Search filters

List of works by Walter Kolch

A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells.

scientific article

A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model.

scientific article published on 12 September 2017

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.

scientific article

A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways.

scientific article published on 22 January 2007

A microfluidic dual gradient generator for conducting cell-based drug combination assays

scientific article published on 16 November 2015

Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines

scientific article published on May 1998

Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy.

scientific article published in July 2004

Addressing the challenge of defining valid proteomic biomarkers and classifiers

scientific article

All over the place: deciphering HRAS signaling from different subcellular compartments

scientific article published on 20 May 2019

An integrated Bayesian framework for identifying phosphorylation networks in stimulated cells

scientific article published in January 2012

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

scientific article published on 21 June 2016

Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1α activity.

scientific article

Big signals from small particles: regulation of cell signaling pathways by nanoparticles

scientific article published on 21 February 2013

Biology using engineering tools: the negative feedback amplifier

scientific article published on July 2011

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

scientific article published on 27 January 2016

CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics

scientific article

Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery

scientific article

Cell Type-Specific Activation of AKT and ERK Signaling Pathways by Small Negatively-Charged Magnetic Nanoparticles ⬇️

scientific article published on November 16, 2012

Cell fate decisions are specified by the dynamic ERK interactome

scientific article

Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors

scientific article published on 26 November 2017

Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells

scientific article published on August 2009

Clinical proteomics: A need to define the field and to begin to set adequate standards

scientific article published on 22 January 2007

Clinical proteomics: a question of technology

scientific article published on 01 January 2004

Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis

scientific article published in December 2002

Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device

scientific article

Computational approaches for analyzing information flow in biological networks

scientific article published on 17 April 2012

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

scientific article

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

scientific article

Conferring specificity on the ubiquitous Raf/MEK signalling pathway

scientific article published on January 2004

Control of the G-protein cascade dynamics by GDP dissociation inhibitors

scientific article published in October 2013

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

scientific article (publication date: November 2005)

Crosstalk and signaling switches in mitogen-activated protein kinase cascades

scientific article published on 18 September 2012

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

scientific article published on May 2002

Defining systems biology: through the eyes of a biochemist

scientific article published on 01 January 2008

Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation

scientific article published on 19 February 2016

Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro

scientific article published on October 1994

Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches

scientific article

ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.

scientific article

Effects of RKIP Loss in Human and in Animal Models of Colorectal Cancer

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise ⬇️

scientific article published on August 24, 2012

Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position

scientific article published in January 2004

Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade

scientific article

Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway

scientific journal article

Evaluating strategies to normalise biological replicates of Western blot data

scientific article

Expression of human c-raf-1 oncogene proteins in E. coli

scientific article

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

scientific article published on 24 January 2020

Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity

scientific article published on 16 September 2013

Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

scientific article

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

scientific article published on 19 August 2010

Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition

scientific article

GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling

scientific article published on 26 November 2013

Giving Space to Cell Signaling

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

scientific article

Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription

scientific article

High-precision FLIM-FRET in fixed and living cells reveals heterogeneity in a simple CFP-YFP fusion protein

scientific article published in February 2007

Identification and analysis of phosphopeptides

scientific article published on April 2004

Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA)

scientific article published on April 2010

Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

scientific article

Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes

scientific article published on September 1995

Identification of the smooth muscle-specific protein, sm22, as a novel protein kinase C substrate using two-dimensional gel electrophoresis and mass spectrometry

scientific article published on 01 July 2000

Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells.

scientific article published on 27 August 2012

Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes

scientific article published on April 1995

In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells.

scientific article published on January 2014

Induction of apoptosis by protein kinase C delta is independent of its kinase activity

scientific article

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species

scientific article published in January 2010

Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology

scientific article

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

scientific article published on 11 December 2015

Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models

scientific article published on 18 August 2010

Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models

scientific article

It takes two to tango--signalling by dimeric Raf kinases

scientific article published on April 2013

LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway

scientific article published on 11 November 2003

Lab-on-a-chip technologies for proteomic analysis from isolated cells

scientific article

Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

scientific article published on 8 June 2017

Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system

scientific article published in October 2004

Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling

scientific article

MAP kinase signalling pathways in cancer

scientific article (publication date: 14 May 2007)

MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance

scientific article

MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability

scientific article published on 12 October 2009

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

scientific article published on 01 November 2012

Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway

scientific article

Mapping of signaling pathways by functional interaction proteomics

scientific article

Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

scientific article

Measuring Transcription Rate Changes via Time-Course 4-Thiouridine Pulse-Labelling Improves Transcriptional Target Identification

scientific article published on 8 September 2015

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

scientific article

Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK.

scientific article published on 9 October 2014

Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis

scientific article published on 7 July 2016

Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization

scientific article published on 20 December 2017

Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension

scientific article

Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2.

