Search filters

List of works by Valina L. Dawson

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

scientific article

A high-affinity cocaine binding site associated with the brain acid soluble protein 1

scientific article published in 2022

Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

scientific article published on July 2016

Alterations in cortical muscarinic receptors following cholinotoxin (AF64A) lesion of the rat nucleus basalis magnocellularis

scientific article published in January 1992

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

scientific article

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

scientific article

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

scientific article published on 11 April 2007

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

scientific article published on 23 May 2008

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

scientific article

Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor

scientific article published in August 1990

Determinants of seeding and spreading of α-synuclein pathology in the brain

scientific article published on 11 November 2020

Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia

scientific article published in January 2006

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

scientific article published on 6 April 2011

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

scientific article

Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains

scientific article published in 2021

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

scientific article published on 13 February 2018

Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia

scientific article

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

scientific article

Functional Identification of Neuroprotective Molecules ⬇️

scientific article published on November 24, 2010

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

scientific article published on 8 January 2018

GTPase activity plays a key role in the pathobiology of LRRK2.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

scientific article

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

scientific article

High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

scientific article

Hippocampal muscarinic supersensitivity after AF64A medial septal lesion excludes M1 receptors

scientific article published in August 1990

Identification and evaluation of NO-regulated genes by differential analysis of primary cDNA library expression (DAzLE).

scientific article published in January 2005

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models ⬇️

scientific article published on July 18, 2011

Involvement of poly ADP ribosyl polymerase-1 in acute but not chronic zinc toxicity

scientific article published in September 2003

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

scientific article

LRRK2 pathobiology in Parkinson's disease

scientific article published on 10 October 2014

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

scientific article

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

scientific article

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

scientific article

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

scientific article published on November 2007

Maiming mitochondria in familial ALS.

scientific article published in September 2004

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury

scientific article published on October 2010

Neurobiology. Of flies and mice

scientific article published on 01 April 2000

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

scientific article

Neuronal activity regulates hippocampal miRNA expression

scientific article (publication date: 2011)

Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities

scientific article published on 01 July 2019

Normalization of subtype-specific muscarinic receptor binding in the denervated hippocampus by septodiagonal band grafts

scientific article published on 01 November 1989

Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease

scientific article published on February 2004

Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

scientific article published on 17 March 2017

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

scientific article

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.

scientific article published on January 2017

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.

scientific article

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

scientific article published on April 2014

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

scientific article

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

scientific article

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease

scientific article published in Science

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

scientific article

Potent neuroprotectants linked to bifunctional inhibition

scientific article

Promising disease-modifying therapies for Parkinson's disease

scientific article published on 01 November 2019

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

scientific article published on 28 February 2007

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder

scientific article

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

scientific article

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

scientific article

Role of AIF in caspase-dependent and caspase-independent cell death

scientific article

Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia

scientific article published in September 1999

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

scientific article published on May 1996

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

scientific article published on 01 July 1998

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article

The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice

scientific article published in July 2005

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.

scientific article published in December 2017

Toward the human cellular microRNAome.

scientific article published on 6 September 2017

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity ⬇️

scientific article published on October 4, 2011

Usp16: key controller of stem cells in Down syndrome

scientific article published on 27 September 2013

What have genetically engineered mice taught us about ischemic injury?

scientific article published on March 2004

Paulina is supported by:

About Paulina

Help