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List of works by Martin Scheffner

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

scientific article

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

scientific article published on May 1995

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

scientific article (publication date: August 2003)

A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein

scientific article

A ubiquitin variant-based affinity approach selectively identifies substrates of the ubiquitin ligase E6AP in complex with HPV-11 E6 or HPV-16 E6

scientific article published on 27 August 2020

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

scientific article

Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome

scientific article published in Journal of Biological Chemistry

Anionic surfactants enhance click reaction-mediated protein conjugation with ubiquitin.

scientific article published on 16 January 2016

Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy

scientific article published on 24 June 2019

Assembly of branched ubiquitin oligomers by click chemistry

scientific article published on 01 October 2019

Cell biology. Proteolytic relay comes to an end.

scientific article published in April 2001

Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

scientific article published in Journal of Biological Chemistry

Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation

scientific article published on December 1998

Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4

scientific journal article

Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate

scientific article published on 04 October 2021

Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation

scientific article published on 24 September 2015

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5

scientific article

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

scholarly article

DNA binding properties and replication activity of the T antigen related D2 phosphoprotein

scientific article published in 1989

Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue

scientific article

Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells

scientific article

Different Enzymatic Processing of γ-Phosphoramidate and γ-Phosphoester-Modified ATP Analogues.

scientific article

Differentiation of Compact and Extended Conformations of Di-Ubiquitin Conjugates with Lysine-Specific Isopeptide Linkages by Ion Mobility-Mass Spectrometry

article

Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains

scientific article published on 4 September 2014

E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins.

scientific article published on January 1994

E6AP promotes the degradation of the PML tumor suppressor

scientific article published on 27 March 2009

Effects of the antifungal agent ciclopirox in HPV-positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis

scientific article published on 31 October 2019

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

scientific article published in 2022

Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time

scientific article published on 17 September 2013

Formation of Ubiquitin Dimers via Azide–Alkyne Click Reaction

scientific article published on 01 January 2012

Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes

scientific article published on 03 September 2019

Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks.

scientific article published in June 2009

Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry

scientific article published on 03 November 2011

Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53

scientific article

HECT E3s and human disease

scientific article

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

scientific article

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

scientific article

Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.

scientific article published on 14 February 2007

Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system

scientific article

Identification of Proteins Interacting with Ubiquitin Chains.

scientific article published on 17 October 2017

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

scientific article

Identification of determinants in E2 ubiquitin-conjugating enzymes required for hect E3 ubiquitin-protein ligase interaction

scientific article (publication date: 12 March 1999)

Improving bioorthogonal protein ubiquitylation by click reaction

scientific article published on 3 April 2013

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

scientific article published on June 2000

Involvement of the DNA repair protein hHR23 in p53 degradation

scientific article

Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects ⬇️

scientific article published on March 29, 2013

Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo

scientific article

Moving protein heads for breakdown

scientific article published in Nature

Mutation of HERC2 causes developmental delay with Angelman-like features.

scientific article

On Biomineralization: Enzymes Switch on Mesocrystal Assembly

scientific article published on 01 February 2019

Oncogenic human papillomaviruses block expression of the B-cell translocation gene-2 tumor suppressor gene

scientific article published in November 2009

Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.

scientific article

Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2

scientific article

Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function.

scientific article

Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses

scientific article

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

scientific article (publication date: 5 January 1995)

Protein-DNA interactions at the simian virus 40 origin of replication

scientific article published in December 1988

RNA helicase activity associated with the human p68 protein

scientific article published in Nature

RNA unwinding activity of SV40 large T antigen

scientific article published on 01 June 1989

Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system

scientific article

Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

scientific article

Role of the histone acetyl transferase Tip60 in the p53 pathway

scientific article published on 13 August 2004

Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc

scientific article published on 13 May 2013

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

scientific article

Roles of larval sea urchin spicule SM50 domains in organic matrix self-assembly and calcium carbonate mineralization

scientific article published on 21 June 2013

Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit

scholarly article by Stephan M. Hacker et al published 5 August 2014 in Angewandte Chemie International Edition

Sequence independent duplex DNA opening reaction catalysed by SV40 large tumor antigen

scientific article published on January 1989

Simian-virus-40 large-T-antigen-catalyzed DNA and RNA unwinding reactions

scientific article published in January 1991

Small-Molecule Inhibitors of the Tumor Suppressor Fhit.

scientific article published on 23 June 2017

Structural and functional consequences of NEDD8 phosphorylation

scientific article published on 12 October 2021

Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex

scientific article published in Nature Communications

Synthesis of defined ubiquitin dimers.

scientific article published on 29 October 2010

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

scientific article

The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation

scientific article

The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins

scientific article published on 3 November 2006

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

scientific article published on July 1991

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

scientific article

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme

scientific article

The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate

scientific article

The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids.

scientific article published in November 2003

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

scientific article

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere

scientific article published on 17 August 2021

Towards a molecular basis of ubiquitin signaling: A dual-scale simulation study of ubiquitin dimers

scientific article published on 16 November 2018

UBE1L2, a novel E1 enzyme specific for ubiquitin

scientific article

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases

scientific article

Ubiquitin ligase E6-AP and its role in human disease

scientific article published on 01 October 2008

Ubiquitin, E6-AP, and Their Role in p53 Inactivation ⬇️

scientific article published on June 1, 1998

Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells.

scientific article published on January 2009

Varshavsky's contributions.

scientific article

c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity

scientific article published on 26 April 2013

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

scientific article

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