scientific article

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

scientific article published on 12 June 2009

Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation

scientific article published on 9 May 2014

Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation

scientific article

Modeling and simulation of intracellular dynamics: choosing an appropriate framework

scientific article

Molecular mechanisms of asymmetric RAF dimer activation

scientific article

Multiple roles of the NF-kappaB signaling pathway regulated by coupled negative feedback circuits

scientific article published on 5 May 2009

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

scientific article

Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis

scientific article published on 17 November 2007

Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs

scientific article

Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease

scientific article

Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration

scientific article

Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90

scientific article published in Journal of Biological Chemistry

Network-based identification of feedback modules that control RhoA activity and cell migration

scientific article published on 16 March 2015

News

scientific article published on 01 June 2005

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

scientific article

On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics

scientific article

On-chip immunoprecipitation for protein purification

scientific article

Oncogenic B-Raf mutations: crystal clear at last

scientific article published in April 2004

Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells

scientific article

One Hippo and many masters: differential regulation of the Hippo pathway in cancer

scientific article

PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

scientific article

Pachinko biology: Gambling on single cells

Personalized Computational Models as Biomarkers

scientific article published on September 2017

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

scientific journal article

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

scientific article published on 8 December 2015

Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

scientific article published in February 2009

Preparation of raf-oncogene-specific antiserum with raf protein produced in E. coli.

scientific article

Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt

scientific article

Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells

scientific article

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

scientific article

Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose–responses

article

Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transduction

scientific article

Proteomics and phosphoproteomics for the mapping of cellular signalling networks

scientific article

Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2

scientific article

Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells

scientific article

RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility

scientific article published on 23 December 2010

RAN GTPase is a RASSF1A effector involved in controlling microtubule organization.

scientific article

RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy

scientific article published on 17 January 2020

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

scientific article

RASSF2 associates with and stabilizes the proapoptotic kinase MST2

scientific article

ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells

scientific article

Raf family kinases: old dogs have learned new tricks

scientific article

Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β.

scientific article published on 8 February 2011

Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients

scientific article published in February 2013

Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients

scientific article published in December 2006

Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation

scientific article

Raf kinase inhibitor protein regulation of raf and MAPK signaling

scientific article

Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability.

scientific article

Raf-1 and B-Raf promote protein kinase C theta interaction with BAD.

scientific article published on 23 August 2006

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

scientific article published in Journal of Biological Chemistry

Ras/Raf signalling and emerging pharmacotherapeutic targets

scientific article

Recommendations for biomarker identification and qualification in clinical proteomics

scientific article published in August 2010

Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines.

scientific article published on August 2004

Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis

scientific article published on October 2005

Regulation and role of Raf-1/B-Raf heterodimerization

scientific article

Regulation of RKIP binding to the N-region of the Raf-1 kinase

scientific article

Regulation of Raf-1 activation and signalling by dephosphorylation

scientific article

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

scientific article published on February 1998

Regulation of human myoblast differentiation by PEBP4

scientific article

Regulation of the MAPK pathway by raf kinase inhibitory protein

scientific article

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

scientific journal article

Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis

scientific article published on January 1995

Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008)

scientific article

Robustness and evolvability of the human signaling network

scientific article (publication date: July 2014)

Role of inhibitory proteins as modulators of oscillations in NFB signalling

scientific article published in March 2009

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

scientific article

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

scientific article published on 22 December 2015

Signalling ballet in space and time

scientific article

Signalling mechanisms regulating phenotypic changes in breast cancer cells

scientific article

Silence on the relevant literature and errors in implementation

scientific article published in April 2015

Snail is a repressor of RKIP transcription in metastatic prostate cancer cells

scientific article published on 22 October 2007

Spatial regulation of ARAF controls the MST2-Hippo pathway.

scientific article

Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development

scientific article published on 26 February 2014

Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.

scientific article published on 29 June 2016

Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts

scientific article published on March 1998

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

scientific article (publication date: 9 September 1999)

Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system

scientific article

Systems biology-embedded target validation: improving efficacy in drug discovery.

scientific article

Systems medicine: helping us understand the complexity of disease

scientific article published on 30 July 2013

Systems medicine: opportunities and challenges for systems biology approaches

scientific article published on 30 October 2013

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

scientific article published on 07 February 2020

Targeting MAPK signalling: Prometheus' fire or Pandora's box?

scientific article published on January 2004

Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: a critical assessment

scientific article

The APC network regulates the removal of mutated cells from colonic crypts.

scientific article published on 27 March 2014

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

scientific article

The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1

scientific article

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

scientific article

The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kappaB signaling pathways.

scientific article published on 31 May 2010

The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.

scientific article published on 24 January 2008

The Renilla luciferase gene as a reference gene for normalization of gene expression in transiently transfected cells

scientific article published on 31 December 2010

The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics

scientific article published on 4 March 2013

The dynamic control of signal transduction networks in cancer cells

scientific article

The future of genomics in Ireland – focus on genomics for health

scientific article published on 04 December 2020

The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathways

scientific article published on February 2003

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

scientific article published on 21 December 2010

The molecular make-up of a tumour: proteomics in cancer research

scientific article

The secret life of kinases: functions beyond catalysis

scientific article published on 28 October 2011

The topology design principles that determine the spatiotemporal dynamics of G-protein cascades

article

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

scientific article

To be or not to be: a question of B-Raf?

scientific article

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

scientific article published on February 2006

Unique reporter-based sensor platforms to monitor signalling in cells

scientific article

Untying the regulation of the Raf-1 kinase

scientific article (publication date: August 2002)

Urinary Proteomic Biomarkers in Coronary Artery Disease

scientific article published on 19 October 2007

When kinases meet mathematics: the systems biology of MAPK signalling

scientific article

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

scientific article

c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway

scientific article published on 21 April 2011

Paulina is supported by:

About Paulina

Help