List of works by Hironori Nakagami

A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke

scientific article

A novel lipoprotein (a) lowering drug, D-47, decreases neointima thickening after vascular injury

scientific article published in January 2017

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms

scientific article published on January 2003

A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

scientific article published on 07 March 2017

ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO.

scientific article published on September 2002

ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth

scientific article

Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy

scientific article (publication date: April 2006)

Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway

scientific article

Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress

scientific article published on 31 March 2017

Angiotensin II accelerates osteoporosis by activating osteoclasts

scientific article published on 6 February 2008

Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.

scientific article published on September 2002

Angiotensin converting enzyme gene polymorphism in essential hypertension based on ambulatory blood pressure monitoring

scientific article published on 01 July 1997

Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells

scientific article published in October 2000

Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide

scientific article

Antiproliferative effects of monoclonal antibodies against (pro)renin receptor in pancreatic ductal adenocarcinoma

scientific article published on 15 July 2020

Can Forkhead Box P1 be a novel therapeutic target for atherosclerosis?

scientific article

Cellular senescence and senescence-associated T cells as a potential therapeutic target

scientific article published on 14 December 2019

Cold shock domain protein A (CSDA) overexpression inhibits tumor growth and lymph node metastasis in a mouse model of squamous cell carcinoma

scientific article published on 10 July 2010

Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element

scientific journal article

Common molecular mechanism of osteoporosis and vascular diseases

scientific article published on 01 January 2011

Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse

scientific article published on 19 February 2015

Contribution of Bcl-2, but not Bcl-xL and Bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells

Contribution of cardiovascular hypersensitivity to orthostatic hypertension and the extreme dipper phenomenon

scientific article

Coronary artery disease and endothelial nitric oxide synthase and angiotensin-converting enzyme gene polymorphisms

scientific article published on 01 October 1999

Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle

scientific article published on 14 June 2011

Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21

scientific article

Design of therapeutic vaccines as a novel antibody therapy for cardiovascular diseases

scientific article published on 08 April 2017

Development of DNA vaccines as an anti-hypertensive therapy or for anti-angiogenesis

scientific article

Development of a novel antimicrobial peptide, AG-30, with angiogenic properties

scientific article

Development of high-throughput functional screening of therapeutic genes, using a hemagglutinating virus of Japan envelope vector

scientific article

Development of novel DNA vaccine for VEGF in murine cancer model

scientific article

Development of nucleic acid drugs for neurological disorders

scientific article published on January 2012

Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice

scientific article published on 13 February 2018

Differential response of vascular hepatocyte growth factor concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice

scientific article published on September 2008

Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells

scientific article

Diurnal blood pressure rhythm in hypertensives with parental history of stroke

scientific article published on 01 May 1997

Do angiotensin receptor blockers protect against Alzheimer's disease?

scientific article published on June 2013

Effect of an antimicrobial agent on atherosclerotic plaques: assessment of metalloproteinase activity by molecular imaging

scientific article published in March 2010

Effect of angiotensin II type 1 receptor blockade on cardiac remodeling in angiotensin II type 2 receptor null mice

scientific article published in January 2002

Effect of angiotensin II receptor blocker, olmesartan, on turnover of bone metabolism in bedridden elderly hypertensive women with disuse syndrome

scientific article published on 3 November 2014

Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells

scientific article published in July 2001

Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis

scientific article published on February 2005

Essential role for miR-196a in brown adipogenesis of white fat progenitor cells

scientific article

Estrogen activates phosphatases and antagonizes growth-promoting effect of angiotensin II.

scientific article published in January 2002

Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice

scientific article published on 7 December 2016

Evaluation of the genetic risk of hypertension-related diseases

scientific article published on 25 February 2015

FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.

scientific article

Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation

scientific article

Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action

scientific article

Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension

scientific article published in December 2007

Gene therapy and cell-based therapies for therapeutic angiogenesis in peripheral artery disease

scientific article

Gene therapy for peripheral arterial disease

scientific article published on 28 April 2014

Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons.

scientific article

Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes

scientific article published on 25 May 2017

HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model.

scientific article published on 6 December 2002

HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function

scientific article

Hepatocyte growth factor as potential cardiovascular therapy

scientific article

Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane

scientific article published in August 2002

Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation

scientific article published in May 2000

Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: role of Bcl-2, Bcl-xL and Bax in tubular injury

scientific article

Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.

scientific article

Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus

scientific article published on September 2007

Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element 'decoy' of nuclear factor-kappaB binding site as a novel molecular strategy

scientific article

Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth

scientific article published in August 1999

Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells

scientific article published on 10 February 2010

Investigator-initiated clinical study of a functional peptide, SR-0379, for limb ulcers of patients with Werner syndrome as a pilot study

scientific article published on 01 November 2019

Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle.

scientific article

Involvement of gamma-secretase in postnatal angiogenesis

scientific article published on 14 September 2007

Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells.

scientific article

Long-term expression of periostin during the chronic stage of ischemic stroke in mice

scientific article published on 20 March 2014

Low alpha-synuclein levels in the blood are associated with insulin resistance

scientific article published on 10 July 2015

Lymphedema and therapeutic lymphangiogenesis

scientific article published on 9 October 2013

Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector

scientific article

Management guideline for Werner syndrome 2020 1. Dyslipidemia and fatty liver associated with Werner syndrome

scientific article published on 01 December 2020

Management guideline for Werner syndrome 2020 8. Calcification in tendons associated with Werner syndrome

scientific article published on 01 December 2020

Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome

scientific article published on 09 November 2020

Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome

scientific article published on 09 November 2020

Management guideline for Werner syndrome 2020. 4. Osteoporosis associated with Werner syndrome

scientific article published on 05 November 2020

Management guideline for Werner syndrome 2020. 5. Infection associated with Werner syndrome

scientific article published on 01 November 2020

Management guideline for Werner syndrome 2020. 6. Skin ulcers associated with Werner syndrome: Prevention and non-surgical and surgical treatment

scientific article published on 22 November 2020

Management guideline for Werner syndrome 2020. 7. Skin ulcer associated with Werner syndrome dermatological treatment

scientific article published on 03 November 2020

Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells

scientific article

Mitral regurgitation reduces the risk of stroke in patients with nonrheumatic atrial fibrillation

scientific article published in September 1998

Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine

scientific article published on 5 June 2006

Moderate to high concentrations of high-density lipoprotein from healthy subjects paradoxically impair human endothelial progenitor cells and related angiogenesis by activating Rho-associated kinase pathways.

scientific article

Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents

scientific article published on July 2012

Modification of decoy oligodeoxynucleotides to achieve the stability and therapeutic efficacy

scientific article published on January 2012

N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression

scientific article published in April 2002

NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy

scientific article

NF-kappaB is a key mediator of cerebral aneurysm formation

scientific article published on 19 November 2007

NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts

scientific article published on 2 March 2006

New concept of vascular calcification and metabolism

scientific article published on 01 January 2011

No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice.

scientific article published on February 2004

Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathway

scientific article

Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells

scientific article

Novel drug delivery system by surface modified magnetic nanoparticles

scientific article published on September 2006

Nucleic acid drugs for preventing restenosis after coronary revascularization

scientific article published on January 2012

OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice

scientific article

Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-γ.

scientific article published in March 2011

Oligonucleotide-based gene therapy for cardiovascular disease

scientific article

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor

scientific article

Peptide Vaccines for Hypertension and Diabetes Mellitus

scientific article

Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity

scientific article published on 07 March 2019

Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells

scientific article published in June 2001

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial.

scientific article published on 13 February 2018

Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers

scientific article published on 10 May 2017

Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway.

scientific article published in February 2009

Pivotal role of tyrosine phosphatase SHP-1 in AT2 receptor-mediated apoptosis in rat fetal vascular smooth muscle cell

scientific article

Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters

scientific article

Potential effect of angiotensin II receptor blockade in adipose tissue and bone

scientific article published on January 2013

Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells

scientific article

Prevention of neointimal formation after angioplasty using nuclear factor-κB decoy oligodeoxynucleotide-coated balloon catheter in rabbit model

scientific article

Priming with angiopoietin-1 augments the vasculogenic potential of the peripheral blood stem cells mobilized with granulocyte colony-stimulating factor through a novel Tie2/Ets-1 pathway.

scientific article

RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages

scientific article published on 12 April 2022

Recent progress in therapeutic angiogenesis

scientific article published on September 2007

Recurrent arterial thrombotic disease on young onset and protein S deficiency

scientific article published on 01 October 1998

Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model: potential application of ribozyme strategy to treat cardiovascular disease

scientific article published on 01 September 2000

Role of angiotensin II-regulated apoptosis through distinct AT1 and AT2 receptors in neointimal formation

scientific article published on 01 August 2002

Role of central nervous system periostin in cerebral ischemia

scientific article published on 2 February 2012

Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury

scientific article published in November 2001

Statins and myocardial hypertrophy

scientific article published in August 2004

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

scientific article

Systemic administration of ribbon-type decoy oligodeoxynucleotide against nuclear factor κB and ets prevents abdominal aortic aneurysm in rat model

scientific article published on 28 September 2010

Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice

scientific article published on 02 May 2019

Teneligliptin : expectations for its pleiotropic action

scientific article

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

scientific article published on 18 May 2020

The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells

scientific article published on 27 May 2015

The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome

scientific article published on 13 March 2014

The mechanism of white and brown adipocyte differentiation

scientific article published on April 2013

The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells

scientific article

Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease

scientific article

Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes

scientific article

Therapeutic effect of ribbon-type nuclear factor-κB decoy oligonucleotides in a rat model of inflammatory bowel disease

scientific article published in December 2012

Therapeutic vaccines for hypertension and dyslipidemia

scientific article

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4

scientific journal article

Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smooth muscle cells

scientific article published on 01 March 2000

Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis

scientific article published on 4 September 2006

Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells

scientific article published in February 2002

Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.

scientific article

Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model

scientific article

Variation in OSBPL10 is associated with dyslipidemia

scientific article published on 12 March 2010

Vascular protective effects of ezetimibe in ApoE-deficient mice

scientific article

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

scientific article

Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis

scientific article

[Activation of osteoclasts by RAAS and strategy of target therapy on bone metabolic diseases].

scientific article

[Bone metabolism and cardiovascular function update. Cross link of hypertension, bone loss and vascular calcification - common back grounds in renin angiotensin system with anti-aging aspect -]

scientific article published on 01 July 2014

[Endothelial cell growth inhibitory gene]

scientific article published on 01 July 2006

[Gene therapy for anti-aging medicine].

scientific article

[Hormones and osteoporosis update. Effect of angiotensin II on bone metabolism]

scientific article published on 01 July 2009

[Hypertension and osteoporosis]

scientific article published on 01 April 2013

[Hypertension, CKD and bone metabolism].

scientific article published in May 2011

[The cutting-edge of medicine; anti-aging and cardiovascular diseases]

scientific article published on 01 June 2011

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