List of works - Masato Koike

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Loss of autophagy in the central nervous system causes neurodegeneration in mice

scientific article (publication date: 15 June 2006)

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

scientific article

Identification of Tim4 as a phosphatidylserine receptor

scientific article

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

scientific article

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

scientific article published on 10 January 2008

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

scientific article

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

scientific article published on 6 October 2012

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

scientific article published on 01 September 2002

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

scientific article

RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation

scientific article

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

scientific article

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

scientific article published on 01 September 2000

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

scientific article

Participation of autophagy in renal ischemia/reperfusion injury

scientific article published on 28 January 2008

The MAP1-LC3 conjugation system is involved in lipid droplet formation

scientific article published on 13 March 2009

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

scientific article

Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway

scientific article published on 11 July 2008

Autophagy-physiology and pathophysiology

scientific article published on 05 March 2008

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

scientific article

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

scientific article

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition

scientific article

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

scientific article published in February 2003

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis

scientific article

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

scientific article published on October 2010

Autophagic neuron death in neonatal brain ischemia/hypoxia

scientific article published on 17 January 2008

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

scientific article (publication date: 2010)

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

scientific article

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

scientific article published on 02 February 2010

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy

scientific article

Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells

scientific article published in December 2013

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

scientific article published on 4 January 2016

Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase

scientific journal article

Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46.

scientific article published on May 2004

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

scientific article published on December 2009

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5

scientific article published on 22 August 2012

Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.

scientific article published in October 2001

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis

scientific journal article

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

scientific article published on 18 December 2012

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

scientific journal article

RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis

scientific article published on June 2006

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

scientific article published on 17 May 2007

Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy

scientific article

Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein

scientific article published on December 2003

Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.

scientific article

Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation

scientific article published on 18 April 2009

Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation

scientific article published on 01 January 2005

Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion

scientific article published on October 2005

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila

scientific article published on 8 May 2017

List of works by Masato Koike

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

Identification of Tim4 as a phosphatidylserine receptor

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

Participation of autophagy in renal ischemia/reperfusion injury

The MAP1-LC3 conjugation system is involved in lipid droplet formation

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway

Autophagy-physiology and pathophysiology

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

Autophagic neuron death in neonatal brain ischemia/hypoxia

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy

Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase

Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46.

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5

Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy

Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein

Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.

Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation

Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation

Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila