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List of works by Stephen J Haggarty

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

scientific article published on 17 October 2019

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

scientific article published on 01 March 2019

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas

scientific article

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

scientific article

A polygenic burden of rare disruptive mutations in schizophrenia

scientific article

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests

scientific article (publication date: 2013)

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch

scientific article

Antidepressant actions of histone deacetylase inhibitors

scientific article

Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles

scientific article published on 7 April 2014

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

scientific article published on 26 December 2019

Brain-penetrant LSD1 inhibitors can block memory consolidation.

scientific article

CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

scientific article

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling

scientific article

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

scientific article

Chemical phylogenetics of histone deacetylases

scientific article

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

scientific article published on 22 June 2018

Detecting binding interactions using microarrays of natural product extracts

scientific article published on 24 August 2007

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

scientific article published on 2 February 2017

Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities

scientific article

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

scholarly article

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

scientific article

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome ⬇️

scientific article published on October 12, 2011

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity

scientific article

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

scientific article published on 08 January 2021

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

scientific article

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease

scientific article published on 18 May 2020

HDAC2 negatively regulates memory formation and synaptic plasticity.

scientific article

High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology

scientific article published in Nature Communications

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

scientific article (publication date: February 1999)

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

scientific journal article

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

scientific article published on 29 September 2020

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

scientific article published on September 2016

Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein

scientific article published on 30 November 2020

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

scientific article

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

scientific article

Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

scientific article

Insights into neuroepigenetics through human histone deacetylase PET imaging.

scientific article

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

scientific article published on 05 August 2019

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

scientific article

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity ⬇️

scientific article published on April 27, 2011

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

scientific article published on 26 June 2020

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

scientific article

Revealing complex traits with small molecules and naturally recombinant yeast strains

scientific article published in March 2006

SpectralNET--an application for spectral graph analysis and visualization

scientific article

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

scientific article published on 21 October 2019

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

scientific article published on 25 March 2019

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

scientific article published on 25 November 2020

The principle of complementarity: chemical versus biological space

scientific article

Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.

scientific article

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4.

scientific article published on 14 July 2017

Will cell alliance breed bureaucracy and leave contributors out?

scientific article published in Nature

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

scientific article

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