Vegetables ⬇️

scientific article published on May 15, 1998

4-Hydroxydibenzyl: a novel metabolite from the human gut microbiota after consuming resveratrol

scientific article published in 2022

A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts.

scientific article

A continuous spectrophotometric method for determining the monophenolase and diphenolase activities of apple polyphenol oxidase.

scientific article published in October 1995

A dietary resveratrol-rich grape extract prevents the developing of atherosclerotic lesions in the aorta of pigs fed an atherogenic diet.

scientific article published on 24 May 2012

A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans.

scientific article published on 18 April 2007

A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype

scientific article published on 23 December 2013

Activation of a latent mushroom (Agaricus bisporus) tyrosinase isoform by sodium dodecyl sulfate (SDS). Kinetic properties of the SDS-activated isoform

scientific article published on 01 September 1999

Agaritine from Agaricus bisporus is capable of preventing melanin formation

scientific article published on 26 July 2002

An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine-Induced Colorectal Carcinogenesis in the Rat

scientific article published on 9 February 2022

An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice.

scientific article published on 2 January 2018

Anthocyanin-based natural colorants: a new source of antiradical activity for foodstuff

scientific article published on 01 May 2000

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism.

scientific article

Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.

scientific article published on 17 December 2015

Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics

scientific article published in June 2002

Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women

scientific article published on 26 October 2013

Bioavailability of the Glucuronide and Sulfate Conjugates of Genistein and Daidzein in Breast Cancer Resistance Protein 1 Knockout Mice

scientific article published on 09 August 2011

Bioavailability of the major bioactive diterpenoids in a rosemary extract: Metabolic profile in the intestine, liver, plasma, and brain of Zucker rats

article

Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far

scientific article

Characterization of the total free radical scavenger capacity of vegetable oils and oil fractions using 2,2-diphenyl-1-picrylhydrazyl radical

scientific article published in March 2000

Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid

scientific article published on 28 August 2015

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial

scientific article published in May 2017

Comparison of different diluents and chromophores for spectrophotometric determination of livestock blood cholinesterase activity

scientific article published on 01 December 1999

Comparison of ozone and UV-C treatments on the postharvest stilbenoid monomer, dimer, and trimer induction in var. 'Superior' white table grapes

scientific article

Complete Genome Sequence of the New Urolithin-Producing Bacterium Gordonibacter urolithinfaciens DSM 27213T.

scientific article published on 14 December 2017

Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved.

scientific article published on 4 December 2015

Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.

scientific article published in May 2010

Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters

scientific article published on 01 September 2019

Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial

scientific article published on 01 May 2012

Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial

scientific article published in 2018

Correction to Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract

scientific article published on 27 February 2020

Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications

scientific article published on 03 December 2018

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

scientific article

Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

scientific article published on 10 August 2020

Dietary phenolics against colorectal cancer--From promising preclinical results to poor translation into clinical trials: Pitfalls and future needs

scientific article

Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.

scientific article published in June 2009

Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model

scientific article published in March 2009

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid.

scientific article

Effect of captopril on mushroom tyrosinase activity in vitro

scientific article (publication date: 12 January 2001)

Effect of low inulin doses with different polymerisation degree on lipid metabolism, mineral absorption, and intestinal microbiota in rats with fat-supplemented diet

article by María Azorín-Ortuño et al published April 2009 in Food Chemistry

Effect of mediterranean forest parasite with Curculio sp. on nutritional value of acorn for Iberian pig feeding and fat characteristics

scientific article published on 16 January 2007

Effect of wounding on phenolic enzymes in six minimally processed lettuce cultivars upon storage

scientific article

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

scientific article

Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention.

scientific article published on 17 August 2011

Ellagibacter isourolithinifaciens gen. nov., sp. nov., a new member of the family Eggerthellaceae, isolated from human gut.

scientific article published on 27 March 2018

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

article

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

scientific article published on 01 May 2012

Ellagitannins, ellagic acid and vascular health.

scientific article published on 15 September 2010

Etiology of UV-C-induced browning in var. Superior white table grapes.

scientific article published in July 2005

Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine

scientific article

Evaluation of Pseudomonas aeruginosa (PAO1) adhesion to human alveolar epithelial cells A549 using SYTO 9 dye.

scientific article

Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice

scientific article published in January 2003

Experimental approach to the kinetic study of unstable site-directed irreversible inhibitors: kinetic origin of the apparent positive co-operativity arising from inactivation of trypsin by p-amidinophenylmethanesulphonyl fluoride

scientific article published on April 1994

Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep

scientific article published on 15 January 2018

Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.

scientific article published on 15 June 2017

Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial.

scientific article published on 27 January 2017

Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins.

scientific article published on June 2009

Genetic Polymorphisms, Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes can Predict Obesity in Childhood-Adolescence

scientific article published on 12 May 2020

Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut.

scientific article

Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells

scientific article published on July 2003

Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease

scientific article published on February 2013

Gut Microbiota, Diet and Health. (We and our gut microbes)

scientific article published on 01 January 2017

Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-α induced human aortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1) levels.

scientific article published on 12 October 2015

Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans.

scientific article published on 9 November 2007

Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract

scientific article published on 28 September 2019

Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds

scientific article

In Vitro Research on Dietary Polyphenols and Health: A Call of Caution and a Guide on How To Proceed

scientific article published on 19 July 2018

Induction of antioxidant flavonol biosynthesis in fresh-cut potatoes. Effect of domestic cooking

scientific article published in October 2002

Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones

scientific article published on 2 May 2012

Interaction between phenolics and gut microbiota: role in human health.

scientific article published on August 2009

Interactions of gut microbiota with dietary polyphenols and consequences to human health.

scientific article

Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts.

scientific article

In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer.

scientific article

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid.

scientific article published on 7 August 2017

Kinetic characterization of the substrate specificity and mechanism of mushroom tyrosinase

scientific article published on 01 March 2000

Kinetic study of the activation process of a latent mushroom (Agaricus bisporus) tyrosinase by serine proteases

scientific article published on 01 September 1999

Kinetic study of the oxidation of 4-hydroxyanisole catalyzed by tyrosinase

scientific article published on 01 May 1997

Kinetic study of the oxidation of gamma-L-glutaminyl-4-hydroxybenzene catalyzed by mushroom (Agaricus bisporus) tyrosinase

scientific article published on 01 September 1999

Kinetics of activation of latent mushroom (Agaricus bisporus) tyrosinase by benzyl alcohol

scientific article published in September 1999

L-galactono-gamma-lactone dehydrogenase aand vitamin C content in fresh-cut potatoes stored under controlled atmospheres

scientific article published in July 2003

Lack of effect of oral administration of resveratrol in LPS-induced systemic inflammation

scientific article published on 04 March 2011

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.

scientific article published on 28 February 2018

Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients

scientific article published on 04 February 2019

Metabolism of Oak Leaf Ellagitannins and Urolithin Production in Beef Cattle

article

Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability

scientific article

Metabolism of different dietary phenolic compounds by the urolithin-producing human-gut bacteria Gordonibacter urolithinfaciens and Ellagibacter isourolithinifaciens

scientific article published on 27 July 2020

Metabolites and tissue distribution of resveratrol in the pig

scientific article published on 28 June 2011

MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts.

scientific article

NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts.

scientific article published on 26 March 2010

NMR Spectroscopic Identification of Urolithin G, a Novel Trihydroxy Urolithin Produced by Human Intestinal <i>Enterocloster</i> Species

scientific article published in 2023

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells.

scientific article published on 2 December 2016

Nutraceuticals for older people: facts, fictions and gaps in knowledge.

scientific article published on 21 June 2013

Nutraceuticals: facts and fiction

scientific article published on 31 October 2007

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice.

scientific article published in March 2010

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

scientific article published on 19 April 2012

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease.

scientific article published in April 2013

Oxymetric and spectrophotometric study of the ascorbate oxidase activity shown by frog epidermis tyrosinase

scientific article published on 01 August 1996

Pharmacokinetic Study oftrans-Resveratrol in Adult Pigs

scientific article published on 01 October 2010

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

scientific article published on April 2014

Phenolic compounds and fatty acids from acorns (Quercus spp.), the main dietary constituent of free-ranged Iberian pigs.

scientific article

Phenolic compounds and related enzymes are not rate-limiting in browning development of fresh-cut potatoes

scientific article published in May 2002

Physiological Relevance of the Antiproliferative and Estrogenic Effects of Dietary Polyphenol Aglycones versus Their Phase-II Metabolites on Breast Cancer Cells: A Call of Caution

scientific article published on 19 July 2018

Polyphenols' Gut Microbiota Metabolites: Bioactives or Biomarkers?

