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List of works by Thomas N. Seyfried

A mathematical model for the determination of steady-state cardiolipin remodeling mechanisms using lipidomic data

scientific article

A novel pre-clinical in vivo mouse model for malignant brain tumor growth and invasion

scientific article published on 13 January 2010

A review of mouse mutants as genetic models of epilepsy

scientific article published on March 1985

A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice.

scientific article

AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system

scientific article

AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival

scientific article

ATP-induced synaptic potentiation in hippocampal slices

scientific article published on 01 July 1989

Absence of brain ganglioside abnormalities in shambling mutant mice

scientific article published on July 1976

Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors

scientific article

Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma

scientific article

Altered ganglioside composition in virally transformed rat embryo fibroblasts

scientific article published on July 1992

Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors

scientific article published on August 2004

Audiogenic seizures in mice

scientific article published on September 1, 1979

Autosomal dominant inheritance of brain cardiolipin fatty acid abnormality in VM/DK mice: association with hypoxic-induced cognitive insensitivity

scientific article

Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms

scientific article

Biochemical Study of Heterosis for Brain Myelin Content in Mice

scientific article published on 01 February 1983

Biochemical correlates of epilepsy in the E1 mouse: analysis of glial fibrillary acidic protein and gangliosides

scientific article published in February 1992

Biography of Dr. Robert K. Yu. Preface

scientific article published on 18 March 2011

Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid

scientific article published on 24 July 2015

Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses

scientific article published on 20 March 2015

Bispectral index (BIS) and suppression ratio (SR) as an early predictor of unfavourable neurological outcome after cardiac arrest

scientific article published on 25 November 2013

Bispectral index monitoring during cardiopulmonary resuscitation repeated twice within 8 days in the same patient: a case report

scientific article published on 19 June 2008

Brain cationic ATPase activities in epileptic (El) mice

scientific article

Brain lipid analysis in mice with Rett syndrome

scientific article

Brain mitochondrial lipid abnormalities in mice susceptible to spontaneous gliomas.

scientific article published on 17 June 2008

Calcium ATPase activities in synaptic plasma membranes of seizure-prone mice

scientific article

Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans

scientific article

Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose

scientific article published in November 2001

Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse

scientific article

Cancer as a metabolic disease

scientific article

Cancer as a metabolic disease: implications for novel therapeutics

scientific article published on 16 December 2013

Cancer as a mitochondrial metabolic disease

scientific article published on 7 July 2015

Caprylic (Octanoic) Acid as a Potential Fatty Acid Chemotherapeutic for Glioblastoma

scientific article published on 30 May 2020

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

scientific article

Cell salvage

scientific article published on April 1, 2011

Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant

scientific article published in October 1984

Cellular localization of gangliosides in the developing mouse cerebellum: analysis using the weaver mutant

scientific article published in August 1983

Cellular localization of gangliosides in the mouse cerebellum: analysis using neurological mutants

scientific article published on 01 January 1984

Cerebellar ganglioside abnormalities in pcd mutant mice

scientific article

Cerebellar gangliosides and phospholipids in mutant mice with ataxia and epilepsy: the Tottering/Leaner syndrome

scientific article published on 01 July 1981

Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease

scientific article published on 27 September 2010

Cerebral, cerebellar, and brain stem gangliosides in mice susceptible to audiogenic seizures

scientific article

Ceruloplasmin gene defect associated with epilepsy in EL mice

article

Ceruloplasmin gene defect associated with epilepsy in EL mice

scientific article published on 01 September 1995

Chemical mutagenesis of a GPCR ligand: Detoxifying "inflammo-attraction" to direct therapeutic stem cell migration

scientific article published on 20 November 2020

Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease

scientific article published on 26 November 2008

Complete correction of enzymatic deficiency and neurochemistry in the GM1-gangliosidosis mouse brain by neonatal adeno-associated virus-mediated gene delivery

scientific article published in January 2007

Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer

scientific article published on 11 March 2020

Dietary restriction promotes vessel maturation in a mouse astrocytoma.

scientific article published on 27 December 2011

Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model

scientific article published on May 2002

Differential Cellular Enrichment of Gangliosides in the Mouse Cerebellum: Analysis Using Neurological Mutants

scientific article published on 01 February 1982

Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain

scientific article published on 12 May 2008

Differentiating N-linked glycan structural isomers in metastatic and nonmetastatic tumor cells using sequential mass spectrometry

scientific article published on 06 February 2008

Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial

scientific article published on 22 August 2020

Does the existing standard of care increase glioblastoma energy metabolism?

scientific article published on 13 July 2010

Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet

scientific article published on 25 November 2008

Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics.

scientific article

Effect of Golgi membrane phospholipid composition on the molecular species of GM3 gangliosides synthesized by rat liver sialyltransferase

scientific article published on November 1994

Effect of Purkinje cell loss on cerebellar gangliosides in nervous mutant mice

scientific article published on January 1987

Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial

scientific article published on 03 July 2020

Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer.

scientific article published on 7 July 2017

Enhanced aspartate release from hippocampal slices of epileptic (El) mice

scientific article

Enhanced aspartate release related to epilepsy in (EL) mice

scientific article published on 01 August 1994

Environmental influences on epilepsy gene mapping in EL mice.

scientific article

Environmental risk factors for multifactorial epilepsy in EL mice

scientific article published in December 1999

Environmental stimuli shape microglial plasticity in glioma.

scientific article published on 29 December 2017

Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice

scientific article published on 16 February 2013

Examination of the brain mitochondrial lipidome using shotgun lipidomics

scientific article published on January 2009

Experimental models of multifactorial epilepsies: the EL mouse and mice susceptible to audiogenic seizures

scientific article

Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice.

scientific article published in July 1999

Fat removal during cell salvage: a comparison of four different cell salvage devices

scientific article published on 23 February 2015

Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain

scientific article

GD3 ganglioside is a glycolipid characteristic of immature neuroectodermal cells

scientific article published in December 1984

GM1-gangliosidosis in American black bears: clinical, pathological, biochemical and molecular genetic characterization

scientific article

Ganglioside Composition of Normal and Mutant Mouse Embryos

article

Ganglioside GD3 biosynthesis in normal and mutant mouse embryos

scientific article published in December 1991

Ganglioside GD3: structure, cellular distribution, and possible function

scientific article

Ganglioside GM1 elevation in DBA/2 mouse embryos

scientific article published on 01 January 1990

Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer

scientific article

Ganglioside abnormalities associated with failed neural differentiation in a T-locus mutant mouse embryo

scientific article

Ganglioside biosynthesis in mouse embryos: sialyltransferase IV and the asialo pathway

scientific article published in 1994

Ganglioside biosynthetic gene expression in experimental mouse brain tumors.

scientific article published on April 1997

Ganglioside composition and histology of a spontaneous metastatic brain tumour in the VM mouse

scientific article

Ganglioside composition of a mouse brain tumor grown in the severe combined immunodeficiency (SCID) mouse

scientific article

Ganglioside composition of an experimental mouse brain tumor.

scientific article published in July 1987

Ganglioside distribution in murine neural tumors

scientific article published on October 1992

Ganglioside storage diseases: on the road to management

scientific article published in January 2014

Gangliosides influence angiogenesis in an experimental mouse brain tumor.

scientific article published on October 1999

Gene expression in the epileptic (EL) mouse hippocampus

scientific article published on 24 October 2020

Gene-linked shift in ganglioside distribution influences growth and vascularity in a mouse astrocytoma

scientific article published on 14 August 2006

Genes differentially expressed in the kindled mouse brain

scientific article published in November 2001

Genes for epilepsy mapped in the mouse.

scientific article

Genetic analysis of audiogenic seizure susceptibility in C57BL/6J X DBA/2J recombinant inbred strains of mice

scientific article

Genetic analysis of cerebellar lipids in mice susceptible to audiogenic seizures

scientific article published in June 1984

Genetic analysis of nucleotide triphosphatase activity in the mouse brain.

scientific article

Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice

Genetic analysis of serum thyroxine content and audiogenic seizures in recombinant inbred and congenic strains of mice

scientific article published on 01 February 1984

Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice

scientific article published in October 2006

Genetic association between Ca2+-ATPase activity and audiogenic seizures in mice

scientific article published in June 1984

Genetic heterogeneity for the development of audiogenic seizures in mice

scientific article

Genetic linkage between the AH locus and a major gene that inhibits susceptibility to audiogenic seizures in mice

scientific article

Genetic study of cationic ATPase activities and audiogenic seizure susceptibility in recombinant inbred and congenic strains of mice.

scientific article

Genetic variability for regional brain gangliosides in five strains of young mice

scientific article published on February 1979

Genomic imprinting and audiogenic seizures in mice

scientific article published on 01 September 1997

Glucose reduces the anticonvulsant effects of the ketogenic diet in EL mice

scientific article published on 02 June 2014

Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.

scientific article published on 27 January 2014

Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model

scientific article

Glycolipid and ganglioside metabolism imbalances in Huntington's disease.

scientific article

Glycosphingolipid biosynthesis may not be necessary for vertebrate brain development

scientific article published in June 1998

Heterosis for brain myelin content in mice

scientific article published in December 1980

Hippocampal neurons and glia in epileptic EL mice

scientific article published in September 2002

Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?

scientific article

Immunocytochemical localization of GD3 ganglioside to astrocytes in murine cerebellar mutants

scientific article published in May 1986

Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets

scientific article

In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours

scientific article published on 27 May 2009

Increased amount of extracellular ATP in stimulated hippocampal slices of seizure prone mice.

scientific article

Influence of Audiogenic Seizures on Synaptic Facilitation in Mouse Hippocampal Slices Is Mediated by N-Methyl-d-Aspartate Receptor

scientific article published on 01 November 1993

Influence of N2 or O2 on two alkylating agents in Neurospora crassa

scientific article published on May 1, 1975

Influence of Serum and Hypoxia on Incorporation of [(14)C]-D-Glucose or [(14)C]-L-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells.

scientific article published on 5 November 2015

Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice.

scientific article

Influence of caloric restriction on constitutive expression of NF-κB in an experimental mouse astrocytoma

scientific article

Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice

scientific article published in May 2006

Influence of ganglioside GM3 and high density lipoprotein on the cohesion of mouse brain tumor cells

scientific article published in January 1997

Influence of growth environment on the ganglioside composition of an experimental mouse brain tumor

scientific article published on February 1994

Influence of host cell infiltration on the glycolipid content of mouse brain tumors.

scientific article published on May 1996

Influence of methotrexate and cisplatin on tumor progression and survival in the VM mouse model of systemic metastatic cancer

scientific article published in January 2010

Influence of the cribriform degeneration (cri) mutation on audiogenic seizures in DBA/2J mice

scientific article published on March 1979

Influence of trichloroacetic acid-phosphotungstic acid on the thin layer chromatographic mobility of gangliosides

scientific article published in November 1977

Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice

scientific article published in August 2004

Inherited convulsive disorders in mice.

scientific article

Inhibition of glycosphingolipid biosynthesis does not impair growth or morphogenesis of the postimplantation mouse embryo

scientific article published on 01 February 1998

Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease

scientific article published on 2 December 2015

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?

scientific article published on 31 August 2011

Isolation and characterization of human liver hematoside

scientific article published in 1978

Itaconic acid is a mammalian metabolite induced during macrophage activation

scientific article published on 27 September 2011

Ketone strong: emerging evidence for a therapeutic role of ketone bodies in neurological and neurodegenerative diseases

scientific article published on 11 July 2014

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

scientific article published on 14 May 2014

Kindling Susceptibility and Genetic Seizure Predisposition in Inbred Mice

scientific article published on 01 January 1991

Lipid Composition of Whole Brain and Cerebellum in Hurler Syndrome (MPS IH) Mice

article

Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria

scientific article

Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up

scientific article published on 29 March 2018

Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies

scientific article

Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice

scientific article published in March 1990

Meal frequency and timing in health and disease

scientific article

Metabolic management of brain cancer

scientific article published on 08 September 2010

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

scientific article

Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle

scientific article published in 2021

Metabolic therapy: a new paradigm for managing malignant brain cancer

scientific article

Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model

scientific article published on July 2008

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis

article

Molecular basis for heterosis for myelin basic protein content in mice

scientific article published on March 1986

Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells.

scientific article

Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis

scientific article

N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours

scientific article

N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice

scientific article

N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis

scientific article published on 01 May 2004

Need for new review of article on ketogenic dietary regimes for cancer patients.

scientific article published on 27 April 2017

Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice

scientific article published on 17 April 2007

Neutral glycolipid abnormalities in a t-complex mutant mouse embryo

scientific article published in December 1992

Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy

scientific article published on 10 June 2015

Nonallelism for the audiogenic seizure prone (Asp1) and the aryl hydrocarbon receptor (Ahr) loci in mice

scientific article published on 01 November 1998

Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma

Novel ketone body therapy for managing Alzheimer's disease: An Editorial Highlight for Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's dise

scientific article

On the Origin of ATP Synthesis in Cancer

scientific article published on 02 November 2020

On the origin of cancer metastasis

scientific article

Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH.

scientific article published on 22 January 2017

Oxygenation prevents sudden death in seizure-prone mice

scientific article published in August 2004

Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse

scientific article published on 27 June 2010

Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis.

scientific article

Personalized Nutrition in Disrupting Cancer - Proceedings From the 2017 American College of Nutrition Annual Meeting

scientific article published on 04 December 2018

Perspectives on brain tumor formation involving macrophages, glia, and neural stem cells

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Perspectives on the mesenchymal origin of metastatic cancer

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Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies

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Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT.

scientific article published on 12 April 2018

Phylogenetic conservation of ganglioside GD3 expression during early vertebrate ontogeny

scientific article published on December 1994

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer.

scientific article published on 23 February 2017

Processing of small volumes in blood salvage devices

scientific article published on 23 June 2014

Provocative Question: Should Ketogenic Metabolic Therapy Become the Standard of Care for Glioblastoma?

scientific article published on 25 April 2019

Quantification of metastatic load in a syngeneic murine model of metastasis.

scientific article published on 17 July 2017

Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia

scientific article published on 19 January 2024

Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice

scientific article published on 3 April 2010

Retinal Gangliosides in RCS Mutant Rats

scientific article published on 01 July 1982

Role of glucose and ketone bodies in the metabolic control of experimental brain cancer

scientific article

Serum gangliosides in mice with metastatic and non-metastatic brain tumors.

scientific article

Sexual dysfunction and sudden death in epileptic male EL mice: inheritance and prevention with the ketogenic diet

scientific article

Spontaneous polyspike discharges in an epileptic mutant mouse (tottering)

scientific article published on 01 December 1979

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.

scientific article

Stimulation-dependent release of adenosine triphosphate from hippocampal slices

scientific article published on 01 April 1989

Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice.

scientific article

Synaptic vesicle glutamate uptake in epileptic (EL) mice

scientific article published in October 1997

Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets

scientific article

Targeting energy metabolism in brain cancer: review and hypothesis

scientific article

The EL mouse: a natural model of autism and epilepsy

scientific article

The Tumor Mitochondrial Lipidome and Respiratory Bioenergetic Insufficiency

The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer

scientific article

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer

scientific article

The influence of ImuVert, a biological response modifier, on the growth and ganglioside composition of murine neural tumors

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The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer

scientific article

The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy

scientific article published in August 2000

The role of metabolic therapy in treating glioblastoma multiforme

scientific article published on 16 April 2015

The total and mitochondrial lipidome of Artemia franciscana encysted embryos.

scientific article published on 16 August 2016

The use of the laryngeal tube disposable by paramedics during out-of-hospital cardiac arrest: a prospectively observational study (2008-2012).

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Thematic Review Series: Sphingolipids.Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a

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Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a

scientific article published on 20 February 2008

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

scientific article published on 29 May 2019

Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice

scientific article published on 25 February 2012

Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy.

scientific article

Thyroid hormone can restore the audiogenic seizure susceptibility of hypothyroid mice

scientific article published on 01 January 1981

Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

scientific article

Tumor-infiltrating macrophages influence the glycosphingolipid composition of murine brain tumors.

scientific article published in November 1998

Ultrastructural characterization of the Mitochondria-associated membranes abnormalities in human astrocytomas: Functional and therapeutics implications

scientific article published on 4 April 2017

Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach

scientific article published on 20 February 2008

Washing of banked blood by three different blood salvage devices

scientific article published on 15 August 2012

Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease

scientific article published on 4 December 2014