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List of works by Stephen High

A biochemical analysis of the constraints of tail-anchored protein biogenesis.

scientific article published on June 2011

A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase

scientific article published on November 2004

A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum

scientific article published on 29 July 2008

Active and passive displacement of transmembrane domains both occur during opsin biogenesis at the Sec61 translocon

scientific article published on 01 July 2006

BAG6 regulates the quality control of a polytopic ERAD substrate

scientific article published on 7 May 2014

Bat3 promotes the membrane integration of tail-anchored proteins

scientific article published on June 2010

Binding of SGTA to Rpn13 selectively modulates protein quality control

scientific article published on 13 July 2015

Biogenesis of tail-anchored proteins: the beginning for the end?

scientific article published on October 2009

Biosynthesis of the dystonia-associated AAA+ ATPase torsinA at the endoplasmic reticulum

scientific article

Ca2+-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane.

scientific article published on 12 October 2011

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

scientific article

Characterizing the selectivity of ER α-glucosidase inhibitors.

scientific article published in July 2019

Chloroplast SRP54 interacts with a specific subset of thylakoid precursor proteins

scientific article published on 01 April 1997

Delivering proteins for export from the cytosol

scientific article published on April 2009

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

scientific article published on 3 December 2012

Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein

scientific article published on 13 October 2009

Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein

scientific article published on December 2002

Discrete cross-linking products identified during membrane protein biosynthesis

scientific article published on 01 January 1997

Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum.

scientific article

Dissecting the physiological role of selective transmembrane-segment retention at the ER translocon

scientific article published on 5 May 2009

EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP.

scientific article published on 4 February 2011

ER targeting signals: more than meets the eye?

scientific article published on 01 December 2006

ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin

scientific article

Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p

scientific article

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

scientific article

Editorial Overview: Elucidation of Protein Translocation Pathways, Part II

scholarly article by Dejana Mokranjac published in March 2015

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways

scientific article

Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca Leakage from the Endoplasmic Reticulum

scientific article published on 21 February 2019

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

scientific article

Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases

scientific article

Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein

scientific article published on December 2009

Formation and turnover of NSF- and SNAP-containing "fusion" complexes occur on undocked, clathrin-coated vesicle-derived membranes

scientific article

Genetic variants of human red-cell membrane sialoglycoprotein beta. Study of the alterations occurring in the sialoglycoprotein-beta gene

scientific article published on March 1988

Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked

scientific article published on 30 November 2012

Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?

scientific article published in June 2000

Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages

scientific article

Human erythrocyte membrane sialoglycoprotein beta. The cDNA sequence suggests the absence of a cleaved N-terminal signal sequence

scientific article published on April 1987

In vitro characterisation of the interaction between newly synthesised proteins and a pancreatic isoform of protein disulphide isomerase

scientific article published on 01 March 1998

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

scientific article published on March 2012

Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins

scientific article published on January 1997

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

scientific article published on 15 May 2019

Ipomoeassin-F inhibits the <i>in vitro</i> biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

scientific article published on 24 November 2020

Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase

scientific article published on 20 January 2012

Making membrane proteins at the mammalian endoplasmic reticulum

scientific article published on December 2003

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

scientific article

Mechanisms that determine the transmembrane disposition of proteins

scientific article

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.

scientific article published on 11 February 2016

Membrane association, localization and topology of rat inositol 1,4,5-trisphosphate 3-kinase B: implications for membrane traffic and Ca2+ homoeostasis.

scientific article published on June 1997

Membrane integration of Sec61α: a core component of the endoplasmic reticulum translocation complex ⬇️

scientific article published on April 1, 1998

Membrane protein biosynthesis - all sewn up?

scientific article published on 01 May 1997

Membrane protein chaperones: a new twist in the tail?

scientific article published on 01 June 2007

Membrane protein insertion into the endoplasmic reticulum--another channel tunnel?

scientific article published on August 1, 1992

Membrane protein topology of oleosin is constrained by its long hydrophobic domain

scientific article published on 22 October 2001

Membrane translocation at the ER: with a little help from my friends

scientific article published on 16 April 2020

Membrane-protein biosynthesis at the endoplasmic reticulum

scientific article

Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.

