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List of works by Martin F Flajnik

A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?

scientific article

A flow cytometric analysis of the embryonic origin of lymphocytes in diploid/triploid chimeric Xenopus laevis

scientific article published in July 1984

A novel "chimeric" antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin

scientific article published in May 1996

A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG.

scientific article

A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey

scientific article

Advances in immunology

scientific article published on September 1994

All GOD's creatures got dedicated mucosal immunity

scientific article published on 01 September 2010

An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish

scientific article published on 13 January 2020

An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks

scholarly article

Ancestral organization of the MHC revealed in the amphibian Xenopus

scientific article

Antibody repertoire development in cartilaginous fish

scientific article

CXCL13 responsiveness but not CXCR5 expression by late transitional B cells initiates splenic white pulp formation

scientific article

Changes in the immune system during metamorphosis of Xenopus

scientific article published on January 1987

Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias).

scientific article published on 20 October 2011

Churchill and the immune system of ectothermic vertebrates

scientific article published on 01 December 1998

Cloning and characterization of ?2-microglobulin

scientific article published on 24 January 2005

Comparative analyses of immunoglobulin genes: surprises and portents

scientific article

Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes.

scientific article published on 07 July 2011

Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system

scientific article

Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey

scientific article published on 3 May 2006

Crystal structure of a shark single-domain antibody V region in complex with lysozyme

scientific article

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

scientific article published on 01 July 2001

Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark

scientific article

Duplication of the MHC-linked Xenopus complement factor B gene

scientific article published on January 1995

Early and natural antibodies in non-mammalian vertebrates

scientific article

Elephant shark genome provides unique insights into gnathostome evolution

scientific article (publication date: 9 January 2014)

Emergence of the acute-phase protein hemopexin in jawed vertebrates

scientific article published on 29 September 2010

Evolution and developmental regulation of the major histocompatibility complex.

scientific article published on January 1995

Evolution and the molecular basis of somatic hypermutation of antigen receptor genes

scientific article

Evolution of innate and adaptive immunity: can we draw a line?

scientific article

Evolution of proteasome subunits delta and LMP2: complementary DNA cloning and linkage analysis with MHC in lower vertebrates

scholarly article

Evolution of somatic hypermutation and gene conversion in adaptive immunity

scientific article published on April 1998

Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.

scientific article published on 11 April 2012

Evolution of the MHC: Antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules

scientific article published on 01 May 1990

Evolution of the MHC: isolation of class II beta-chain cDNA clones from the amphibian Xenopus laevis.

scientific article published in April 1993

Evolution of the major histocompatibility complex: a current overview

scientific article published on March 1995

Evolution of the major histocompatibility complex: isolation of class II A cDNA clones from the cartilaginous fish

scientific article published on August 1992

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus

scientific article

Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark

scientific article published on 19 May 2010

Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis

scientific article published on 23 January 2008

Exon-intron organization of Xenopus MHC class II beta chain genes

scientific article published in January 1995

Experimental analysis of ventral blood island hematopoiesis in Xenopus embryonic chimeras

scientific article published in February 1989

Expression of MHC class II antigens during Xenopus development

scientific article published on January 1990

Expression of MHC class Ia and class Ib during ontogeny: high expression in epithelia and coregulation of class Ia and lmp7 genes

scientific article published in March 1998

First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate.

scholarly article

Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates

scientific article

High-affinity lamprey VLRA and VLRB monoclonal antibodies

scientific article published on 22 July 2009

Histology and Immunology of the Placenta in the Atlantic Sharpnose Shark, Rhizoprionodon terraenovae

scientific article published on 28 February 2006

Homologs of CD83 from elasmobranch and teleost fish

scientific article published on October 2004

Hsp70 genes are linked to the Xenopus major histocompatibility complex

scientific article published on January 1994

Humoral response of captive zebra sharks Stegostoma fasciatum to salivary gland proteins of the leech Branchellion torpedinis

scientific article published on 28 August 2012

Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions

scientific article published on April 2002

Identification and genetic mapping of Xenopus TAP2 genes.

scientific article

Identification of class I genes in cartilaginous fish, the most ancient group of vertebrates displaying an adaptive immune response

scientific article published on December 1997

Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus

scientific article published on 01 January 1984

IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates

scientific article

IgM-mediated opsonization and cytotoxicity in the shark

scientific article published on 01 February 1997

Immunogenetics: alternative strategies in adaptive immunity and the rise of comparative immunogenomics

scientific article published on 24 August 2007

Immunoglobulin heavy chain exclusion in the shark

scientific article

Immunoglobulins in the eggs of the nurse shark, Ginglymostoma cirratum

scientific article published on 21 October 2004

Immunology: The Origin of Sweetbreads in Lampreys?

scientific article published on 01 March 2011

Immunology: another manifestation of GOD.

scientific article published in July 2004

Insight into the primordial MHC from studies in ectothermic vertebrates

scientific article

Involvement of thyroid hormones in the expression of MHC class I antigens during ontogeny in Xenopus

scientific article published on January 1997

Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries.

scientific article

Isolation and characterization of a cDNA encoding a Xenopus 70-kDa heat shock cognate protein, Hsc70.I.

scientific article

Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC.

scientific article published on August 1995

Isolation of a classical MHC class I cDNA from an amphibian. Evidence for only one class I locus in the Xenopus MHC.

scientific article published on November 1993

Isolation of a shark immunoglobulin light chain cDNA clone encoding a protein resembling mammalian kappa light chains: implications for the evolution of light chains

scientific article published on November 1993

Isolation of low molecular mass polypeptide complementary DNA clones from primitive vertebrates. Implications for the origin of MHC class I-restricted antigen presentation

scholarly article

Isolation of the Xenopus complement factor B complementary DNA and linkage of the gene to the frog MHC.

scholarly article

Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci

scientific article published in October 1999

J chain in the nurse shark: implications for function in a lower vertebrate

scientific article

Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development

scientific article published in November 2007

MHC class I antigens as surface markers of adult erythrocytes during the metamorphosis of Xenopus

scientific article published on 01 July 1988

MHC restriction of T-cell proliferative responses in Xenopus

scientific article published on September 1993

Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization

scientific article

Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis

scientific article published on 01 December 1986

Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding

scientific article

Molecular cloning of C4 gene and identification of the class III complement region in the shark MHC.

scientific article published in September 2003

Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

article

Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny.

scientific article

Nucleotide sequence of a nurse shark immunoglobulin heavy chain cDNA clone

scientific article

Origin and evolution of the adaptive immune system: genetic events and selective pressures

scientific article

Origin and evolution of the class I gene family: why are some of the mammalian class I genes encoded outside the major histocompatibility complex?

scientific article published on June 1996

Primitive vertebrate immunity: what is the evolutionary derivative of molecules that define the adaptive immune system?

scientific article published on January 1994

Primordial linkage of β2-microglobulin to the MHC

scientific article

Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages

scientific article published in January 2002

Putting J chain back on the map: how might its expression define plasma cell development?

scientific article

Re-evaluation of the immunological Big Bang

scientific article

Rearrangement of immunoglobulin genes in shark germ cells

scientific article (publication date: 15 May 2000)

Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display

scientific article

Shark Ig light chain junctions are as diverse as in heavy chains

scientific article published in November 2004

Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.

scientific article

Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum

article

Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark

scientific article published in December 2005

Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers

scientific article published on November 1998

Somatic mutation in ectothermic vertebrates: musings on selection and origins.

scientific article published on January 1998

Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins

scientific article

Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development

scientific article published on 23 July 2002

Structural conservation of hypervariable regions in immunoglobulins evolution

scientific article published in December 1994

Studies on the Xenopus major histocompatibility complex

Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebrates

scientific article published on 25 October 2003

The Development of Primary and Secondary Lymphoid Tissues in the Nurse Shark Ginglymostoma cirratum: B-Cell Zones Precede Dendritic Cell Immigration and T-Cell Zone Formation During Ontogeny of the Spleen

article

The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes.

scientific article

The evolutionary origin of the major histocompatibility complex: polymorphism of class II alpha chain genes in the cartilaginous fish

scientific article

The generation and selection of single-domain, v region libraries from nurse sharks

scientific article published in January 2009

The immune system of Xenopus

scientific article published on January 1989

The immune system of cartilaginous fish.

scientific article

The immune system of ectothermic vertebrates

scientific article

The last flag unfurled? A new immunoglobulin isotype in fish expressed in early development

article

The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45.

scientific article

The major histocompatibility complex of frogs

scientific article published on February 1990

The multiple shark Ig H chain genes rearrange and hypermutate autonomously

scientific article

The plasticity of immunoglobulin gene systems in evolution

scientific article

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

scientific article

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

scientific article

Trans-species polymorphism of the major histocompatibility complex-encoded proteasome subunit LMP7 in an amphibian genus, Xenopus

scientific article published in March 2000

Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC.

scientific article published in October 1999

Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes

scientific article published in November 2003

Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish

scientific article published on July 2004

Venkatesh et al. reply

scientific article published in July 2014

Which came first, MHC class I or class II?

scientific article published on 01 January 1991

Xenopus class II A genes: studies of genetics, polymorphism, and expression.

scientific article

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