List of works by James D Brenton

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes

scientific article

A Bayesian adaptive design for biomarker trials with linked treatments

scientific article published on 11 August 2015

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

article

A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

scientific article published on 25 June 2019

A consensus prognostic gene expression classifier for ER positive breast cancer

scientific article published on 31 October 2006

A gene-expression signature to predict survival in breast cancer across independent data sets.

scientific article

A metadata approach for clinical data management in translational genomics studies in breast cancer.

scientific article

A metadata-aware application for remote scoring and exchange of tissue microarray images

scientific article

A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice.

scientific article published on August 1999

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

scientific article

A variational Bayesian mixture modelling framework for cluster analysis of gene-expression data

scientific article

A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles

scientific article

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition

scientific article published on May 2006

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition

scientific article

Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.

scientific article published on 13 February 2012

An imprinting element from the mouse H19 locus functions as a silencer in Drosophila.

scientific article published in June 1997

Anatomy of an ovarian cancer

scientific article published in Nature

Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4

article

Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development.

scientific article published on 6 August 2009

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

scientific article published on 30 July 2018

Astronomical algorithms for automated analysis of tissue protein expression in breast cancer

scientific article published on 17 January 2013

BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines

scientific article

Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer

scientific article

Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists

scientific article

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

scientific article published on 17 February 2017

Chromosomal instability determines taxane response

scholarly article

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium

scientific article published on 18 June 2020

Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier

scientific article

Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma

scientific article published on 06 April 2020

Complex stiffness gradient substrates for studying mechanotactic cell migration.

scientific article published on 18 September 2012

Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.

scientific article published on 16 February 2016

Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women

scientific article

Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence

article

Copy number signatures and mutational processes in ovarian carcinoma

scientific article published on 13 August 2018

Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers

scientific article published on 03 November 2020

Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch

scientific article published in August 2000

Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE)

scientific article published on 17 June 2020

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

scientific article published on 5 December 2016

Differential expression of selected histone modifier genes in human solid cancers

scientific article

Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer

scientific article published on 24 July 2019

Diffusion-weighted MRI in Advanced Epithelial Ovarian Cancer: Apparent Diffusion Coefficient as a Response Marker

scientific article published on 01 October 2019

Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.

scientific article published on 12 October 2017

Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

scientific article

Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease.

scientific article

Enhanced detection of circulating tumor DNA by fragment size analysis

scientific article published on 01 November 2018

Epirubicin, Cisplatin, and Capecitabine for Primary Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer: Results of a Retrospective, Single-Institution Study

scientific article published on July 2015

Evaluation of Nonenhancing Tumor Fraction Assessed by Dynamic Contrast-Enhanced MRI Subtraction as a Predictor of Decrease in Tumor Volume in Response to Chemoradiotherapy in Advanced Cervical Cancer

article

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study

scientific article

Evolution of platinum resistance in high-grade serous ovarian cancer

scientific article published on 01 November 2011

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

scientific article

Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling

scientific article

Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer

scientific article published on 31 October 2008

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

scientific article published on April 2013

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

scientific article published on 17 December 2018

Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.

scientific article

Genomic analysis of the 8p11-12 amplicon in familial breast cancer

article

Genomic imprinting and cancer

scientific article published on 01 January 1995

Genomic landscape of platinum resistant and sensitive testicular cancers

scientific article published on 04 May 2020

Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer

scientific article

Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene

scientific article published on 3 March 2017

High resolution melting for mutation scanning of TP53 exons 5-8

scientific article

High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer

scientific article

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

scientific article

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

scientific article

Image-guided biopsy in patients with suspected ovarian carcinoma: a safe and effective technique?

scientific article published on 15 August 2008

Imprinting and gene silencing in mice and Drosophila.

scientific article published in January 1998

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.

scientific article published on 18 January 2012

Integration of proteomics with CT-based qualitative and radiomic features in high-grade serous ovarian cancer patients: an exploratory analysis

scientific article published on 06 April 2020

Intensive cisplatin/oral etoposide for epithelial ovarian cancer: the Cambridge Gynae-Oncology Centre experience: too toxic for relapse?

scientific article published on 16 November 2015

Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer.

scientific article

Liquid biopsies come of age: towards implementation of circulating tumour DNA.