scientific article

Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins

scientific article published on 11 October 2017

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis.

scientific article published on 20 February 2017

OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation

scientific journal article

On the road to nowhere: cross-talk between post-translational protein targeting and cytosolic quality control.

scientific article

Polytopic membrane protein folding and assembly in vitro and in vivo

scientific article published on May 2004

Polytopic proteins: preventing aggregation in the membrane

scientific article

Positional editing of transmembrane domains during ion channel assembly

scientific article published on 10 December 2012

Post-translational integration of tail-anchored proteins is facilitated by defined molecular chaperones

scientific article published on 24 April 2007

Post-translational translocation into the endoplasmic reticulum

scientific article published on 20 December 2012

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle

scientific article published on 30 September 2020

Protein targeting and translocation at the endoplasmic reticulum membrane--through the eye of a needle?

scientific article

Protein translocation across membranes: common themes in divergent organisms

scientific article published on 01 October 1993

Protein translocation at the membrane of the endoplasmic reticulum.

scientific article published on January 1995

Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.

scientific article published on December 2013

Requirements for the membrane insertion of signal-anchor type proteins

scientific article published on April 1991

Ribophorin I acts as a substrate-specific facilitator of N-glycosylation

scientific article

Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core

scientific article

Role of calnexin in the glycan-independent quality control of proteolipid protein

scientific article

SGTA antagonizes BAG6-mediated protein triage

scientific journal article

SGTA associates with nascent membrane protein precursors

scientific article published on 25 March 2020

SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.

scientific article published on 9 November 2016

SGTA regulates the cytosolic quality control of hydrophobic substrates

scientific article published on September 2014

SMIM1, carrier of the Vel blood group, is a tail-anchored transmembrane protein and readily forms homodimers in a cell-free system

scientific article published on 17 April 2020

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

scientific article published on 14 August 2018

Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion.

scientific article published on May 1993

Signal recognition particle mediates post-translational targeting in eukaryotes

scientific article

Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex

scientific article published in Nature

Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A

scientific article

Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis

scientific article published on 01 May 2008

Structural and functional insights into the E3 ligase, RNF126.

scientific article

Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.

scientific article published on 11 July 2018

Structure and function of signal recognition particle (SRP).

scientific article published on January 1990

Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins ⬇️

scientific article published on January 7, 2013

Studying endoplasmic reticulum function in vitro using siRNA.

scientific article published in January 2010

TRC40 can deliver short secretory proteins to the Sec61 translocon

scientific article

Tail-anchored and signal-anchored proteins utilize overlapping pathways during membrane insertion

scientific article published on 02 December 2002

Tail-anchored protein biosynthesis at the endoplasmic reticulum: the same but different.

scientific article published in November 2004

The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein

scientific article

The Escherichia coli SRP and SecB targeting pathways converge at the translocon

scientific article published on May 1998

The Sec61 complex is essential for the insertion of proteins into the membrane of the endoplasmic reticulum

scientific article published on 01 April 1995

The association of BAG6 with SGTA and tail-anchored proteins

scientific article

The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence

scientific article published on December 1988

The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER.

scientific article published in April 1991

The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences ⬇️

scientific article published on April 1, 1992

The oligomeric state of Derlin-1 is modulated by endoplasmic reticulum stress

scientific article

The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation

scientific journal article

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER

scientific article (publication date: April 2014)

The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association

scientific article published on 10 February 2004

The signal sequence influences post-translational ER translocation at distinct stages

scientific article

The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle

scientific article published on April 1991

The thiol-dependent reductase ERp57 interacts specifically with N-glycosylated integral membrane proteins

scientific article published on 01 May 1997

The transient association of ERp57 with N-glycosylated proteins is regulated by glucose trimming

scientific article published on August 1998

The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells

scientific article published on May 1995

The use of tail-anchored protein chimeras to enhance liposomal cargo delivery

scientific article published on 22 February 2019

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