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List of works by Philip W Ingham

'Smoothening' the path for hedgehogs

scientific article published in December 1996

A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B.

scientific article published on 22 November 2016

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

scientific article

A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila

scientific article published on July 1984

A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo

scientific article published on 12 January 2005

A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies

scientific article published in December 2013

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

scientific article published in October 1989

A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion

scientific article (publication date: September 2007)

A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material

scientific article published in March 1994

A transgenic zebrafish model of neutrophilic inflammation

scientific article

Abdominal gene organization

scientific article published in January 1985

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

scientific article published on 9 May 2011

Adaxial cell migration in the zebrafish embryo is an active cell autonomous property that requires the Prdm1a transcription factor

scientific article

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

scientific article published on 04 April 2016

Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease.

scientific article published on 26 September 2011

Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression

scientific article published in April 1989

Axial (HNF3beta) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter

scientific article

Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos

scientific article

Boning up on Hedgehog's movements ⬇️

scientific article published on July 2, 1998

Boundaries and fields in early embryos

scientific article

Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling

scientific article published in April 1999

Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene distal-less

scientific article

Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development

scientific article published in June 2002

Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development

scientific article

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).

scientific article

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

scientific article published in July 1993

Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling

scientific article published in December 1999

Control of muscle fibre-type diversity during embryonic development: the zebrafish paradigm

scientific article

Deep sequencing of small RNA facilitates tissue and sex associated microRNA discovery in zebrafish.

scientific article published on 16 November 2015

Development and evolution. Mice and flies head to head

scientific article published in August 1992

Developmental biology. Catch of the decade

scientific article published in May 1994

Developmental biology. Patterning goes sonic.

scientific article published in May 1995

Developmental regulation of Tbx5 in zebrafish embryogenesis

scientific article published in February 2000

Divergence of zebrafish and mouse lymphatic cell fate specification pathways

scientific article published on 12 February 2014

Drosophila Segment Polarity Mutants and the Rediscovery of the Hedgehog Pathway Genes

scientific article published on 13 February 2016

Drosophila development

scientific article published on December 1989

Drosophila melanogaster as a model host for Staphylococcus aureus infection

scientific article published in July 2004

Drugging Hedgehog: signaling the pathway to translation ⬇️

scientific article published on April 15, 2013

Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models

scientific article published on 9 January 2017

Editorial overview: Cilia in development and disease

scientific article published on 01 June 2019

Elephant shark genome provides unique insights into gnathostome evolution

scientific article (publication date: 9 January 2014)

Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility.

scientific article published on 11 August 2017

Expression of engrailed in the parasegment of Drosophila

scientific article published in Nature

Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity.

scientific article published on 14 May 2008

Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling

scientific article published in January 2009

Expression screening and annotation of a zebrafish myoblast cDNA library

scientific article

Fibrodysplasia ossificans progressiva: current concepts from bench to bedside

scientific article published on 21 September 2020

From segmentation to human cancer therapy

scientific article published on 09 November 2018

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

scientific article published on June 2004

G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

scientific article published on 6 February 2018

Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes

scientific article

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish.

scientific article

Guidelines for morpholino use in zebrafish.

scientific article

Has the quest for a Wnt receptor finally frizzled out?

scientific article published on October 1996

Hedgehog Signaling ⬇️

scientific article published on June 1, 2012

Hedgehog Signaling: A Tale of Two Lipids ⬇️

scientific article published on November 30, 2001

Hedgehog signaling in animal development: paradigms and principles ⬇️

scientific article (publication date: December 2001)

Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo

scientific article published in September 2001

Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish

scientific article

Hedgehog signalling

scientific article

Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo

scientific article

Hedgehog signalling.

scientific article

Hedgehog signalling: Kif7 is not that fishy after all.

scientific article published in September 2009

Hedgehogs tryst with the cell cycle

scientific article

How cholesterol modulates the signal

scientific article

Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates

scientific article published on 2 August 2016

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

scientific article

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

scientific article

Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

scientific article

Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

scientific article published in May 2004

Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish.

scientific article

Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library.

scientific article

Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos

scientific article published in February 2000

Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome

scientific article published on February 2011

Ischemia is not required for arteriogenesis in zebrafish embryos

scientific article

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

scientific article published in December 1993

Mechanisms and functions of Hedgehog signalling across the metazoa

scientific article (publication date: June 2011)

Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos.

scientific article

Microcephalin coordinates mitosis in the syncytial Drosophila embryo

scientific article published on 25 September 2007

Micromanaging the response to Hedgehog

scientific article published on 01 February 2007

MoD Special Issue celebrating 100 years since “On Growth and Form” by D’Arcy Wentworth Thompson

scientific article published on 01 June 2017

Modeling cardiovascular disease in the zebrafish

scientific article published on May 2008

Modeling inflammation in the zebrafish: how a fish can help us understand lung disease

scientific article published on December 2007

Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

scientific article published in July 2003

Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish

scientific article published on 19 June 2020

Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing

scientific article published in August 2002

Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.

scientific article published on September 1997

On the origin of SCPP genes

article

Open questions: how to get developmental biology into shape?

scientific article published on 22 February 2019

Orchestrating ontogenesis: variations on a theme by sonic hedgehog

scientific article published on November 2006

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

scientific article published in October 2000

Pattern formation. Hedgehog points the way.

scientific article published on April 1994

Pattern formation: Form and diffusion

scientific article published in Nature

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

scientific article

Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest

scientific article published in March 2001

Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo

scientific article published on 5 December 2013

Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo

scientific article published on 6 June 2008

Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryo

scientific article

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

scientific article

Region-specific alleles of the Drosophila segmentation gene hairy

scientific article published in August 1988

Regulation of left-right asymmetries in the zebrafish by Shh and BMP4.

scientific article published in June 1999

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

scientific article

Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis

scientific article published in December 2003

Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm

scientific article published in March 1986

Retinoic acid signaling restricts the cardiac progenitor pool

scientific article published in January 2005

Ribozyme Mediated gRNA Generation for In Vitro and In Vivo CRISPR/Cas9 Mutagenesis

scientific article

Role of the Drosophila patched gene in positional signalling

scientific article

Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants

scientific article published on 31 January 2007

Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila

scientific article published in June 1995

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

scientific article

Signal transduction. Dorsal developments

scientific article published in December 1994

Signalling by hedgehog family proteins in Drosophila and vertebrate development ⬇️

scientific article published on August 1, 1995

Signalling change: signal transduction through the decades

scientific article published on 02 May 2013

Small-Scale Marker-Based Screening for Mutations in Zebrafish Development

article

Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo

scientific article published on 01 September 2018

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

scientific article

Switching on the notochord

scientific article

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish

scientific article published on 19 February 2013

Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish

scientific article published on 09 September 2013

Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates

scientific article

The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

scientific article published on 21 December 2003

The X, Y, Z of head development

scientific article published in August 1990

The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease

scientific article published on 06 December 2007

The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance.

scientific article

The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene

scientific article published on December 1986

The extracellular matrix protein TGFBI promotes myofibril bundling and muscle fibre growth in the zebrafish embryo

scientific article

The generation and interpretation of positional information within the vertebrate myotome

scientific article published on April 1998

The influence of the zebrafish genetic background on Parkinson's disease-related aspects

scientific article published on 11 July 2011

The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development

scientific article published on 7 September 2011

The molecular genetics of embryonic pattern formation in Drosophila

scientific article published on September 1988

The patched gene in development and cancer

scientific article published on February 1998

The patched gene in development and cancer

The power of the zebrafish for disease analysis

scientific article published on April 2009

The regulation of the bithorax complex

The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis

scientific article

The transformation of the model organism: a decade of developmental genetics

scientific article

The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo

scientific article

Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish, Danio rerio: developmental and evolutionary perspectives

scientific article published in June 1996

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

scientific article published on December 2013

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins

scientific article published in August 1996

Transducing Hedgehog: the story so far ⬇️

scientific article published on July 1, 1998

Trithorax: A new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments

article

Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways

scientific article published in March 2000

Zebrafish as a new animal model for movement disorders

scientific article published on 04 May 2008

Zebrafish genetics and its implications for understanding vertebrate development ⬇️

scientific article published on January 1, 1997

Zebrafish genetics gets the Scube on Hedgehog secretion

scientific article published on November 2012

Zebrafish models of the immune response: taking it on the ChIn ⬇️

scientific article published on December 22, 2010

iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo

scientific article published on 15 June 2004

p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease

scientific article published on 12 December 2006

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

scientific article published on August 1996

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