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List of works by Lan K Nguyen

A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network

article

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

scientific article published on 6 February 2013

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

scientific article published on 27 January 2016

Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device

scientific article

Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells

scientific article published on 23 July 2019

DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks

scientific article published on 29 July 2015

Distinct noise-controlling roles of multiple negative feedback mechanisms in a prokaryotic operon system ⬇️

scientific article published on March 1, 2011

Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1

scientific article published on 16 September 2021

Dynamical modelling of feedback gene regulatory networks ⬇️

2009 doctoral thesis by Lan K. Nguyen at Lincoln University

Dynamics of ubiquitin-mediated signalling: insights from mathematical modelling and experimental studies

scientific article published on 25 July 2015

Feedback regulation in cell signalling: Lessons for cancer therapeutics

scientific article

Hypoxia-inducible factor (HIF) network: insights from mathematical models

scientific article published on 10 June 2013

Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells

scientific article published on 5 October 2014

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

scientific article published in Nature Communications

MST2-RASSF protein-protein interactions through SARAH domains

scientific article published on 5 October 2015

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

scientific article

On multiple regulatory mechanisms in the tryptophan operon system in Escherichia coli: in silico study of perturbation dynamics

scientific article published in January 2008

On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems

scientific article published on 11 May 2009

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

scientific article published on 8 December 2015

Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation

scientific article published on 24 January 2014

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

scientific article

Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose–responses

article

Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops ⬇️

scientific article published on March 14, 2012

Relationship between serum response factor and androgen receptor in prostate cancer

scientific article published on 7 August 2015

Signalling by protein phosphatases and drug development: a systems-centred view.

scientific article

Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate

scientific article published on 20 February 2015

Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system

scientific article

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.

scientific article published on 19 June 2018

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

scientific article

Ubiquitin chain specific auto-ubiquitination triggers sustained oscillation, bistable switches and excitable firing

scientific article published on 01 December 2014

Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling

scientific article published on 29 January 2016

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling ⬇️

scientific article published on July 31, 2013

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