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List of works by Charles E de Bock

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

scientific article published on 28 June 2018

A mitochondrial brake on vascular repair

scientific article published in Nature

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding

scientific article published in 2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

scientific article published on 9 October 2014

Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo

scientific article published on 08 June 2010

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

scientific article

Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer

scientific article published on January 2004

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

scientific article published on 20 November 2017

Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products

scientific article

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress.

scientific article

Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033.

scientific article

Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing

scientific journal article

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.

scientific article

FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue

scientific article

Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia

scientific article published on 20 February 2013

Furin processing dictates ectodomain shedding of human FAT1 cadherin

scientific article published on 18 February 2014

Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes—expression of extracellular matrix genes and its implications for tendon-healing

article

Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing

scientific article published on 8 March 2016

HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.

scientific article published in March 2018

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

scientific article

Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells

scientific article published on July 2005

Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion.

scientific article published on May 2010

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

scientific article (publication date: 5 September 2014)

JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

scientific article published on 04 April 2018

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma

scientific article

Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III beta-tubulin levels

scientific article published on 18 December 2007

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.

scientific article published on 30 August 2017

Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

scientific article published on 29 November 2017

Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome

scientific article

Novel protein interactors of urokinase-type plasminogen activator receptor

scientific article

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

scientific article published on 06 July 2021

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

scientific article published on January 2013

Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum

scientific article published on 13 July 2010

Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels

scientific article published on 27 January 2017

Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia

scientific article published on 16 October 2020

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

scientific article published on 08 April 2020

Sleeping giants: emerging roles for the fat cadherins in health and disease

scientific article

T-ALL: Home Is where the CXCL12 Is.

scientific article published in June 2015

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

scientific article published on 04 December 2018

The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia

scientific article

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

scientific article published on 21 August 2020

The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line

scientific article published in March 2002

Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.

scientific article published in August 2008

miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense

scientific article

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