List of works - Markus C Wahl

1.8 A bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants

scientific article

A NusE:NusG complex links transcription and translation

scientific article

A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast

scientific article published on 20 March 2020

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

scientific article

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

scientific article published on 14 August 2015

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions

scientific article published on 01 March 2022

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

scientific article published on 03 March 2022

A new role for FBP21 as regulator of Brr2 helicase activity

scientific article published on July 2017

A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein

scientific article

A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation

scientific article

A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching

scientific article

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling

scientific article

An Autoinhibited State in the Structure of Thermotoga maritima NusG

scientific article

An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA

scientific article

An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex

scientific article published on 22 September 2008

B-form to A-form conversion by a 3'-terminal ribose: crystal structure of the chimera d(CCACTAGTG)r(G)

scientific article

Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent

scientific article published on 30 November 2016

Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP

scientific article

Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

scientific article published on March 2006

C-H...O hydrogen bonding in biology

scientific article published on March 1997

CASK Functions as a Mg2+-independent neurexin kinase

scientific article

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

scholarly article by Tim Clausen published in January 1999

Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.

scientific article published in September 1997

Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals.

scientific article

Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.

scientific article

Comparative anatomy of a regulatory ribosomal protein.

scientific article

Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster

scientific article published on 16 December 2004

Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB

scientific article

Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

scientific article

CryoEM analysis of small plant biocatalysts at sub-2 Å resolution

scientific article published on 01 January 2022

Crystal Structure Analysis Reveals Functional Flexibility in the Selenocysteine-Specific tRNA from Mouse

scientific article

Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB

scientific article published on 30 August 2018

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution

scientific article

Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide

scientific article

Crystal structure of an alternating octamer r(GUAUGUA)dC with adjacent G x U wobble pairs

scientific article

Crystal structure of d(GCGCGCG) with 5'-overhang G residues ⬇️

scientific article published on September 1, 1997

Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon

scientific article

Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex

scientific article

Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

scientific article

Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding

scientific article published on November 2004

Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities

scientific article

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

scientific article (publication date: March 2003)

Drep-2 is a novel synaptic protein important for learning and memory

scientific article

Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies

scientific article

Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency

scientific article published in August 2002

Elimination of frequency drift from Fourier transform ion cyclotron resonance mass spectra by digital quadrature heterodyning: ultrahigh mass resolving power for laser-desorbed molecules

scientific article published on December 1993

Enhanced mass resolving power, sensitivity, and selectivity in laser desorption Fourier transform ion cyclotron resonance mass spectrometry by ion axialization and cooling.

scientific article published on July 1993

Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein

scientific article

Evolution of CASK into a Mg2+-sensitive kinase

scientific article

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

scientific article published on 25 April 2019

Exploiting phage strategies to modulate bacterial transcription

scientific article published on 01 August 2019

Expression, purification, crystallization and preliminary X-ray diffraction studies of bacterial and archaeal L4 ribosomal proteins

scientific article published in May 2000

Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination

scientific article

Fluorine teams up with water to restore inhibitor activity to mutant BPTI.

scientific article published on 12 June 2015

Functional organization of the Sm core in the crystal structure of human U1 snRNP

scientific article

Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion

scientific article

Functions and regulation of the Brr2 RNA helicase during splicing

scientific article published on 28 October 2016

Helical extension of the neuronal SNARE complex into the membrane

scientific article

Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.

scientific article

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

scientific article

Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins

scientific article published on 21 February 2017

Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.

scientific article published on 23 November 2016

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

scientific article published on 13 March 2019

Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.

scientific article published in February 2018

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

scientific article published on 26 May 2021

MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density

scientific journal article

MS/MS with High Detection Efficiency and Mass Resolving Power for Product Ions in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

scientific article published on 01 April 1994

Mechanism for Aar2p function as a U5 snRNP assembly factor

scientific article

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment

scientific article published on 17 August 2006

Molecular Basis of the Light-driven Switching of the Photochromic Fluorescent Protein Padron

scientific article

Molecular insights into antibiotic resistance - how a binding protein traps albicidin

scientific article published in Nature Communications

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.

scientific article

Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome

scientific article published on 16 December 2015

New crystal structures of nucleic acids and their complexes

scientific article

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

scientific article published on 05 March 2014

Oligomeric state and mode of self-association of Thermotoga maritima ribosomal stalk protein L12 in solution.

scientific article published in March 2005

Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks

scientific article published on 18 March 2019

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

scientific article

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

scientific article

Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress

scientific article published on 14 December 2016

RNA – Synthesis, Purification and Crystallization

scientific article published on 01 July 1996

Scaffolding in the Spliceosome via Single α Helices

scientific article published on 13 October 2016

SnapShot: Spliceosome Dynamics II.

scientific article

SnapShot: Spliceosome Dynamics III.

scientific article published on July 2015

Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ

scientific article

Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor

scientific article published on 19 February 2019

Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED.

scientific article published on 11 April 2016

Structural Investigations of the Highly Flexible Recombinant Ribosomal Protein L12 from Thermotoga maritima

article

Structural and Functional Analysis of the E. coli NusB-S10 Transcription Antitermination Complex

scientific article

Structural and functional investigation of a putative archaeal selenocysteine synthase

scientific article published on October 2005

Structural basis for dual roles of Aar2p in U5 snRNP assembly

scientific article

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

scientific article

Structural basis for reversible photoswitching in Dronpa

scientific article

Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31

scientific article

Structural basis for the function of SuhB as a transcription factor in ribosomal RNA synthesis

scientific article published on 01 July 2019

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

scientific article published on July 2005

Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda

scholarly article

Structural basis for λN-dependent processive transcription antitermination

scientific article published on 28 April 2017

Structure and catalytic mechanism of eukaryotic selenocysteine synthase

scientific article

Structure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27

scientific article

Structure and function of an RNase H domain at the heart of the spliceosome

scientific article

Structure and function of the acidic ribosomal stalk proteins

scientific article

Structure and mechanism of the reversible photoswitch of a fluorescent protein

scientific article

Structure determination by multiple-wavelength anomalous dispersion (MAD) at the Pr LIII edge

scientific article published on 31 July 2012

Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa

scientific article

Structure of the Purine–Pyrimidine Alternating RNA Double Helix, r(GUAUAUA)d(C), with a 3'-Terminal Deoxy Residue

scientific article published on 01 July 1996

Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.

scientific article published on January 2015

Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.

scientific article published on 7 February 2005

Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase

scientific article published on 27 June 2016

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

scientific article published on November 2012

The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein

scientific article

The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous control

scientific article

The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit

scientific article published on 30 December 2019

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations

scientific article published on 02 November 2020

The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling

scientific article published on 01 March 2022

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

scientific article published on 4 December 2015

The origin of eubacteria with three L7/L12 protein dimers in the ribosome

scientific article published in September 2008

The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

scientific article

The right pick: structural basis of snRNA selection by Gemin5.

scientific article published on November 2016

The spliceosome: design principles of a dynamic RNP machine

scientific article (publication date: 20 February 2009)

The structure of r(UUCGCG) has a 5'-UU-overhang exhibiting Hoogsteen-like trans U.U base pairs

scientific article

The thermodynamic influence of trapped water molecules on a protein-ligand interaction

scientific article

The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module

scientific article

The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling

scientific article published on 18 December 2020

Thin gold film-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of biomolecules

scientific article published on December 1993

Towards understanding selenocysteine incorporation into bacterial proteins

scientific article published on October 2007

List of works by Markus C Wahl

1.8 A bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants

A NusE:NusG complex links transcription and translation

A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

A new role for FBP21 as regulator of Brr2 helicase activity

A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein

A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation

A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling

An Autoinhibited State in the Structure of Thermotoga maritima NusG

An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA

An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex

B-form to A-form conversion by a 3'-terminal ribose: crystal structure of the chimera d(CCACTAGTG)r(G)

Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent

Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP

Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

C-H...O hydrogen bonding in biology

CASK Functions as a Mg2+-independent neurexin kinase

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.

Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals.

Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.

Comparative anatomy of a regulatory ribosomal protein.

Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster

Conformational switches in winged-helix domains 1 and 2 of bacterial translation elongation factor SelB

Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex

CryoEM analysis of small plant biocatalysts at sub-2 Å resolution

Crystal Structure Analysis Reveals Functional Flexibility in the Selenocysteine-Specific tRNA from Mouse

Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution

Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide

Crystal structure of an alternating octamer r(GUAUGUA)dC with adjacent G x U wobble pairs

Crystal structure of d(GCGCGCG) with 5'-overhang G residues ⬇️

Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon

Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex

Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding

Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

Drep-2 is a novel synaptic protein important for learning and memory

Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies

Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency

Elimination of frequency drift from Fourier transform ion cyclotron resonance mass spectra by digital quadrature heterodyning: ultrahigh mass resolving power for laser-desorbed molecules

Enhanced mass resolving power, sensitivity, and selectivity in laser desorption Fourier transform ion cyclotron resonance mass spectrometry by ion axialization and cooling.

Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein

Evolution of CASK into a Mg2+-sensitive kinase

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain

Exploiting phage strategies to modulate bacterial transcription

Expression, purification, crystallization and preliminary X-ray diffraction studies of bacterial and archaeal L4 ribosomal proteins

Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination

Fluorine teams up with water to restore inhibitor activity to mutant BPTI.

Functional organization of the Sm core in the crystal structure of human U1 snRNP

Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion

Functions and regulation of the Brr2 RNA helicase during splicing

Helical extension of the neuronal SNARE complex into the membrane

Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins

Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.

Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density

MS/MS with High Detection Efficiency and Mass Resolving Power for Product Ions in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Mechanism for Aar2p function as a U5 snRNP assembly factor

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment

Molecular Basis of the Light-driven Switching of the Photochromic Fluorescent Protein Padron

Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.

Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome

New crystal structures of nucleic acids and their complexes

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

Oligomeric state and mode of self-association of Thermotoga maritima ribosomal stalk protein L12 in solution.

Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis