List of works - Adam R Renslo

2-Aminothiazoles as therapeutic leads for prion diseases

scientific article

2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease

scientific article published on 18 March 2013

A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models

scientific article published on 12 December 2016

A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials

scientific article published on 13 July 2007

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite

scientific article published on 24 January 2011

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

scientific article

A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines

scientific article

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery

scientific article published on 15 April 2019

Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases

scientific article

Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases

scientific article published on 27 July 2018

Antibacterial oxazolidinones: emerging structure-toxicity relationships

scientific article published on May 2010

Antimalarial Drug Discovery: From Quinine to the Dream of Eradication

scientific article published on December 2013

Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.

scientific article

Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice

scientific article published on 21 August 2013

Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases

scientific article

Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

scientific article published on 4 January 2013

Concerning the Regiochemical Course of the Diels-Alder Reaction in Supercritical Carbon Dioxide

scientific article published on 01 June 1997

Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones

scientific article published on 4 January 2006

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

scientific article published in July 2005

Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei.

scientific article published on 23 July 2013

Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

scientific article published on 17 April 2020

Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major

scientific article published on 14 October 2013

Discovery of 2-aminothiazoles as potent antiprion compounds

scientific article

Divergent modes of enzyme inhibition in a homologous structure-activity series

scientific article published on August 2009

Drug discovery and development for neglected parasitic diseases

scientific article published on December 2006

Drug discovery for neglected tropical diseases at the Sandler Center

scientific article

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening

scientific article

Drug resistance confounding prion therapeutics

scientific article published on 15 October 2013

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

scientific article published on 11 November 2020

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

scientific article published on 10 July 2017

Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite

scientific article published on December 2012

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo

scientific article published on 21 October 2013

Fragment-based inhibitor discovery against β-lactamase

scientific article published on March 2014

Genetic and neural mechanisms that inhibit Drosophila from mating with other species

scientific article

Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases

scientific article published on 13 September 2019

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases

scientific article

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].

scientific article published on 09 July 2013

Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes

scientific article

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system

scientific article

In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.

scientific article

Intramolecular [4 + 2] cycloadditions of iminoacetonitriles: a new class of azadienophiles for hetero Diels-Alder reactions

scientific article

Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes

scientific article published on 9 November 2011

Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We are pleased to acknowledge advice from Professors

scientific article published on 01 April 2001

Mining a cathepsin inhibitor library for new antiparasitic drug leads

scientific article

Modulating caspase activity: beyond the active site

scientific article

Molecular Recognition with Introverted Functionality We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We thank Prof. Dmitry Rudkevich and Dr. Paul Wash and Dr. Laura Pasternack for help

scientific article published on 01 September 2000

Nanoscale Container Structures and Their Host - Guest Properties We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. Dr. Laura Pasternack and Dr. Takeharu Haino are sincerely acknowledged

scientific article published on 01 March 2000

Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells

scientific article

Oscillatory cAMP signaling rapidly alters H3K4 methylation

scientific article published on 27 December 2019

Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice

scientific article published on 16 February 2013

Pharmacological brake-release of mRNA translation enhances cognitive memory

scientific article published in 2013

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

scientific article published on 22 November 2007

Predicting and improving the membrane permeability of peptidic small molecules.

scientific article

Predicting binding to p-glycoprotein by flexible receptor docking

scientific article

Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels

scientific article published on 22 August 2018

Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis

scientific article published on 30 October 2020

Recent developments in the identification of novel oxazolidinone antibacterial agents

scientific article

Simple one-pot synthesis of disulfide fragments for use in disulfide-exchange screening

scientific article

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

scientific article

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

scientific article

Successes and challenges in phenotype-based lead discovery for prion diseases

scientific article

Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings

scientific article published on 27 April 2006

Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate

scientific article published on 01 June 2005

Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor

scientific article published on 11 June 2019

Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.

scientific article published on 23 March 2018

UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area

scientific article

List of works by Adam R Renslo

2-Aminothiazoles as therapeutic leads for prion diseases

2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease

A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models

A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery

Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases

Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases

Antibacterial oxazolidinones: emerging structure-toxicity relationships

Antimalarial Drug Discovery: From Quinine to the Dream of Eradication

Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.

Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice

Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases

Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Concerning the Regiochemical Course of the Diels-Alder Reaction in Supercritical Carbon Dioxide

Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei.

Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major

Discovery of 2-aminothiazoles as potent antiprion compounds

Divergent modes of enzyme inhibition in a homologous structure-activity series

Drug discovery and development for neglected parasitic diseases

Drug discovery for neglected tropical diseases at the Sandler Center

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening

Drug resistance confounding prion therapeutics

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite

Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo

Fragment-based inhibitor discovery against β-lactamase

Genetic and neural mechanisms that inhibit Drosophila from mating with other species

Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].

Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes

Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system

In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.

Intramolecular [4 + 2] cycloadditions of iminoacetonitriles: a new class of azadienophiles for hetero Diels-Alder reactions

Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes

Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We are pleased to acknowledge advice from Professors

Mining a cathepsin inhibitor library for new antiparasitic drug leads

Modulating caspase activity: beyond the active site

Molecular Recognition with Introverted Functionality We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We thank Prof. Dmitry Rudkevich and Dr. Paul Wash and Dr. Laura Pasternack for help

Nanoscale Container Structures and Their Host - Guest Properties We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. Dr. Laura Pasternack and Dr. Takeharu Haino are sincerely acknowledged

Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells

Oscillatory cAMP signaling rapidly alters H3K4 methylation

Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice

Pharmacological brake-release of mRNA translation enhances cognitive memory

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

Predicting and improving the membrane permeability of peptidic small molecules.

Predicting binding to p-glycoprotein by flexible receptor docking

Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels

Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis

Recent developments in the identification of novel oxazolidinone antibacterial agents

Simple one-pot synthesis of disulfide fragments for use in disulfide-exchange screening

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase

Successes and challenges in phenotype-based lead discovery for prion diseases

Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings

Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate

Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor

Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.

UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area