List of works - Tim Clausen

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

scientific article published on 27 August 2020

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors

scientific article published on February 2000

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

scientific article

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

scientific article published in January 2008

Arginine phosphorylation marks proteins for degradation by a Clp protease

scientific article

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins

scientific article

Characterization of recombinant Arabidopsis thaliana threonine synthase

scientific article published in July 1999

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

scientific article

Chemical Biology Interrogates Protein Arginine Phosphorylation

scientific article published in August 2016

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

scholarly article by Tim Clausen published in January 1999

Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase

scientific article published on January 1996

Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.

scientific article published in September 1997

Conversion of a regulatory into a degradative protease

scientific article published on 22 February 2010

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization

scientific article

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

scientific article

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution

scientific article

Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly

scientific article

Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme

scientific article

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

scientific article

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis

scientific article

Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes

scientific article

Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A

scientific article

Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor

scientific article

Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5′-phosphate synthesizing enzyme

scientific article published on 01 August 2000

CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis

scientific article

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

scientific article

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

scientific article (publication date: March 2003)

Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis

scientific article

Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases

scientific article

HTRA proteases: regulated proteolysis in protein quality control

scientific article published on 16 February 2011

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

scientific article published on 22 July 2021

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

scientific article published in 2024

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

scientific article

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

scientific article

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates

scientific article published on 25 April 2012

Implications of the serine protease HtrA1 in amyloid precursor protein processing

scientific article

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

scholarly article

Involvement of Tyr24 and Trp108 in substrate binding and substrate specificity of glycolate oxidase

scientific article

Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

scientific article

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR

scientific article

Mode of action of cystathionine beta-lyase

scientific article

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

scientific article

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

scientific article published on 21 October 2019

Molecular machines for protein degradation

scientific article

Molecular shredders: how proteasomes fulfill their role

scientific article

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

scientific article

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

scientific article published on 23 June 2020

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities

scientific article

Myosin chaperones

scientific article

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

scientific article

Protein quality control in the bacterial periplasm

scientific article published on January 2011

Proteolysis as a regulatory mechanism

scientific article

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response

scientific article published on 20 November 2013

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1

scientific article

Rational correction of pathogenic conformational defects in HTRA1

scientific article published in 2024

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

scientific article

Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study

scientific article

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

scientific article

Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin

scientific article

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

scientific article

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

scientific article

Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation

scientific article published in August 2004

Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria

scientific article

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex

scientific article published on 09 February 2023

Structural basis for the disaggregase activity and regulation of Hsp104.

scientific article published on 30 November 2016

Structural basis for the function of pyridoxine 5'-phosphate synthase

scientific article

Structural basis for the regulated protease and chaperone function of DegP

scientific article

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases

scientific article

Structure and function of threonine synthase from yeast

scientific article

Structure of McsB, a protein kinase for regulated arginine phosphorylation

scientific article published on 08 April 2019

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

scientific article published on 18 August 2009

Substrate-induced remodeling of the active site regulates human HTRA1 activity

scientific article

The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes

scientific article published on 12 May 2005

The HtrA Family of Proteases

scientific article (publication date: September 2002)

The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans

scientific article

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

scientific article published on August 2015

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

scientific article published on 27 November 2017

The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity

scientific article

The role of human HtrA1 in arthritic disease

scientific article

UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

scientific article

Versatile in vitro system to study translocation and functional integration of bacterial outer membrane proteins

scientific article

X-ray structure of 12-oxophytodienoate reductase 1 provides structural insight into substrate binding and specificity within the family of OYE

scientific article

X-ray structure of MalY from Escherichia coli: a pyridoxal 5′-phosphate-dependent enzyme acting as a modulator in mal gene expression

scientific article

List of works by Tim Clausen

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

Arginine phosphorylation marks proteins for degradation by a Clp protease

Augmenting β-augmentation: structural basis of how BamB binds BamA and may support folding of outer membrane proteins

Characterization of recombinant Arabidopsis thaliana threonine synthase

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

Chemical Biology Interrogates Protein Arginine Phosphorylation

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

Cloning, purification, and crystallization of Escherichia coli cystathionine beta-lyase

Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli.

Conversion of a regulatory into a degradative protease

Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution

Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly

Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis

Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes

Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A

Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor

Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5′-phosphate synthesizing enzyme

CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis

Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison

Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis

Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases

HTRA proteases: regulated proteolysis in protein quality control

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates

Implications of the serine protease HtrA1 in amyloid precursor protein processing

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

Involvement of Tyr24 and Trp108 in substrate binding and substrate specificity of glycolate oxidase

Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR

Mode of action of cystathionine beta-lyase

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

Molecular machines for protein degradation

Molecular shredders: how proteasomes fulfill their role

Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities

Myosin chaperones

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

Protein quality control in the bacterial periplasm

Proteolysis as a regulatory mechanism

Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response

RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1

Rational correction of pathogenic conformational defects in HTRA1

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation

Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex

Structural basis for the disaggregase activity and regulation of Hsp104.

Structural basis for the function of pyridoxine 5'-phosphate synthase

Structural basis for the regulated protease and chaperone function of DegP

Structural basis of substrate specificity of plant 12-oxophytodienoate reductases

Structure and function of threonine synthase from yeast

Structure of McsB, a protein kinase for regulated arginine phosphorylation

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli

Substrate-induced remodeling of the active site regulates human HTRA1 activity

The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes

The HtrA Family of Proteases

The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.

The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity

The role of human HtrA1 in arthritic disease