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List of works by Erwin G. Van Meir

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

scientific article published on June 2006

-OMICS AND PROGNOSTIC MARKERS

scientific article published on 21 October 2011

A Chimeric Signal Peptide-Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell-Specific Apoptosis

scientific article published on 22 January 2020

A NOVEL P53 BYSTANDER EFFECT INDUCES GLIOBLASTOMA CELL DEATH THROUGH A GLYCOSYLATION-DEPENDENT MECHANISM.

scientific article published in July 2014

A conspiracy of glioma and endothelial cells to invade the normal brain

scientific article published on January 2011

A novel cyclic analog of neuropeptide Y specific for the Y2 receptor

scientific article

A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy

scientific article published in April 2003

A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.

scientific article

A simple genotyping method to detect small CRISPR-Cas9 induced indels by agarose gel electrophoresis

scientific article published on 14 March 2019

Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma

scientific article

Absence of KLF6 gene mutations in human astrocytic tumors and cell lines.

scientific article published in September 2004

Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay

scientific article published in June 1998

Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review).

scientific article

An integrative approach for in silico glioma research

scientific article published on 23 July 2010

Analysis of the p53 gene and its expression in human glioblastoma cells

scientific article published on February 1994

Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains

scientific article (publication date: 18 September 2002)

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.

scientific article published on June 2002

Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model

scientific article published on December 2006

Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma

scientific article published on 18 December 2018

Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.

scientific article published on 24 August 2012

At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop

scientific article published on February 2011

Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.

scientific article published on November 2006

Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor.

scientific article published on 21 June 2012

Biology of advanced uveal melanoma and next steps for clinical therapeutics

scientific article

Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression

scientific article

Brain cancer propagating cells: biology, genetics and targeted therapies

scientific article

Brain tumor-polyposis syndrome: two genetic diseases?

scientific article published on July 1997

Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density

scientific article

CD44 expression and growth factors

scientific article published in July 1998

Cancer scene investigation: how a cold virus became a tumor killer

scientific article

Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors

scientific article published in December 2004

Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.

scientific article published in October 1999

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

scientific article

Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway

scientific article published on 01 January 2020

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

Cytokine regulation of intercellular adhesion molecule-1 (ICAM-1) expression on human glioblastoma cells

scientific article published in July 1990

Cytokines and tumors of the central nervous system

scientific article published on November 1995

Cytosolic pH sensitivity of an expressed human NHE-1 Na(+)-H+ exchanger

scientific article published on April 1993

Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents

scientific article published on 24 July 2012

Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility.

scientific article published in December 2017

Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway

scientific article published on 23 November 2011

Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma

scientific article

Differential expression of the CD44 molecule in human brain tumours

scientific article published in February 1992

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway

scientific article published on 03 October 2019

Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms

scientific article published on July 2006

Emerging molecular therapies for brain tumors

scientific article published on April 2004

Emerging roles for the BAI1 protein family in the regulation of phagocytosis, synaptogenesis, neurovasculature, and tumor development

scientific article published on 21 April 2011

Engineering human tumor-specific cytotoxic T cells to function in a hypoxic environment

scientific article published on 29 January 2008

Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity

scientific article published on 10 March 2009

Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma

scientific article

Expression of the CD44 adhesion molecule in tumours of the central and peripheral nervous system

scientific article published on December 1995

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

scientific article published on March 1997

Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors

scientific article published in July 1997

Fine structure of the vaccinia virus gene encoding the precursor of the major core protein 4 a.

scientific article

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

scientific article

Functional analysis of the 5' flanking sequence of a vaccinia virus late gene

scientific article

Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization

scientific article

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells

scientific article published in May 2002

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

scientific article

Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation

scientific article

Genetic and hypoxic regulation of angiogenesis in gliomas

scientific article

Genetic instability leads to loss of both p53 alleles in a human glioblastoma

scientific article

Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors

scientific article

Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy

scientific article published on May 2006

Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment

scientific article published on January 2012

Glomeruloid microvascular proliferation orchestrated by VPF/VEGF: a new world of angiogenesis research

scientific article

Granulocyte-macrophage colony-stimulating factor (GM-CSF) production by glioblastoma cells. Despite the presence of inducing signals GM-CSF is not expressed in vivo

scientific article published in May 1992

Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin

scientific article

Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5

scientific article (publication date: 16 May 2001)

Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma

scientific article

Human astrocytomas and glioblastomas express monocyte chemoattractant protein-1 (MCP-1) in vivo and in vitro

scientific article published in July 1994

Human glioblastoma cells produce 77 amino acid interleukin-8 (IL-8(77)).

scientific article published in April 1993

Human glioblastoma cells release interleukin 6 in vivo and in vitro

scientific article published on October 1990

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

scientific article published on April 2005

Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.

scientific article published on April 2013

Hypoxia inducible factor-1: a novel target for cancer therapy

scientific article

Hypoxia-mediated selection of cells with diminished apoptotic potential to solid tumours

scientific article published in October 1996

IL-6 Stimulates Growth and Inhibits Constitutive, Protein Synthesis-Independent Apoptosis of Murine B-Cell Hybridoma 7TD1

article

Identification of a novel small molecule HIF-1alpha translation inhibitor

scientific article

Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway

scientific article published in January 2005

Identification of nude mice in tumorigenicity assays

scientific article published on 01 April 1997

Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase.

scientific article published in March 2000

Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells.

scientific article published on December 2003

Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells

scientific article

Inhibitors of hypoxia-inducible factor-1 signaling.

scientific article published on December 2006

Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesion.

scientific article

Integrative, multimodal analysis of glioblastoma using TCGA molecular data, pathology images, and clinical outcomes

scientific article

Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system

scientific article published in August 1992

Intertumoral Heterogeneity within Medulloblastoma Subgroups

scientific article published on June 2017

Intervening sequences in the ribosomal RNA genes of Ascaris lumbricoides: DNA sequences at junctions and genomic organization

scientific article

KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology

scientific article

Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumors

scientific article

MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development

scientific article

Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion

scientific article published on June 2004

Microsatellite instability in human brain tumors

scientific article

Natural mutagenesis of human genomes by endogenous retrotransposons

scientific article (publication date: 25 June 2010)

Necrogenesis and Fas/APO-1 (CD95) expression in primary (de novo) and secondary glioblastomas

scientific article published on March 1998

New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26.

scientific article published in August 1997

Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth

scientific article published on August 2004

Opening the chamber of peer-review secrets

scientific article published in Nature

Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1

scientific article

Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.

scientific article

P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.

scientific article published in March 2012

P14ARF suppresses tumor-induced thrombosis by regulating the tissue factor pathway.

scientific article published on 7 January 2014

PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.

scientific article published on February 2005

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

scientific article published on 01 June 2020

Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome?

scientific article published in December 1998

Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.

scientific article published in December 1998

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

scientific article published on 11 March 2016

Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers

scientific article published in December 2006

Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients

scientific article published on February 2007

Proteomic identification of the wt-p53-regulated tumor cell secretome.

scientific article published on 9 October 2006

Proteomics of gliomas: initial biomarker discovery and evolution of technology

scientific article

Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population

scientific article published on February 2004

Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas.

scientific article published in March 2001

Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma

scientific article published on 31 August 2018

Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma

article

Replicative oncolytic adenoviruses in multimodal cancer regimens

scientific article

Replicative oncolytic herpes simplex viruses in combination cancer therapies

scientific article published on March 2004

Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis

article

Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis

scientific article

Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression

scientific article

SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma

scientific article published on October 2014

Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells

scientific article

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas

scientific article published in June 1998

Stat3 activation is required for the growth of U87 cell-derived tumours in mice

scientific article

Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway [...]

scientific article (publication date: 15 July 2012)

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors

scientific article

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways.

scientific article

Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4

scientific article

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.

scientific article published in November 1999

The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis

scientific article

The somatic genomic landscape of glioblastoma

scientific article

The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma

scientific article

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells

scientific article

Thrombospondins and tumor angiogenesis

scientific article

Tumor initiating cells in malignant gliomas: biology and implications for therapy

scientific article published on 03 February 2009

Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.

scientific article published on October 2003

Tumor-specific gene expression using the survivin promoter is further increased by hypoxia

scientific article

Turcot's syndrome of glioma and polyposis occurs in the absence of germ line mutations of exons 5 to 9 of the p53 gene.

scientific article published in March 1993

Turcot's syndrome: Phenotype of brain tumors, survival and mode of inheritance ⬇️

scientific article published on January 5, 1998

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

scientific article published on 30 January 2014

Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis

scientific article

Use of replicating oncolytic adenoviruses in combination therapy for cancer

scientific article published in August 2004

Vaccinia virus produces late mRNAs by discontinuous synthesis

scientific article

Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas

scientific article published in November 1993

Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism

scientific article

Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor

scientific article

Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma

scientific article published on April 2004

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

scientific article

[Overexpression of p53 protein in gliomas].

scientific article published in February 1994

p53 and brain tumors: from gene mutations to gene therapy

scientific article published in October 1998

p53 and the CNS: tumors and developmental abnormalities

scientific article

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma

scientific article published in August 2000

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