List of works by Ana Martínez

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

scientific article published in December 2018

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation

scientific article published on 29 April 2019

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

scientific article published on 14 July 2015

5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

scientific article published on 28 January 2012

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

scientific article published on 3 February 2012

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

scientific article

A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

scientific article published on 15 January 2019

A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice.

scientific article published on 19 December 2016

A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation

scientific article

AMPA glutamate receptors and neuropathic pain

scientific article published on November 2003

Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals.

scientific article published on 31 January 2012

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.

scientific article published on 20 February 2018

An application of two MIFs-based tools (Volsurf+ and Pentacle) to binary QSAR: the case of a palinurin-related data set of non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors.

scientific article

Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.

scientific article published on 18 April 2015

Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.

scientific article published in December 2009

Arylimino-1,2,4-thiadiazolidinones: a new family of potassium channel openers

scientific article published on July 1997

Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis.

scientific article published in August 2000

Benzothiadiazine dioxide human cytomegalovirus inhibitors: synthesis and antiviral evaluation of main heterocycle modified derivatives.

scientific article

Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity

scientific article published in May 2003

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

scientific article published on 26 December 2019

Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors

scientific article

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease

scientific article published on 30 August 2017

CB1 blockade potentiates down-regulation of lipogenic gene expression in perirenal adipose tissue in high carbohydrate diet-induced obesity

scientific article

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

scientific article published on 21 December 2007

CODES/Neural Network Model: a Useful Tool for in Silico Prediction of Oral Absorption and Blood-Brain Barrier Permeability of Structurally Diverse Drugs

article

Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors

scientific article published on 5 January 2018

CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-alpha]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors

scientific article published in April 2001

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis.

scientific article published on October 2013

Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3

scientific article published on 01 December 2019

Correction of Glycogen Synthase Kinase 3β in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice

scientific article published on 11 October 2019

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

scientific article published on 17 January 2014

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

scientific article published on 24 September 2018

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors

scientific article

Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

article

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

scientific article published on 01 December 2020

Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase

scientific article published on 23 September 2005

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

scientific article published on November 2005

Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity

scientific article published on 27 July 2016

Dioxides of bicyclic thiadiazines: a new family of smooth muscle relaxants.

scientific article published on February 1995

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

scientific article published on 01 July 2019

Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.

scientific article published on 17 October 2005

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

scientific article published on 13 September 2018

Drugs in clinical development for the treatment of amyotrophic lateral sclerosis

scientific article published on 6 March 2017

Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD.

scientific article

Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice

scientific article

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

scientific article published on 16 March 2012

Electron correlated ab initio study of amino group flexibility for improvement of molecular mechanics simulations on nucleic acid conformations and interactions.

scientific article published in December 2007

Enantioselective LC/MS method for the determination of an antimalarial agent Fenozan B07 in dog plasma

scientific article

Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders

scientific article published on 26 April 2016

Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.

scientific article

Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

scientific article

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

scientific article published in March 2002

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

scientific article published on 12 August 2015

From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.

scientific article published on 26 August 2017

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)

scientific article published on 01 December 2019

GSK-3 Inhibitors: From the Brain to the Retina and Back Again

scientific article published on 01 January 2019

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

scientific article published in 2011

GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?

scientific article published on October 2008

GSK-3 inhibitors: discoveries and developments

scientific article published on March 2004

GSK-3β inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice.

scientific article published on 2 March 2017

Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

scientific article

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).

scientific article published on 9 November 2016

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

scientific article

Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment

scientific article published on 30 June 2011

Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.

scientific article

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

scientific article

Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice

scientific article published on 13 September 2013

Glycogen synthase kinase-3.

scientific article

Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques

scientific article

High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses

scientific article published on 23 October 2018

Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease

scientific article published on 23 December 2018

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

scientific article

Identification of new allosteric sites and modulators of AChE through computational and experimental tools.

scientific article published in December 2018

Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3.

scientific article

Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

scientific article published on 10 May 2013

Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?

scientific article published on 21 March 2017

Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

scientific article published on 26 June 2019

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

scientific article

Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.

scientific article published on 23 March 2017

Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.

scientific article published on January 2013

Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents

scientific article published on 29 June 2017

Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases ⬇️

scientific article

Marine compounds for the therapeutic treatment of neurological disorders

Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits.

