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List of works by Leonard H. Rome

A protein involved in central nervous system myelination: localization in the extracellular matrix and induction in neuroblastoma cells

scientific article published in January 1994

A vault nanoparticle vaccine induces protective mucosal immunity

scientific article published on 30 April 2009

A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells

scientific article

Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope.

scientific article

Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP.

scientific article published in April 2004

Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry

scientific article published on 01 February 2000

Aspirin as a quantitative acetylating reagent for the fatty acid oxygenase that forms prostaglandins

scientific article

Assay and purification of a solubilized membrane receptor that binds the lysosomal enzyme alpha-L-iduronidase

scientific article published on 01 April 1982

Assembly of vault-like particles in insect cells expressing only the major vault protein

scientific article published on 10 May 2001

Axonal proteins involved in myelination: characterization of a collagen-like protein

scientific article published on 01 January 1997

Binding and internalization of lysosomal enzymes by primary cultures of rat glia

scientific article

Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery

scientific article

Butanedione treatment reduces receptor binding of a lysosomal enzyme to cells and membranes

scientific article published on 01 February 1980

Cation-independent mannose 6-phosphate receptor contains covalently bound fatty acid

scientific article published on 01 September 1988

Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit

scientific article published on June 1995

Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus

scientific journal article

Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.

scientific article published in November 2004

Development of the Vault Particle as a Platform Technology ⬇️

scientific article published on December 31, 2012

Direct demonstration of binding of a lysosomal enzyme, alpha-L-iduronidase, to receptors on cultured fibroblasts

scientific article published on May 1979

Draft Crystal Structure of the Vault Shell at 9-Å Resolution

scientific article

Dual pH- and Temperature-Responsive Protein Nanoparticles

scientific article

Encapsulation of semiconducting polymers in vault protein cages.

scientific article

Engineering of vault nanocapsules with enzymatic and fluorescent properties

scientific article

Evidence that an RGD-dependent receptor mediates the binding of oligodendrocytes to a novel ligand in a glial-derived matrix

scientific article

Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination

scientific article published on March 1994

Expression of multiple integrins and extracellular matrix components by C6 glioma cells

scientific article published on March 1992

Functional evidence for the role of axolemma in CNS myelination

scientific article published on 01 August 1994

Genetic evidence for transmembrane acetylation by lysosomes

scientific article published in September 1986

Glass micro-fibers: a model system for study of early events in myelination

scientific article published on 01 November 1990

Human kidney α-l-Iduronidase: Purification and characterization ⬇️

scientific article published on August 1, 1978

Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene

scientific article (publication date: 8 May 2003)

Immobilization of recombinant vault nanoparticles on solid substrates

scientific article published in March 2010

Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis

scientific article published in October 2005

Interaction of rat liver lysosomal membranes with actin

scientific article

Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways

scientific article published on June 1987

Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts

scientific article published on 01 May 1984

Movement of vault particles visualized by GFP-tagged major vault protein.

scientific article

Multidrug resistance: Locked in the vault? ⬇️

scientific article published on June 1, 1995

Myelination in cerebellar slice cultures: development of a system amenable to biochemical analysis

scientific article published on 01 December 1993

Nanobiology: particles slip cell security

scientific article published on 01 July 2008

Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth

scientific article

Nuclear localization of the major vault protein in U373 cells

scientific article published on 18 May 2005

Polyribosomes are molecular 3D nanoprinters that orchestrate the assembly of vault particles

scientific article

Preparative agarose gel electrophoresis for the purification of small organelles and particles

scientific article published on 01 July 1986

Properties of a partially-purified preparation of the prostaglandin-forming oxygenase from sheep vesicular gland

scientific article published in November 1975

RGD-containing peptides inhibit the synthesis of myelin-like membrane by cultured oligodendrocytes

scientific article published on October 1988

Recombinant major vault protein is targeted to neuritic tips of PC12 cells

scientific article

Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs

scientific article published on January 1996

Reversible pH lability of cross-linked vault nanocapsules

scientific article

Role of axonal components during myelination.

scientific article

Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility

scientific article published on 16 April 2007

Smart vaults: thermally-responsive protein nanocapsules

scientific article published on 10 January 2013

Stimulation of in vitro myelin synthesis by microglia

scientific article published on 01 August 1994

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

scientific article published on December 1975

Structural stability of vault particles

scientific article

Structure of the vault, a ubiquitous celular component.

scientific article

Subpopulations of liver coated vesicles resolved by preparative agarose gel electrophoresis

scientific article published on July 1986

Synthesis and assembly of human vault particles in yeast

scientific article published on 25 September 2018

Synthesis of a myelin-like membrane by oligodendrocytes in culture

scientific article published in January 1986

Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm

scientific article

Targeting vault nanoparticles to specific cell surface receptors

scientific article published on January 2009

The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle

scientific article

The sequence of a cDNA encoding the major vault protein from Rattus norvegicus

scientific article published in December 1994

The transport of lysosomal enzymes

scientific article published on 01 January 1977

The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior.

scientific article published on October 2006

Two species of lysosomal organelles in cultured human fibroblasts

scientific article published on May 1979

Unlocking vaults: organelles in search of a function

scientific article (publication date: August 1991)

Up-regulation of vaults may be necessary but not sufficient for multidrug resistance

scientific article

Utilization of a protein "shuttle" to load vault nanocapsules with gold probes and proteins

scientific article published in October 2009

Vault Nanocapsules as Adjuvants Favor Cell-Mediated over Antibody-Mediated Immune Responses following Immunization of Mice ⬇️

scientific article published on July 11, 2012

Vault Nanoparticles Packaged with Enzymes as an Efficient Pollutant Biodegradation Technology.

scientific article published on 23 October 2015

Vault nanocapsule dissociation into halves triggered at low pH.

scientific article

Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer

scientific article

Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake

scientific article

Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo

scientific article

Vaults and telomerase share a common subunit, TEP1

scientific article (publication date: 12 November 1999)

Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange

scientific article

Vaults are the answer, what is the question?

scientific article published in May 1996

Vaults are up-regulated in multidrug-resistant cancer cell lines

scientific article published in April 1998

Vaults engineered for hydrophobic drug delivery

scientific article published on 20 April 2011

Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes ⬇️

scientific article published on April 1, 1990

Vaults: large cytoplasmic RNP's that associate with cytoskeletal elements

scientific article published on January 1990

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