List of works - Lars Ellgaard

A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4.

scientific article published on 14 December 2009

A male with unilateral microphthalmia reveals a role for TMX3 in eye development

scientific article

A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells

scientific article published on 02 October 2008

Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262.

scientific article published on April 2014

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

scientific article published on 25 February 2016

Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding

scientific article published on January 2003

Cellular functions and molecular mechanisms of non-lysine ubiquitination

scientific article published on 18 September 2019

Co- and Post-Translational Protein Folding in the ER

scientific article

Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

scientific article published on 22 July 2020

Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of alpha 2-macroglobulin receptor and urokinase receptor expression

scientific article published on April 1995

Dissection of the domain architecture of the alpha2macroglobulin-receptor-associated protein

scientific article published on March 1997

Disulphide production by Ero1α-PDI relay is rapid and effectively regulated

scientific article

Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.

scientific article

ER quality control: towards an understanding at the molecular level

scientific article

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

scientific article published on 31 October 2018

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

scientific article published on 22 February 2014

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

scientific article published on 10 June 2016

HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin

scientific article

How Are Proteins Reduced in the Endoplasmic Reticulum?

scientific article published on 15 November 2017

Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response

scientific article

Identification of the PDI-family member ERp90 as an interaction partner of ERFAD

scientific article

In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms

scientific article published on January 2008

Interactions of substrate with calreticulin, an endoplasmic reticulum chaperone

scientific article

Ligand binding properties of the very low density lipoprotein receptor. Absence of the third complement-type repeat encoded by exon 4 is associated with reduced binding of Mr 40,000 receptor-associated protein

scientific article published in Journal of Biological Chemistry

Localization of a single transglutaminase-reactive glutamine in the third domain of RAP, the alpha2-macroglobulin receptor-associated protein

scientific article published on 01 January 1999

Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

scientific article

Multiple ways to make disulfides

scientific article published on 19 July 2011

Mutational analysis provides molecular insight into the carbohydrate-binding region of calreticulin: pivotal roles of tyrosine-109 and aspartate-135 in carbohydrate recognition.

scientific article published on January 2004

NMR structure of the calreticulin P-domain

scientific article

NMR structures of 36 and 73-residue fragments of the calreticulin P-domain

scientific article

Nested sets of protein fragments and their use in epitope mapping: characterization of the epitope for the S4D5 monoclonal antibody binding to receptor associated protein

scientific article published on 01 March 1995

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.

scientific article published on November 2011

Quality control in the endoplasmic reticulum

scientific article (publication date: March 2003)

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

scientific article published on 8 March 2016

Setting the standards: quality control in the secretory pathway

scientific article

Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells

scientific article

Specialized insulin is used for chemical warfare by fish-hunting cone snails.

scientific article

Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.

scientific article

TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain

scientific article

The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin

scientific article

The human PDI family: versatility packed into a single fold.

scientific article

The human protein disulphide isomerase family: substrate interactions and functional properties

scientific article published in January 2005

The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

scientific article published on 14 June 2012

The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D

scientific article

The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein

scientific article

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

scientific article published on 11 April 2019

Three-dimensional structure topology of the calreticulin P-domain based on NMR assignment

scientific article

List of works by Lars Ellgaard

A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4.

A male with unilateral microphthalmia reveals a role for TMX3 in eye development

A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells

Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262.

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding

Cellular functions and molecular mechanisms of non-lysine ubiquitination

Co- and Post-Translational Protein Folding in the ER

Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of alpha 2-macroglobulin receptor and urokinase receptor expression

Dissection of the domain architecture of the alpha2macroglobulin-receptor-associated protein

Disulphide production by Ero1α-PDI relay is rapid and effectively regulated

Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.

ER quality control: towards an understanding at the molecular level

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin

How Are Proteins Reduced in the Endoplasmic Reticulum?

Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response

Identification of the PDI-family member ERp90 as an interaction partner of ERFAD

In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms

Interactions of substrate with calreticulin, an endoplasmic reticulum chaperone

Ligand binding properties of the very low density lipoprotein receptor. Absence of the third complement-type repeat encoded by exon 4 is associated with reduced binding of Mr 40,000 receptor-associated protein

Localization of a single transglutaminase-reactive glutamine in the third domain of RAP, the alpha2-macroglobulin receptor-associated protein

Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

Multiple ways to make disulfides

Mutational analysis provides molecular insight into the carbohydrate-binding region of calreticulin: pivotal roles of tyrosine-109 and aspartate-135 in carbohydrate recognition.

NMR structure of the calreticulin P-domain

NMR structures of 36 and 73-residue fragments of the calreticulin P-domain

Nested sets of protein fragments and their use in epitope mapping: characterization of the epitope for the S4D5 monoclonal antibody binding to receptor associated protein

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.

Quality control in the endoplasmic reticulum

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

Setting the standards: quality control in the secretory pathway

Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells

Specialized insulin is used for chemical warfare by fish-hunting cone snails.

Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.

TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain

The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin

The human PDI family: versatility packed into a single fold.

The human protein disulphide isomerase family: substrate interactions and functional properties

The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D

The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Three-dimensional structure topology of the calreticulin P-domain based on NMR assignment