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List of works by Søren Kragh Moestrup

2. Receptors in HDL metabolism

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

scientific article published on May 2017

A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis.

scientific article published on 21 June 2016

A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans

scientific article

A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II.

scientific article

A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex

scientific article published on 13 November 2006

Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers

scientific article

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo

scientific article published on 21 April 2005

Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein

scientific article

Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats

scientific article published on June 2016

Anti-CD163-dexamethasone protects against apoptosis after ischemia/reperfusion injuries in the rat liver

scientific article

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model.

scientific article published on September 2016

Anti-inflammatory liposomes have no impact on liver regeneration in rats

scientific article

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes

scientific article published on 24 December 2016

Application of a fluorescent cobalamin analogue for analysis of the binding kinetics

scientific article published on 19 September 2006

Assembly of the Intrinsic Factor Domains and Oligomerization of the Protein in the Presence of Cobalamin†

scientific article published on 01 November 2004

Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis

scientific article

Binding and Endocytosis of Proteins Mediated by Epithelial gp330

scientific article published on 01 September 1994

Binding and receptor-mediated endocytosis of pregnancy zone protein-proteinase complex in rat macrophages

scientific article published on 01 October 1987

Biodistribution and PET imaging of a novel [68Ga]-anti-CD163-antibody conjugate in rats with collagen-induced arthritis and in controls

scientific article published in February 2015

CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects ⬇️

scientific article published on October 19, 2012

CD163 binding to haptoglobin-hemoglobin complexes involves a dual-point electrostatic receptor-ligand pairing

scientific article published on 13 May 2013

CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes.

scientific article

CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response

scientific article

CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response.

scientific article

CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma

scientific article

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.

scientific article

Changes in fat mass correlate with changes in soluble sCD163, a marker of mature macrophages, in patients with CKD.

scientific article published in December 2006

Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin

scientific article

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation

scientific journal article

Characterization of an enzyme-linked immunosorbent assay for soluble CD163

scientific article published on 01 January 2002

Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein

scientific article

Characterization, size estimation and solubilization of alpha-macroglobulin complex receptors in liver membranes

scientific article published in April 1989

Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.

scientific article

Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression.

scientific article published on 22 February 2011

Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor

scientific article

Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex

scientific article published on 23 June 2005

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

scientific article

Cubilin, a high-density lipoprotein receptor

scientific article

Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.

scientific article published in October 2000

Decreased Expression of Megalin and Cubilin and Altered Mitochondrial Activity in Tenofovir Nephrotoxicity

scientific article published on 5 January 2018

Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion

scientific article published on 22 December 2014

Differential expression of monocyte CD163 in single ? and dual-asthmatic responders during allergen-induced bronchoconstriction

scientific article published on 01 December 2006

Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

scientific article published in September 1992

Dominant Thermodynamic Role of the Third Independent Receptor Binding Site in the Receptor-Associated Protein RAP†

scientific article published on 01 December 2001

Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.

scientific article published on 24 May 2007

Drug Trafficking into Macrophages via the Endocytotic Receptor CD163.

scientific article published on 23 June 2015

Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice

scientific article published in May 2008

Effects of glycosylation on the structure and function of the extracellular chaperone clusterin

scientific article published on February 2007

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

scientific article published on 27 January 2012

Electron Microscopic Visualization of the Human ?2-Macroglobulin Receptor and Its Interaction with ?2-Macroglobulin/Chymotrypsin Complex

scientific article published on 01 September 1994

Evidence for binding of human pregnancy zone protein-proteinase complex to α2-macroglobulin receptors

scientific article published on 01 October 1986

Evidence for the Role of Megalin in Renal Uptake of Transthyretin

scientific article published in Journal of Biological Chemistry

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor

scientific article published in December 1990

Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.

scientific article

Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163.

scientific article

Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes

scientific article

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

scientific article published on 16 March 2006

Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.

scientific article

Haptoglobin.

scientific article published on 21 September 2016

Haptoglobin: the hemoglobin detoxifier in plasma

scientific article published on 07 November 2012

Hemoglobin and heme scavenger receptors.

scientific article published on February 2010

Hemoglobin is a co-factor of human trypanosome lytic factor

scientific article published on 28 September 2007

High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy

scientific article

How calcium makes endocytic receptors attractive

scientific article published on 04 January 2014

Human intrinsic factor expressed in the plant Arabidopsis thaliana

scientific article

Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin.

scientific article published on 6 November 2009

Identification of the haemoglobin scavenger receptor.

scientific article

Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma

scientific article published on 01 January 2002

Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP.

scientific article published in July 2000

Identification of the receptor scavenging hemopexin-heme complexes

scientific article published on 9 June 2005

Immunocytochemical identification of the human alpha 2-macroglobulin receptor in monocytes and fibroblasts: monoclonal antibodies define the receptor as a monocyte differentiation antigen

scientific article published on October 1990

Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain

scientific article published in January 1993

Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin

article

Interactions between cytokines and α2 macroglobulin

scientific article published on 01 December 1990

Is classical pseudoxanthoma elasticum a consequence of hepatic ‘intoxication’ due to ABCC6 substrate accumulation in the liver?

