List of works by Ken J. Ishii

'Toll' gates for future immunotherapy

scientific article published on January 2006

A Polysaccharide Carrier to Effectively Deliver Native Phosphodiester CpG DNA to Antigen-Presenting Cells

article

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

scientific article

A critical role of IL-33 in experimental allergic rhinitis

scholarly article by Yoko Haenuki et al published July 2012 in The Journal of Allergy and Clinical Immunology

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

scientific article

A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.

scientific article published on 27 April 2011

A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests

scientific article published on 4 January 2017

Activity and safety of DNA plasmids encoding IL-4 and IFN gamma

scientific article published in February 1999

Adjuvants in influenza vaccines

scientific article published on 19 October 2012

Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

scientific article published on December 2016

Age-Specific Profiles of Antibody Responses against Respiratory Syncytial Virus Infection

scientific article

Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) enhanced inflammatory cytokine productions

scientific article published on 13 April 2012

Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children

scientific article published on 24 October 2012

An Antigen-Free, Plasmacytoid Dendritic Cell-Targeting Immunotherapy To Bolster Memory CD8+ T Cells in Nonhuman Primates.

scientific article published on 5 February 2018

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

scientific article

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant

scientific article published on 21 May 2019

Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner

scientific article

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

scientific article published on 18 March 2014

CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8+ T Cell Responses.

scientific article

Characteristic of K3 (CpG-ODN) as a Transcutaneous Vaccine Formulation Adjuvant

scientific article published on 15 March 2020

Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells

scientific article published on July 2016

Clinical development of malaria vaccine

article

Combination and inducible adjuvants targeting nucleic acid sensors

scientific article published on 02 June 2018

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

scientific article published on 13 February 2012

Contribution of interferon-beta to the immune activation induced by double-stranded DNA.

scientific article

Contribution of nitric oxide to CpG-mediated protection against Listeria monocytogenes

scientific article published on June 2005

CpG DNA: recognition by and activation of monocytes

scientific article

CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection.

scientific article

CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression

scientific article

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody

scientific article

CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection.

scientific article published in August 2005

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis

scientific article published on 23 March 2016

Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation.

scientific article published on 11 March 2016

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

scientific article published on 26 June 2015

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor

scientific article published on 26 September 2019

DNA Vaccine: Does it Target the Double Stranded-DNA Sensing Pathway?

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

scientific article published on 6 February 2013

DNA released from dying host cells mediates aluminum adjuvant activity

scholarly article by Thomas Marichal et al published 17 July 2011 in Nature Medicine

DNA vaccines: a simple DNA sensing matter?

scientific article

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

scientific article published on 9 January 2017

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

scientific article published on 9 July 2006

Development and application of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine

scientific article published on January 2013

Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use.

scientific article

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

scientific article (publication date: 4 May 2006)

Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis

scientific article published on 01 October 2014

Effect of CpG oligodeoxynucleotides on the immunogenicity of Pfs25, a Plasmodium falciparum transmission-blocking vaccine antigen

scientific article

Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors

scientific article published on 16 June 2005

Efficient antigen delivery to the draining lymph nodes is a key component in the immunogenic pathway of the intradermal vaccine

scientific article published on 22 November 2015

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency

scientific article

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

scientific article published in February 2018

Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum.

scientific article published on 22 November 2014

Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

scholarly article published in Nature Immunology

Essential Role of CARD14 in Murine Experimental Psoriasis

scientific article published on 17 November 2017

Essential role of IPS-1 in innate immune responses against RNA viruses

scientific article published on 19 June 2006

Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36.

scientific article published on 20 May 2010

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

scientific article published on March 2010

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance

scientific article published on 6 May 2016

Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.

scientific article

Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid

scientific article published on 8 February 2011

Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis.

scientific article

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells

scientific article

Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine.

scientific article published on 6 August 2014

Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets

scientific article published on 8 April 2014

Heparin induces neutrophil elastase dependent vital and lytic NET formation

scientific article published on 27 December 2019

High-dose cutaneous exposure to mite allergen induces IgG-mediated protection against anaphylaxis

scientific article

Host innate immune receptors and beyond: making sense of microbial infections

scientific article

Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon

Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.

scientific article

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

scientific article

Immune interventions of human diseases through toll-like receptors

scientific article published on January 2009

Immune recognition of foreign DNA: a cure for bioterrorism?

scientific article

Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs

scientific article

Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

scientific article published in January 2010

In vitro marker gene expression analyses in human peripheral blood mononuclear cells: A tool to assess safety of influenza vaccines in humans.

scientific article published in December 2018

Induction of humoral and cellular immune response to hepatitis B virus (HBV) vaccine can be upregulated by CpG oligonucleotides complexed with Dectin-1 ligand.

scientific article published on 3 November 2016

Induction of humoural and cellular immunity by immunisation with HCV particle vaccine in a non-human primate model.

scientific article

Induction of type I interferon by adenovirus-encoded small RNAs

scientific article

Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo

scientific article published on 3 July 2017

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

scholarly article by Rainald A. Zeuner et al published June 2003 in Arthritis and Rheumatism

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation

scientific article published in December 2016

Innate and adaptive immune responses to viral infection and vaccination

scientific article published on 30 July 2011

Innate immune control of nucleic acid-based vaccine immunogenicity

scientific article published on August 2009

Innate immune recognition of nucleic acids: beyond toll-like receptors

scientific article

Innate immune recognition of, and regulation by, DNA.

scientific article published on 18 September 2006

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

scientific article published on 11 December 2013

Innate immune response to viral infection

scientific article published on 09 August 2008

Innate immunity

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

scientific journal article

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

scientific article

Intracellular DNA sensors in immunity

scientific article published on 23 June 2008

Intranasal hydroxypropyl-β-cyclodextrin-adjuvanted influenza vaccine protects against sub-heterologous virus infection

scientific article

Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice

scientific article published on 8 April 2009

Intranasal vaccination with pneumococcal surface protein A plus poly(I:C) protects against secondary pneumococcal pneumonia in mice

article by Hirokazu Ezoe et al published February 2011 in Vaccine

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

scientific article published on June 2016

Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism

scientific article published in November 2012

Manifold mechanisms of Toll-like receptor-ligand recognition

scientific article

Manipulation of host innate immune responses by the malaria parasite

scientific article published on 26 April 2007

Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice

scientific article published on 30 May 2016

Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.

scientific article published on 3 February 2016

Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells

scientific article published on 27 January 2011

NLRP4 negatively regulates autophagic processes through an association with beclin1.

scientific article published on 5 January 2011

Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

scientific article published in 2022

Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

scientific article

Novel strategies to improve DNA vaccine immunogenicity

scientific article published on December 2011

Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

scientific article published on 22 June 2012

Nucleic acid sensing by T cells initiates Th2 cell differentiation

scientific article published on 10 April 2014

Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria

scientific article published on May 2014

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner.

scientific article published on 19 March 2018

Optimization of physiological properties of hydroxyapatite as a vaccine adjuvant

scholarly article by Masayuki Hayashi et al published January 2016 in Vaccine

Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects

scientific article published on April 2013

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

scientific article published on 21 September 2014

Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36.

scientific article

Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes

scientific article published in March 2010

Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate

scientific article published on 28 June 2011

Plasmodium products persist in the bone marrow and promote chronic bone loss.

scientific article

Potential link between the immune system and metabolism of nucleic acids

scientific article published on 06 August 2008

Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

scientific article

Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor

scientific article published in November 1999

Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis

scientific article

Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences.

scientific article

Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice

scientific article published on 12 August 2014

Prothymosin-alpha preconditioning activates TLR4-TRIF signaling to induce protection of ischemic retina

scientific article published on 14 September 2015

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

scholarly article by Seiki Fujiwara et al published 19 November 2018 in Nature Microbiology

Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine

scientific article

Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data

scientific article published on 9 October 2017

RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma

scientific article

RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine

scientific article published on 04 July 2016

RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression

scientific article

Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination

scientific article

Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides

scholarly article by Rainald A. Zeuner et al published August 2002 in Arthritis and Rheumatism

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

scientific article published on 30 May 2008

Requirement for memory B-cell activation in protection from heterologous influenza virus reinfection

scientific article published on 01 November 2019

Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides

article

Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia

scientific article published on 13 May 2013

Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage

scientific article published on 23 May 2013

Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors

STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques

article

Screening of posttranscriptional regulatory molecules of IκB-ζ.

scientific article published on 19 December 2015

Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivax

scientific article

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

scientific journal article

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

article

Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan

scientific article published on 19 January 2016

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

scholarly article by Li Dong et al published February 2005 in Arthritis and Rheumatism

Suppressive oligodeoxynucleotides inhibit CpG-induced inflammation of the mouse lung

scientific article

Suppressive oligonucleotides protect against collagen-induced arthritis in mice

scientific article

Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier

scientific article published on September 2006

System vaccinology for the evaluation of influenza vaccine safety by multiplex gene detection of novel biomarkers in a preclinical study and batch release test.

scientific article

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector

scientific article published on 20 October 2015

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

scientific article published in Nature

TLR ignores methylated RNA?

scientific article

TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models

scientific article published on 04 January 2013

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.

scientific article

TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

scientific article published on July 2010

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF

scientific article

The Atg5 Atg12 conjugate associates with innate antiviral immune responses

scholarly article

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant

scientific article

The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector

scientific article

The malarial metabolite hemozoin and its potential use as a vaccine adjuvant

scientific article published on 24 April 2010

Therapeutic targeting of Toll-like receptors

Toll or toll-free adjuvant path toward the optimal vaccine development

scientific article published on 17 March 2007

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

scientific article published on January 2005

Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity

scientific article

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

article

Vaccine adjuvants as potential cancer immunotherapeutics

scientific article

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