List of works - Natasha A Karp

A common control group - optimising the experiment design to maximise sensitivity

scientific article

A gene expression resource generated by genome-wide lacZ profiling in the mouse

scientific article

A high-throughput in vivo micronucleus assay for genome instability screening in mice

scientific article published on 31 December 2014

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization

scientific article published on 2 November 2017

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

scientific article published on 12 October 2017

A mouse informatics platform for phenotypic and translational discovery.

scientific article

A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic tumour case study

scientific article published on 10 April 2020

Addressing accuracy and precision issues in iTRAQ quantitation

scientific article published on 10 April 2010

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

scientific article published on 29 April 2016

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors

scientific article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics

article

Applying the ARRIVE Guidelines to an In Vivo Database

scientific article

Author Correction: Reproducibility of animal research in light of biological variation

scientific article published on 08 June 2020

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

scientific article published on 6 September 2017

Comparison of DIGE and post-stained gel electrophoresis with both traditional and SameSpots analysis for quantitative proteomics

article

DNA microarray normalization methods can remove bias from differential protein expression analysis of 2D difference gel electrophoresis results.

scientific article published on 25 March 2004

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome

scientific article

Design and analysis issues in quantitative proteomics studies

scientific article published on September 2007

Determining a significant change in protein expression with DeCyder during a pair-wise comparison using two-dimensional difference gel electrophoresis

scientific article published in May 2004

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

scientific article published on 26 June 2017

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia

scientific article published on 12 August 2014

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts

scientific article published on 07 March 2019

Evaluating and Optimizing Fish Health and Welfare During Experimental Procedures

scientific article published on 25 February 2016

Experimental and Statistical Considerations to Avoid False Conclusions in Proteomics Studies Using Differential In-gel Electrophoresis

scientific article published on 17 May 2007

Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests

scientific article

Gel-Based Proteomics Approach to the Study of Metabolic Changes in Pear Tissue during Storage

scientific article published on 01 August 2009

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation

scientific article published on 12 September 2017

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

scientific article

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

scientific article published on 4 January 2017

Glucocorticoid signaling synchronizes the liver circadian transcriptome

scientific article published on 01 June 2007

High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.

scientific article published on 28 May 2013

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

scientific article (publication date: May 2014)

IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.

scientific article

Identification of clock genes using difference gel electrophoresis

scientific article

Identification of genes required for eye development by high-throughput screening of mouse knockouts

scientific article published on 21 December 2018

Impact of replicate types on proteomic expression analysis

scientific article published in September 2005

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies

scientific article

Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics

scientific article published on 07 December 2016

Investigating sample pooling strategies for DIGE experiments to address biological variability

scientific article

Maximising sensitivity for detecting changes in protein expression: Experimental design using minimal CyDyes

scientific article published on 01 August 2005

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project

scientific article

Optimising experimental design for high-throughput phenotyping in mice: a case study

scientific article

Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response

scientific article published on 31 October 2018

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data

scientific article

Prevalence of sexual dimorphism in mammalian phenotypic traits

scientific article

Protein profiling of human postmortem brain using 2-dimensional fluorescence difference gel electrophoresis (2-D DIGE).

scientific article published in February 2004

Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock

scientific article published on 12 November 2009

Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines

scientific article

Reply to 'It is time for an empirically informed paradigm shift in animal research'

scientific article published on 21 August 2020

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

scientific article published on 14 July 2020

Reporting phenotypes in mouse models when considering body size as a potential confounder

scientific article

Reproducibility of animal research in light of biological variation

scientific article published on 02 June 2020

Reproducible preclinical research-Is embracing variability the answer?

scientific article published on 5 March 2018

Revision of the ARRIVE guidelines: rationale and scope

scientific article published in June 2018

Robust and sensitive analysis of mouse knockout phenotypes

scientific article

Sex bias in preclinical research and an exploration of how to change the status quo

article

Sex differences and sex bias in human circadian and sleep physiology research

scientific article published on 18 February 2022

Standardized Welfare Terms for the Zebrafish Community

scientific article published on 20 April 2016

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

scientific article

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

scientific article published on 14 July 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

scientific article published on 15 July 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

scientific article published on 14 July 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

scientific article published on 20 July 2020

The Experimental Design Assistant

scientific article published on 28 September 2017

The Experimental Design Assistant

scientific article published on 29 September 2017

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

scientific article

The fallacy of ratio correction to address confounding factors

scientific article

The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice

scientific article

List of works by Natasha A Karp

A common control group - optimising the experiment design to maximise sensitivity

A gene expression resource generated by genome-wide lacZ profiling in the mouse

A high-throughput in vivo micronucleus assay for genome instability screening in mice

A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

A mouse informatics platform for phenotypic and translational discovery.

A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic tumour case study

Addressing accuracy and precision issues in iTRAQ quantitation

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics

Applying the ARRIVE Guidelines to an In Vivo Database

Author Correction: Reproducibility of animal research in light of biological variation

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

Comparison of DIGE and post-stained gel electrophoresis with both traditional and SameSpots analysis for quantitative proteomics

DNA microarray normalization methods can remove bias from differential protein expression analysis of 2D difference gel electrophoresis results.

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome

Design and analysis issues in quantitative proteomics studies

Determining a significant change in protein expression with DeCyder during a pair-wise comparison using two-dimensional difference gel electrophoresis

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts

Evaluating and Optimizing Fish Health and Welfare During Experimental Procedures

Experimental and Statistical Considerations to Avoid False Conclusions in Proteomics Studies Using Differential In-gel Electrophoresis

Experimental and husbandry procedures as potential modifiers of the results of phenotyping tests

Gel-Based Proteomics Approach to the Study of Metabolic Changes in Pear Tissue during Storage

Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Glucocorticoid signaling synchronizes the liver circadian transcriptome

High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.

Identification of clock genes using difference gel electrophoresis

Identification of genes required for eye development by high-throughput screening of mouse knockouts

Impact of replicate types on proteomic expression analysis

Impact of temporal variation on design and analysis of mouse knockout phenotyping studies

Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics

Investigating sample pooling strategies for DIGE experiments to address biological variability

Maximising sensitivity for detecting changes in protein expression: Experimental design using minimal CyDyes

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project

Optimising experimental design for high-throughput phenotyping in mice: a case study

Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data

Prevalence of sexual dimorphism in mammalian phenotypic traits

Protein profiling of human postmortem brain using 2-dimensional fluorescence difference gel electrophoresis (2-D DIGE).

Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock

Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines

Reply to 'It is time for an empirically informed paradigm shift in animal research'

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

Reporting phenotypes in mouse models when considering body size as a potential confounder

Reproducibility of animal research in light of biological variation

Reproducible preclinical research-Is embracing variability the answer?

Revision of the ARRIVE guidelines: rationale and scope

Robust and sensitive analysis of mouse knockout phenotypes

Sex bias in preclinical research and an exploration of how to change the status quo

Sex differences and sex bias in human circadian and sleep physiology research

Sex differences and sex bias in human circadian and sleep physiology research

Standardized Welfare Terms for the Zebrafish Community

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

The Experimental Design Assistant

The Experimental Design Assistant

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

The fallacy of ratio correction to address confounding factors

The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice