List of works - Michael K Lee

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

scientific journal article

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

scientific article published in February 1997

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

scientific article published in October 1997

Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice

scientific article published in March 2002

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

scientific article published on March 2012

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

scientific article published in November 1999

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

scientific article

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

scientific article published on June 2005

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

scientific article published on January 1996

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

scientific article published in December 2008

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

scientific article published in June 1995

Animal models of PD: pieces of the same puzzle?

scientific article

Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity

scientific article

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

scientific article published on December 1996

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

scientific article

Axonal transport of human α-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations

scientific article published on 12 December 2003

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.

scientific article published in July 1998

Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

scientific article published in August 2005

Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry

scientific article

Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases

scientific article published on 20 February 2007

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

scientific article published on 6 April 2011

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

scientific article

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

scientific article

Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine

scientific article published on February 2000

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

scientific article

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

scientific article

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

scientific article published in July 1997

Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron

scientific article published in December 1997

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

scientific article published in April 2006

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

scientific article

Inherited Neurodegenerative Diseases and Transgenic Models

scientific article published in October 1996

Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice

scientific article

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

scientific article published on November 2007

Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease

scientific article

Memory enhancement with posttraining intraventricular glucose injections in rats

scientific article

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

scientific article (publication date: 15 January 2004)

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

scientific article

Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility

scientific article

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

scientific article

Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease

scientific article published in February 1994

Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport

scientific article

Neurofilaments are obligate heteropolymers in vivo

scientific article

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

scientific article published in May 1998

Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future

scientific article

Nucleotide sequence of the chromosome 14-encodedS182cDNA and revised secondary structure prediction

scientific article published in January 1995

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

scientific article published in January 2006

Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice

scientific article

Posttranslational modification of class III beta-tubulin

scientific article

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

scientific article

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

scientific article

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses

scientific article

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

scientific article published on August 2004

Subunit composition of neurofilaments specifies axonal diameter.

scientific article published on June 1996

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

scientific article published on August 1994

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

scientific article

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

scientific article published on 06 June 2019

Transgenic models of neurodegenerative diseases

scientific article published on October 1996

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

scientific article

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

scientific article published on April 2006

Vision for the future

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.

scientific article published on 24 January 2007

α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

scientific article published on 16 April 2020

List of works by Michael K Lee

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Animal models of PD: pieces of the same puzzle?

Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

Axonal transport of human α-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.

Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry

Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

Inherited Neurodegenerative Diseases and Transgenic Models

Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Magnetization transfer and adiabatic R 1ρ MRI in the brainstem of Parkinson's disease

Memory enhancement with posttraining intraventricular glucose injections in rats

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease

Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport

Neurofilaments are obligate heteropolymers in vivo

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future

Nucleotide sequence of the chromosome 14-encodedS182cDNA and revised secondary structure prediction

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice

Posttranslational modification of class III beta-tubulin

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

Subunit composition of neurofilaments specifies axonal diameter.

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Transgenic models of neurodegenerative diseases

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Vision for the future

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.

α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment