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Authors whose works are in public domain in at least one jurisdiction

List of works by Michael Maes

"Functional" or "psychosomatic" symptoms, e.g. a flu-like malaise, aches and pain and fatigue, are major features of major and in particular of melancholic depression

scientific article published in January 2009

(Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: from antioxidants to kinase inhibitors

scientific article published on 2 March 2011

A New Schizophrenia Model: Immune Activation is Associated with the Induction of Different Neurotoxic Products which Together Determine Memory Impairments and Schizophrenia Symptom Dimensions

scientific article published on 01 January 2019

A further investigation of basal HPT axis function in unipolar depression: effects of diagnosis, hospitalization, and dexamethasone administration

scientific article published in February 1994

A game-based neurofeedback training system to enhance cognitive performance in healthy elderly subjects and in patients with amnestic mild cognitive impairment

scientific article published on 19 February 2019

A model of the mitochondrial basis of bipolar disorder.

scientific article published on 13 January 2017

A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior.

scientific article

A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome

scientific article published on 21 June 2012

A neuro-immune, neuro-oxidative and neuro-nitrosative model of prenatal and postpartum depression

scientific article

A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months

scientific article published on 9 January 2013

A novel approach of substitution therapy with inhalation of essential oil for the reduction of inhalant craving: A double-blinded randomized controlled trial.

scientific article

A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis

scientific article

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

scientific article published on 12 May 2010

A significantly increased number and percentage of B cells in depressed subjects: results of flow cytometric measurements

scientific article published on 01 March 1992

Abnormal pituitary function during melancholia: reduced alpha-melanocyte-stimulating hormone secretion and increased intact ACTH non-suppression

scientific article published on July 1991

Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby.

scientific article published on 6 July 2017

Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression

article

Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis

scientific article published on 26 December 2018

Activation of the inflammatory response system in autism

scientific article published in January 2002

Activation of the inflammatory response system: A new look at the etiopathogenesis of major depression

article

Acute administration of buspirone increases the escape of hypothalamic-pituitary-adrenal-axis hormones from suppression by dexamethasone in depression

scientific article published on 01 January 1996

Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs

scientific article published on 01 January 1997

Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study

scientific article

Addition of vitamin D reverses the decline in GFR following treatment with ACE inhibitors/angiotensin receptor blockers in patients with chronic kidney disease.

scientific article published on 24 October 2017

Adjunctive minocycline treatment for major depressive disorder: A proof of concept trial.

scientific article published in June 2017

Adrenocorticotropic hormone, β-endorphin and cortisol responses to oCRH in Unipolar Depressed Patients Pretreated with Dexamethasone

article

Affective symptoms in schizophrenia are strongly associated with neurocognitive deficits indicating disorders in executive functions, visual memory, attention and social cognition.

scientific article

Affective temperaments and emotional traits are associated with a positive screening for premenstrual dysphoric disorder

scientific article published on 18 August 2016

Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice

scientific article published in November 2009

Albumin and Protein Oxidation are Predictors that Differentiate Relapsing-Remitting from Progressive Clinical Forms of Multiple Sclerosis

scientific article published on 30 March 2016

Alterations in immune functions during normal aging and Alzheimer's disease

scientific article published in January 1999

Alterations in iron metabolism and the erythron in major depression: Further evidence for a chronic inflammatory process

article

Alterations in plasma prolyl endopeptidase activity in depression, mania, and schizophrenia: effects of antidepressants, mood stabilizers, and antipsychotic drugs

scientific article

An IgM-mediated immune response directed against nitro-bovine serum albumin (nitro-BSA) in chronic fatigue syndrome (CFS) and major depression: evidence that nitrosative stress is another factor underpinning the comorbidity between major depression a

article

An augmented escape of androstenedione from suppression by dexamethasone in melancholia: relationships to intact ACTH and cortisol nonsuppression

scientific article published on 01 August 1995

An augmented escape of beta-endorphins to suppression by dexamethasone in severely depressed patients

scientific article published in March 1990

An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: results of a large-scaled and controlled study

scientific article published in January 1993

An inducible nitric oxide synthase polymorphism is associated with the risk of recurrent depressive disorder.

scientific article

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

scientific article published on 04 July 2010

Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia

scientific article published on 12 August 2015

Antenatal and postnatal risk factors of postpartum depression symptoms in Thai women: A case-control study

scientific article published on 11 March 2016

Antenatal depression and hematocrit levels as predictors of postpartum depression and anxiety symptoms.

scientific article published on 17 February 2016

Anti-Inflammatory effects of antidepressants through suppression of the interferon-gamma/interleukin-10 production ratio.

scientific article

Antiphospholipid, antinuclear, Epstein-Barr and cytomegalovirus antibodies, and soluble interleukin-2 receptors in depressive patients

scientific article published in February 1991

Anxiety Disorders: Sex Differences in Serotonin and Tryptophan Metabolism

scientific article published on 01 January 2018

Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts

scientific article published on 31 August 2017

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

scientific article

Association between Single-Nucleotide Polymorphisms of the hOGG1,NEIL1,APEX1, FEN1,LIG1, and LIG3 Genes and Alzheimer's Disease Risk

scientific article

Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy.

scientific article published in January 2002

Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy

scientific article published in November 2001

Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder.

scientific article

Association between single nucleotide polymorphisms of MUTYH, hOGG1 and NEIL1 genes, and depression

scientific article published on 3 June 2015

Association between −G308A tumor necrosis factor alpha gene polymorphism and schizophrenia

article

Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.

scientific article published on 6 November 2014

Associations between severity of anxiety and clinical and biological features of major affective disorders.

scientific article published on 8 November 2017

Associations of Serum Cytokine Receptor Levels with Melancholia, Staging of Illness, Depressive and Manic Phases, and Severity of Depression in Bipolar Disorder.

scientific article published on 23 September 2016

Atopic disorders and depression: findings from a large, population-based study

scientific article published on 19 November 2013

Auditory event related potentials in major depression: prolonged P300 latency and increased P200 amplitude

scientific article published in March 1998

Autobiographical memory dysfunctions in depressive disorders.

