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List of works by Michael Fromm

13C-urea breath test in Helicobacter pylori diagnosis and eradication. Correlation to histology, origin of 'false' results, and influence of food intake

scientific article published in April 1997

A colonic mineralocorticoid receptor cell model expressing epithelial Na+ channels

scientific article published on 9 March 2009

A rice kinase-protein interaction map

article

Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-α-induced barrier dysfunction in intestinal epithelial cells.

scientific article published on 28 October 2015

Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK.

scientific article published on 12 April 2017

Active and passive involvement of claudins in the pathophysiology of intestinal inflammatory diseases

scientific article published on 30 November 2016

Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect

scientific article published on 27 June 2010

Adaptation of the jejunal mucosa in the experimental blind loop syndrome: changes in paracellular conductance and tight junction structure

scientific article published in January 1987

Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells

scientific article

Aeromonas hydrophila beta-hemolysin induces active chloride secretion in colon epithelial cells (HT-29/B6).

scientific article published on August 2004

Aldosterone low-dose, short-term action in adrenalectomized glucocorticoid-substituted rats: Na, K, Cl, HCO3, osmolyte, and water transport in proximal and rectal colon

scientific article published in July 1990

Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease

scientific article published on 17 February 2008

Altered expression of tight junction proteins in mammary epithelium after discontinued suckling in mice

scientific article

Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

scientific article published on 01 February 1999

Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier

scientific article published on 17 December 2015

Analysis of absorption enhancers in epithelial cell models

scientific article published on July 2012

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction

scientific article published on 18 May 2017

Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K+ conductance

scientific article published in July 2001

Arcobacter butzleri induces barrier dysfunction in intestinal HT-29/B6 cells

scientific article

Autocrine release of angiopoietin-2 mediates cerebrovascular disintegration in Moyamoya disease

scientific article published on 5 July 2016

Barrier effects of nutritional factors.

scientific article

Biophysical Methods to Study Tight Junction Permeability

article

Butyrate induces intestinal sodium absorption via Sp3-mediated transcriptional up-regulation of epithelial sodium channels

scientific article published in January 2007

CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity.

scientific article published on 10 June 2013

Cartography of barrier defects in human colon by low-resolution conductance scanning.

scientific article published in November 1998

Celiac Disease: Role of the Epithelial Barrier

scientific article

Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease

scientific article published on 24 August 2011

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease

scientific article

Changes in permeability after ileoanal pouch anastomosis and in pouchitis

scientific article published on January 1, 1998

Charge-selective claudin channels

scientific article

Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function.

scientific article published on 21 April 2009

Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2

scientific article published on 08 July 2019

Claudin-16 affects transcellular Cl- secretion in MDCK cells

scientific article

Claudin-17 forms tight junction channels with distinct anion selectivity

scientific article

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

scientific article (publication date: 15 December 2002)

Claudin-2, a component of the tight junction, forms a paracellular water channel

scientific article

Claudin-2-mediated cation and water transport share a common pore.

scientific article published on 30 June 2016

Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes

scientific article published on 22 July 2010

Claudin-related intestinal diseases.

scientific article published on 19 May 2015

Claudins and Other Tight Junction Proteins ⬇️

scientific article published on July 1, 2012

Claudins in the tight junctions of stria vascularis marginal cells

scientific article published in April 2003

Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function

scientific article published on January 2011

Clinical models of intestinal adaptation

scientific article published on November 1998

Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel

scientific journal article

Comparative analysis of theophylline and cholera toxin in rat colon reveals an induction of sealing tight junction proteins

scientific article

Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells

scientific article published on July 2005

Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes

scientific article

Creation and biochemical analysis of a broad-specific claudin binder.

scientific article

Cross-talk Between Host, Microbiome and Probiotics: A Systems Biology Approach for Analyzing the Effects of Probiotic Enterococcus faecium NCIMB 10415 in Piglets.

