List of works - Paul Mathews

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

scientific article

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

scientific article

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

scientific article

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

scientific article published on 10 July 2009

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

scientific article

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo

scientific article

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

scientific article

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

scientific article

Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments

scientific article published on 18 December 2016

Apolipoprotein E4 genotype compromises brain exosome production

Aβ measurement by enzyme-linked immunosorbent assay

scientific article

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

scientific article

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

scientific article published on 17 August 2004

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.

scientific article

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes.

scientific article published on April 2016

Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

scientific article published on 26 June 2002

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

scientific article

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

scientific article

Cerebral hemorrhage after passive anti-Abeta immunotherapy

scientific article published in November 2002

Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model

scientific article

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

scientific article published on April 2004

Complexes of amyloid-beta and cystatin C in the human central nervous system

scientific article published on January 2009

Cystatin C in aging and in Alzheimer's disease

scientific article published on 19 June 2016

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models

scientific article

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

scientific article

Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice

scientific article published on 6 September 2012

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

scientific article

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

scientific article

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects

scientific article published on 5 June 2008

Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice

scientific article published on January 2013

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor

scientific article

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

scientific article published on 6 February 2008

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

scientific article

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.

scientific article

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

scientific article

Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases

scientific article published on 12 December 2019

Extracellular amyloid formation and associated pathology in neural grafts

scientific article published in April 2003

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

scientific article

High resolution approaches for the identification of amyloid fragments in brain

scientific article published on 24 October 2018

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.

scientific article published on 17 April 2018

Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.

scientific article

In vivo reduction of amyloid-beta by a mutant copper transporter

scientific article

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice

scientific article

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

scientific article published on August 2008

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

scientific article published on 15 April 2013

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

scientific article

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

scientific article

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

scientific article

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins

scientific article

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide

scientific article published in January 2004

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

scientific article published on 2 December 2015

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

scientific article

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin

scientific article

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.

scientific article published in August 2004

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

scientific article published on July 2003

Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice

scientific article

Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

scientific article published on 15 August 2019

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

scientific article

Synaptic autoregulation by metalloproteases and γ-secretase

scientific article

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment

scientific article published in May 2006

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

scientific article published on 12 December 2017

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

scientific article

The neuronal endosomal-lysosomal system in Alzheimer's disease

scientific article published on 01 February 2001

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

scientific article

Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ.

scientific article

List of works by Paul Mathews

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments

Apolipoprotein E4 genotype compromises brain exosome production

Aβ measurement by enzyme-linked immunosorbent assay

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-β Alterations in a Monkey Model of Type 1 Diabetes.

Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

Cerebral hemorrhage after passive anti-Abeta immunotherapy

Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model

Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

Complexes of amyloid-beta and cystatin C in the human central nervous system

Cystatin C in aging and in Alzheimer's disease

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice

Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects

Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice

Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice

Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age.

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases

Extracellular amyloid formation and associated pathology in neural grafts

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

High resolution approaches for the identification of amyloid fragments in brain

Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice.

Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model.

In vivo reduction of amyloid-beta by a mutant copper transporter

In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice

Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

Synaptic autoregulation by metalloproteases and γ-secretase

Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment

The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

The neuronal endosomal-lysosomal system in Alzheimer's disease

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ.