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List of works by Alexander Dobrovic

"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic

scientific article

A HindIII RFLP for the HPRT pseudogene on chromosome 3 (HPRTP1).

scientific article published on February 1987

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

scientific article

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

scientific article published on 4 January 2013

A frequent HindIII RFLP on chromosome 3p21-25 detected by a genomic erbA beta sequence

scientific article published on February 1988

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes

scientific article

A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting

scientific article published on 08 October 2009

A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues

scientific article

A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma

scientific article published on January 2013

A new approach to primer design for the control of PCR bias in methylation studies

scientific article

A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer

scientific article published on 29 April 2005

A rapid and reliable PCR method for genotyping the ABO blood group

article published in 1993

A rapid and reliable PCR method for genotyping the ABO blood group. II: A2 and O2 alleles

scientific article published on 01 January 1996

A rare translocation (4;11)(q21;p14–15) in an acute lymphoblastic leukemia expressing T-cell and myeloid markers

scientific article published on 01 October 1991

A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma

article

A simple, rapid, and sensitive method for the detection of the JAK2 V617F mutation

scientific article

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer

scientific article published on 14 July 2011

An optimised direct lysis method for gene expression studies on low cell numbers

scientific article published on 5 August 2015

Analysing DNA methylation using bisulphite pyrosequencing

scientific article

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

scientific article

Assessing Gene-Specific Methylation Using HRM-Based Analysis

article

Assessing alternative base substitutions at primer CpG sites to optimise unbiased PCR amplification of methylated sequences

scientific article published on 04 April 2017

Assessing combined methylation-sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation

scientific article

Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

scientific article

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

scientific article published on 9 October 2015

Associations between the IASLC/ATS/ERS lung adenocarcinoma classification and EGFR and KRAS mutations

scientific article

BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition.

scientific article published on 4 November 2013

BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage

scientific article published on 5 July 2013

BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group

scientific article

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype

scientific article

Bioinformatics pipelines for targeted resequencing and whole-exome sequencing of human and mouse genomes: a virtual appliance approach for instant deployment

scientific article

Characterization of a <i>RAD51C</i>-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance

scientific article published on 09 July 2021

Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5

scientific article

Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.

scientific article published on January 2014

Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma

scientific article

Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma.

scientific article

Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT

scientific article

Closed-tube PCR methods for locus-specific DNA methylation analysis

scientific article published on January 2011

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies

scientific article published on 07 September 2016

Clustered somatic mutations are frequent in transcription factor binding sites in melanoma and other cutaneous malignancies

article

Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies

scientific article published on 01 February 2001

Comparison of 3 Methodologies for Genotyping of Small Deletion and Insertion Polymorphisms

scientific article published on July 2016

Complete molecular response of e6a2 BCR-ABL-positive acute myeloid leukemia to imatinib then dasatinib

scientific article published on 11 December 2007

Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

scientific article

Copy number analysis of ductal carcinoma in situ with and without recurrence

scientific article

DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum-Implications for the Choice of Circulating Tumour DNA Methylation Markers

scientific article published on 28 August 2018

DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing.

scientific article published on October 2014

DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas

scientific article published on 19 August 2010

DNA methylation and genetic inactivation at thymidine kinase locus: Two different mechanisms for silencing autosomal genes

article

DNA methylation biomarkers in cancer: progress towards clinical implementation

scientific article published on June 2012

DNA methylation in ductal carcinoma in situ of the breast

scientific article published on 28 June 2013

DNA methylation of the ABO promoter underlies loss of ABO allelic expression in a significant proportion of leukemic patients

scientific article

DNA methylation profiling of breast cancer cell lines along the epithelial mesenchymal spectrum - implications for the choice of circulating tumour DNA methylation markers

article published in 2017

DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast

DNA methylation, epimutations and cancer predisposition

scientific article published on 16 September 2008

DNA repair gene inactivation in non-Hodgkin's lymphoma

article

Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders

scientific article published on December 2011

Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism.

scientific article

Detection of NPM1 exon 12 mutations and FLT3 - internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

scientific article published on 29 July 2008

Detection of circulating tumor cells in colorectal cancer by immunobead-PCR is a sensitive prognostic marker for relapse of disease

scientific article

Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction

scientific article published in December 1988

Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting

scientific article

Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

scientific article

Digital PCR of Genomic Rearrangements for Monitoring Circulating Tumour DNA.

scientific article published on January 2016

Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis

scientific article published in May 2008

Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanoma

scientific article published on 7 December 2006

Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophagogastric cancer: the AGITG ATTAX2 trial

scientific article published on 14 February 2013

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase

scientific article

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer

scientific article

EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma

scientific article

Erratum

scientific article published on 01 January 1994

Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

scientific article

Fc-γ Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.

scientific article

Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation

scientific article

GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly

GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly.

scientific article

Gene mapping in marsupials and monotremes. II. Assignments to the X chromosome of dasyurid marsupials

article

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas

scientific article published on 18 July 2016

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver

scientific article published on 14 October 2014

Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis.

scientific article published on 29 November 2016

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

scientific article

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

High frequency of germline TP53 mutations in a prospective adult-onset sarcoma cohort

scientific article published on 22 July 2013

High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

scientific article

High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.