scientific article

Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment

scientific article

Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders

scientific article

Bias in emerging biomarkers for bipolar disorder

scientific article published on 19 May 2016

Biochemical, metabolic and immune correlates of seasonal variation in violent suicide: a chronoepidemiologic study

scientific article published on January 1996

Biography

scientific article published in March 2001

Biological heterogeneity of melancholia: results of pattern recognition methods

scientific article published on January 1991

Biological mechanisms of depression following treatment with interferon for chronic hepatitis C: A critical systematic review.

scientific article published on 27 November 2016

Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome.

scientific article published on 17 August 2013

Biological underpinnings of the commonalities in depression, somatization, and Chronic Fatigue Syndrome.

scientific article

Blood coagulation and platelet aggregation in major depression

article

Body image dissatisfaction in pregnant and non-pregnant females is strongly predicted by immune activation and mucosa-derived activation of the tryptophan catabolite (TRYCAT) pathway.

scientific article published on 18 July 2016

Borna disease virus and deficit schizophrenia

scientific article published in October 2003

Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone.

scientific article published on 11 May 2017

Breakdown of the Paracellular Tight and Adherens Junctions in the Gut and Blood Brain Barrier and Damage to the Vascular Barrier in Patients with Deficit Schizophrenia

scientific article published on 10 May 2019

Breastfeeding and the gut-brain axis: is there a role for melatonin?

scientific article

Bright light and oxygen therapies decrease delirium risk in critically ill surgical patients by targeting sleep and acid-base disturbances.

scientific article published on 18 December 2017

CO2 challenge induced HPA axis activation in panic

scientific article published in November 2006

CO2 challenge results in hypothalamic-pituitary-adrenal activation in healthy volunteers

scientific article published in May 2005

Cannabis use and suicide attempts among 86,254 adolescents aged 12–15 years from 21 low- and middle-income countries

scientific article published on 15 November 2018

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists.

scientific article published on 19 October 2017

Cell adhesion molecules and plasminogen activator inhibitor type-1 (PAI-1) in patients with rheumatoid arthritis: influence of metabolic syndrome

scientific article published on 14 July 2018

Central nervous system symptoms related to the use of efavirenz in HIV-seropositive patients

article

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

scientific article

Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test.

scientific article published in August 2007

Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in Semantic and Episodic Memory Coupled with Increased False-Memory Creation in Deficit Schizophren

scientific article

Changes in platelet alpha-2-adrenoceptors in fibromyalgia: effects of treatment with antidepressants

scientific article published in September 1999

Characteristics of Mild Cognitive Impairment Using the Thai Version of the Consortium to Establish a Registry for Alzheimer's Disease Tests: A Multivariate and Machine Learning Study

scientific article published on 04 April 2018

Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates

scientific article published on 23 September 2020

Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins.

scientific article

Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways

scientific article published on 15 June 2010

Chronic fatigue syndrome: la bête noire of the Belgian health care system.

scientific article

Chronobiological Fluctuations in Semen Parameters with a Constant Abstinence Period

scientific article published on 01 September 1996

Clara cell protein: concentrations in cerebrospinal fluid, serum and amniotic fluid

scientific article published in June 1998

Clinical psychology and behavioral medicine

Cluster analytic validation of the DSM melancholic depression. The threshold model: integration of quantitative and qualitative distinctions between unipolar depressive subtypes

article

Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder.

scientific article published in January 2009

Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications

scientific article published on 13 June 2013

Cognitive Impairment in Euthymic Pediatric Bipolar Disorder: A Systematic Review and Meta-Analysis

scientific article published on 2 February 2017

Combination of serum markers related to several mechanisms in Alzheimer's disease

scientific article published in November 2003

Common Environmental Factors May Underpin the Comorbidity Between Generalized Anxiety Disorder and Mood Disorders Via Activated Nitro-oxidative Pathways

scientific article published on 01 January 2018

Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways

scientific article published on 26 August 2015

Components of biological variation in plasma haptoglobin: relationships to plasma fibrinogen and immune variables, including interleukin-6 and its receptor.

scientific article published on July 1995

Components of biological, including seasonal, variation in hematological measurements and plasma fibrinogen concentrations in normal humans

scientific article published on February 1995

Computed tomography of the brain in unipolar depression

scientific article

Construct validity of the Beck Depression Inventory in a depressive population

article

Corrigendum to "Oxidative and nitrosative stress biomarkers in chronic schizophrenia"

scientific article published on 01 March 2019

Corrigendum to “Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs” [Pharmacol. Rep. 65 (2013) 1237–1246]

scientific article published on 31 March 2017

Cortisol escape from suppression by dexamethasone during depression is strongly predicted by basal cortisol hypersecretion and increasing age combined

scientific article published in January 1991

Could Alzheimer's Disease Originate in the Periphery and If So How So?

scientific article published on 29 April 2018

Cytokine Profile in Patients with Progressive Multiple Sclerosis and Its Association with Disease Progression and Disability.

scientific article published on 29 March 2016

Cytokines and major depression

scientific article

Cytokines in detoxified patients with chronic alcoholism without liver disease: increased monocytic cytokine production

scientific article published in May 1999

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles.

scientific article published on 26 June 2017

Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS.

scientific article

Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells

article

Decreased platelet alpha-2 adrenoceptor density in major depression: effects of tricyclic antidepressants and fluoxetine

scientific article published in February 1999

Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation

scientific article published on 14 March 2017

Deficit schizophrenia and its features are associated with PON1 Q192R genotypes and lowered paraoxonase 1 (PON1) enzymatic activity: effects on bacterial translocation

scientific article published on 23 June 2020

Deficit schizophrenia is a discrete diagnostic category defined by neuro-immune and neurocognitive features: results of supervised machine learning

scientific article published on 11 March 2018

Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid

scientific article published on 08 February 2017

Depression and Anxiety in Adults With Hidradenitis Suppurativa: A Systematic Review and Meta-analysis

scientific article published on 05 June 2019

Depression and myocardial infarction: relationship between heart and mind

scientific article

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

scientific article

Depression in cancer: The many biobehavioral pathways driving tumor progression.

scientific article

Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus

scientific article published in December 2002

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

scientific article

Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways.

scientific article published on January 2011

Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis

scientific article

Depression, traumatic stress and interleukin-6.

scientific article published in January 2010

Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation

scientific article published in September 2002

Depressive, anxiety and hypomanic symptoms in schizophrenia may be driven by tryptophan catabolite (TRYCAT) patterning of IgA and IgM responses directed to TRYCATs

scientific article published on 6 July 2017

Development of a Novel Neuro-immune and Opioid-Associated Fingerprint with a Cross-Validated Ability to Identify and Authenticate Unknown Patients with Major Depression: Far Beyond Differentiation, Discrimination, and Classification

scientific article published on 23 May 2019

Development of a Novel Staging Model for Affective Disorders Using Partial Least Squares Bootstrapping: Effects of Lipid-Associated Antioxidant Defenses and Neuro-Oxidative Stress

article

Diagnosis of myalgic encephalomyelitis: where are we now?

scientific article published on 27 February 2013

Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway

scientific article published on 24 February 2012

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

scientific article

Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures

scientific article published on 13 July 2019

Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness

scientific article published on July 1992

Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?

scientific article published on 25 July 2018

Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences

scientific article published on 20 November 2018

Early increase in vegetative symptoms predicts IFN-alpha-induced cognitive-depressive changes

scientific article published in March 2005

Effect of amantadine and imipramine on immunological parameters of rats subjected to a forced swimming test

scientific article published on 28 June 2005

Effects of age and gender on the classification and phenomenology of unipolar depression

Effects of age on spontaneous cortisolaemia of normal volunteers and depressed patients

scientific article published on 01 January 1994

Effects of antidepressants on the production of cytokines

scientific article

Effects of experimental panic on neuroimmunological functioning

scientific article published in March 2008

Effects of ipsapirone on plasma cortisol and body temperature in major depression

scientific article published on 01 October 1995

Effects of meta-chlorophenylpiperazine on neuroendocrine and behavioral responses in male schizophrenic patients and normal volunteers

scientific article published in October 1996

Effects of pregnancy and delivery on serum concentrations of Clara Cell Protein (CC16), an endogenous anticytokine: lower serum CC16 is related to postpartum depression

scientific article published in October 1999

Effects of pregnancy and delivery on serum prolyl endopeptidase (PEP) activity: alterations in serum PEP are related to increased anxiety in the early puerperium and to postpartum depression

scientific article published in January 2000

Effects of pregnancy and delivery on the availability of plasma tryptophan to the brain: relationships to delivery-induced immune activation and early post-partum anxiety and depression

scientific article published in July 2001

Effects of psychological stress on serum immunoglobulin, complement and acute phase protein concentrations in normal volunteers

scientific article published in August 1997

Effects of psychological stress on serum prolyl endopeptidase and dipeptidyl peptidase IV activity in humans: higher serum prolyl endopeptidase activity is related to stress-induced anxiety

scientific article

Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice

scientific article published on 01 November 2000

Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10.

scientific article published in July 2000

Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6.

scientific article

Effects of serotonin precursors on the negative feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal axis function in depression

scientific article published on 01 January 1995

Effects of subchronic treatment with valproate on L-5-HTP-induced cortisol responses in mania: evidence for increased central serotonergic neurotransmission

scientific article published in July 1997

Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine.

scientific article

Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression

scientific article published in December 1996

Elevated C-reactive Protein Levels in Women with Bipolar Disorder may be Explained by a History of Childhood Trauma, Especially Sexual Abuse, Body Mass Index and Age.

scientific article published on 7 April 2017

Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events

scientific article published on April 1999

Emerging role of innate B1 cells in the pathophysiology of autoimmune and neuroimmune diseases: Association with inflammation, oxidative and nitrosative stress and autoimmune responses

scientific article published on 24 August 2019

Environmental risk factors and nonpharmacological and nonsurgical interventions for obesity: An umbrella review of meta-analyses of cohort studies and randomized controlled trials

scientific article published on 13 July 2018

Eotaxin, an Endogenous Cognitive Deteriorating Chemokine (ECDC), Is a Major Contributor to Cognitive Decline in Normal People and to Executive, Memory, and Sustained Attention Deficits, Formal Thought Disorders, and Psychopathology in Schizophrenia P

scholarly article by Sunee Sirivichayakul et al published 28 July 2018 in Neurotoxicity Research

Epidemiologic and phenomenological aspects of post-traumatic stress disorder: DSM-III-R diagnosis and diagnostic criteria not validated

scientific article published in November 1998

Episodic memory and delayed recall are significantly more impaired in younger patients with deficit schizophrenia than in elderly patients with amnestic mild cognitive impairment.

scientific article published on 15 May 2018

Erratum to “Cytokines and major depression” [Prog. Neuropsychopharmacol. Biol. Psychiat. 29(2) (2005) 201–217]

scholarly article published in Progress in Neuro-Psychopharmacology & Biological Psychiatry

Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin

scientific article published on 4 October 2011

Exercising the worry away: how inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours

scientific article published on 13 February 2013

Expression levels of interferon-ɣ and type 2 deiodinase in patients diagnosed with recurrent depressive disorders.

scientific article published on 20 January 2018

Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder.

scientific article published on 2 April 2015

Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids

article

Fatty acid composition of phospholipids and cholesteryl esters in maternal serum in the early puerperium

scientific article published in May 2003

Fatty acid profile and affective dysregulation in irritable bowel syndrome

scientific article published in May 2004

Faulty serotonin--DHEA interactions in autism: results of the 5-hydroxytryptophan challenge test.

scientific article published in June 2008

Fibromyalgia and Bipolar Disorder: Emerging Epidemiological Associations and Shared Pathophysiology.

scientific article published on 26 January 2016

Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder

scientific article published in July 1997

Food addiction: Prevalence, psychopathological correlates and associations with quality of life in a large sample.

scientific article published on 12 October 2017

Generalized Anxiety Disorder (GAD) and Comorbid Major Depression with GAD Are Characterized by Enhanced Nitro-oxidative Stress, Increased Lipid Peroxidation, and Lowered Lipid-Associated Antioxidant Defenses

scientific article published on 07 May 2018

Genetic, Immune-Inflammatory, and Oxidative Stress Biomarkers as Predictors for Disability and Disease Progression in Multiple Sclerosis.

scientific article published on 5 January 2016

Gradert treningsterapi kan ha skadelige effekter

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.

scientific article published on 25 November 2016

Gut Permeability and Microbiota in Parkinson's Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatonergic Pathways.

scientific article published on 6 September 2016

HPA axis and cytokines dysregulation in schizophrenia: potential implications for the antipsychotic treatment

scientific article

Haloperidol plasma ‘threshold’ levels for relapse prevention in schizophrenia: a study with haloperidol decanoate

scientific article published on 01 January 1995

Haptoglobin polymorphism and schizophrenia: genetic variation on chromosome 16.

scientific article

Herpes Viruses, Cytokines, and Altered Hemostasis in Vital Exhaustion

scientific article published on 01 March 2003

High incidence of body image dissatisfaction in pregnancy and the postnatal period: Associations with depression, anxiety, body mass index and weight gain during pregnancy.

scientific article published on 07 August 2017

Higher serum prolyl endopeptidase activity in patients with post-traumatic stress disorder

scientific article published in April 1999

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression: Disease and staging biomarkers and new drug targets.

scientific article published on 6 February 2016

How Immune-inflammatory processes link CNS and psychiatric disorders: Classification and Treatment Implications

scientific article published on 22 November 2016

How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations

scientific article published on 01 June 2020

Hypothalamic-pituitary-adrenal axis function following a 35% CO2 inhalation in healthy volunteers

scientific article published in March 2004

Hypothalamic-pituitary-thyroid-axis function in treatment resistant depression

scientific article

Hypozincemia in depression

scientific article published on 01 June 1994

IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity

scientific article published in June 2005

IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity.

scientific article

IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder

scientific article published on 21 January 2019

IgA/IgM Responses to Gram-Negative Bacteria are not Associated with Perinatal Depression, but with Physio-Somatic Symptoms and Activation of the Tryptophan Catabolite Pathway at the End of Term and Postnatal Anxiety.

scientific article published on 7 April 2017

IgA/IgM responses to tryptophan and tryptophan catabolites (TRYCATs) are differently associated with prenatal depression, physio-somatic symptoms at the end of term and premenstrual syndrome.

scientific article published in April 2016

IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression

scientific article

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology

article

IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite

scientific article published on 9 June 2017

Immune activation in the early puerperium is related to postpartum anxiety and depressive symptoms

scientific article published in February 2000

Immune markers in fibromyalgia: comparison with major depressed patients and normal volunteers.

scientific article published in February 1998

Immune-Inflammatory and Oxidative and Nitrosative Stress Biomarkers of Depression Symptoms in Subjects with Multiple Sclerosis: Increased Peripheral Inflammation but Less Acute Neuroinflammation

scientific article

Immune-inflammatory pathways and clinical changes in fibromyalgia patients treated with Mindfulness-Based Stress Reduction (MBSR): A randomized, controlled clinical trial

scientific article published on 25 February 2019

Immune-inflammatory, oxidative stress and biochemical biomarkers predict short-term acute ischemic stroke death

scientific article published on 14 March 2019

Immuno-inflammatory, oxidative and nitrosative stress, and neuroprogressive pathways in the etiology, course and treatment of schizophrenia

scientific article published on 18 October 2012

Immunoendocrine Findings in Patients with Eating Disorders

Immunoendocrine aspects of major depression

scientific article published on 01 January 1995

Immunological differences between patients with major depression and somatization syndrome

scientific article published on 01 December 2001

Immunosuppressive effects of clozapine and haloperidol: enhanced production of the interleukin-1 receptor antagonist

article

Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms.

scientific article published in December 2001

Impact of Single Nucleotide Polymorphisms of Base Excision Repair Genes on DNA Damage and Efficiency of DNA Repair in Recurrent Depression Disorder

scientific article published on 21 June 2016

Impaired mitogen-induced lymphocyte responses and the hypothalamic-pituitary-adrenal axis in depressive disorders

scientific article published in January 1989

Impairments in Peripheral Blood T Effector and T Regulatory Lymphocytes in Bipolar Disorder Are Associated with Staging of Illness and Anti-cytomegalovirus IgG Levels

scientific article published on 11 September 2020

In Schizophrenia, Deficits in Natural IgM Isotype Antibodies Including those Directed to Malondialdehyde and Azelaic Acid Strongly Predict Negative Symptoms, Neurocognitive Impairments, and the Deficit Syndrome

scientific article published on 27 November 2018

In Schizophrenia, Depression, Anxiety, and Physiosomatic Symptoms Are Strongly Related to Psychotic Symptoms and Excitation, Impairments in Episodic Memory, and Increased Production of Neurotoxic Tryptophan Catabolites: a Multivariate and Machine Le

scientific article published on 29 January 2018

In Schizophrenia, Increased Plasma IgM/IgA Responses to Gut Commensal Bacteria Are Associated with Negative Symptoms, Neurocognitive Impairments, and the Deficit Phenotype

article

In Thai Nationals, the ApoE4 Allele Affects Multiple Domains of Neuropsychological, Biobehavioral, and Social Functioning Thereby Contributing to Alzheimer's Disorder, while the ApoE3 Allele Protects Against Neuropsychiatric Symptoms and Psychosocia

scientific article published on 6 January 2018

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

scientific article published on 07 September 2010

In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation

scientific article

In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes

scientific article published on 17 August 2012

In humans, corticotropin releasing hormone antagonizes some of the negative immunoregulatory effects of serotonin.

scientific article published in December 2003

In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress

article

In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide

scientific article published on July 2004

In major affective disorders, early life trauma predict increased nitro-oxidative stress, lipid peroxidation and protein oxidation and recurrence of major affective disorders, suicidal behaviors and a lowered quality of life.

scientific article published on 14 March 2018

In major depression, increased kappa and mu opioid receptor levels are associated with immune activation

scientific article published on 14 January 2020

In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation.

scientific article published on 10 May 2013

In schizophrenia, psychomotor retardation is associated with executive and memory impairments, negative and psychotic symptoms, neurotoxic immune products and lower natural IgM to malondialdehyde

scientific article published on 07 February 2020

In the puerperium, primiparae exhibit higher levels of anxiety and serum peptidase activity and greater immune responses than multiparae

scientific article published in January 2004

In vitro immunoregulatory effects of lithium in healthy volunteers.

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In vivo immunomodulatory effects of clozapine in schizophrenia

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Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

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Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

scientific article published in January 2009

Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut.

scientific article published on 11 March 2012

Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome

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Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life.

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Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia Is Present

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Increased adhesion molecule levels in systemic lupus erythematosus: relationships with severity of illness, autoimmunity, metabolic syndrome and cortisol levels.

scientific article published in January 2018

Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression

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Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression

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Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system

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Increased lipid and protein oxidation and lowered anti-oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules, and Th1 and Th17 immune shift.

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Increased mitogen-induced lymphocyte proliferation in treatment resistant depression: a preliminary study.

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Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response

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Increased nuclear factor-κB and loss of p53 are key mechanisms in Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS).

scientific article published on 27 August 2012

Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression

scientific article published on 01 August 1995

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

scholarly article by Michael Maes et al published September 2010 in Journal of Affective Disorders

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

scientific article published on April 2011

Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression

scientific article published in November 1997

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability

scientific article published on 27 September 2006

Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS a

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Increased serum albumin, gamma globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism.

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Increased serum interleukin-1-receptor-antagonist concentrations in major depression

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Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor

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Increased serum soluble CD8 or suppressor/cytotoxic antigen concentrations in depression: suppressive effects of glucocorticoids

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Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis

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Indicators of immune activation in major depression

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Indices of insulin resistance and glucotoxicity are not associated with bipolar disorder or major depressive disorder, but are differently associated with inflammatory, oxidative and nitrosative biomarkers.

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Inflammation markers in relation to cognition in a healthy aging population

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Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization.

scientific article published on January 2012

Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression

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Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome

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Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms

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Inflammatory markers in depressed post-myocardial infarction patients

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Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer's disease

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Influence of academic examination stress on hematological measurements in subjectively healthy volunteers

scientific article published in September 1998

Influence of antidepressants on intracellular levels of cyclic adenosine monophosphate in human peripheral blood mononuclear cells

scientific article published on January 2003

Influence of psychological stress on immune-inflammatory variables in normal humans. Part II. Altered serum concentrations of natural anti-inflammatory agents and soluble membrane antigens of monocytes and T lymphocytes

scientific article published in March 1999

Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction

scientific article published in January 2012

Inhibitory effects of amantadine on the production of pro-inflammatory cytokines by stimulated in vitro human blood

scientific article published in November 2009

Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: Associations with inflammatory and oxidative stress biomarkers and uric acid.

scientific article published on 27 December 2016

Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut

scientific article published on 01 January 2019

Interaction of the immune-inflammatory and the kynurenine pathways in rats resistant to antidepressant treatment in model of depression

scientific article published on 05 June 2019

Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation.

scientific article published on 16 February 2017

Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol

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Interleukin-1beta and the etiology of depression

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Interleukin-2 and interleukin-6 in schizophrenia and mania: Effects of neuroleptics and mood stabilizers

scientific article published on 01 March 1995

International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder

scientific article published on 03 September 2019

Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function.

scientific article published on 16 March 2018

Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes.

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Introduction to the special section

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Is a diagnostic blood test for chronic fatigue syndrome on the horizon?

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Is dynapenia associated with the onset and persistence of depressive and anxiety symptoms among older adults? Findings from the Irish longitudinal study on ageing

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Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors

scientific article published on 12 March 2019

Letter to the Editor: Plausible explanations for neurocognitive deficits in ME/CFS, aggravation of neurocognitive impairment induced by exertion

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Letters to the Editor

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Leukocyte telomere length variation in different stages of schizophrenia

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Leukocytosis, monocytosis and neutrophilia: Hallmarks of severe depression

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Linear CT-scan measurements in alcohol-dependent patients with and without delirium tremens

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Lipid Peroxidation and Immune Biomarkers Are Associated with Major Depression and Its Phenotypes, Including Treatment-Resistant Depression and Melancholia

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Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

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Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms.

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Lower activities of serum peptidases predict higher depressive and anxiety levels following interferon-alpha-based immunotherapy in patients with hepatitis C.

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Lower activity of serum peptidases in abstinent alcohol-dependent patients.

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Lower angiotensin I converting enzyme activity in melancholic subjects: A pilot study

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Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia

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Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients

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Lower omega-3 polyunsaturated fatty acids and lower docosahexaenoic acid in men with pedophilia.