scientific article published on 20 March 2018

Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial

scientific article published in February 2006

Postharvest UV-C-irradiated grapes as a potential source for producing stilbene-enriched red wines

scientific article published in February 2003

Postharvest induction modeling method using UV irradiation pulses for obtaining resveratrol-enriched table grapes: a new "functional" fruit?

scientific article

Postharvest stilbene-enrichment of red and white table grape varieties using UV-C irradiation pulses

scientific article published in October 2002

Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents

scientific article published on October 2010

Production of bioavailable flavonoid glucosides in fruit juices and green tea by use of fungal alpha-L-rhamnosidases.

scientific article published in October 2004

Purification and Kinetic Characterization of an Anionic Peroxidase from Melon (Cucumis meloL.) Cultivated under Different Salinity Conditions

scientific article published on 01 May 2000

Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation

scientific article published on 12 March 2016

Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite

scientific article published on 01 April 2019

Reevaluation of the roles of ABCG2 in the disposition of genistein.

scientific article published on November 2012

Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic

scientific article published in May 2003

Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence

scientific article

Resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives reduce Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes Scott A adhesion to colonic epithelial cell lines

scientific article published on 18 July 2012

Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective.

scientific article

Role of ABCG2 in transport of the mammalian lignan enterolactone and its secretion into milk in Abcg2 knockout mice.

scientific article published on 25 February 2014

Safety evaluation of an oak-flavored milk powder containing ellagitannins upon oral administration in the rat.

scientific article

Slow-binding inhibition of mushroom (Agaricus bisporus) tyrosinase isoforms by tropolone

scientific article published on 01 July 1999

Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans.

scientific article

Study of stereospecificity in mushroom tyrosinase

scientific article published on April 1998

Synthesis of the antioxidant hydroxytyrosol using tyrosinase as biocatalyst

scientific article published in March 2001

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

scientific article published on 16 February 2014

The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial

scientific article published on 17 May 2018

The Human Metabolism of Nuts Proanthocyanidins does not Reveal Urinary Metabolites Consistent with Distinctive Gut Microbiota Metabotypes

scientific article published on 26 November 2018

The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.

scientific article published on 11 October 2005

The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.

scientific article

The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells

scientific article published on May 2015

The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in human SK-Mel-28 melanoma cells.

scientific article

The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).

scientific article

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.

scientific article published on 16 March 2017

The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells

scientific article published on 13 March 2020

The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging

scientific article published in 2018

The gut microbiota: A key factor in the therapeutic effects of (poly)phenols.

scientific article published on 5 May 2017

The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism

scientific article published on 24 November 2015

The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans

scientific article

There is No Distinctive Gut Microbiota Signature in the Metabolic Syndrome: Contribution of Cardiovascular Disease Risk Factors and Associated Medication

scientific article published on 15 March 2020

Time course production of urolithins from ellagic acid by human gut microbiota.

scientific article

Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

scientific article published on 01 June 2019

Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice

scientific article published on October 2007

UV and MS identification of Urolithins and Nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals.

scientific article published on 25 January 2011

Ultraviolet-C and induced stilbenes control ochratoxigenic Aspergillus in grapes.

scientific article

Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice.

scientific article published on 24 July 2006

Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist

scientific article published on 29 November 2018

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes.

scientific article

Urolithin Metabotypes Can Determine the Modulation of Gut Microbiota in Healthy Individuals by Tracking Walnuts Consumption over Three Days

scientific article published on 16 October 2019

Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum

scientific article published on 03 September 2019

Urolithins Are the Main Urinary Microbial-Derived Phenolic Metabolites Discriminating a Moderate Consumption of Nuts in Free-Living Subjects with Diagnosed Metabolic Syndrome

scientific article published on 05 June 2012

Urolithins in Human Breast Milk after Walnut Intake and Kinetics of Gordonibacter Colonization in Newly Born: The Role of Mothers' Urolithin Metabotypes

scientific article published on 02 November 2020

Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities

scientific article

Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

scientific article published on 9 May 2016

Validated Method for the Characterization and Quantification of Extractable and Nonextractable Ellagitannins after Acid Hydrolysis in Pomegranate Fruits, Juices, and Extracts.

scientific article published on 17 July 2015

Valorization of cauliflower (Brassica oleracea L. var. botrytis) by-products as a source of antioxidant phenolics

scientific article published in April 2003

Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS.

scientific article

Vitamin C retention in fresh-cut potatoes

article by J.A. Tudela et al published August 2002 in Postharvest Biology and Technology

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

scientific article published on 20 March 2020

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