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List of works by Bernhard Hube

A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans

scientific article published on 07 March 2014

A functional link between hyphal maintenance and quorum sensing in Candida albicans

scientific article published on 14 September 2016

A method for recovery of Candida albicans DNA from larger blood samples and its detection by polymerase chain reaction on proteinase genes.

scientific article

A novel immune evasion strategy of candida albicans: proteolytic cleavage of a salivary antimicrobial peptide

scientific article

A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation

scientific article

A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence.

scientific article published on September 1997

Adaptive prediction as a strategy in microbial infections

scientific article

Ahr1 and Tup1 Contribute to the Transcriptional Control of Virulence-Associated Genes in Candida albicans

scientific article published on 28 April 2020

Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes

scientific article published in February 1998

Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis in M. furfur by cDNA subtraction technology

scientific article published on 24 July 2008

Anti-fungal therapy at the HAART of viral therapy

scientific article published in April 2002

Biphasic zinc compartmentalisation in a human fungal pathogen.

scientific article

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

scientific article published on 11 September 2018

Candida albicans PLD I activity is required for full virulence

scientific article published in 2004

Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole ⬇️

scientific article

Candida albicans adhesion to central venous catheters: Impact of blood plasma-driven germ tube formation and pathogen-derived adhesins

scientific article published on 01 December 2020

Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs ⬇️

scientific article published on July 2002

Candida albicans interactions with epithelial cells and mucosal immunity

scientific article

Candida albicans iron acquisition within the host

scientific article published on 21 August 2009

Candida albicans pathogenicity mechanisms.

scientific article published on 9 January 2013

Candida albicans proteinases and host/pathogen interactions

scientific article published in October 2004

Candida albicans proteinases: resolving the mystery of a gene family

scientific article

Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway

scientific article published on 26 October 2009

Candida albicans scavenges host zinc via Pra1 during endothelial invasion ⬇️

scientific article

Candida albicans secreted aspartyl proteinases

scientific article published on December 1, 1996

Candida albicans secreted aspartyl proteinases in virulence and pathogenesis

scientific article

Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.

scientific article

Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process

scientific article

Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis

scientific article

Candida glabrata tryptophan-based pigment production via the Ehrlich pathway

scientific article

Candida survival strategies

scientific article published on 24 February 2015

Candida, Proteasen und Gene

article

CandidaDB: a genome database for Candida albicans pathogenomics

scientific article

Candidaand Candidosis today: where are we, and where to go? The Interdisciplinary Forum on Candidosis (IFOCAN) 2005, Göttingen (Germany), 23â 25 September 2005

article

Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells

scientific article published on 12 March 2020

Candidalysin Is the Hemolytic Factor of Candida albicans

scientific article published in 2022

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

article

Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa.

scientific article published on 6 November 2017

Candidalysin is a fungal peptide toxin critical for mucosal infection

scientific article

Candidalysin triggers epithelial cellular stresses that induce necrotic death

scientific article published on 16 June 2021

Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes

scientific article published on 27 October 2009

Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress

scientific article

Characterization of UDP-glucose:ceramide glucosyltransferases from different organisms

scientific article published on December 2000

Characterization of a Candida albicans Mutant Defective in All MAPKs Highlights the Major Role of Hog1 in the MAPK Signaling Network

scientific article published on 17 October 2020

Charakterisierung der Interaktion zwischen Candida albicans und Wirtszellen

scientific article published on 01 December 2008

Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors

scientific article

Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum

scientific article

Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection

scientific article published on 29 July 2013

Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

scientific article

Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence

scientific article

Comparison of susceptibility and transcription profile of the new antifungal hassallidin A with caspofungin

scientific article published on 28 August 2006

Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs

scientific article published on 01 April 2012

Correction: Pathogenesis of Candida albicans Infections in the Alternative Chorio-Allantoic Membrane Chicken Embryo Model Resembles Systemic Murine Infections

scientific article

Correction: Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis

scientific article published on 21 August 2013

Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis

scientific article published on 22 May 2015

Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival

scientific article published on 07 February 2015

Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity

scientific article published on 01 July 1998

Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans

scientific article

Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice

scientific article published on 27 May 2014

Disruption of Membrane Integrity by the Bacterium-Derived Antifungal Jagaricin

scientific article published on 23 August 2019

Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence.

scientific article published on September 1997

Distinct roles of Candida albicans-specific genes in host-pathogen interactions

scientific article

Effect of antimycotic agents on the activity of aspartyl proteinases secreted by Candida albicans

scientific article published in March 2003

Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients.

scientific article published on August 1999

Embryonated Chicken Eggs as Alternative Infection Model for Pathogenic Fungi

scientific article published on 01 January 2012

Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence

scientific article

Enemies and brothers in arms: Candida albicans and gram-positive bacteria

scientific article

Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach

scientific article published on 20 November 2013

Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.

scientific article

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

scientific article

Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes

scientific article published on 8 April 2005

Expression analysis of the lipase gene family during experimental infections and in patient samples

article

Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans

scientific article published in October 1994

Extracellular hydrolytic enzymes and their relevance during Candida albicans infections

scientific article published in January 2000

Extracellular proteinases of human pathogenic fungi

scientific article

Factors supporting cysteine tolerance and sulfite production in Candida albicans

scientific article

Forschungsbericht zum Dr.-Manfred-Plempel-Stipendium

scientific article published on 01 January 1998

From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells ⬇️

scientific article

From attachment to invasion: infection associated genes of Candida albicans

scientific article published on January 2008

From commensal to pathogen: stage- and tissue-specific gene expression of Candida albicans

scientific article

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

scholarly article published in 2022

Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans

scientific article

Functional aspects of secreted Candida proteinases

scientific article published on January 1998

Fungal adaptation to the host environment

scientific article published on 02 July 2009

Fungal biotin homeostasis is essential for immune evasion after macrophage phagocytosis and virulence

scientific article published on 21 February 2020

Fungal factors involved in host immune evasion, modulation and exploitation during infection

scientific article published on 26 September 2020

Game theoretical modelling of survival strategies of Candida albicans inside macrophages

scientific article published on 25 January 2010

Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases

scientific article published on 31 March 2011

Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis

scientific article

Global Identification of Biofilm-Specific Proteolysis in Candida albicans

scientific article published on 13 September 2016

Global transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensis

scientific article

Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi

scientific article published on 6 July 2001

Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions

scientific article published on 3 November 2005

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood

scientific article published in April 2005

HIV-1 and its transmembrane protein gp41 bind to different Candida species modulating adhesion

scientific article published on June 2003

Haemoperfused liver as an ex vivo model for organ invasion of Candida albicans

scientific article published in February 2007

Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation

scientific article

Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections

scientific article published on 08 May 2011

Hsp21 potentiates antifungal drug tolerance in Candida albicans

scientific article

Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity

scientific article published on 25 October 2013

Hydrolytic enzymes as virulence factors of Candida albicans

scientific article

IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms

scientific article published on 11 June 2018

Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages

scientific article

Identification, cloning and characterization of the gene for the secretory aspartate protease of Candida albicans

scientific article published in January 1991

Identifying infection-associated genes of Candida albicans in the postgenomic era.

scientific article published on 27 April 2009

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages

scientific article published on 20 December 2013

Immunoproteomic Analysis of Antibody Responses to Extracellular Proteins of Candida albicans Revealing the Importance of Glycosylation for Antigen Recognition

scientific article published on 8 July 2016

Importance of the Candida albicans cell wall during commensalism and infection ⬇️

scientific article published on May 18, 2012

In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans

scientific article published in May 2006

In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion

scientific article published in March 2007

In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients

scientific article

In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy

scientific article

In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans.

scientific article published on 29 April 2016

In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination

scientific article

Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice

scientific article published in February 2002

Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils

scientific article published on 21 November 2007

Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response.

scientific article

Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence

scientific article published in April 2002

Infection-associated genes of Candida albicans

scientific article published on August 2006

Integrity under stress: Host membrane remodelling and damage by fungal pathogens

scientific article published on 07 March 2019

Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota

scientific article published on 27 February 2016

Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape

scientific article published on 04 June 2010

Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence

scientific article published on 10 June 2015

Introduction: Host Responses

article

Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis

scientific article published in April 2000

Isolation and Amplification of Fungal RNA for Microarray Analysis from Host Samples

scientific article published on 01 January 2012

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model

scientific article published on 12 September 2019

Kex2 protease converts the endoplasmic reticulum alpha1,2-mannosidase of Candida albicans into a soluble cytosolic form.

scientific article

Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

scientific article published on 09 June 2022

Limitation of (1→3)-β-D-glucan monitoring in major elective surgery involving cardiopulmonary bypass

scientific article published on 12 June 2013

MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur

scientific article

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant

scientific article (publication date: December 2014)

Mode of action of ciclopiroxolamine on Candida albicans

scientific article

Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia

scientific article published on January 2006

Molecular biological and biochemical aspects of fungal dimorphism.

scientific article published on January 1994

Multiple functions of DOA1 in Candida albicans

scientific article published in April 2007

Multiplicity of genes encoding secreted aspartic proteinases in Candida species.

scientific article published on July 1994

Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts

scientific article published on 18 March 2015

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin

scientific article published in November 2017

Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans

scientific article published on 24 March 2005

Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections

scientific article

Pathogenicity mechanisms and host response during oral Candida albicans infections

scientific article published on 07 May 2014

Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages

scientific article

Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.

scientific article published on 29 March 2016

Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis

scientific article

Possible role of secreted proteinases in Candida albicans infections.

scientific article published in June 1998

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence.

scientific article published on 23 January 2018

Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris

scientific article

Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10

scientific article

Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium

scientific article published in August 2003

Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells

scientific article

Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils

scientific article published on 4 August 2011

Secreted aspartic proteases of Candida albicansactivate the NLRP3 inflammasome

scientific article published on 31 January 2013

Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis

scientific article published on 01 October 1999

Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells.

scientific article

Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members

scientific article

Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice

scientific article published on 2 June 2015

Sequence of the Candida albicans gene encoding the secretory aspartate proteinase

scientific article published on January 1991

Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney

scientific article

Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.

scientific article

Stage-specific gene expression of Candida albicans in human blood

scientific article published in March 2003

Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes

scientific article (publication date: June 2014)

Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes

scientific article

The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension

scientific article (publication date: 2011)

The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity

scientific article published on 16 August 2010

The KEX2 gene of Candida glabrata is required for cell surface integrity

scientific article

The Role of Secreted Aspartyl Proteinases in Candida albicans Keratitis

scientific article published on 01 August 2007

The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications

scientific article published on 4 December 2006

The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation.

scientific article

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

scientific article published in Nature Communications

The genes encoding the secreted aspartyl proteinases of Candida albicans constitute a family with at least three members

scientific article published on August 1993

The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils

scientific article published on 5 October 2009

The novel Candida albicans transporter Dur31 Is a multi-stage pathogenicity factor

scientific article

The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion

scientific article published on 6 January 2011

The role and relevance of phospholipase D1 during growth and dimorphism of Candida albicans

scientific article published on 01 April 2001

The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium

scientific article

The yeast Candida albicans evades human complement attack by secretion of aspartic proteases

scientific article published on 31 October 2009

Thriving within the host: Candida spp. interactions with phagocytic cells

scientific article published on 25 January 2013

Tissue infection and site-specific gene expression in Candida albicans.

scientific article published on January 2003

Transcriptomics in human blood incubation reveals the importance of oxidative stress response in Saccharomyces cerevisiae clinical strains

scientific article

Two unlike cousins: C andida albicans and C . glabrata infection strategies ⬇️

scientific article published on January 14, 2013

Virulence profile: Bernhard Hube

scientific article

Welche Funktionen haben sechs verschiedene Gene für sekretorische Proteinasen von Candida albicans?

article

When Green and Red Mycology Meet: Impressions From an Interdisciplinary Forum on Virulence Mechanisms of Phyto- and Human-Pathogenic Fungi.

scientific article published on 19 July 2017

Zinc exploitation by pathogenic fungi

scientific article

the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin

scientific article

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