scientific article published on 21 December 2006

High resolution melting for mutation scanning of TP53 exons 5-8

scientific article

High-Resolution Assessment of Copy Number Variation

Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR

scientific article published on 05 June 2009

Immunobead-PCR: a technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction

scientific article published on August 1993

Imprinting and loss of ABO antigens in leukemia

scientific article published on 01 September 1993

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

scientific article published on 17 March 2009

In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

scientific article published on July 2008

Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer

scientific article published on 24 April 2007

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.

scientific article

Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors

scientific article

Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome

scientific article

KIT immunohistochemistry and mutation status in gastrointestinal stromal tumours (GISTs) evaluated for treatment with imatinib.

scientific article published on July 2006

Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies

scientific article published on 08 October 2009

Localization of the human growth arrest-specific gene (GAS1) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies

scientific article

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

scientific article

Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers

scientific article

Loss of red cell A, B, and H antigens is frequent in myeloid malignancies

article

Mapping of actionable mutations to histological subtype domains in lung adenocarcinoma: implications for precision medicine.

scientific article

Mapping of the chromosome 11 breakpoint of the t(4;11)(q21;p14–15) translocation

scientific article published on 01 September 1993

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status i

scientific article

Melting curve assays for DNA methylation analysis

scientific article published on January 2009

MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing

scientific article

Methylation analysis of formalin-fixed, paraffin-embedded sections using a nontoxic DNA extraction protocol

article

Methylation of the BRCA1 gene in sporadic breast cancer ⬇️

scientific article published on August 15, 1997

Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features

scientific article

Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes

scientific article

Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation

scientific article

Methylation-sensitive high-resolution melting

Methylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylation

scientific article (publication date: 1999)

Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.

scientific article published on 02 February 2015

Molecular analysis of the Philadelphia chromosome

scientific article published on September 1991

Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

scientific article published on 01 January 2000

Molecular detection of residual lymphoma cells in peripheral blood stem cell harvests and following autologous transplantation

scientific article published on 01 January 1993

Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations.

scientific article published on 22 June 2015

Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC.

scientific article published on 27 February 2014

Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations

scientific article

Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure

scientific article published on 20 January 2010

Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

scientific article published on December 2006

Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail

scientific article

No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia

scientific article published on 31 January 2012

No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer

scientific article published on 3 August 2010

No evidence for PALB2 methylation in high-grade serous ovarian cancer

scientific article published on 12 April 2013

No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer

scientific article

Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations

scientific article published on 30 April 2013

Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer

scientific article published on 24 January 2014

Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells

scientific article

PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

scientific article published on January 2013

Pathological response of gastrointestinal stromal tumour to imatinib treatment correlates with tumourKITmutational status in individual tumour clones

article

Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors

scientific article

Probe-Free Digital PCR Quantitative Methodology to Measure Donor-Specific Cell-Free DNA after Solid-Organ Transplantation

scientific article

Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma

scientific article published on January 2000

Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma

scientific article published on 21 January 2020

Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome

scientific article

Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2 V617F mutant allele detection

scientific article

Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene

scientific article published on 3 November 2008

Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis.

scientific article

Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis

scientific article

Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting

article by Tomasz K. Wojdacz et al published October 2008 in Human Mutation

Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung

scientific article published on 13 November 2010

Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis

scientific article published on 01 February 2002

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

scientific article published on 10 January 2017

Reducing Sequence Artifacts in Amplicon-Based Massively Parallel Sequencing of Formalin-Fixed Paraffin-Embedded DNA by Enzymatic Depletion of Uracil-Containing Templates

scientific article published on 06 May 2013

Relationship between M-BCR breakpoint position in blast crisis and length of chronic phase in chronic myeloid leukemia

scientific article

Role of p53 in the progression of gastric cancer

scientific article published on December 2014

SCL gene in human tumors.

scientific article

Screening for and analysis of methylation differences using methylation-sensitive single-strand conformation analysis

article

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf

scientific article

Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection

scientific article

Sensitive detection of KIT D816V in patients with mastocytosis

scientific article published on 13 October 2006

Sensitive quantification of somatic mutations using molecular inversion probes

scientific article

Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

scientific article

Sequence artifacts in DNA from formalin-fixed tissues: causes and strategies for minimization

scientific article

Significance of molecular marker-positive cells after autologous peripheral-blood stem-cell transplantation for non-Hodgkin's lymphoma

scientific article published in May 1995

Somatic mutations, acetylator status, and prognosis in colorectal cancer

scientific article

Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours

scientific article published on 13 December 2013

Temporal changes of EGFR mutations and T790M levels in tumour and plasma DNA following AZD9291 treatment.

scientific article

The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia

scientific article published in September 1999

The clinical relevance of pathologic subtypes in metastatic lung adenocarcinoma

scientific article

The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

scientific article

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

scientific article published on 21 September 2013

The implications of heterogeneous DNA methylation for the accurate quantification of methylation

scientific article

The role of BRAF mutations in primary melanoma growth rate and survival

scientific article published on 13 June 2015

The significance of oncogene amplification in primary breast cancer

scientific article

Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer

scientific article published on 01 February 2000

Using tumour pathology to identify people at high genetic risk of breast and colorectal cancers.

scientific article published on February 2012

Validation of a primer optimisation matrix to improve the performance of reverse transcription - quantitative real-time PCR assays

scientific article

Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer

scientific article published in February 2002

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

scientific article

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

scientific article (publication date: April 2009)

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