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List of works by Nicholas R Casewell

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

scientific article published on 30 July 2019

A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii).

scientific article

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

scientific article published on 15 December 2020

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management ⬇️

scientific article published on 20 August 2020

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

scientific article published on 24 June 2020

Anti-angiogenic activities of snake venom CRISP isolated from Echis carinatus sochureki.

scientific article

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

scientific article published on 16 January 2020

Author Correction: A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

correction of a scholarly article

Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation

scientific article published on 02 August 2019

Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

scientific article published on 25 March 2021

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

scientific article published on 18 February 2021

Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus).

scientific article

Coevolution takes the sting out of it: Evolutionary biology and mechanisms of toxin resistance in animals.

scientific article

Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts

scientific article

Complex cocktails: the evolutionary novelty of venoms

scientific article published on 5 December 2012

Correction: Molecular Evolution of Vertebrate Neurotrophins: Co-Option of the Highly Conserved Nerve Growth Factor Gene into the Advanced Snake Venom Arsenalf.

scientific article published on 17 December 2013

Cytotoxic activities of [Ser⁴⁹]phospholipase A₂ from the venom of the saw-scaled vipers Echis ocellatus, Echis pyramidum leakeyi, Echis carinatus sochureki, and Echis coloratus

scientific article

De novo designed proteins neutralize lethal snake venom toxins

scientific article published on 15 January 2025

Defining the pathogenic threat of envenoming by south african shield-nosed and coral snakes (genus aspidelaps), and revealing the likely efficacy of available antivenom

article

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

scientific article published in 2024

Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains.

scientific article

Differential evolution and neofunctionalization of snake venom metalloprotease domains

scientific article published on 12 December 2012

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.

scientific article published on 25 August 2017

Domain loss facilitates accelerated evolution and neofunctionalization of duplicate snake venom metalloproteinase toxin genes

scientific article

Dynamic evolution of venom proteins in squamate reptiles ⬇️

scientific article published on January 1, 2012

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

scientific article published on 19 May 2011

Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

scientific article published on 23 October 2019

Evolution: Gene Co-option Underpins Venom Protein Evolution.

scientific article

Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

scientific article published on 30 June 2022

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

scientific article published on 11 July 2022

Expression of venom gene homologs in diverse python tissues suggests a new model for the evolution of snake venom.

scientific article

Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture

scientific article published on 02 February 2021

Extreme venom variation in Middle Eastern vipers: a proteomics comparison of Eristicophis macmahonii, Pseudocerastes fieldi and Pseudocerastes persicus.

scientific article published on 18 September 2014

Firing the sting: chemically induced discharge of cnidae reveals novel proteins and peptides from box jellyfish (Chironex fleckeri) venom

scientific article published on 18 March 2015

Friends or Foes? Emerging Impacts of Biological Toxins

scientific article published on 14 January 2019

Gene tree parsimony of multilocus snake venom protein families reveals species tree conflict as a result of multiple parallel gene loss

scientific article published on 8 November 2010

Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise.

scientific article published on 24 February 2017

Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb

scientific article published on 19 August 2014

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms

scientific article published on 03 December 2020

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey

scientific article published on 11 February 2019

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms

scientific article published on 09 August 2018

Long-term physicochemical and immunological stability of a liquid formulated intact ovine immunoglobulin-based antivenom

scientific article published on 11 January 2013

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

scientific article published on 23 January 2020

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

scientific article published in 2020

Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

scientific article

Molecular adaptations for sensing and securing prey and insight into amniote genome diversity from the garter snake genome

scientific article published on 01 August 2018

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf

scientific article (publication date: 2013)

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

scientific article published on 04 May 2018

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins

scientific article published on 20 August 2020

Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

scientific article published on 19 August 2020

Novel transcripts in the maxillary venom glands of advanced snakes

scientific article

On the ancestral recruitment of metalloproteinases into the venom of snakes ⬇️

scientific article published on March 3, 2012

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms

scientific article published on 18 August 2021

Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom

scientific article

Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa

scientific article published on 18 October 2017

Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite

scientific article published on 01 May 2020

Production and assessment of ovine antisera for the manufacture of a veterinary adder antivenom

scientific article published on 10 March 2014

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

scientific article published on 23 March 2022

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins

scientific article published on 07 July 2018

Research strategies to improve snakebite treatment: challenges and progress.

scientific article published on 25 June 2011

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part A. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function"

scientific article published on 17 November 2012

Response to "Replies to Fry et al. (Toxicon 2012, 60/4, 434-448). Part B. Analyses of squamate reptile oral glands and their products: A call for caution in formal assignment of terminology designating biological function"

scientific article published on 07 January 2013

Single-reagent one-step procedures for the purification of ovine IgG, F(ab')2 and Fab antivenoms by caprylic acid

scientific article

Small Molecule Drug Discovery for Neglected Tropical Snakebite

scientific article published on 24 March 2021

Snake antivenom trial

scientific article published on 01 February 2014

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals

scientific article published on 26 November 2019

Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons

scientific article

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

scientific article published in 2024

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

scientific article published on 14 March 2022

The Burmese python genome reveals the molecular basis for extreme adaptation in snakes

scientific article

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

scientific article published on 01 May 2017

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

scientific article published on 29 June 2021

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

scientific article

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

scientific article published on 23 August 2017

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms

article

The structural and functional diversification of the Toxicofera reptile venom system

scientific article

The time is now: a call for action to translate recent momentum on tackling tropical snakebite into sustained benefit for victims

scientific article published on 01 December 2019

The Cardiovascular and Neurotoxic Effects of the  Venoms of Six Bony and Cartilaginous Fish Species

scientific article published on 16 February 2017

VTBuilder: a tool for the assembly of multi isoform transcriptomes.

scientific article

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis

scientific article published in Scientific Reports

Venom Evolution: Gene Loss Shapes Phenotypic Adaptation

scientific article

Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom

scientific article

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades

scientific article published on 14 January 2014

Visual Pigments, Ocular Filters and the Evolution of Snake Vision.

scientific article

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus

scientific article published on 24 January 2017

Widespread convergence in toxin resistance by predictable molecular evolution

scientific article

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad

scientific article published on 01 June 2018

Widespread vulnerability of Malagasy predators to the toxins of an introduced toad

scientific article published on 01 July 2018

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