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List of works by Michael McManus

A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission

scientific article published in September 2018

A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response

scientific article published on 28 February 2017

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

scientific article

A resource for the conditional ablation of microRNAs in the mouse.

scientific article

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.

scientific article published on 24 November 2014

A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.

scientific article

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

scientific article

An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production ⬇️

scientific article published on January 12, 2012

Analysis of microRNA knockouts in mice

scientific article published on 30 August 2010

Behind the scenes of a small RNA gene-silencing pathway

scientific article published on January 2008

Biochemical methods for analysis of kinetoplastid RNA editing.

scientific article published in May 1998

Biogenesis, delivery, and function of extracellular RNA.

scientific article

CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

scientific article

CRISPR/Cas9-based screening of long noncoding RNAs (lncRNAs) in macrophages with an NF-kappa B reporter

scientific article published on 19 October 2017

Chd1 regulates open chromatin and pluripotency of embryonic stem cells

scientific article

Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.

scientific article

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus

scientific article published on April 2008

Correction: Let-7b/c Enhance the Stability of a Tissue-Specific mRNA during Mammalian Organogenesis as Part of a Feedback Loop Involving KSRP

Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.

scientific article

Cre-lox-regulated conditional RNA interference from transgenes

scientific article

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland

scientific article published on 2 June 2017

Dicer ablation in oligodendrocytes provokes neuronal impairment in mice

scientific article

Dicer function is essential for lung epithelium morphogenesis

scientific article

Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina

scientific article published in May 2008

Dicer is required for proper liver zonation

scientific article published in November 2009

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

scholarly article

Dicer regulates differentiation and viability during mouse pancreatic cancer initiation

scientific article

Dicer1 is required for differentiation of the mouse male germline

scientific article published on 16 July 2008

Discovering the complexity of the metazoan transcriptome

scientific article

Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis

scientific article

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

scientific article

Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals

scientific article published in January 2018

Dual gene activation and knockout screen reveals directional dependencies in genetic networks

scientific article published on 15 January 2018

Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium.

scientific article published on September 2006

Epigenetic and transcriptional determinants of the human breast

scientific article

Erratum: Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

article

Essential role for Dicer during skeletal muscle development.

scientific article published on 25 August 2007

Expanded RNA-binding activities of mammalian Argonaute 2.

scientific article published on December 2009

Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells

scientific article

Far away from the lamppost

scientific article published on 11 December 2018

Gene silencing in mammals by small interfering RNAs

scientific article

Gene silencing using micro-RNA designed hairpins

scientific article

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2

scientific article published on 01 November 2018

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract

scientific article published on 24 January 2009

Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.

scientific article published on 9 April 2018

High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions

scientific article published on 01 April 2019

High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways

scientific article published on 01 December 2020

Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity

scientific article published on 06 February 2020

Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.

scientific article

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

scientific article published on 04 October 2012

Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells

scientific article published on 13 August 2015

Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei

scientific article

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages

scientific article

Lentivirus production

scientific article published on 2 October 2009

Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP

scientific article

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo

scientific article published on 01 July 2020

Massively parallel functional annotation of 3' untranslated regions

scientific article published on 16 March 2014

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

scientific article

MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production

scientific article published on February 2016

MicroRNAs and cancer

scientific article published on August 2003

MicroRNAs and endocrine biology

scientific article

MicroRNAs in ectodermal appendages

scientific article published on 16 January 2017

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes

scientific article

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.

scientific article published on 09 March 2014

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

scientific article

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

scientific article published on 24 October 2016

Partially penetrant postnatal lethality of an epithelial specific MicroRNA in a mouse knockout

scientific article

Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs

scientific article

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease

scientific article published on 05 September 2008

Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs

scientific article

Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells

scientific article published on 13 January 2011

Precursor microRNA-programmed silencing complex assembly pathways in mammals

scientific journal article

Processing of polycistronic guide RNAs is associated with RNA editing complexes in Trypanosoma brucei

scientific article

Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin

scientific article published on 01 October 2018

RNA interference in embryonic stem cells and the prospects for future therapies

scientific article

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

scholarly article

Rapid creation and quantitative monitoring of high coverage shRNA libraries

scientific article published on 17 May 2009

Renewable RNAi

scientific article published in April 2013

Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.

scientific article

Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice

scientific article

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

scientific article

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

scientific article

Sertoli cell Dicer is essential for spermatogenesis in mice

scientific article

Small RNAs and immunity

scientific article

Systematic identification of barriers to human iPSC generation

scientific article published on July 2014

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

scientific article published on 4 February 2013

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

scientific article published on 01 April 2019

The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.

scientific article published on 17 July 2013

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb

scientific article

The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output.

scientific article published in March 2018

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development

scientific article

The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning

scientific article

Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding

scientific article published on 06 February 2019

Trypanosoma brucei guide RNA poly(U) tail formation is stabilized by cognate mRNA.

scientific article

Unexplored therapeutic opportunities in the human genome

scientific article published on 23 March 2018

Unexplored therapeutic opportunities in the human genome.

scientific article published on 23 February 2018

Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report

scientific article

Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.

scientific article published on 06 May 2009

Widespread RNA 3'-end oligouridylation in mammals

scientific article published on 30 January 2012

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

scientific article published on 01 August 2019

miR-205 is a critical regulator of lacrimal gland development

scientific article published on 13 May 2017

miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling

scientific article published on 01 December 2020

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