scientific article published on 01 January 2013

Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS

scientific article published on 14 May 2011

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

scientific article published on 19 February 2008

Lipid metabolism: an apolipoprotein-derived weapon combating trypanosoma infection

scientific article published on December 2006

Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF).

scientific article

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163*

scientific article published on 01 October 2006

Mechanism of Trypanosoma brucei gambiense resistance to human serum

scientific article

Megalin antagonizes activation of the parathyroid hormone receptor.

scientific article

Megalin binds and mediates cellular internalization of folate binding protein

scientific article published in September 2005

Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.

scientific article published on 11 August 2005

Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia

scientific article

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

scientific article

Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family

scientific article

Molecular Dissection of the Intrinsic Factor-Vitamin B12Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding

scientific article published in Journal of Biological Chemistry

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein

scientific article

Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.

scientific article published on 24 September 2004

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

scientific article

Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4.

scientific article published on January 2010

New immunological serum markers in bacteraemia: anti-inflammatory soluble CD163, but not proinflammatory high mobility group-box 1 protein, is related to prognosis

article

New insights into carrier binding and epithelial uptake of the erythropoietic nutrients cobalamin and folate

scientific article

Obesity alters adipose tissue macrophage iron content and tissue iron distribution.

scientific article published on 15 October 2013

Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals

scientific article published on 28 June 2016

Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption

scientific article published on 29 August 2012

Plasma level of the macrophage-derived soluble CD163 is increased and positively correlates with severity in Gaucher's disease.

scientific article published in February 2004

Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients

scientific article published on 01 September 2005

Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery

scientific article published on 01 June 2005

Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding

scientific article

Purification of the human placental α2 -macroglobulin receptor

scientific article published on 01 September 1989

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging

scientific article published on 20 April 2009

Receptor-binding domain of human alpha 2-macroglobulin. Expression, folding and biochemical characterization of a high-affinity recombinant derivative.

scientific article

Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes

scientific article published on February 1994

Receptors for alpha 2-macroglobulin- and pregnancy zone protein-proteinase complexes in the human placental syncytiotrophoblast.

scientific article published in September 1988

Recombinant ?2M Receptor Binding Domain Binds to the ?2M Receptor with High Affinity

scientific article published on 01 September 1994

Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ

scientific article published on 8 December 2015

Serum Soluble CD163 Predicts Risk of Type 2 Diabetes in the General Population

scientific article published on 24 November 2010

Serum markers of macrophage activation in pre-eclampsia: no predictive value of soluble CD163 and neopterin

scientific article published on 01 January 2007

Soluble CD163 and interleukin-6 are increased in aqueous humour from patients with endothelial rejection of corneal grafts

scientific article published on 01 April 2005

Soluble CD163 levels in children with sickle cell disease

scientific article published on 20 February 2011

Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection

scientific article published on March 2017

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma

scientific article published on 13 January 2017

Soluble haemoglobin scavenger receptor (sCD163) in patients with suspected community-acquired infections

scientific article published on 01 February 2006

Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

scientific article published in January 2005

Soluble macrophage-derived CD163: a homogenous ectodomain protein with a dissociable haptoglobin-hemoglobin binding

scientific article published on 5 July 2009

Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes

scientific journal article

Specific Binding of α-Macroglobulin to Complement-Type Repeat CR4 of the Low-Density Lipoprotein Receptor-Related Protein†

scientific article published on 01 September 2000

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression

scientific article published on 02 August 2019

Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.

scientific article published in November 2002

Standardizing scavenger receptor nomenclature

scientific article

Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages

scientific article published on 25 November 2013

Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes

scientific article

Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system

scientific article

Structure of the haptoglobin-haemoglobin complex

scientific article

Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain.

scientific article

Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells

scientific article published on 01 January 1992

Targeting dexamethasone to macrophages in a porcine endotoxemic model

scientific article published in November 2013

Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone.

scientific article

The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen.

scientific article published on 28 September 2016

The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes

scientific article published in January 2017

The alpha 2-macroglobulin receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands

scientific article

The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin

scientific article

The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis

scientific article published on 27 June 2010

The conserved scavenger receptor cysteine-rich superfamily in therapy and diagnosis

scientific article

The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake

scientific journal article

The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

scientific article

The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging

scientific article

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.

scientific article

The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.

scientific article

The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor

scientific article published on 12 March 2007

The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants.

scientific article

The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis

scientific article published on 23 June 2005

The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.

scientific article published in September 1994

The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition

scientific article

Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions

scientific article published on 2 April 2016

Trimerization of apolipoprotein A-I retards plasma clearance and preserves antiatherosclerotic properties

scientific article published on February 2008

Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163.

scientific article published on 31 August 2010

Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells

scientific article published on 28 March 2012

Untargeted Metabolomics Analysis of ABCC6-Deficient Mice Discloses an Altered Metabolic Liver Profile

scientific article published on 19 October 2016

Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway

scientific article published on May 2012

Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: biological and clinical implications

scientific article published on 21 September 2006

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