List of works - Masato Koike

A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5

article

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

scientific journal article

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

scientific article published on December 2009

Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.

scientific article

Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1

scientific article

Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions

scientific journal article

Alternative mitochondrial quality control mediated by extracellular release

scientific article published on 20 November 2020

Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains

scientific article

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

scientific article

Autophagic neuron death

scientific article published in January 2009

Autophagic neuron death in neonatal brain ischemia/hypoxia

scientific article published on 17 January 2008

Autophagy-physiology and pathophysiology

scientific article published on 05 March 2008

Biogenesis and proteolytic processing of lysosomal DNase II

scientific article

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis

scientific article

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

scientific article published on 01 September 2000

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.

scientific article published on 28 January 2016

Cathepsin D is specifically inhibited by deoxyribonucleic acids

scientific article

Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization

scientific article published on 19 March 2010

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

scientific article published on 01 March 2021

Cellular localization and tissue distribution of endogenous DFCP1 protein

scientific article

Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein

scientific article published on December 2003

Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice

scientific article published on 05 August 2011

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

scholarly article by Yusuke Osonoi published in January 2018

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

scientific article published on 17 May 2007

Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.

scientific article published in February 2008

Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.

scientific article

Developmental changes in dendritic spine morphology in the striatum and their alteration in an A53T α-synuclein transgenic mouse model of Parkinson's disease

scientific article published on 17 August 2020

Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system

scientific article published on 20 December 2012

Different distribution patterns of the two mannose 6-phosphate receptors in rat liver.

scientific article published in November 2001

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.

scientific article

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS

scientific article published on 30 September 2016

Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46.

scientific article published on May 2004

Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons

scientific article

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation

scientific article published on 3 February 2016

Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system

scientific article published on 18 December 2020

Exendin-4 improves β-cell function in autophagy-deficient β-cells

scientific journal article

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

scientific article published on October 2010

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice

scientific article published on 20 July 2016

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

scientific article

Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine.

scientific article published on 5 November 2007

Geometry and the organizational principle of spine synapses along a dendrite

scientific article published on 27 October 2020

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

scientific article

Human Herpesvirus 6A U14 Is Important for Virus Maturation

scientific article published on 11 November 2015

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy

scientific article

Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion

scientific article published on October 2005

Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway

scientific article published on 11 July 2008

Identification of Tim4 as a phosphatidylserine receptor

scientific article

Increased Immunoreactivity of Cathepsins in the Rat Esophagus under Chronic Acid Reflux Esophagitis

scientific article published on 18 June 2014

Inefficient phagosome maturation in infant macrophages

scientific article published on 08 August 2008

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

scientific article published on 10 January 2008

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

scientific article published on 22 March 2018

Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance

scientific article published on 22 July 2020

Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.

scientific article published in October 2001

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

scientific article published in February 2003

L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain

scientific article

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

scientific article published on 02 February 2010

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells

scientific article published in December 2013

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition

scientific article

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

scientific article (publication date: 2010)

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

scientific article published on 26 December 2019

Loss of autophagy in the central nervous system causes neurodegeneration in mice

scientific article (publication date: 15 June 2006)

Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice

scientific article published on 19 October 2016

Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils

scientific article published in January 2015

Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain

scientific article published on 23 February 2017

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

scientific article published on 6 October 2012

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

scientific article

Morphological process of podocyte development revealed by block-face scanning electron microscopy

scientific article

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

scientific article

Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface

scientific article published on 28 August 2019

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system

scientific article published on 09 January 2020

NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization

scientific article published on 25 February 2014

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

scientific article published on 4 January 2016

Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice

article

Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2.

scientific article published on 16 October 2017

P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway

scientific article

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis

scientific journal article

Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.

scientific article

Participation of autophagy in renal ischemia/reperfusion injury

scientific article published on 28 January 2008

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

scientific article

Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation

scientific article published on 01 January 2005

Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation

scientific article published on 18 April 2009

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

scientific article

Possible involvement of iron-induced oxidative insults in neurodegeneration.

scientific article published on 27 December 2014

Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice.

scientific article published on 30 June 2005

Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues

scientific journal article

Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.

scientific article published on 11 May 2017

RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis

scientific article published on June 2006

RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway

scientific article

RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation

scientific article

Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions

scientific article published on 9 November 2012

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5

scientific article published on 22 August 2012

Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth

scientific article published on August 2006

Specific localization of lysosomal aminopeptidases in type II alveolar epithelial cells of the rat lung

scientific article

Suppression of Ischemia-Induced Hippocampal Pyramidal Neuron Death by Hyaluronan Tetrasaccharide through Inhibition of Toll-Like Receptor 2 Signaling Pathway

scientific article published on 11 June 2016

Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase

scientific journal article

TDP-43 accelerates age-dependent degeneration of interneurons

scientific article

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

scientific article

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress

scientific article published on 29 January 2016

The MAP1-LC3 conjugation system is involved in lipid droplet formation

scientific article published on 13 March 2009

The expression of tripeptidyl peptidase I in various tissues of rats and mice

scientific article published in August 2002

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

scientific article

Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy

scientific article

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

scientific article published on 01 September 2002

Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway

scientific article published on 12 June 2013

VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.

scientific article

Very-high-dose alpha-tocopherol supplementation increases blood pressure and causes possible adverse central nervous system effects in stroke-prone spontaneously hypertensive rats

scientific article published on February 2009

Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein

scientific article (publication date: April 2015)

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila

scientific article published on 8 May 2017

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

scientific article published on 18 December 2012

List of works by Masato Koike

A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.

Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1

Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions

Alternative mitochondrial quality control mediated by extracellular release

Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

Autophagic neuron death

Autophagic neuron death in neonatal brain ischemia/hypoxia

Autophagy-physiology and pathophysiology

Biogenesis and proteolytic processing of lysosomal DNase II

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.

Cathepsin D is specifically inhibited by deoxyribonucleic acids

Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization

Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)

Cellular localization and tissue distribution of endogenous DFCP1 protein

Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein

Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.

Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.

Developmental changes in dendritic spine morphology in the striatum and their alteration in an A53T α-synuclein transgenic mouse model of Parkinson's disease

Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system

Different distribution patterns of the two mannose 6-phosphate receptors in rat liver.

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS

Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46.

Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation

Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system

Exendin-4 improves β-cell function in autophagy-deficient β-cells

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine.

Geometry and the organizational principle of spine synapses along a dendrite

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

Human Herpesvirus 6A U14 Is Important for Virus Maturation

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy

Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion

Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway

Identification of Tim4 as a phosphatidylserine receptor

Increased Immunoreactivity of Cathepsins in the Rat Esophagus under Chronic Acid Reflux Esophagitis

Inefficient phagosome maturation in infant macrophages

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance

Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice

Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils

Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

Morphological process of podocyte development revealed by block-face scanning electron microscopy

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system

NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice

Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2.

P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway