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List of works by Stephen M. Beverley

'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana

scientific article published on 10 December 2012

A Narnavirus in the Trypanosomatid Protist Plant Pathogen Phytomonas serpens

scientific article published on 28 July 2016

A Narnavirus-Like Element from the Trypanosomatid Protozoan Parasite Leptomonas seymouri

scientific article

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

scientific article published on 01 April 1984

A lipophosphoglycan-independent development of Leishmania in permissive sand flies

scientific article

A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation

scientific article published on 01 October 2001

A molecular docking strategy identifies Eosin B as a non-active site inhibitor of protozoal bifunctional thymidylate synthase-dihydrofolate reductase

scientific article

A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major

scientific article

A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.

scientific article

A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum

scientific article published on July 1999

A survey of the Leishmania major Friedlin strain V1 genome by shotgun sequencing: a resource for DNA microarrays and expression profiling

article

A test for genetic exchange in mixed infections of Leishmania major in the sand fly Phlebotomus papatasi

scientific article published on May 1991

A transposon toolkit for gene transfer and mutagenesis in protozoan parasites.

scientific article published on 10 September 2009

A transposon-based tool for transformation and mutagenesis in trypanosomatid protozoa

scientific article published on January 2015

African Trypanosomes Find a Fat Haven

scientific article published on June 2016

Amplification of a new region of DNA in an unselected laboratory stock of L. tarentolae: the T region

scientific article published on May 1989

Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.

scientific article

An alternative in vitro drug screening test using Leishmania amazonensis transfected with red fluorescent protein

scientific article published on 10 January 2013

An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans.

scientific article published in August 2003

Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition.

scientific article published on September 1993

Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor.

scientific article published on 17 January 2017

Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia.

scientific article

Base J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination

scientific article published on 29 April 2016

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.

scientific article

Blasticidin resistance: a new independent marker for stable transfection of Leishmania

scientific article published on 01 May 2000

Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.

scientific article

Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major

scientific article published on December 2004

Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization

scientific article

Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major

scientific article published on 31 July 2002

Characterization of the 'unusual' mobility of large circular DNAs in pulsed field-gradient electrophoresis

scientific article published on February 1988

Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant

scientific article

Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis.

scientific article published on 18 September 2015

Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major

scientific article

Concomitant Immunity Induced by Persistent Leishmania major Does Not Preclude Secondary Re-Infection: Implications for Genetic Exchange, Diversity and Vaccination

scientific article

Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification

scientific article published in April 2001

Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts

scientific article published on 17 January 2017

Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector

scientific article

Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1)

scientific article published on 01 September 1999

Deficiency of Leishmania phosphoglycans influences the magnitude but does not affect the quality of secondary (memory) anti-Leishmania immunity

scientific article

Degradation of host sphingomyelin is essential for Leishmania virulence.

scientific article

Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major

scientific article

Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase

scientific article published on 4 November 2005

Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis

scientific article published in November 1993

Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector

scientific article

Detection of Leishmania RNA virus in Leishmania parasites

scientific article

Development of a safe live Leishmania vaccine line by gene replacement.

scientific article

Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes

scientific article

Developmentally regulated sphingolipid synthesis in African trypanosomes

scientific article published on 11 August 2008

Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells

scientific article published on 2 December 2015

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species

scientific article

Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes

scientific article

Discrimination amongst Leishmania by polymerase chain reaction and hybridization with small subunit ribosomal DNA derived oligonucleotides.

scientific article published in July 1994

Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events

scientific article

Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation.

scientific article published on April 1997

Estimation of circular DNA size using gamma-irradiation and pulsed-field gel electrophoresis

scientific article published in February 1989

Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

scientific article published on 27 August 2003

Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens

scientific article

Evaluation of α,β-unsaturated ketones as antileishmanial agents.

scientific article published on 23 March 2015

Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan

scientific article published on September 1994

Evolution of nuclear DNA and the occurrence of sequences related to new small chromosomal DNAs in the trypanosomatid genus Endotrypanum

scientific article published in May 1990

Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity

scientific article

Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major

scientific article published in July 2004

Flypaper for parasites

scientific article published in October 2004

Folate metabolic pathways in Leishmania

scientific article published on January 2011

Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major

scientific article published on August 2003

Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions

scientific article published on 24 February 2003

Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage

scientific article published on 12 September 2017

Gene amplification and drug resistance in cultured animal cells.

scientific article published on March 1984

Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania.

scientific article

Genetic nomenclature for Trypanosoma and Leishmania.

scientific article

Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications

scientific article published on 11 January 2006

Golgi GDP-mannose uptake requires Leishmania LPG2. A member of a eukaryotic family of putative nucleotide-sugar transporters

scientific article

Heterologous expression of Trypanosoma cruzi trans-sialidase in Leishmania major enhances virulence

scientific article

Hijacking the cell: parasites in the driver's seat

scientific article

Host-microbe interactions: fungi/viruses/parasites

scientific article published on 01 August 1999

Identification of a DNA fragment that increases mitotic stability of episomal linear DNAs in Leishmania major

scientific article

Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies

scientific article

Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major

scientific article published on 15 May 2003

Immunization with persistent attenuated Delta lpg2 Leishmania major parasites requires adjuvant to provide protective immunity in C57BL/6 mice

scientific article

Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha

scientific article published on 2 April 2015

Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania

scientific article

In vivo imaging of transgenic Leishmania parasites in a live host

scientific article published on 27 July 2010

Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis

scientific article

Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan.

scientific article published on 22 February 2012

Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process.

scientific article published on 06 August 2009

Insertional mutagenesis by a modified in vitro Ty1 transposition system

scientific article published on October 1997

Intergenic region typing (IRT): a rapid molecular approach to the characterization and evolution of Leishmania

scientific article published on 01 July 1995

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

scientific article

Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.

scientific article

Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis

scientific article published on 8 February 2012

Kinetoplastid-specific histone variant functions are conserved in Leishmania major.

scientific article published on 27 September 2013

Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability

scientific article

Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis

scientific article published on February 2011

Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response

scientific article

Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity

scientific article

Leishmania donovani has distinct mannosylphosphoryltransferases for the initiation and elongation phases of lipophosphoglycan repeating unit biosynthesis

scientific article published on 01 July 1998

Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts

scientific article published on 27 March 2009

Leishmania donovani possess a NADPH-dependent alkylglycerol cleavage enzyme

scientific article published on 01 October 1996

Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors

scientific article

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice

scientific article

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

scientific article published on 20 January 2009

Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions

scientific article published on June 2009

Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern

scientific article

Leishmania major: promastigotes induce expression of a subset of chemokine genes in murine macrophages

scientific article published on 01 March 1997

Leishmania mexicana promastigotes induce cytotoxic T lymphocytes in vivo that do not recognize infected macrophages.

scientific article

Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis

scientific article published on March 2005

Leishmania tarentolae taxonomic relatedness inferred from phylogenetic analysis of the small subunit ribosomal RNA gene

scientific article

Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A.

scientific article

Leishmanicidal activity of two naphthoquinones against Leishmania donovani ⬇️

scientific article published on January 2012

Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania

scientific article published on January 1998

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.

scientific article

Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex

scientific article published on January 1992

Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil

scientific article published on 18 August 2016

Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence

scientific article

Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major

scientific article published on 16 January 2009

Migratory dermal dendritic cells act as rapid sensors of protozoan parasites

scientific article (publication date: November 2008)

Molecular evolution in Drosophila and the higher Diptera II. A time scale for fly evolution

scientific article published on 01 January 1984

Molecular evolution of Drosophila and higher Diptera. I. Micro-complement fixation studies of a larval hemolymph protein

scientific article published in January 1982

Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP.

scientific article

Mucocutaneous leishmaniasis and an undesired passenger

scientific article published on 30 November 2011

Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in Leishmania infantum.

scientific article published on March 2014

New Mos1 mariner transposons suitable for the recovery of gene fusions in vivo and in vitro.

scientific article published in December 2001

Non-pathogenic trypanosomatid protozoa as a platform for protein research and production

scientific article published on 01 July 2002

Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major

scientific article published in November 1990

On the introduction of genetically modified Leishmania outside the laboratory.

scientific article

PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

scientific article published on 25 April 2009

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

scientific article published in November 1994

Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.

scientific article published on 04 March 2013

Parasitology: CRISPR for Cryptosporidium

scientific article

Persistence without pathology in phosphoglycan-deficient Leishmania major

scientific article published in August 2003

Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major

scientific article

Phospholipid and sphingolipid metabolism in Leishmania

scientific article

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage

scientific article

Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.

scientific article

Priming of a beta-galactosidase (beta-GAL)-specific type 1 response in BALB/c mice infected with beta-GAL-transfected Leishmania major

scientific article

Protective role of the neuropeptide urocortin II against experimental sepsis and leishmaniasis by direct killing of pathogens

scientific article

Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.

scientific article

Protozomics: trypanosomatid parasite genetics comes of age.

scientific article

Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

scientific article

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

scientific article published on April 2001

Purified mariner (Mos1) transposase catalyzes the integration of marked elements into the germ-line of the yellow fever mosquito, Aedes aegypti

scientific article published on November 2000

Putting the Leishmania genome to work: functional genomics by transposon trapping and expression profiling

scientific article

REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation SEquencing data

scientific article

Reconstitution of GDP-mannose transport activity with purified Leishmania LPG2 protein in liposomes.

scientific article

Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species

scientific article published in August 1990

Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania

scientific article published on 8 February 2007

Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins

scholarly article

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin

scientific article published in April 2001

Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes

scientific article

Retention and loss of RNA interference pathways in trypanosomatid protozoans

scientific article

SODB1 is essential for Leishmania major infection of Macrophages and Pathogenesis in Mice

scientific article published on 29 October 2018

Sequence and S1 nuclease mapping of the 5' region of the dihydrofolate reductase-thymidylate synthase gene of Leishmania major

scientific article

Sequence of the dihydrofolate reductase-thymidylate synthase (DHFR-TS) gene of Leishmania amazonensis

scientific article published on May 1990

Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus

scientific article published on February 2016

Shuttle cosmid vectors for the trypanosomatid parasite Leishmania

scientific article published on September 1993

Simultaneous transient expression assays of the trypanosomatid parasite Leishmania using beta-galactosidase and beta-glucuronidase as reporter enzymes

scientific article published on 01 July 1991

Sphingolipids are essential for differentiation but not growth in Leishmania

scientific article

Sphingolipids in parasitic protozoa

scientific article

Stable DNA transfection of a wide range of trypanosomatids

scientific article

Stable amplification of a linear extrachromosomal DNA in mycophenolic acid-resistant Leishmania donovani

scientific article published on October 1992

Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant

scientific article published in October 1998

Structural alterations of chromosome 2 in Leishmania major as evidence for diploidy, including spontaneous amplification of the mini-exon array.

scientific article

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

scientific article published in September 2005

Tests of heterologous promoters and intergenic regions in Leishmania major

scientific article

The H region HTBF gene mediates terbinafine resistance in Leishmania major.

scientific article published in September 2003

The LPG1 gene family of Leishmania major

scientific article published on July 2004

The Leishmania GDP-mannose transporter is an autonomous, multi-specific, hexameric complex of LPG2 subunits

scientific article published in February 2000

The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1).

scientific article

The PGPA gene of Leishmania major mediates antimony (SbIII) resistance by decreasing influx and not by increasing efflux.

scientific article

The application of gene expression microarray technology to kinetoplastid research

scientific article published in September 2004

The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major

scientific article published on 05 April 2009

The genome of the kinetoplastid parasite, Leishmania major

scientific article

The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis.

scientific article

The mating competence of geographically diverse Leishmania major strains in their natural and unnatural sand fly vectors

scientific article

The role of phosphoglycans in Leishmania-sand fly interactions

scientific article published on January 2000

The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major

scientific article

The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts

scientific article

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

scientific article

The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway.

scientific article published on 26 December 2012

The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing

scientific article

Therapeutic efficacy of stable analogues of vasoactive intestinal peptide against pathogens.

scientific article

Thymidine kinase as a negative selectable marker in Leishmania major

scientific article published in April 1992

Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response.

scientific article published on 18 October 2016

Trans-kingdom transposition of the Drosophila element mariner within the protozoan Leishmania.

scientific article

Transposition of the Drosophila element mariner within the human malaria parasite Plasmodium falciparum

scientific article published in October 2000

Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival

scientific article

Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major

scientific article

Two more independent selectable markers for stable transfection of Leishmania

scientific article published on 01 November 1993

Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.

scientific article published on 24 April 2017

Uncovering Leishmania-macrophage interplay using imaging flow cytometry

scientific article published on 9 May 2015

Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization.

scientific article

Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans.

scientific article published on 13 February 2013

Use of the green fluorescent protein as a marker in transfected Leishmania

scientific article published on 01 April 1996

Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania.

scientific article published on 28 December 2017

Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro

scientific article published in February 2000

Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania

scientific article published on 15 May 2019

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