List of works - Marie Malissen

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

scientific article published on 19 October 2009

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

scholarly article by Diana Ordoñez-Rueda et al published September 2012 in European Journal of Immunology

A novel model for treatment of hypertrophic pachymeningitis

ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding

scientific article published on 15 March 2021

Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization.

scientific article published in December 2001

CD6 modulates thymocyte selection and peripheral T cell homeostasis

scientific article published on 04 July 2016

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

scientific article

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation

scientific journal article

Complexity, polymorphism, and recombination of mouse T-cell receptor α gene families

article

Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation

scientific article

DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death

scientific article published on 16 November 2011

Deletion of the LIME adaptor protein minimally affects T and B cell development and function

scientific article published in November 2007

Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes

article

Distinct mechanisms of peripheral tolerance in transgenic mice

scientific article published on June 1991

Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells

scientific article published on 24 February 2012

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

scientific article published on 19 September 2016

Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment

scientific article published on March 2004

Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments

scientific article published on 20 February 2015

Exon/intron organization and complete nucleotide sequence of an HLA gene

scientific article

Expression of human class I histocompatibility antigens at the surface of DNA-transformed mouse L cells

scientific article published on 01 January 1982

Expression of human histocompatibility antigens on the surface of murine cells transformed by cosmid clones containing HLA genes

scientific article published in October 1982

Germline genomic structure of the B10.A mouse Tcra-V2 gene subfamily

scientific article published in January 1996

HLA cosmid clones show complete, widely spaced human class I genes with occasional clusters

scientific article published on December 1982

Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria

scientific article published on June 2007

In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.

scientific article published on March 2015

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

scientific article

Integrative biology of T cell activation

scientific article

Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage

scientific article

LAT regulates gammadelta T cell homeostasis and differentiation

scientific article published on 14 September 2003

LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity

scientific article published on 09 June 2010

LatY136F knock-in mouse model for human IgG4-related disease.

scientific article published on 14 June 2018

Linker for activation of T cells integrates positive and negative signaling in mast cells

scientific article published in October 2004

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

scientific article published on 13 August 2009

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

scientific article published on 01 July 2020

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

scientific article published on 28 January 2010

Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation

scientific article

Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide

scientific article published in July 1984

Mouse model carrying H222P- Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies

scientific article published on 17 November 2004

Multiplicity and plasticity of natural killer cell signaling pathways

scientific article published on 15 November 2005

Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.

scientific article

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

scientific article published on 5 March 2012

Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus

scientific article

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

scientific article

Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells

scientific article published in March 2008

Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d.

scientific article published in August 1983

Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice

scientific article

Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression

scientific article published on September 1999

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.

scientific article published on March 2017

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

scientific article published on 07 October 2019

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

scientific journal article

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

scientific article

Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells

scientific article

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

scientific article published in Nature

Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor

scientific article

Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells

scientific journal article

Role of the LAT adaptor in T-cell development and Th2 differentiation

scientific article

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation

scientific journal article

STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells

scientific article published in March 2009

Selective Defect in Antigen-Induced TCR Internalization at the Immune Synapse of CD8 T Cells Bearing the ZAP-70(Y292F) Mutation

scientific article published on 01 September 2005

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function

scientific article published on June 2005

Sox17 regulates liver lipid metabolism and adaptation to fasting

scientific article

T cell development in mice lacking the CD3-zeta/eta gene.

scientific article

T cell receptor gamma gene regulatory sequences prevent the function of a novel TCRgamma/pTalpha pre-T cell receptor

scientific article published in June 1998

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

scientific article published in Nature

Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

scientific article published in February 2008

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

scientific article

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

scientific article published on 01 February 2021

The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans

scientific article published on July 1984

The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity

scientific article published in August 2006

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

scientific article (publication date: 2000)

The common cytokine receptor gamma chain controls survival of gamma/delta T cells

scientific article

The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

scientific article published on June 1984

The joining of germ-line V alpha to J alpha genes replaces the preexisting V alpha-J alpha complexes in a T cell receptor alpha, beta positive T cell line.

scientific article published in October 1988

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

scientific journal article

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

scientific article published on 13 April 2008

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.

scientific article published on 19 September 2016

The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex

scientific article published in February 1997

The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis

scientific article published on 30 September 2019

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement

scientific article

The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling

scientific article published on 7 September 2016

The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells

scientific journal article

Thymocytes and RelB-dependent medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cells

scientific article published on June 1997

Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes

scientific article published in April 2009

Tracts of high or low sequence divergence in the mouse major histocompatibility complex.

scientific article published on December 1984

Transformation of LMTK? cells with purified HLA class I genes

article

Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses

scientific article

Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor

scientific article published in February 2002

Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

scientific article published on 06 March 2018

Use of TCR ADV gene segments by the δ chain is independent of their position and of CD3 expression

article

Visualization of the earliest steps of gammadelta T cell development in the adult thymus

scientific article published on 30 July 2006

List of works by Marie Malissen

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

A novel model for treatment of hypertrophic pachymeningitis

ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding

Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization.

CD6 modulates thymocyte selection and peripheral T cell homeostasis

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation

Complexity, polymorphism, and recombination of mouse T-cell receptor α gene families

Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation

DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death

Deletion of the LIME adaptor protein minimally affects T and B cell development and function

Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes

Distinct mechanisms of peripheral tolerance in transgenic mice

Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment

Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments

Exon/intron organization and complete nucleotide sequence of an HLA gene

Expression of human class I histocompatibility antigens at the surface of DNA-transformed mouse L cells

Expression of human histocompatibility antigens on the surface of murine cells transformed by cosmid clones containing HLA genes

Germline genomic structure of the B10.A mouse Tcra-V2 gene subfamily

HLA cosmid clones show complete, widely spaced human class I genes with occasional clusters

Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria

In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

Integrative biology of T cell activation

Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage

LAT regulates gammadelta T cell homeostasis and differentiation

LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity

LatY136F knock-in mouse model for human IgG4-related disease.

Linker for activation of T cells integrates positive and negative signaling in mast cells

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation

Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide

Mouse model carrying H222P- Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies

Multiplicity and plasticity of natural killer cell signaling pathways

Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling

Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells

Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d.

Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice

Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor

Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells

Role of the LAT adaptor in T-cell development and Th2 differentiation

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation

STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells

Selective Defect in Antigen-Induced TCR Internalization at the Immune Synapse of CD8 T Cells Bearing the ZAP-70(Y292F) Mutation

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function

Sox17 regulates liver lipid metabolism and adaptation to fasting

T cell development in mice lacking the CD3-zeta/eta gene.

T cell receptor gamma gene regulatory sequences prevent the function of a novel TCRgamma/pTalpha pre-T cell receptor

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans

The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

The common cytokine receptor gamma chain controls survival of gamma/delta T cells

The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

The joining of germ-line V alpha to J alpha genes replaces the preexisting V alpha-J alpha complexes in a T cell receptor alpha, beta positive T cell line.

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.

The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex

The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement