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List of works by Alistair J P Brown

A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique

scientific article published on 25 December 2009

A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans

scientific article

A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions.

scientific article

A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections.

scientific article published on 17 August 2009

A proteomic analysis of the salt, cadmium and peroxide stress responses in Candida albicans and the role of the Hog1 stress-activated MAPK in regulating the stress-induced proteome

scientific article

A quantitative model for mRNA translation in Saccharomyces cerevisiae

scientific article published in October 2010

A systematic approach to modeling, capturing, and disseminating proteomics experimental data

scientific article

A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi

scientific article

A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase.

scientific article

ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p

scientific article published on July 2004

APSES proteins regulate morphogenesis and metabolism in Candida albicans

scientific article published in July 2004

Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans

scientific article

Adapting to survive: How Candida overcomes host-imposed constraints during human colonization

scientific article published on 21 May 2020

Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation

scientific article

Antifungal agents: mechanisms of action

scientific article

Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans

scientific article

Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo.

scientific article published on 22 November 2007

Bioluminescent fungi for real-time monitoring of fungal infections

scientific article published in May 2010

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

scientific article

Candida albicans Iff11, a secreted protein required for cell wall structure and virulence

scientific article published on 19 March 2007

Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence.

scientific article

Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching.

scientific article published in February 2006

Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

scientific article published on 25 November 2014

Candida albicans genome sequence: a platform for genomics in the absence of genetics

scientific article

Candida albicans hypha formation and mannan masking of β-glucan inhibit macrophage phagosome maturation

scientific article

Candida albicans morphogenesis and host defence: discriminating invasion from colonization. ⬇️

scientific article published on 12 December 2011

Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans

scientific article published on November 2012

Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance.

scientific article

Cell wall protection by the Candida albicans class I chitin synthases

scientific article

Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress

scientific article

Combinatorial stresses kill pathogenic Candida species.

scientific article published on 2 April 2012

Conflicting interests in the pathogen-host tug of war: fungal micronutrient scavenging versus mammalian nutritional immunity

scientific article

Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans

scientific article published on 3 June 2015

Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.

scientific article

Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1

scientific article

Differential regulation of kidney and spleen cytokine responses in mice challenged with pathology-standardized doses of Candida albicans mannosylation mutants

scientific article

Drug-mediated metabolic tipping between antibiotic resistant states in a mixed-species community

scientific article published on 09 July 2018

Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.

scientific article published on 13 February 2018

Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections

scientific article

Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus

scientific article published on August 2004

Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of Candida albicans: implications for antifungal drug target discovery

scientific article

Elevated catalase expression in a fungal pathogen is a double-edged sword of iron

scientific article

Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction

scientific article

Epitope Shaving Promotes Fungal Immune Evasion

scientific article published on 07 July 2020

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

scientific article

Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes

scientific article published on 8 April 2005

Expression of one-hybrid fusions with Staphylococcus aureus lexA in Candida albicans confirms that Nrg1 is a transcriptional repressor and that Gcn4 is a transcriptional activator

scientific article published in August 2005

From START to FINISH: the influence of osmotic stress on the cell cycle ⬇️

scientific article (publication date: 2013)

Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans

scientific article

Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs

scientific article published on October 2012

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events

scientific article

Fungal morphogenesis and host invasion

scientific article

GFP as a quantitative reporter of gene regulation in Candida albicans.

scientific article published on March 2004

Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans

scientific article published on October 2002

Gene disruption in Candida albicans using a synthetic, codon-optimised Cre-loxP system

scientific article published in September 2005

Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney.

scientific article

Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress

scientific article published on 23 February 2009

Genomics and the development of new diagnostics and anti-Candida drugs

scientific article published on 14 June 2007

Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.

scientific article published on October 2005

Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans

scientific article

Glucose promotes stress resistance in the fungal pathogen Candida albicans.

scientific article published on 16 September 2009

Glucose triggers different global responses in yeast, depending on the strength of the signal, and transiently stabilizes ribosomal protein mRNAs

scientific article published on May 2003

Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling.

scientific article

Growth of Candida albicans cells on the physiologically relevant carbon source lactate affects their recognition and phagocytosis by immune cells.

scientific article published on 31 October 2012

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

scientific article

Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections

scientific article

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

scientific article

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

scientific article

Human gut bifidobacteria inhibit the growth of the opportunistic fungal pathogen <i>Candida albicans</i>

scientific article published in 2022

Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling

article by Arnab Pradhan et al published 6 November 2018 in mBio

Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans.

