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List of works by David J. Waxman

1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levels

scientific article published on 01 September 1994

17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement

scientific article published in May 1986

3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.

scientific article

44 P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography

scientific article published on January 1, 1991

7 in vitro methods for evaluation of p450-based anticancer gene therapy

scientific article published in January 2000

8 tumor models for evaluation of p450 gene therapy in vivo

scientific article published in January 2000

A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition

article

Activation of PPARalpha and PPARgamma by environmental phthalate monoesters

scientific article (publication date: August 2003)

Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer

scientific article

Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids

scientific article

Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes

scientific article published on 01 April 1993

Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics

scientific article published in May 2004

Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+

scientific article

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression.

scientific article published in August 1988

Amino acid sequence homologies between Escherichia coli penicillin-binding protein 5 and class a β-lactamases

scientific article published on 01 March 1982

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

scholarly article

An isocratic high-performance liquid chromatographic assay for CYP7A1-catalyzed cholesterol 7 alpha-hydroxylation

scientific article published on 01 January 1998

An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7alpha-hydroxylation

scientific article published on 01 January 2006

Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1)

scientific article published on May 1989

Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2

scientific article published on 26 June 2014

Antiangiogenesis enhances intratumoral drug retention

scientific article published on 29 March 2011

Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2.

scientific article

Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism

scientific article

Antitumor alkylating agents: in vitro cross-resistance and collateral sensitivity studies

scientific article published on January 1993

Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene

scientific article published on 27 October 2005

CYP2C19-Mediated ( S)-Mephenytoin 4'-Hydroxylation Assayed by High-Performance Liquid Chromatography With Radiometric Detection

scientific article published on 01 January 2006

CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection

scientific article published on 01 January 1998

CYP2D6-Dependent Bufuralol 1'-Hydroxylation Assayed by Reverse-Phase Ion-Pair High-Performance Liquid Chromatography With Fluorescence Detection

article

CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection

scientific article published on 01 January 1998

Cancer chemotherapy and drug metabolism.

scientific article published in August 2005

Catalytic Assays for Human Cytochrome P450: An Introduction

scientific article published on 01 January 2006

Catalytic assays for human cytochrome P450

scientific article published on 01 January 1998

Cephalosporin-sensitive penicillin-binding proteins of Staphylococcus aureus and Bacillus subtilis active in the conversion of [14C]penicillin G to [14C]phenylacetylglycine

scientific article published on December 1979

Changes in Cytochromes P-450, 2E1, 2B1, and 4A, and Phospholipases A and C in the Intragastric Feeding Rat Model for Alcoholic Liver Disease: Relationship to Dietary Fats and Pathologic Liver Injury

article

Changes in Microsomal Phospholipases and Arachidonic Acid in Experimental Alcoholic Liver Injury: Relationship to Cytochrome P-450 2E1 Induction and Conjugated Diene Formation

article

Changes in mouse uterine transcriptome in estrus and proestrus

scientific article

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism

scientific article published in Journal of Biological Chemistry

Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver

scientific journal article

Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome

scientific article

Child health, developmental plasticity, and epigenetic programming

scientific article

Chiral sulfoxidations catalyzed by rat liver cytochromes P-450.

scientific article published on May 1982

Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice

scientific article published in September 2008

Cleavage of a COOH-terminal hydrophobic region from D-alanine carboxypeptidase, a penicillin-sensitive bacterial membrane enzyme. Characterization of active, water-soluble fragments

scientific article published on June 1979

Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha

scientific article published on 20 October 2005

Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment

scientific article published on 7 November 2007

Combination of antiangiogenesis with chemotherapy for more effective cancer treatment

scientific article published on December 2008

Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.

scientific article

Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug res

scientific article

Complex modulation of androgen responsive gene expression by methoxyacetic acid

scientific article

Computational Screening of Phthalate Monoesters for Binding to PPARγ

scientific article published on 01 August 2006

Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver.

scientific article

Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450.

scientific article

Conditionally replicating adenoviruses for cancer treatment.

scientific article

Construction of p450-expressing tumor cell lines using retroviruses

scientific article published in January 2000

Correction: Chemical and Hormonal Effects on STAT5b- Dependent Sexual Dimorphism of the Liver Transcriptome

scientific article

CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model

scientific article published on 3 December 2015

Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver

scientific article

Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated

scientific article

Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.

scientific article published in December 2001

Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.

scientific article published in June 1993

Cytochrome P-450 cholesterol 7 alpha-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors

scientific article published on August 1987

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase

scientific article published in Journal of Biological Chemistry

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

scientific journal article

Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5

scientific article published on 01 September 1983

Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy

scientific article

Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer

scientific article

Cytochrome P450-based cancer gene therapy: recent advances and future prospects

scientific article

Cytochrome p450-based gene therapies for cancer.

scientific article published on January 2004

Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells

scientific article published on 21 April 2010

DNase I digestion of isolated nulcei for genome-wide mapping of DNase hypersensitivity sites in chromatin

scientific article published on January 2013

Dehydroepiandrosterone 3 beta-sulphate is an endogenous activator of the peroxisome-proliferation pathway: induction of cytochrome P-450 4A and acyl-CoA oxidase mRNAs in primary rat hepatocyte culture and inhibitory effects of Ca(2+)-channel blocker

scientific article published on August 1994

Denitrosation of the Anti-Cancer Drug 1,3-Bis(2-chloroethyl)-1-nitrosourea Catalyzed by Microsomal Glutathione S-Transferase and Cytochrome P450 Monooxygenases

scientific article published on 01 December 1993

Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5 alpha-reductase

scientific article

Determination of CYP2B6 Component of 7-Ethoxy-4-Trifluoromethylcoumarin O -Deethylation Activity in Human Liver Microsomes

scientific article published on 01 January 2006

Determination of CYP2C9-Catalyzed Diclofenac 4'-Hydroxylation by High-Performance Liquid Chromatography

scientific article published on 01 January 2006

Determination of CYP2C9-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography

scientific article published on 01 January 1998

Determination of CYP4A11-Catalyzed Lauric Acid 12-Hydroxylation by High-Performance Liquid Chromatography With Radiometric Detection

scientific article published on 01 January 2006

Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection

scientific article published on 01 January 1998

Determination of the CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes

scientific article published on 01 January 1998

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

scientific article published on June 1999

Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms?

scientific article published in May 1992

Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth hormone regulating expression of sex-dependent forms of cytochrome P450.

scientific article published in May 1991

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

scientific article

Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event

scientific article

Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids

scientific article published on April 1991

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption

scientific article published in March 1999

Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib

scientific article

Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma

scientific article published in August 2003

Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation

scientific article published on February 1999

Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT.

scientific article published on 24 September 2010

Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites

scientific article published on 07 May 2009

Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver

scientific article published on 12 December 2011

Early programing of uterine tissue by bisphenol A: Critical evaluation of evidence from animal exposure studies.

scientific article

Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy

scientific article published on 17 March 2006

Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of

scientific article

Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.

scientific article

Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.

scientific article published on March 2006

Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.

scientific article

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

article

Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model

scientific article published on 14 September 2007

Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandi

scientific article published on September 2004

Environmental phthalate monoesters activate pregnane X receptor-mediated transcription

scientific article published on September 2004

Enzymatic Analysis of cDNA-Expressed Human CYP1A1, CYP1A2, and CYP1B1 With 7-Ethoxyresorufin as Substrate

scientific article published on 01 January 2006

Enzymatic Analysis of cDNA-Expressed Human CYPIAI, CYPlA2, and CYPIBI with 7-Ethoxyresorufin as Substrate

scientific article published on January 1, 1998

Evaluation of thyroid hormone effects on liver P450 reductase translation

scientific article published in January 2003

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

scientific article published on June 1994

Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene

scientific article published in August 1994

Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping

scientific article published in February 2005

Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms

scientific article

Feminization of male mouse liver by persistent growth hormone stimulation: Activation of sex-biased transcriptional networks and dynamic changes in chromatin states

scientific article published on 10 July 2017

Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes

scientific article published on October 1988

Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy

scientific article

Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs ⬇️

scientific article (publication date: 15 October 1992)

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice

scientific article published on 02 December 2020

Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver

scientific article published on 08 July 2013

Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

scientific article published on October 1990

Growth Hormone-Dependent and -Independent Sexually Dimorphic Regulation of Phenobarbital-Induced Hepatic Cytochrome P450 2B1 and -2B2

scientific article published on 01 July 1994

Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation

scientific article

Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice

scientific article published on 16 November 2005

Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression

scientific article

Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate

scientific article published on 01 November 1995

Growth hormone, but not prolactin, maintains, low-level activation of STAT5a and STAT5b in female rat liver

scientific article published on 01 November 1999

H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity.

scientific article published on 12 December 2013

Harnessing apoptosis for improved anticancer gene therapy

scientific article published on December 2003

Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model

scientific article published on 09 November 2021

Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone

scientific article

Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback.

scientific article published in September 1990

Hepatic P450 Expression in Hypothyroid Rats: Differential Responsiveness of Male-Specific P450 Forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to Thyroid Hormone

scientific article published on 01 January 1991

High-Performance Liquid Chromatographic–Fluorescent Method to Determine Chloroacetaldehyde, a Neurotoxic Metabolite of the Anticancer Drug Ifosfamide, in Plasma and in Liver Microsomal Incubations

scientific article published on 01 August 1999

High-molecular-weight penicillin-binding proteins from membranes of bacilli

scientific article

High-performance liquid chromatographic analysis of CYP2C8-catalyzed paclitaxel 6 alpha-hydroxylation

scientific article published on 01 January 1998

High-performance liquid chromatography analysis of CYP2C8-catalyzed paclitaxel 6alpha-hydroxylation

scientific article published on 01 January 2006

Hormonal perturbations in patients with testicular cancer treated with cisplatin

scientific article published on 01 May 1992

Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450.

scientific article published in February 1990

Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450

scientific article published in Journal of Biological Chemistry

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation ⬇️

scientific article published on August 1, 1997

Human telomerase reverse transcriptase promoter-driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions

scientific article published on December 2008

Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells

scientific article published on May 1995

Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer

scientific article published in January 2003

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

scientific article published on June 1997

Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

scientific article published on 17 July 2020

Impact of CAR agonist ligand TCPOBOP on mouse liver chromatin accessibility.

scientific article published on 2 April 2018

Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes

scientific article

Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes

scientific article published on April 2004

Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model

scientific article published in July 2000

Impact of methoxyacetic acid on mouse Leydig cell gene expression

scientific article

Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone

scientific article published on 28 November 2012

Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model.

scientific article published on May 2013

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity

scientific article published in March 1999

Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats

scientific article

Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl

scientific article published in March 1988

Influence of lipophilicity and carboxyl group content on the rate of hydroxylation of methotrexate derivatives by aldehyde oxidase

scientific article published in August 1990

Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression

scientific journal article

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

scientific article published in Journal of Biological Chemistry

Interaction of a novel sex-dependent, growth hormone-regulated liver nuclear factor with CYP2C12 promoter

scientific article published in November 1996

Interaction of anticancer drugs with hepatic monooxygenase enzymes

scientific article

Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression

scientific article published on January 1988

Interactions of methoxyacetic acid with androgen receptor

scientific article published on 07 April 2008

Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression

scientific article published on January 2014

Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription

scientific article published on June 1995

Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450.

scientific article published on August 1991

Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy

scientific article published on February 1995

Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liver

scientific article

Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate.

scientific article published in May 1993

Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1.

scientific article

Isolation of nuclei for use in genome-wide DNase hypersensitivity assays to probe chromatin structure

scientific article published on January 2013

Linear, uncross-linked peptidoglycan secreted by penicillin-treated Bacillus subtilis. Isolation and characterization as a substrate for penicillin-sensitive D-alanine carboxypeptidases

scientific article published in Journal of Biological Chemistry

Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.

scientific article published on 14 February 2008

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

scientific article published on 17 November 2020

Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer

scientific article

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus

scientific article published on 22 February 2007

MAnorm2 for quantitatively comparing groups of ChIP-seq samples

scientific article published on 18 November 2020

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

scientific article

Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5

scientific article published on October 2009

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats

scientific article

Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases

scientific article published on June 1979

Mechanisms of cyclophosphamide action on hepatic P-450 expression

scientific article published in September 1990

Metabolism of methotrexate and γ-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro

article

Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance

scientific article

Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators

scientific article

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8(+) T-cell responses and immune memory

scientific article published on 18 February 2015

Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model

scientific article

Microheterogeneity of a male-specific rat hepatic cytochrome P-450: Existence of three allozymic forms

scientific article published on 01 November 1985

Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo

scientific article

Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors

scientific article

Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib

scientific article published on January 2008

Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism.

scientific article published in July 1995

Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations

scientific article published in November 1987

Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism.

scientific article published in September 1989

Monoclonal antibodies to rat liver microsomal cytochrome b5.

scientific article

Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

scientific journal article

Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression

scientific article published on May 1994

N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents

scientific article published on 01 May 1991

Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile

scientific article

Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation

article

P450 enzyme expression patterns in the NCI human tumor cell line panel

scientific article

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

scientific article

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

scientific article published on February 1996

PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis ⬇️

scientific article published on December 29, 2010

Participation of two structurally related enzymes in rat hepatic microsomal androstenedione 7 alpha-hydroxylation

scientific article published on January 1990

Penicillin is an active-site inhibitor for four genera of bacteria

scientific article

Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics

scientific article published on January 1983

Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis

scientific article published on May 1980

Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate

scientific article published on July 1996

Phenobarbital induction of cytochrome P-450 gene expression

scientific article published in February 1992

Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization

scientific article published on 01 September 1987

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

scientific article published on October 1990

Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms

scientific article published on September 1982

Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats

scientific article published on 01 February 1987

Phosphorylation of carcinogen metabolizing enzymes: regulation of the phosphorylation status of the major phenobarbital inducible cytochromes P-450 in hepatocytes

scientific article

Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;.

scientific article

Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression

scientific article published in September 2000

Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats

scientific article

Post-transcriptional regulation of hepatic NADPH-cytochrome P450 reductase by thyroid hormone: independent effects on poly(A) tail length and mRNA stability

scientific article

Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo

article

Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene

scientific article published on November 1997

Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer

scientific article

Pregnane X receptor-mediated transcription

scientific article published in January 2005

Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450.

scientific article

Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs.

scientific article

Progress and prospects: gene therapy clinical trials (part 2).

scientific article published on November 2007

Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH action

scientific article

Rat hepatic cholesterol 7α-hydroxylase: Biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes

scientific article published on 01 June 1986

Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme.

scientific article published in December 1984

Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and immunological identification of a constitutive P450 2B3-like protein in rat liver

scientific article published on August 1994

Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide

scientific article published on 8 January 2007

Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver

scientific article published in Journal of Biological Chemistry

Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol

scientific article published in Journal of Biological Chemistry

Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone

scientific article published on April 2009

Regulation of liver-specific steroid metabolizing cytochromes P450: Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases ⬇️

scientific article published on December 1, 1992

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

scientific article published in July 1985

Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation

scientific journal article

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

scientific article published on July 1997

Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.

scientific article published on October 1998

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

scientific article published on 29 May 2007

Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells

scientific article published on March 1994

Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of liver cytochromes P450.

scientific article published in June 2004

Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.

scientific article

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

scientific article published on 01 April 2000

Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator.

scientific article

Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone

scientific article published in Journal of Biological Chemistry

Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization

scientific article published on 8 September 2005

SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

scientific article (publication date: 10 December 1999)

STAT5 regulation of sex-dependent hepatic CpG methylation at distal regulatory elements mapping to sex-biased genes

scientific article published on 16 November 2020

STAT5 signaling in sexually dimorphic gene expression and growth patterns

scientific article

STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain

scientific article published in Journal of Biological Chemistry

Secondary structure relations between beta-lactamases and penicillin-sensitive D-alanine-carboxypeptidases

scientific article published on 01 February 1981

Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy

scientific article published in January 2000

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

scientific article published on March 1996

Sequence of active site peptides from the penicillin-sensitive D-alanine carboxypeptidase of Bacillus subtilis. Mechanism of penicillin action and sequence homology to beta-lactamases

scientific article published on May 1980

Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity

scientific article published in December 2001

Sex differences in the expression of hepatic drug metabolizing enzymes

scientific article published on 29 May 2009

Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver

scientific article published on 01 May 2019

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2

scientific article published on 19 May 2020

Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone

scientific article

Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver

scientific article published on August 1993

Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.

scientific article published on 9 February 2006

Sex-specific early growth hormone response genes in rat liver

scientific article published on 15 May 2008

Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

scientific article

Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed

article

Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis.

scientific article

Sexual dimorphism of rat liver nuclear proteins: regulatory role of growth hormone

scientific article published on 29 September 2004

Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice

scientific article published on 20 May 2004

Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450.

scientific article published in December 1989

Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b

scientific article published in September 2004

Spectrofluorometric Analysis of CYP2A6-Catalyzed Coumarin 7-Hydroxylation

scientific article published on 01 January 2006

Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation

scientific article published on 01 January 1998

Spectrophotometric Analysis of Human CYP2E1-Catalyzed p -Nitrophenol Hydroxylation

scientific article published on 01 January 2006

Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation

article

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

scientific article published on 01 October 1991

Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver FAD-containing monooxygenase

scientific article published on 01 May 1982

Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone

scientific article published on 01 June 1989

Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene

scientific article published in September 1987

Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy

scientific article published in August 2003

Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver

scientific article

Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

scientific article

Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.

scientific article

Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity

scientific article published on 01 November 2001

Termination of growth hormone pulse-induced STAT5b signaling

scientific article published on January 1999

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

scientific article

The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha

scientific article published on June 2008

The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation

scientific article

The structural basis of pregnane X receptor binding promiscuity

scientific article published on December 2009

Thin-layer chromatographic analysis of human CYP3A-catalyzed testosterone 6 beta-hydroxylation

scientific article published on 01 January 1998

Thin-layer chromatography analysis of human CYP3A-catalyzed testosterone 6beta-hydroxylation

article

Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis

scientific article published on 8 December 2012

Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms ⬇️

scientific article published in Journal of Biological Chemistry

Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene

article

Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression

scientific article published on 30 December 2007

Transcriptional induction of hepatic NADPH: cytochrome P450 oxidoreductase by thyroid hormone

scientific article

Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease

scientific article

Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts

scientific article published on 8 May 2015

Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression

article

Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression

scientific article

Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families

scientific article published on 01 January 2006

Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families

scientific article published on 01 January 1998

Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy

scientific article published on January 2004

Use of reverse transcription-polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods

scientific article published on 01 June 1994

VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression.

scientific article published on 11 January 2012

Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures

scientific article published on November 2011

Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 2: early spectral changes during apoptosis are linked to apoptotic volume decrease

scientific article published on November 2011

Widespread Dysregulation of Long Noncoding Genes Associated With Fatty Acid Metabolism, Cell Division, and Immune Response Gene Networks in Xenobiotic-exposed Rat Liver

scientific article published on 01 April 2020

Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR

scientific article published on 24 June 2019

Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes

scientific article

Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver

scientific article published on 01 October 1987

[24] Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes

scientific article published on 01 January 1991

[29] P450 Phosphorylation in isolated hepatocytes and in Vivo

article

trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals

scientific article

trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals

scientific article published on 7 April 2004

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