scientific article published on 12 February 2014

Crypts are the site of intestinal fluid and electrolyte secretion

scientific article published in Science

Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis

scientific article

Defective tight junctions in refractory celiac disease

scientific article published in July 2012

Determinants contributing to claudin ion channel formation

scientific article

Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

scientific article published on 04 January 2012

Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol

scientific article published on March 1997

Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16

scientific article

Disrupted barrier function through epithelial cell apoptosis

scientific article published on August 2006

Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport

scientific article

Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment

scientific article published in September 2004

Dual versus triple therapy: comparison of five antibiotic regimens for eradication of Helicobacter pylori in a prospective, randomized study

scientific article published on 01 September 1998

Duodenal biopsies of HIV-infected patients with diarrhoea exhibit epithelial barrier defects but no active secretion

scientific article published on January 1998

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

scientific journal article

Effect of acute Yersinia enterocolitica infection on intestinal barrier function in the mouse

scientific article published on September 1994

Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum

scientific article

Effects of quercetin studied in colonic HT-29/B6 cells and rat intestine in vitro

scientific article

Endothelin antagonism as an active principle for glaucoma therapy

scientific article

Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility

scientific article published in March 2006

Endothelin receptor B in trabecular meshwork

scientific article

Enzyme- and mineralocorticoid receptor-controlled electrogenic Na+ absorption in human rectum in vitro ⬇️

scientific article published on July 1, 1995

Epithelial Tight Junction Structure in the Jejunum of Children with Acute and Treated Celiac Sprue

Epithelial and subepithelial contributions to transmural electrical resistance of intact rat jejunum, in vitro

scientific article published in December 1985

Epithelial and subepithelial resistance of rat large intestine: segmental differences, effect of stripping, time course, and action of aldosterone

scientific article published in December 1986

Epithelial barrier and ion transport in coeliac sprue: electrical measurements on intestinal aspiration biopsy specimens

scientific article published on December 1995

Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging

scientific article published in December 2001

Epithelial barrier dysfunction as permissive pathomechanism in human intestinal graft-versus-host disease

scientific article published on 9 March 2018

Epithelial barriers in intestinal inflammation

scientific article published on 11 May 2011

Epithelial ion transport in the ileal J-pouch after proctocolectomy in the rat.

scientific article

Epithelial tight junctions in intestinal inflammation

scientific article published on May 2009

Epithelial transport and barrier function in occludin-deficient mice

scientific article

Erratum to: Laurate Permeates the Paracellular Pathway for Small Molecules in the Intestinal Epithelial Cell Model HT-29/B6 via Opening the Tight Junctions by Reversible Relocation of Claudin-5.

scientific article published in February 2015

Escherichia coli alpha-haemolysin induces focal leaks in colonic epithelium: a novel mechanism of bacterial translocation

scientific article published on 24 June 2007

Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity

scientific article (publication date: 20 February 2004)

Functionality of MDCK kidney tubular cells on flat polymer membranes for biohybrid kidney

scientific article published on December 1998

Gelatinolytic activity of autocrine matrix metalloproteinase-9 leads to endothelial de-arrangement in Moyamoya disease.

scientific article published in January 2018

Gene expression of the tight junction protein occludin includes differential splicing and alternative promoter usage

scientific article published on November 2002

Gestational age dependence of 11 beta-hydroxysteroid dehydrogenase and its relationship to the enzymes of phosphatidylcholine synthesis in lung and liver of fetal rat.

scientific article published in January 1994

Glucocorticoid receptor is indispensable for physiological responses to aldosterone in epithelial Na+ channel induction via the mineralocorticoid receptor in a human colonic cell line ⬇️

scientific article published on February 26, 2011

Glucocorticoids and tumor necrosis factor-alpha synergize to induce absorption by the epithelial sodium channel in the colon

scientific article published on 10 December 2008

High-resolution analysis of barrier function

scientific article

IL-1beta and TNF-alpha, but not IFN-alpha, IFN-gamma, IL-6 or IL-8, are secretory mediators in human distal colon

scientific article published in June 1998

IL-1beta and TNFalpha regulate sodium absorption in rat distal colon

scientific article published on April 2004

Impairment of epithelial transport but not of barrier function in idiopathic pouchitis after ulcerative colitis

scientific article published on June 2002

Impairment of the antiproliferative effect of glucocorticosteroids by 11beta-hydroxysteroid dehydrogenase type 2 overexpression in MCF-7 breast-cancer cells.

scientific article published in July 2004

Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients

scientific article

Impedance analysis for the determination of epithelial and subepithelial resistance in intestinal tissues

scientific article published in September 1998

Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium

scientific article

Increased bacterial permeation in long-lasting ileoanal pouches

scientific article published in August 2006

Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease

scientific article

Inhibition of 11β-hydroxysteroid dehydrogenase and its effect on epithelial sodium transport

scientific article published on 01 October 1990

Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution

scientific article

Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis

scientific article

Intestinal microcirculation and gut permeability in acute pancreatitis: early changes and therapeutic implications

scientific article published on 01 November 1998

Ion transport and barrier function are disturbed in microscopic colitis

scientific article published in July 2012

Ion transport and enteric nervous system (ENS) in rat rectal colon: mechanical stretch causes electrogenic Cl-secretion via plexus Meissner and amiloride-sensitive electrogenic Na-absorption is not affected by intramural neurons

scientific article published in June 1989

Ion transport in rat colon measured by medium-resolution conductance scanning

scientific article published in November 1998

Ion transport in the experimental short bowel syndrome of the rat ⬇️

scientific article published on February 1, 1992

Lack of effect of EGF on epithelial barrier function in experimental TNBS colitis

scientific article published on January 1, 1998

Laurate permeabilizes the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5. [Corrected].

scientific article

Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis

scientific article published in September 2000

Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3

scientific article published on 22 October 2020

Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells

scientific article published on 16 April 2009

Localization of cAMP- and aldosterone-induced K+ secretion in rat distal colon by conductance scanning

scientific article

Low edge damage container insert that adjusts intestinal forceps biopsies into Ussing chamber systems

scientific article published in June 1999

Measurement of paracellular epithelial conductivity by conductance scanning.

scientific article published on November 1997

Mechanisms of diarrhea in collagenous colitis

scientific article published on 01 August 2002

Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation

scientific article

Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprue

scientific article

Modulation of tight junction proteins in the perineurium for regional pain control.

scientific article published on June 2012

Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia

scientific article

Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site

scientific article published on January 2009

Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport

scientific article published on 27 December 2016

Myrrh exerts barrier-stabilising and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells

scientific article published on 15 December 2016

Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation

scientific article

Net ion fluxes and zero flux limiting concentrations in rat upper colon and rectum during anaesthesia-induced aldosterone liberation

scientific article published in February 1987

Nonmalabsorptive Mechanisms of Diarrhea in HIV Infection

article

Ontogeny of 11beta-hydroxysteroid dehydrogenase: activity in the placenta, kidney, colon of fetal rats and rabbits

scientific article published in February 2001

Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells

scientific article

Patients with dyspepsia benefit from eradication of Helicobacter pylori if other organic causes for dyspepsia were carefully ruled out.

scientific article published in March 2000

Permanently increased mucosal permeability in patients with backwash ileitis after ileoanal pouch for ulcerative colitis

scientific article published in January 2008

Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis

scientific article

Perspectives on tight junction research

scientific article published on June 2012

Pharmacological and functional characterization of endothelin receptors in bovine trabecular meshwork and ciliary muscle

scientific article published on 21 June 2005

Potassium transport across rabbit descending colon in vitro: evidence for single-file diffusion through a paracellular pathway

scientific article published in January 1981

Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1

scientific article published on 17 August 2019

Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3

scientific article

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins

scientific article

Prostaglandin I(2) sensory input into the enteric nervous system during distension-induced colonic chloride secretion in rat colon

scientific article published on 5 February 2010

Protamine alters structure and conductance of Necturus gallbladder tight junctions without major electrical effects on the apical cell membrane

scientific article

Protamine reversibly decreases paracellular cation permeability in Necturus gallbladder

scientific article

Protein-protein interactions of tandem affinity purified protein kinases from rice

scientific article

Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: a novel model for studying the pathomechanisms of inflammatory bowel disease cytokines

scientific article

Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells

scientific article published on 5 January 2006

Restoration of ENaC expression by glucocorticoid receptor transfection in human HT-29/B6 colon cells

scientific article

Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine

article published in 2010

Segmental heterogeneity of epithelial transport in rat large intestine

scientific article

Segmental heterogeneity of swelling-induced Cl- transport in rat small intestine

scientific article

Sheep rumen and omasum primary cultures and source epithelia: barrier function aligns with expression of tight junction proteins

scientific article

Significant water absorption goes paracellular in kidney proximal tubules

scientific article published on 23 October 2013

Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions

scientific article published on December 2002

Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells.

scientific article

Some properties of KCl-filled microelectrodes: correlation of potassium "leakage" with tip resistance.

scientific article

Special Issue on "The Tight Junction and Its Proteins: More than Just a Barrier" ⬇️

scientific article published on 29 June 2020

Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells

scientific article published on 08 July 2019

Structural and functional changes of the duodenum in human norovirus infection

scientific article published on 26 November 2008

Supernatants of HIV-infected immune cells affect the barrier function of human HT-29/B6 intestinal epithelial cells

scientific article published in May 2002

TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling

scientific article

TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling

scientific article published on 9 November 2010

TRPV4-mediated regulation of epithelial permeability

scientific article published on September 2006

TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signaling in HT-29/B6 cells

scientific article published on 31 July 2013

The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir but not indinavir impair the epithelial barrier in the human intestinal cell line HT-29/B6.

scientific article published in December 1999

The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier

scientific article published on 9 January 2012

The interleukin-2-deficient mouse model

scientific article

The mechanism of diarrhea in HIV is based on an impaired epithelial barrier function that could be induced by a specific cytokine pattern

scientific article published on November 1998

The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs

scientific article published in 2012

The specific fates of tight junction proteins in apoptotic epithelial cells

scientific article published on 30 March 2004

Tight junction proteins as channel formers and barrier builders.

scientific article

Tight junction proteins contribute to barrier properties in human pleura

scientific article published on 25 December 2010

Tight junction proteins: a novel class of integral membrane proteins. Expression in human epidermis and in HaCaT keratinocytes

scientific article

Tight junction regulation during impaired ion transport in blind loops of rat jejunum ⬇️

scientific article published on January 1, 1990

Tight junction, selective permeability, and related diseases

scientific article published on 16 September 2014

Tight junctions and paracellular permeability in cultured bovine corneal endothelial cells

scientific article

Tight junctions form a barrier in human epidermis

scientific article published on 21 August 2010

Tight junctions of the proximal tubule and their channel proteins

scientific article

Tight junctions: molecular structure meets function.

scientific article published in May 2009

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment

scientific article published on 08 November 2019

Time course of aldosterone and corticosterone plasma levels in rats during general anaesthesia and abdominal surgery

scientific article published in December 1983

Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats

scientific article published on 06 January 2019

Trans- and Paracellular Conductivity of HT-29/B6 Cells Measured by High-Resolution Conductance Scanning

scientific article published on 01 November 1998

Trans/paracellular, surface/crypt, and epithelial/subepithelial resistances of mammalian colonic epithelia

scientific article published in February 2000

Transforming Growth Factor-β, a Whey Protein Component, Strengthens the Intestinal Barrier by Upregulating Claudin-4 in HT-29/B6 Cells1,2 ⬇️

scientific article published on March 23, 2011

Transient opening of the perineurial barrier for analgesic drug delivery

scientific journal article

Tricellulin Effect on Paracellular Water Transport

scientific article published on 14 November 2019

Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability

scientific article

Tricellulin forms homomeric and heteromeric tight junctional complexes.

scientific article published on 7 March 2010

Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance

scientific article published on October 2009

Uncoupled basal sodium absorption and chloride secretion in prairie dog (Cynomys ludovicianus) gallbladder

scientific article

Ussing chamber for high-frequency transmural impedance analysis of epithelial tissues

article

Versatile piezoelectric driver for cell puncture

article

Water channels and barriers formed by claudins

scientific article

Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers

scientific article published on 18 October 2010

Zinc acts as a protective agent on the mucosal barrier in experimental TNBS colitis

scientific article published on January 1, 1998

Zinc strengthens the jejunal barrier by reversibly tightening the paracellular route

scientific article

pH dependence of protamine action on apical membrane permeability in Necturus gallbladder epithelium

scientific article

α-Haemolysin of Escherichia coli in IBD: a potentiator of inflammatory activity in the colon

scientific article

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