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List of works by Tim J. Yen

A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

scientific journal article

A modified HSP70 inhibitor shows broad activity as an anticancer agent

scientific article

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells

scientific article published on January 2014

Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not

scientific article

Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint

scientific article

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E ⬇️

scientific article published on September 21, 1998

Anti-CENP-H antibodies in patients with Sjogren's syndrome

scientific article published on 08 February 2005

Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases

scientific article published on 24 August 2011

Astrin regulates Aurora-A localization.

scientific article published on 24 March 2008

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

scientific article published on 01 October 1987

BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex

scientific article

CENP-E function at kinetochores is essential for chromosome alignment.

scientific article published in December 1997

CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay.

scientific article

Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override

scientific article

Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation

scientific article

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

scientific article

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

scientific article

Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization

scientific article

Chromosome instability in tumor cells due to defects in Aurora B mediated error correction at kinetochores

scientific article published on 04 December 2018

Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)

scientific article published on November 2011

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells

scientific article published on 30 December 2008

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.

scientific article

Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity

scientific article

Crystal structure of the motor domain of the human kinetochore protein CENP-E

scientific article

DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization

scientific article published in May 2003

Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells

scientific article

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).

scientific article

Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine

scientific article

Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death

scientific article

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

scientific article

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

scientific article published on 4 April 2003

Expression and behaviour of CENP-E at kinetochores during mouse spermatogenesis

scientific article published on 01 March 2002

G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression

scientific article published on 5 January 2012

HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

scientific article published on 13 November 2006

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

scientific article

HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells

scientific article

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

scientific article

Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

scientific article

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

scientific article

Immunolocalization of alpha-tubulin, gamma-tubulin, and CENP-E in male rat and male mouse meiotic divisions: pathway of meiosis I spindle formation in mammalian spermatocytes

scientific article

Interaction between ATM protein and c-Abl in response to DNA damage

scientific article (publication date: 29 May 1997)

Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

scientific article

Kinetochore function: molecular motors, switches and gates

scientific article

Kinetochore structure and function

scientific article

Lack of correlation between ATM protein expression and tumour cell radiosensitivity

scientific article published on August 1998

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

scientific article

Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B.

scientific article published on 17 February 2005

Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase ⬇️

scientific article published on December 1, 1997

Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

scientific article published in December 1998

Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells

scientific article

Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

scientific article published on December 2011

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

scientific article published on November 2008

Polo delivers a PICH to the kinetochore.

scientific article published in January 2007

Protein architecture of the human kinetochore microtubule attachment site

scientific article

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

scientific article

Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints

scientific article

Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen

scientific article published on 25 September 2013

Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention.

scientific article published on 3 September 2004

Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA.

scientific article

Specific regulation of CENP-E and kinetochores during meiosis I/meiosis II transition in pig oocytes

scientific article published in May 2000

Targeting mitosis for anti-cancer therapy

scientific article published on January 2007

Targeting the kinetochore for mitosis-specific inhibitors.

scientific article

The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

scientific article

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

scientific article

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

scientific article

The role of mitotic checkpoint in maintaining genomic stability

scientific article published on January 2003

Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein

scientific article

Timeless links replication termination to mitotic kinase activation

scientific article

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

scientific article

Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20

scientific article

Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

scientific article published in February 2001

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions

scientific article

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