scientific article published on 24 February 2017

MMASS: an optimized array-based method for assessing CpG island methylation

scientific article published on 13 October 2006

Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.

scientific article published in October 2009

Metabolic consequences of p300 gene deletion in human colon cancer cells

scientific article published on August 2006

Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples.

scientific article published on 17 December 2015

Microarray segmentation methods significantly influence data precision

scientific article published on 17 March 2004

Microarrays and breast cancer clinical studies: forgetting what we have not yet learnt

scientific article

Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma

scientific article

Molecular classification and molecular forecasting of breast cancer: ready for clinical application?

scientific article

Molecular pathogenesis of ovarian clear cell carcinoma

scientific article published on January 2015

Molecular profiling of breast cancer: portraits but not physiognomy

scientific article

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

scientific article published on 10 June 2009

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer.

scientific article published in March 2018

New paradigms for BRCA1/BRCA2 testing in women with ovarian cancer: results of the Genetic Testing in Epithelial Ovarian Cancer (GTEOC) study ⬇️

scientific article published on 12 May 2016

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

scientific article (publication date: 2 May 2013)

Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.

scientific article

Novel conserved elements upstream of the H19 gene are transcribed and act as mesodermal enhancers

scientific article published in March 2002

One-stop diagnostic breast clinics: how often are breast cancers missed?

scientific article published on 19 May 2009

Optimal Amounts of Fluorescent Dye Improve Expression Microarray Results in Tumor Specimens

scientific article published on 01 June 2005

Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma.

scientific article published on 13 July 2016

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes

scientific article

Ovarian clear cell carcinoma--bad endometriosis or bad endometrium?

scientific article published on 01 October 2011

Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control.

scientific article

Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays

article

PathGrid: a service-orientated architecture for microscopy image analysis

scientific article published on August 2010

Phylogenetic quantification of intra-tumour heterogeneity

scientific article (publication date: April 2014)

Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer

scientific article published on 16 June 2020

Predictive cancer genomics--what do we need?

scientific article published in August 2003

Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation

scientific article

Prolonged response of relapsed high grade serous ovarian carcinoma to the oral angiokinase inhibitor nintedanib in a patient with a germline BRCA1 mutation.

scientific article published on 17 October 2012

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

scientific article published on 23 September 2019

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

scientific article published on 28 July 2020

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

scientific article

Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: test-retest measurements for tumor FDG uptake, diameter, and volume.

scientific article published on 26 February 2014

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Rethinking ovarian cancer: recommendations for improving outcomes

scientific article

Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

scientific article published on 13 November 2018

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

scientific article published on 28 November 2016

SPARC Regulates Transforming Growth Factor Beta Induced (TGFBI) Extracellular Matrix Deposition and Paclitaxel Response in Ovarian Cancer Cells

scientific article

Semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging measurements predict radiation response in cervix cancer.

scientific article

Sequencing Structural Variants in Cancer for Precision Therapeutics.

scientific article

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

scientific article published on 10 November 2010

Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium.

scientific article

Shared heritability and functional enrichment across six solid cancers

scientific article published in Nature Communications

Shared heritability and functional enrichment across six solid cancers

Sizing up miRNAs as cancer genes.

scientific article published in July 2005

Slingshot: a PiggyBac based transposon system for tamoxifen-inducible 'self-inactivating' insertional mutagenesis

scientific article published on 5 August 2010

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

scientific article published on 9 June 2008

Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis

scientific article

Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes

scientific article

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

scientific article

The External RNA Controls Consortium: a progress report.

scientific article published in October 2005

The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling.

scientific article published on 13 December 2012

The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel

scientific article

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer

scientific article

The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors

scientific article

Tissue Banking of Diagnostic Lung Cancer Biopsies for Extraction of High Quality RNA

article

Total syntheses of subereamollines A and B

article by James W. Shearman et al published 2011 in Organic and Biomolecular Chemistry

Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44

article published in 2010

Two novel determinants of etoposide resistance in small cell lung cancer.

scientific article

Ultrasound-guided targeted biopsies of CT-based radiomic tumour habitats: technical development and initial experience in metastatic ovarian cancer

scientific article published in 2020

Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy

scientific article published on 01 June 2020

Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

scientific article published on 25 September 2006

p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study

scientific article published on 22 March 2023

ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells.

scientific article

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