scientific article published on 5 January 2011

Immune recognition of Candida albicans beta-glucan by dectin-1.

scientific article published on 31 October 2007

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

scientific article

Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome

scientific article published in January 2010

Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans

scientific article

In-host microevolution of Aspergillus fumigatus: A phenotypic and genotypic analysis.

scientific article published on 22 February 2018

Infection-related gene expression in Candida albicans

scientific article published on 17 August 2007

Information quality in proteomics.

scientific article

Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans.

scientific article published on 14 September 2015

Lactate signalling regulates fungal β-glucan masking and immune evasion

scientific article

MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans

scientific article published on 23 July 2008

Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency

scientific article

Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes.

scientific article

Melanin externalization in Candida albicans depends on cell wall chitin structures

scientific article published on 11 June 2010

Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels

scientific article published on 31 July 2014

Metabolism in fungal pathogenesis

scientific article

Microbial signaling and systems biology

scientific article published on 17 May 2010

Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.

scientific article

Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans

scientific article published on 20 March 2012

Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans

scientific article

Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans.

scientific article published on October 2004

New Clox Systems for rapid and efficient gene disruption in Candida albicans.

scientific article

Niche-specific activation of the oxidative stress response by the pathogenic fungus Candida albicans.

scientific article published on 5 March 2007

Niche-specific regulation of central metabolic pathways in a fungal pathogen.

scientific article

Nitric oxide and nitrosative stress tolerance in yeast.

scientific article published on January 2011

Nitrosative and oxidative stress responses in fungal pathogenicity

scientific article published on 16 July 2009

Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion

scientific article published on 22 November 2019

Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses.

scientific article

Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans

scientific article published in November 2005

PEDRo: a database for storing, searching and disseminating experimental proteomics data

scientific article

Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis

scientific article

Phosphorylation regulates polarisation of chitin synthesis in Candida albicans

scientific article

Phylogenetic diversity of stress signalling pathways in fungi

scientific article

Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata

scientific article published on 28 June 2019

Plasmids for in vivo construction of integrative Candida albicans vectors in Saccharomyces cerevisiae.

scientific article

Posttranslational modifications of proteins in the pathobiology of medically relevant fungi

scientific article

Property differences among the four major Candida albicans strain clades

scientific article published on 16 January 2009

Protein A‐tagging for purification of native macromolecular complexes from Candida albicans ⬇️

scientific article published on November 1, 2003

Proteomic analysis of the pH response in the fungal pathogen Candida glabrata

scientific article

Proteomic and phenotypic profiling of the amphibian pathogen Batrachochytrium dendrobatidis shows that genotype is linked to virulence.

scientific article

Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene

article

Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae

scientific article

Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans

scientific article published on 11 February 2010

Recognition and blocking of innate immunity cells by Candida albicans chitin

scientific article published on 28 February 2011

Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs.

scientific article

Reporters for the analysis of N-glycosylation in Candida albicans.

scientific article published on 19 April 2013

Role of the Candida albicans MNN1 gene family in cell wall structure and virulence.

scientific article

Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans

scientific article published on 7 December 2005

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.

scientific article published on 8 October 2009

Sfp1 and Rtg3 reciprocally modulate carbon source-conditional stress adaptation in the pathogenic yeast Candida albicans

scientific article published on 2 June 2017

Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.

scientific article

Specificity of the osmotic stress response in Candida albicans highlighted by quantitative proteomics

scientific article published in Scientific Reports

Stress Adaptation.

scientific article published in July 2017

Stress adaptation in a pathogenic fungus

scientific article published on January 2014

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen.

scientific article published on 30 October 2017

The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence

scientific article

The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans

scientific article

The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans.

scientific article published on March 2007

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

scientific article

The environmental stress sensitivities of pathogenic Candida species, including Candida auris, and implications for their spread in the hospital setting

scientific article published on 07 January 2020

The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans.

scientific article

The relevance of heat shock regulation in fungal pathogens of humans

scientific article

The zygomycetous fungus, Benjaminiella poitrasii contains a large family of differentially regulated chitin synthase genes

article

Thoughts on the evolution of Core Environmental Responses in yeasts

scientific article published on 16 January 2020

Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris

scientific article published on 24 August 2020

Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata

scientific article published in 2021

Universal Metrics for Quality Assessment of Protein Identifications by Mass Spectrometry

scientific article published on 27 March 2006

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