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Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs

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Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness

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Lower serum L-tryptophan availability in depression as a marker of a more generalized disorder in protein metabolism

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Lower serum activity of prolyl endopeptidase in anorexia and bulimia nervosa

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Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia

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Lower serum dipeptidyl peptidase IV activity in treatment resistant major depression: Relationships with immune-inflammatory markers

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Lower serum prolyl endopeptidase enzyme activity in major depression: further evidence that peptidases play a role in the pathophysiology of depression

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Lower serum transcortin (CBG) in major depressed females: relationships with baseline and postdexamethasone cortisol values

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Lower serum vitamin E concentrations in major depression

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Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

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Lower serum zinc in major depression in relation to changes in serum acute phase proteins

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Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness

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Lower thiol, glutathione, and glutathione peroxidase levels in prostate cancer: a meta-analysis study

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Lower total serum protein, albumin, and beta- and gamma-globulin in major and treatment-resistant depression: effects of antidepressant treatments

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Lowered Antioxidant Defenses and Increased Oxidative Toxicity Are Hallmarks of Deficit Schizophrenia: a Nomothetic Network Psychiatry Approach

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Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life

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Lowered Serum Dipeptidyl Peptidase IV Activity is Associated with Depressive Symptoms and Cytokine Production in Cancer Patients Receiving Interleukin-2-Based Immunotherapy

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Lowered omega-3 PUFAs are related to major depression, but not to somatization syndrome

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Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

scientific article published in March 1999

Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naïve first episode psychosis

scientific article published on 27 June 2015

Lowered quality of life in mood disorders is associated with increased neuro-oxidative stress and basal thyroid-stimulating hormone levels and use of anticonvulsant mood stabilizers

scientific article published on 17 April 2018

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

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Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: further evidence that lowered n-PUFAs are related to major depression

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Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation

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Machine Learning to Understand the Immune-Inflammatory Pathways in Fibromyalgia ⬇️

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Major Differences in Neurooxidative and Neuronitrosative Stress Pathways Between Major Depressive Disorder and Types I and II Bipolar Disorder

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Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations

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Major neurocognitive psychosis: a novel schizophrenia endophenotype class that is based on machine learning and resembles Kraepelin’s and Bleuler’s conceptions

scientific article published in 2022

Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder

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Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings.

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Mechanisms of interferon-alpha-induced depressive symptoms

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Mechanisms underlying neurocognitive dysfunctions in recurrent major depression

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Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

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Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects

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Metabolic syndrome and the decreased levels of uric acid by leflunomide favor redox imbalance in patients with rheumatoid arthritis

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Methamphetamine (MA) Use Induces Specific Changes in LINE-1 Partial Methylation Patterns, Which Are Associated with MA-Induced Paranoia: a Multivariate and Neuronal Network Study

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Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder

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Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

scientific article published on 10 September 2013

Mood, prolactin and cortisol responses following intravenous L-tryptophan challenge: evidence for serotonergic vulnerability in first-degree relatives of bipolar patients

scientific article published in September 2002

Multicenter Study on Reproducibility of Sperm Morphology Assessments

scientific article published on 01 September 1998

Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis.

scientific article published on 2 January 2018

Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients

scientific article published on 16 June 2010

Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data

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Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

scientific article published on 13 February 2019

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics

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Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities

scientific article published on 08 September 2019

Natural killer cell activity in major depression: Relation to circulating natural killer cells, cellular indices of the immune response, and depressive phenomenology

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Natural regulatory IgM-mediated autoimmune responses directed against malondialdehyde regulate oxidative and nitrosative pathways and coupled with IgM responses to nitroso adducts attenuate depressive and physiosomatic symptoms at the end of term pr

scientific article published in December 2017

Negative Immunoregulatory Effects of Antidepressants Inhibition of Interferon-γ and Stimulation of Interleukin-10 Secretion

scientific article published on 01 April 1999

Negative immunoregulatory effects of noradrenaline through alpha2-adrenoceptor activation

scientific article published in January 2000

Neuroimmunological parameters in panic disorder

scientific article published on April 2004

Neutrophil chemotaxis, phagocytosis, and superoxide release in depressive illness

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New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

scientific article published on 24 January 2012

Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder

scientific article published on 17 January 2012

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

scientific article published on 23 June 2016

No borna disease virus-specific RNA detected in blood of race horses and jockeys

scientific article published on June 2006

Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.

scientific article

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

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Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome.

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Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta.

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Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis

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Nutrient intakes and the common mental disorders in women

scientific article published on 6 March 2012

Overlapping the Tryptophan Catabolite (TRYCAT) and Melatoninergic Pathways in Alzheimer's Disease.

scientific article published on 29 December 2014

Oxidative and nitrosative stress biomarkers in chronic schizophrenia

scientific article published on 21 March 2017

Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts

scientific article published on 12 July 2013

Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia

scientific article published on 27 February 2019

Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score.

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Parkinson's Disease is Accompanied by Intertwined Alterations in Iron Metabolism and Activated Immune-inflammatory and Oxidative Stress Pathways.

scientific article published on 23 February 2017

Partial posttraumatic stress disorder revisited

scientific article published on January 2004

Pathophysiology of autism: current opinions

scientific article published in April 2002

Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors

scientific article published on 08 October 2010

Pattern of Methamphetamine Use and the Time Lag to Methamphetamine Dependence

scientific article published on 23 November 2017

Pedophilia is accompanied by increased plasma concentrations of catecholamines, in particular epinephrine.

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Pedophilia: a biological disorder?

Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis.

scientific article published on 13 June 2017

Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype Are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer's Disease

scientific article published on 01 January 2019

Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies

scientific article published on 25 January 2017

Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder

scientific article published in March 2000

Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway.

scientific article published on 3 March 2017

Pindolol and mianserin augment the antidepressant activity of fluoxetine in hospitalized major depressed patients, including those with treatment resistance

scientific article published in April 1999

Pindolol pretreatment blocks stimulation by meta-chlorophenylpiperazine of prolactin but not cortisol secretion in normal men

scientific article published on 01 September 1995

Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression

scientific article published on 01 January 1995

Plasma indoleamine-2,3-dioxygenase (IDO) is increased in drug-naïve major depressed patients and treatment with sertraline and ketoprofen normalizes IDO in association with pro-inflammatory and immune-regulatory cytokines

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Plasma soluble interleukin-2-receptor in depression: relationships to plasma neopterin and serum IL-2 concentrations and HPA-axis activity

scientific article published on 01 January 1995

Plasma-soluble interleukin-2 and transferrin receptor in schizoprenia and major depression

scientific article published on 01 January 1995

Platelet alpha2-adrenoceptor density in humans: relationships to stress-induced anxiety, psychasthenic constitution, gender and stress-induced changes in the inflammatory response system

scientific article published in July 2002

Polymorphisms of iodothyronine deiodinases (DIO1, DIO3) genes are not associated with recurrent depressive disorder

scientific article published on 12 May 2016

Polyunsaturated fatty acids in depression

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Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism?

scientific article published in August 2006

Postpartum depression: psychoneuroimmunological underpinnings and treatment

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Pre- and post-disaster negative life events in relation to the incidence and severity of post-traumatic stress disorder

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Prediction of the DST results in depressives by means of urinary-free cortisol excretion, dexamethasone levels, and age.

scientific article published in August 1990

Proinflammatory and anti-inflammatory cytokine profiles in psoriasis: use as laboratory biomarkers and disease predictors

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Prolactin is Not Associated with Disability and Clinical Forms in Patients with Multiple Sclerosis

scientific article published on 31 August 2019

Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depression

Prolyl endopeptidase and dipeptidyl peptidase IV are associated with externalizing and aggressive behaviors in normal and autistic adolescents.

scientific article published on 10 July 2015

Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems

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Psychoimmunology as a common pathogenetic pathway in myocardial infarction, depression and cardiac death

Psychological and behavioural effects of interferons

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Psychological stress and the inflammatory response system

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Psychological stress and the inflammatory response system

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Psychological stress, cytokines and the inflammatory response system

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Psychomotor retardation, anorexia, weight loss, sleep disturbances, and loss of energy: psychopathological correlates of hyperhaptoglobinemia during major depression

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Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers

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Psychomotor, neuroendocrine and behavioural effects after oral administration of levodopa in normal volunteers

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Putative neuroprotective agents in neuropsychiatric disorders

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Recognizing the Leaky Gut as a Trans-diagnostic Target for Neuroimmune Disorders Using Clinical Chemistry and Molecular Immunology Assays

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Reduced grey matter volume in frontal and temporal areas in depression: contributions from voxel-based morphometry study

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Regional cerebral blood flow in unipolar depression measured with Tc-99m-HMPAO single photon emission computed tomography: negative findings

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Relation of levels of serum lipoproteins to depression after acute myocardial infarction

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Relationship between MHPG and anxiety

scientific article published on 01 June 1992

Relationships between basal hypothalamic-pituitary-thyroid-axis activity and plasma haptoglobin levels in depression

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Relationships between increased haptoglobin plasma levels and activation of cell-mediated immunity in depression

scientific article published on 01 November 1993

Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

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Relationships of climatic data to immune and hematologic variables in normal human.

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Reply to a reader's comment

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Research into the specificity of depression after stroke: a review on an unresolved issue

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Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs.

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Risk and preventive factors of post-traumatic stress disorder (PTSD): alcohol consumption and intoxication prior to a traumatic event diminishes the relative risk to develop PTSD in response to that trauma

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Risk and preventive factors of post-traumatic stress disorder and its co-morbid disorders

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Role of the Immune System in Autism Spectrum Disorders (ASD)

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Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway

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STin2 VNTR polymorphism is associated with comorbid tobacco use and mood disorders.

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Salivary cortisol in panic: are males more vulnerable?

scientific article published in October 2004

Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways

scientific article published on 22 August 2012

Schizophrenia phenomenology revisited: positive and negative symptoms are strongly related reflective manifestations of an underlying single trait indicating overall severity of schizophrenia

scientific article published on 20 May 2020

Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression.

scientific article published on 16 July 2012

Seasonal and circadian rhythms in suicide in Cagliari, Italy

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Seasonal variation and meteotropism in various self-rated psychological and physiological features of a normal couple

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Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and -6 receptor concentrations in normal volunteers

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Seasonal variation in platelet [3H]paroxetine binding in healthy volunteers. Relationship to climatic variables

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Seasonal variation in postdexamethasone cortisol values in depressed inpatients. Results of least squares cosine spectral analysis

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Serological observations in patients suffering from acute manic episodes

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Serotonergic and noradrenergic markers of post-traumatic stress disorder with and without major depression

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Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls

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Serotonergic markers and lowered plasma branched-chain-amino acid concentrations in fibromyalgia

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Serotonin-immune interactions in detoxified chronic alcoholic patients without apparent liver disease: activation of the inflammatory response system and lower plasma total tryptophan

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Serum Interleukin Levels and Insulin Resistance in Major Depressive Disorder

scientific article published on 01 January 2018

Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders

scientific article published on 01 January 2018

Serum activity of prolyl endopeptidase, but not of dipeptidyl peptidase IV, is decreased by immunotherapy with IFN-alpha in high-risk melanoma patients

scientific article published in July 2004

Serum agrin and talin are increased in major depression while agrin and creatine phosphokinase are associated with chronic fatigue and fibromyalgia symptoms in depression

scientific article published on 16 November 2019

Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients

scientific article published in July 2003

Serum postdexamethasone prolactin measures in depressive patients and control subjects

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Serum testosterone concentration in male autistic youngsters.

scientific article published on January 2010

Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders

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Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities

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Shorter leukocyte telomere length in patients at ultra high risk for psychosis

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Significantly increased expression of T-cell activation markers (interleukin-2 and HLA-DR) in depression: Further evidence for an inflamatory process during that illness

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Skin picking disorder: prevalence, correlates, and associations with quality of life in a large sample.

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Sleep disorders and anxiety as symptom profiles of sympathoadrenal system hyperactivity in major depression

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So depression is an inflammatory disease, but where does the inflammation come from?

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Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations

scientific article published on 26 January 2019

Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity

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Stability of interleukin 6, soluble interleukin 6 receptor, interleukin 10 and CC16 in human serum

scientific article published in September 2002

Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice

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Stimulatory effect of antidepressants on the production of IL-6.

scientific article published in February 2004

Stimulatory effect of desipramine on lung metastases of adenocarcinoma MADB 106 in stress highly-sensitive and stress non-reactive rats

scientific article published on 19 April 2017

Stimulatory effects of L-5-hydroxytryptophan on postdexamethasone beta-endorphin levels in major depression

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Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia

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Suppressive effect of TRH and antidepressants on human interferon-γ production in vitro

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Suppressive effects of dexamethasone on hypothalamic-pituitary-thyroid axis function in depressed patients

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T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model

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Targeting IL-1 in depression

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Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression

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The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder

The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.

scientific article published on 27 August 2015

The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver

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The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling

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The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications.

