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List of works by Christian Widmann

14-3-3 proteins interact with specific MEK kinases

scientific article

A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells

scientific article

A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide

scientific article

ABC transporters: HDL-regulated gatekeepers at the endothelial border

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells

scientific article published on 30 November 2020

Acetate is the master of its fate, genetics, and molecular biology bimonthly update

article

Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas

scientific article published on August 1995

Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma

scientific article

Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction

scientific article published on 15 July 2008

Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death

scientific article published in September 1998

Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.

scientific article

Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments

scientific article published on 8 January 2002

Are HDL receptors really located where we think they are in the liver?

article by Sabine Rütti & Christian Widmann published August 2016 in Current Opinion in Lipidology

Assessment of the chemosensitizing activity of TAT-RasGAP317-326 in childhood cancers

scientific article

Bacterial surface properties influence the activity of the TAT-RasGAP<sub>317-326</sub> antimicrobial peptide

scientific article published on 30 July 2021

Burning fat to keep your stem cells? The role of fatty acid oxidation in various tissue stem cells

scientific article published on 01 October 2018

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma

scientific article published on 17 December 2019

Caspase substrates and neurodegenerative diseases

scientific article published on 16 July 2009

Caspase-3 and RasGAP: a stress-sensing survival/demise switch.

scientific article published on 2 September 2013

Caspase-3 protects stressed organs against cell death

scientific article

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

scientific article published on March 1998

Cholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinases

scientific article published in September 2005

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

scientific article

Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation

scientific article published on 15 July 2015

DNA-damage sensitizers: potential new therapeutical tools to improve chemotherapy

scientific article published on June 2007

Delineation of several DR-restricted tetanus toxin T cell epitopes

scientific article published on 01 January 1989

Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP- 1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate

Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate

scientific article published on 01 January 1996

Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents

scientific article published on April 1999

Differential stability of antigenic MHC class I-restricted synthetic peptides

scientific article published in December 1991

Effect of RasGAP N2 fragment-derived peptide on tumor growth in mice.

scientific article published on 26 May 2009

Effect of the TAT-RasGAP(317-326) peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light

scientific article

Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

scientific article

Evaluation and validation of commercial antibodies for the detection of Shb.

scientific article published in December 2017

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway

scientific article published on 5 February 2008

Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion

scientific article

Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes

scientific article published on 20 August 2009

Fatty acid metabolism regulates cell survival in specific niches

scientific article published on 01 June 2017

Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression

scientific article published on 4 March 2014

GAP-independent functions of DLC1 in metastasis

scientific article published on March 2014

Generation of a tightly regulated all-cis beta cell-specific tetracycline-inducible vector

scientific article published on October 2008

Genetics and molecular biology

scholarly article by Sabine Rütti published in December 2015

Genetics and molecular biology

scholarly article by Christian Widmann published in February 2013

Genetics and molecular biology

scholarly article by Romano Regazzi published in April 2012

Genetics and molecular biology

scholarly article by Jannick Pétremand published in August 2011

Genetics and molecular biology: so, so complex HDLs!

scientific article published in June 2009

Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop

scientific article published on 28 April 2009

Glucose metabolism in cancer cells

scientific article published on July 2010

H-2-restricted cytolytic T lymphocytes specific for HLA display T cell receptors of limited diversity

scientific article

HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking

scientific article published on 7 March 2012

HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality

scientific article published on 28 August 2013

HDLs, diabetes, and metabolic syndrome

scientific article

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy.

scientific article published on 24 May 2018

High resolution crystal structures of the p120 RasGAP SH3 domain

scientific article

High-density lipoprotein, beta cells, and diabetes .

scientific article

Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells

scientific article published on 17 April 2007

Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion

scientific article published on 05 March 2019

Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule

scientific article published in March 1992

Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157

scientific article

In vitro activity of MEKK2 and MEKK3 in detergents is a function of a valine to serine difference in the catalytic domain

scientific article published on May 2001

Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor

scientific article published on 11 November 2013

Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure

scientific article

Internalization and Homologous Desensitization of the GLP-1 Receptor Depend on Phosphorylation of the Receptor Carboxyl Tail at the Same Three Sites

scholarly article by Christian Widmann published in July 1997

Internalization and homologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites

scientific article published on 01 July 1997

Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells

scientific article

Islet-brain (IB)/JNK-interacting proteins (JIPs): future targets for the treatment of neurodegenerative diseases?

scientific article

LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway

scientific article published in September 2003

LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase

scientific article published in 2008

Lipid metabolism: sphingolipids- from membrane constituents to signaling molecules that control cell-to-cell communications

Lipoproteins and mitogen-activated protein kinase signaling: a role in atherogenesis?

scientific article

MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein

scientific article

MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation

scientific article

MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?

scientific article published on February 1997

Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions

scientific article

Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1.

scientific article

Promises of apoptosis-inducing peptides in cancer therapeutics

scientific article published on August 2011

RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.

scientific article published on 24 June 2015

RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes

scientific article

RasGTPase-activating protein is a target of caspases in spontaneous apoptosis of lung carcinoma cells and in response to etoposide

scientific article published on 23 January 2004

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent

scientific article published on 19 November 2019

Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun

scientific article

Reovirus-induced apoptosis is mediated by TRAIL

scientific article

Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1

scientific article published on 19 December 2011

Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection

scientific article

Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis.

scientific article published on February 2002

Role of the sub-cellular localization of RasGAP fragment N2 for its ability to sensitize cancer cells to genotoxin-induced apoptosis

scientific article published on 27 March 2009

Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure

scientific article

Signal transduction and desensitization of the glucagon-like peptide-1 receptor

scientific article published on 01 July 1996

Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain

scientific journal article

Splice variant-specific stabilization of JNKs by IB1/JIP1.

scientific article published on 31 July 2007

Squalene: friend or foe for cancers

scientific article published on 01 August 2019

Surviving the kiss of death

scientific article published in September 2004

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire

scientific article

T helper epitopes enhance the cytotoxic response of mice immunized with MHC class I-restricted malaria peptides

scientific article published in October 1992

TAT-RasGAP317-326 Enhances Radiosensitivity of Human Carcinoma Cell Lines In Vitro and In Vivo through Promotion of Delayed Mitotic Cell Death

scientific article published on 21 March 2017

TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak.

scientific article published on April 2014

TAT-RasGAP<sub>317-326</sub> kills cells by targeting inner-leaflet-enriched phospholipids

scientific article published on 30 November 2020

The Anticancer Peptide TAT-RasGAP317-326 Exerts Broad Antimicrobial Activity.

scientific article

The HDL: adipocyte connection

The PI3K/Akt pathway is not a main driver in HDL-mediated cell protection

scientific article published on 20 June 2019

The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation

scientific article published in Journal of Biological Chemistry

The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner

scientific article published on 02 September 2016

The caspase-3-p120-RasGAP module generates a NF- B repressor in response to cellular stress

scientific article published on 29 July 2015

The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice

scientific article published on 2 February 2017

The control of lipid-induced inflammation by macrophages

scientific article

The functional half-life of H-2Kd-restricted T cell epitopes on living cells

scholarly article by Gérard Eberl et al published September 1996 in European Journal of Immunology

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

scientific article

The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases

scientific article published on 19 June 2021

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

scientific article published in July 1997

The role of endogenous and exogenous RasGAP-derived fragment N in protecting cardiomyocytes from peroxynitrite-induced apoptosis

scientific article

The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.

scientific article

Triglyceride and HDL

UV-B induces cytoplasmic survivin expression in mouse epidermis

scientific article published on 15 June 2012

[Survival mechanisms to cellular stress]

scientific article published on 01 April 2005

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