List of works - Winfried Barchet

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

scientific article

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA

scientific article

Accessing the therapeutic potential of immunostimulatory nucleic acids

scientific article published on 30 July 2008

Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer.

scientific article

Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus.

scientific article published in May 2009

Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection

scientific article published on September 1998

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

scientific article

Approaching the RNA ligand for RIG-I?

scientific article published on January 2009

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

scientific article

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids

scientific article published on January 2007

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

scientific article

Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation.

scientific article published on 20 October 2005

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

scientific article published on 01 November 2005

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

scientific article

Delivery with polycations extends the immunostimulant Ribomunyl® into a potent antiviral Toll-like receptor 7/8 agonist

article published in 2011

Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways

scientific article published in January 2005

Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells

scientific article

Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo

scientific article published in May 2000

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

scientific article published on 24 August 2011

Donor cell persistence and activation-induced unresponsiveness of peripheral CD8+ T cells

scientific article published in March 2000

Endothelial RIG-I activation impairs endothelial function

scientific article published in 2012

Enhanced skin expression of melanoma differentiation-associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases.

scientific article

Exonuclease TREX1 also Has a Sweet Tooth.

scientific article published on September 2015

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

scientific article published on 16 October 2003

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

scientific article published on 20 July 2009

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

scientific article

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

scientific article

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

scientific article

Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.

scientific article

MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis

scientific article

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist

scientific article published on 11 September 2013

Monocyte-Mediated Inhibition of TLR9-Dependent IFN- Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates

scientific article published on 05 November 2010

Nitrosative stress: a hallmark of the junctional inflammation in cutaneous lupus erythematosus

Nucleic acid adjuvants: toward an educated vaccine

scientific article published on January 2012

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

scientific article published on 29 August 2013

PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

scientific article (publication date: July 2006)

Paracoccus yeeii sp. nov. (formerly CDC group EO-2), a novel bacterial species associated with human infection

scientific article

Plasmacytoid dendritic cells--virus experts of innate immunity

scientific article

Plasmacytoid dendritic cells: in search of their niche in immune responses

scientific article

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease

scientific article published on 13 October 2010

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

scientific article published on 12 October 2012

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

scientific article

RNA recognition via TLR7 and TLR8.

scientific article published on January 2008

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

scientific article

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

scientific article

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

scientific article

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8.

scientific article published on 10 April 2009

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

scientific article

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

scientific article

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

article

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells

scientific article published on 15 June 2010

Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

scientific article

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

scientific article published on 13 January 2015

The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM

scientific article

Translating nucleic acid-sensing pathways into therapies

scientific article published on 21 August 2015

Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo

scientific article published on February 2002

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites

scientific article published on October 2016

List of works by Winfried Barchet

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA

Accessing the therapeutic potential of immunostimulatory nucleic acids

Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer.

Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus.

Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

Approaching the RNA ligand for RIG-I?

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation.

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Delivery with polycations extends the immunostimulant Ribomunyl® into a potent antiviral Toll-like receptor 7/8 agonist

Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways

Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells

Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

Donor cell persistence and activation-induced unresponsiveness of peripheral CD8+ T cells

Endothelial RIG-I activation impairs endothelial function

Enhanced skin expression of melanoma differentiation-associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases.

Exonuclease TREX1 also Has a Sweet Tooth.

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.

MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist

Monocyte-Mediated Inhibition of TLR9-Dependent IFN- Induction in Plasmacytoid Dendritic Cells Questions Bacterial DNA as the Active Ingredient of Bacterial Lysates

Nitrosative stress: a hallmark of the junctional inflammation in cutaneous lupus erythematosus

Nucleic acid adjuvants: toward an educated vaccine

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

Paracoccus yeeii sp. nov. (formerly CDC group EO-2), a novel bacterial species associated with human infection

Plasmacytoid dendritic cells--virus experts of innate immunity

Plasmacytoid dendritic cells: in search of their niche in immune responses

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells

RNA recognition via TLR7 and TLR8.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells

Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM

Translating nucleic acid-sensing pathways into therapies

Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites