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List of works by Leigh C. Murphy

A bi-faceted role of estrogen receptor β in breast cancer

scientific article

A framework for biobank sustainability

scientific article

A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer

scientific article published on 3 June 2010

A point mutation in the human estrogen receptor gene is associated with the expression of an abnormal estrogen receptor mRNA containing a 69 novel nucleotide insertion

scientific article published on 01 June 1997

A practical tool for modeling biospecimen user fees

scientific article published in August 2014

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

scientific article

Altered expression of estrogen receptor-alpha variant messenger RNAs between adjacent normal breast and breast tumor tissues

scientific article

Altered expression of exon 6 deleted progesterone receptor variant mRNA between normal human breast and breast tumour tissues

scientific article published on May 1999

Analysis of human breast cancer nuclear proteins binding to the promoter elements of the c-myc gene

scientific article published on 01 March 1996

Antiestrogen action and growth factor regulation

scientific article published on January 1994

Assay development for the determination of phosphorylation stoichiometry using multiple reaction monitoring methods with and without phosphatase treatment: application to breast cancer signaling pathways

scientific article

Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions

scientific article published on 17 May 2006

C-myc gene chromatin of estrogen receptor positive and negative breast cancer cells

scientific article published on 01 February 1993

CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells

scientific article

Certification for biobanks: the program developed by the Canadian Tumour Repository Network (CTRNet).

scientific article published on October 2012

Claudin 1 expression in basal-like breast cancer is related to patient age

scientific article

Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype.

scientific article published on 23 April 2009

Clinical significance of estrogen receptor phosphorylation ⬇️

scientific article published on January 19, 2011

Comparative evaluation of ERα and ERβ significance in breast cancer: state of the art

scientific article published on 01 May 2011

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

scientific article published on 13 September 2021

Differential expression and comparative subcellular localization of estrogen receptor beta isoforms in virally transformed and normal cultured human lens epithelial cells

scientific article

Differential regulation of c-myc by progestins and antiestrogens in T-47D human breast cancer cells

scientific article published on July 1991

Differential regulation of estrogen receptors α and β by 4-(E)-{(4-hydroxyphenylimino)-methylbenzene,1,2-diol}, a novel resveratrol analog.

scientific article

Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer

scientific article published in June 2012

ERβ splice variant expression in four large cohorts of human breast cancer patient tumors

scientific article published on 10 July 2014

Effects of transforming growth factors and regulation of their mRNA levels in two human endometrial adenocarcinoma cell lines

scientific article published on 01 June 1992

Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

scientific article published on 6 June 2016

Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target

scientific article published on 08 December 2007

Estrogen receptor alpha phosphorylated at tyrosine 537 is associated with poor clinical outcome in breast cancer patients treated with tamoxifen

scientific article published on August 2010

Estrogen receptor beta: mine is longer than yours?

scientific article published on 01 October 1998

Estrogen receptor variants and mutations.

scientific article

Estrogen receptor variants in human breast cancer

scientific article published on December 1990

Estrogen receptor variants in normal human mammary tissue

scientific article published on 01 March 1996

Estrogen receptor-alpha mRNA variants in murine and human tissues

scientific article published on 01 December 1999

Estrogen receptor-alpha phosphorylated at Ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression

scientific article published on October 2006

Estrogen receptor-beta mRNA variants in human and murine tissues

scientific article

Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer

scientific article published on 29 September 2006

Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors

scientific article published on 28 July 2007

Estrogen regulates the association of intermediate filament proteins with nuclear DNA in human breast cancer cells.

scientific article published on October 1998

Estrogen regulation of nuclear matrix-intermediate filament proteins in human breast cancer cells

scientific article published on 01 November 1996

Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis

scientific article

Expression of both estrogen receptor-beta 1 (ER-β1) and its co-regulator steroid receptor RNA activator protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with estrogen receptor-alpha (ER-α)-negative early breast cancer (EB

scientific article

Expression of estrogen receptor-beta in human breast tumors

scientific article published on 01 July 1997

Expression of insulin-like growth factor binding proteins by T-47D human breast cancer cells: regulation by progestins and antiestrogens

scientific article published on January 1994

Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours

scientific article published on August 2006

Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers

scientific article

High-affinity anti-oestrogen binding site distinct from the oestrogen receptor

scientific article published in Nature

Hormonal regulation of proliferation and transforming growth factors gene expression in human endometrial adenocarcinoma xenografts

scientific article published on 01 July 1994

Identification of new human coding steroid receptor RNA activator isoforms

scientific article

Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue

scientific article published on 01 November 1996

Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas

scientific article

Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides

scientific article

Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells

scientific article

Influence of evolution in tumor biobanking on the interpretation of translational research.

scientific article

Inhibition of transcription selectively reduces the level of ubiquitinated histone H2B in chromatin

scientific article published on August 1994

Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor alpha in human breast carcinoma

scientific article published in December 2004

Intratumoural inflammation and endocrine resistance in breast cancer

scientific article

Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?

scientific article

Lumican and decorin are differentially expressed in human breast carcinoma

scientific article published on 01 November 2000

Mammaglobin, a potential marker of breast cancer nodal metastasis

scientific article published on 01 September 1999

Measurement of the relative binding affinity of zearalenone, alpha-zearalenol and beta-zearalenol for uterine and oviduct estrogen receptors in swine, rats and chickens: an indicator of estrogenic potencies

scientific article published on 01 January 1989

Mechanisms of growth inhibition by antiestrogens and progestins in human breast and endometrial cancer cells

scientific article published on September 1, 1992

Mechanisms of oestrogen antagonism by nonsteroidal antioestrogens

scientific article published on January 1982

Modifications in the aminoether side chain of clomiphene influence affinity for a specific antiestrogen binding site in MCF 7 cells cytosol

scientific article published on 01 June 1981

New insights into estrogen receptor function in human breast cancer

scientific article published on January 2003

Novel mutations in the estrogen receptor messenger RNA in human breast cancers

scientific article published on April 1996

Oestradiol and progesterone: soluble receptor levels and metabolism in the uterus of the ovariectomized ewe.

scientific article published in December 1976

Oestrogen receptor-alpha variant mRNA expression in primary human breast tumours and matched lymph node metastases

scientific article published on February 1999

Oncostatin M suppresses oestrogen receptor-α expression and is associated with poor outcome in human breast cancer.

scientific article published on 10 April 2012

Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo

scientific article published on February 2004

Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen

scientific article published in September 2004

Potential role of estrogen receptor alpha (ERalpha) phosphorylated at Serine118 in human breast cancer in vivo

scientific article published on 7 November 2006

Preferential estrogen receptor β ligands reduce Bcl-2 expression in hormone-resistant breast cancer cells to increase autophagy.

scientific article published on 30 April 2014

Progestin regulation of EGF-receptor mRNA accumulation in T-47D human breast cancer cells

scientific article published on 01 January 1988

Psoriasin (S100A7)

scientific article

Putative functional characteristics of human estrogen receptor-beta isoforms

scientific article published on 01 February 2003

RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer

scientific article

Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha

scientific article published on 21 October 2008

Regulation of c-jun and jun-B by progestins in T-47D human breast cancer cells

scientific article published on 01 October 1992

Regulation of transforming growth factor gene expression in human endometrial adenocarcinoma cells

scientific article published on March 1992

Relationship between mammaglobin expression and estrogen receptor status in breast tumors

scientific article published on August 2003

Relationship of coregulator and oestrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancer

scientific article published on December 2002

Role of wild-type estrogen receptor-beta in mitochondrial cytoprotection of cultured normal male and female human lens epithelial cells

scientific article published on 24 June 2008

S100 proteins and their influence on pro-survival pathways in cancer

scientific article

S100A7 (psoriasin) influences immune response genes in human breast cancer

scientific article published on 30 March 2007

S100A7 and the progression of breast cancer

scientific article

Stabilisation of the cytoplasmic oestrogen receptor by molybdate

scientific article published on 01 April 1981

Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients

scientific article published on January 2009

Steroid receptor RNA activator protein (SRAP) expression as a prognostic factor in ER+ human breast tumors

scientific article published on 2 August 2013

Steroid receptors in human breast tumorigenesis and breast cancer progression

scientific article

Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice

scientific article published in October 2009

Targeting the EGFR pathway for cancer therapy

scientific article published on January 2006

The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer

scientific article published on July 2005

The effect of estradiol on a 25-hydroxycholecalciferol binding protein in the uterus of the mouse

scientific article published on 01 January 1980

The kinome associated with estrogen receptor-positive status in human breast cancer

scientific article

The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo

scientific article

The pathophysiological role of estrogen receptor variants in human breast cancer.

scientific article published in April 1998

The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo

scientific article published on 06 February 2009

The role of estrogen receptor-β in breast cancer

scientific article published on 23 January 2012

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

scientific article

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