scientific article published on 16 August 2017

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.

scientific article

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

scientific article published on 8 October 2014

Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase

scientific article published on 01 May 1997

Morphometric and neurochemical alterations found in l-BMAA treated rats

scientific article

Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment

scientific article published on 10 March 2020

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors

scientific article

NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders

scientific article

NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells

scientific article published on 21 February 2009

Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: implication of ERK1/2 and PPARgamma receptors

scientific article published on 25 March 2008

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

scientific article

New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation

scientific article published on November 1995

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

scientific article published on 25 March 2016

Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives

scientific article published on 14 September 2007

Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease

scientific article

Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives

scientific article

Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.

scientific article published on 5 February 2016

Novel agents for the treatment of human cytomegalovirus infection

Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease

scientific article

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

scientific article

On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds

PDE 7 inhibitors: new potential drugs for the therapy of spinal cord injury

scientific article published on 31 January 2011

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

scientific article

Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease

scientific article

Peripheral and dual binding site inhibitors of acetylcholinesterase as neurodegenerative disease-modifying agents

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

scientific article published on 09 May 2017

Phosphodiesterase 10 inhibitors: new disease modifying drugs for Parkinson's disease?

scientific article published on April 2014

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

scientific article published on 29 April 2015

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

scientific article (publication date: 24 February 2011)

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

scientific article published on 9 April 2013

Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

scientific article published in March 1998

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

scientific article published on 19 August 2016

Potent beta-amyloid modulators.

scientific article published on 06 March 2008

Preclinical efficacy on GSK-3 inhibitors: towards a future generation of powerful drugs

scientific article published on September 2008

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.

scientific article published on 3 March 2017

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

scientific article

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

scientific article

QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

scientific article published on 14 February 2019

Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients

scientific article published on 20 July 2018

Recent strategies in the development of new human cytomegalovirus inhibitors.

scientific article

Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity

scientific article published on December 2011

Regioselective lipase-mediated acylation-deacylation in thiadiazine diacyclonucleosides

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

scientific article published on 19 April 2013

Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation

scientific article

Rotational isomerism in 6-β-D-glucopyranosides of methyl-1,2,6-thiadiazin-3(2H)-one 1,1-dioxides

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

scientific article published in November 2005

Selective carriers of norepinephrine and ammonium ions: Ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit

scientific article published on 01 February 1997

Semiempirical (AM1, PM3 and SAM1) calculations of the protonation enthalpies of proton sponges related to 1,8-diaminonaphthalene. Estimation of the aqueous basicity of new designed superbases

Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases

scientific article published on 18 February 2020

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

scientific article published on 13 October 2014

Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

scientific article (publication date: 2016)

Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa.

scientific article published in December 2017

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

scientific article published on 6 January 2016

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

scientific article published on 26 May 2017

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds

scientific article published on 17 May 2011

Synthesis and Cytostatic Screening of an SO2 Analogue of Doridosine

scientific article published on 01 February 1988

Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds

scientific article published on 01 June 1999

Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors.

scientific article published on January 2005

Synthesis and intramolecular cyclization of bisthiadiazinylmethane derivatives

Synthesis and muscarinic activities of O-[(benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone.

scientific article published in May 2003

Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties.

scientific article published in May 2000

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

scientific article

TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis

scientific article published on 04 March 2019

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice

scientific article published on 13 February 2018

Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties

scientific article published on May 2009

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.

scientific article published on 4 September 2017

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia.

scientific article published on 30 April 2016

Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors

scientific article published on January 2006

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

article

Tautomerism of benzo- and cyclopenta-[1,2,6]thiadiazine S,S-dioxides

The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis

scientific article published on 21 December 2016

The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats.

scientific article published on 29 June 2018

The first enantioselective synthesis of palinurin.

scientific article published on 5 May 2009

The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

scientific article

Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS)

scientific article published on 06 July 2020

Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching

scientific article published in October 2003

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.

scientific article published on 22 August 2009

Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice.

scientific article published in July 2016

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

scientific article published on 01 December 2020

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

scientific article published on 22 October 2013

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

scientific article published on 22 December 2015

cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases

scientific article published on 04 October 2014

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.

scientific article published on 25 April 2013

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