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The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease

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The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders.

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The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression

scientific article published on 22 July 2020

The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.

scientific article

The Neuroimmune and Neurotoxic Fingerprint of Major Neurocognitive Psychosis or Deficit Schizophrenia: a Supervised Machine Learning Study

scientific article published on 08 January 2020

The Prolonged P 300 Latency in Recently Detoxified Alcohol-Dependent Patients Is Related to Activation of the Inflammatory Response System

The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes.

scientific article

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability.

scientific article published on 17 June 2015

The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia

scientific article published on 31 August 2019

The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome

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The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

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The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue.

scientific article published on 17 March 2015

The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses

article

The compensatory antioxidant response system with a focus on neuroprogressive disorders

scientific article published on 24 July 2019

The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression

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The effect of cocaine sensitization on mouse immunoreactivity

scientific article

The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice

scientific article published on 01 November 2000

The effects of anticoagulation and processing on assays of IL-6, sIL-6R, sIL-2R and soluble transferrin receptor

scientific article published in September 1997

The effects of glucocorticoids on the availability of L-tryptophan and tyrosine in the plasma of depressed patients

scientific article published in February 1990

The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products

article

The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety.

scientific article published in April 1998

The effects of psychological stress on leukocyte subset distribution in humans: evidence of immune activation

scientific article

The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder.

scientific article

The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression

scientific article published on 01 February 2008

The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation

scientific article published in December 2007

The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines

scientific article published in May 1999

The immunoregulatory effects of antidepressants

scientific article

The in vitro immunosuppressive effects of moclobemide in healthy volunteers

scientific article (publication date: April 2000)

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

scientific article

The inflammatory response following delivery is amplified in women who previously suffered from major depression, suggesting that major depression is accompanied by a sensitization of the inflammatory response system

article

The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression

scientific article published in June 1998

The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6.

scientific article

The influence of psychological stress on total serum protein and patterns obtained in serum protein electrophoresis

scientific article published on 01 March 1998

The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1) - A potential diagnostic biomarkers of Alzheimer's disease.

scientific article published on 9 July 2016

The macrophage-T-lymphocyte theory of schizophrenia: Additional evidence

article

The menstrual cycle may not be limited to the endometrium but also may impact gut permeability

scientific article published on 14 October 2019

The monocyte-T-lymphocyte hypothesis of major depression

scientific article published on 01 January 1995

The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway

scientific article

The negative immunoregulatory effects of serotonin (5-HT) moduline, an endogenous 5-HT1B receptor antagonist with anti-anxiety properties

scientific article published in September 2002

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

scientific article published on 24 April 2012

The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute

scientific article

The periodicities in and biometeorological relationships with bed occupancy of an acute psychiatric ward in Antwerp, Belgium

scientific article

The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans

scientific article

The relationships between the availability ofL-tryptophan to the brain, the spontaneous HPA-axis activity, and the HPA-axis responses to dexamethasone in depressed patients

scientific article published in February 1991

The relevance of the in- versus outpatient status for studies on HPA-axis in depression: spontaneous hypercortisolism is a feature of major depressed inpatients and not of major depression per se.

scientific article published in May 1994

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases.

scientific article published on 05 August 2017

The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression

scientific article published on January 2004

The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

scientific article published on 05 September 2015

The role of the cytokine network in psychological stress

scientific article published on June 2003

The two-factorial symptom structure of post-traumatic stress disorder: depression-avoidance and arousal-anxiety

scientific article published in November 1998

Thyroid autoimmunity in bipolar disorder: A systematic review.

scientific article published on 13 June 2017

Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation

scientific article published on 10 July 2019

Total antioxidant status correlates with cognitive impairment in patients with recurrent depressive disorder

scientific article published on 5 May 2012

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

scientific article published on 02 May 2015

Towards a new classification of stable phase schizophrenia into major and simple neuro-cognitive psychosis: Results of unsupervised machine learning analysis

scholarly article by Buranee Kanchanatawan et al published 23 May 2018 in Journal of Evaluation in Clinical Practice

Towards a new model and classification of mood disorders based on risk resilience, neuro-affective toxicity, staging, and phenome features using the nomothetic network psychiatry approach

scientific article published on 07 January 2021

Toxic rise of clozapine plasma concentrations in relation to inflammation

scientific article published in October 2003

Treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a multisystem disease, should target the pathophysiological aberrations (inflammatory and oxidative and nitrosative stress pathways), not the psychosocial “barriers” for a

article

Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation.

scientific article published in July 2001

Trichotillomania-psychopathological correlates and associations with health-related quality of life in a large sample

scientific article published on 08 April 2020

Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.

scientific article published in April 2018

Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia

scientific article published on 10 April 2019

Upregulation of the nitrosylome in bipolar disorder type 1 (BP1) and major depression, but not BP2: Increased IgM antibodies to nitrosylated conjugates are associated with indicants of leaky gut

scientific article published on 16 July 2019

Validation of the Thai version of the short Boston Naming Test (T-BNT) in patients with Alzheimer's dementia and mild cognitive impairment: clinical and biomarker correlates

scientific article published on 23 October 2018

Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development

scientific article published on 11 May 2013

Vascular endothelial growth factor receptor 2 gene (KDR) polymorphisms and expression levels in depressive disorder

scientific article

Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging

scientific article

Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients

scientific article published on 11 May 2020

Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response.

scientific article published in December 2007

Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS.

scientific article published on January 2009

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases.

scientific article published on 28 December 2017

Zika Virus as an Emerging Neuropathogen: Mechanisms of Neurovirulence and Neuro-Immune Interactions

scientific article published on 11 June 2017

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