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List of works by Noel Southall

155. High Throughput screen for identifying small molecule modulators of alpha-glucosidase for the potential treatment of Pompe disease

5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2

A High-Throughput Assay for Developing Inhibitors of PhoP, a Virulence Factor of Mycobacterium tuberculosis

scientific article

A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration

scientific article

A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis

scientific article published on 27 April 2020

A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis

scientific article published on 29 August 2013

A View of the Hydrophobic Effect

A View of the Hydrophobic Effect

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

scientific article

A cell-based PDE4 assay in 1536-well plate format for high-throughput screening

scientific article published on 30 June 2008

A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor

scientific article published on February 2007

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

scientific article

A high throughput screening assay system for the identification of small molecule inhibitors of gsp

scientific article

A high-throughput screening assay using Krabbe disease patient cells

scientific article

A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity

scientific article published on 17 March 2021

A high-throughput sphingomyelinase assay using natural substrate.

scientific article

A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase

scientific article published on 31 December 2012

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha

scientific article published on 09 January 2019

A multiplex calcium assay for identification of GPCR agonists and antagonists

scientific article

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

scientific article

A new resorufin-based alpha-glucosidase assay for high-throughput screening

scientific article published on 14 April 2009

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

scientific article published on 23 October 2015

A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries

scientific article

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.

scientific article

Advancing precision medicine with personalized drug screening

scientific article published on 17 August 2018

Agonist-specific voltage-dependent gating of lysosomal two-pore Na channels

scientific article published on 11 December 2019

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration

scientific article

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction

scientific article

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

scientific article

An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD)

scientific article published on 12 November 2020

Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells

scientific article published on 28 February 2020

Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.

scientific article published on 17 April 2018

BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.

scientific article

Biolink Model: A Universal Schema for Knowledge Graphs in Clinical, Biomedical, and Translational Science ⬇️

scientific article

CATMoS: Collaborative Acute Toxicity Modeling Suite

scientific article published in April 2021

COPI complex is a regulator of lipid homeostasis

scientific article

Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

scientific article

Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease

scientific article published on November 2016

Characterization of chemical libraries for luciferase inhibitory activity

scientific article

Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening

scientific article published on 19 February 2008

Chemical signatures and new drug targets for gametocytocidal drug development

scientific article published on 17 January 2014

Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1

scientific article published on 30 April 2020

Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format

scientific article published on 11 July 2008

Compound cytotoxicity profiling using quantitative high-throughput screening

scientific article

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

scientific article

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

scientific article (publication date: 10 September 2013)

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

scientific article (publication date: 17 October 2013)

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

scientific article published in Scientific Reports

Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources

scientific article

Deconstructing the Translational Tower of Babel

scientific article published on 09 November 2018

Defining clinical outcome pathways

scientific article published in June 2022

Discovery and Development of Small Molecules That Reduce PNC Prevalence

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor

scientific article

Discovery of Small Molecule Influenza Virus NS1 Antagonist

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro

scientific article published on 31 October 2017

Discovery of a novel noniminosugar acid α glucosidase chaperone series

scientific article

Discovery of novel antigiardiasis drug candidates

scientific article

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

scientific article published on 24 November 2015

Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators

scientific article published in October 2011

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase

Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)

Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists

Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists

scientific article

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase

scientific article

Discovery, synthesis, and biological evaluation of novel SMN protein modulators

scientific article

Dose-response modeling of high-throughput screening data

scientific article

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus

scientific article

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

scientific article

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity

scientific article

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Fluorescence spectroscopic profiling of compound libraries

scientific article

Global Substance Registration System: consistent scientific descriptions for substances related to health

scientific article published on 02 November 2020

HTS for Identification of Inhibitors against the ERK Signaling Pathway using a Homogenous Cell-based Assay

High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1

scientific article

High throughput screening for SMA

High throughput screening for inhibitors of alpha-galactosidase

scientific article

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase

scientific article

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model

scientific article

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

scientific article published on 31 March 2016

High-Throughput Screening for Modulators of the D2 Dopamine Receptor Yields Unique and Selective Pharmacological Chemotypes

scholarly article published 2014

High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells

scientific article published on 21 May 2015

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

scientific article published on 2 September 2015

High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

scientific article

High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements

scientific article

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.

scientific article

High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter

scientific article

How ions affect the structure of water

scientific article published on October 2002

How to Illuminate the Druggable Genome Using Pharos

scientific article published on 01 March 2020

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

scientific article

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

scientific article published on 15 September 2017

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions

scientific article published on 13 December 2018

Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 2

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

scientific article

Identification of Positive Allosteric Modulators of the D Dopamine Receptor That Act at Diverse Binding Sites

scientific article published on 01 August 2018

Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists

Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor

Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

scientific article published on 30 March 2020

Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists

scientific article published on 10 May 2013

Identification of a potent new chemotype for the selective inhibition of PDE4

scientific article

Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity

scientific article

Identification of activators for the M2 isoform of human pyruvate kinase

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction

scientific article

Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory

scholarly article

Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay

scientific article published on 26 October 2015

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

scientific article

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay

scientific article

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists

scientific article published on 26 February 2019

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

scientific article

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

scientific article published on 19 December 2017

Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins

scientific article

Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction

scientific article published on 10 May 2013

Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches

scientific article published on 20 December 2012

Kinase Patent Space Visualization Using Chemical Replacements

scholarly article by Noel Southall & Ajay published March 2006 in Journal of Medicinal Chemistry

Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

scientific article

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

scientific article

ML223: A Small Molecule Probe With In Vivo Activity Against Acute Myeloid Leukemia Subtype M4Eo

scientific article published on 10 May 2013

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice

scientific article

Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs

scientific article

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

scientific article published on 01 February 2020

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

scientific article published in May 2018

Mitochondrial DNA damage by bleomycin induces AML cell death

scientific article

Monitoring compound integrity with cytochrome P450 assays and qHTS.

scientific article

NCATS Inxight Drugs: a comprehensive and curated portal for translational research

scientific article published on 14 October 2021

Non-iminosugar glucocerebrosidase small molecule chaperones

scientific article

Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds.

scientific article

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models

scientific article published on 25 October 2019

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

scientific article

Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds

scientific article

Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease

scientific article

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile

scientific article published on 07 June 2018

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras;Tp53 (KPC) mice, a genetically engineered model of pancreatic cancer

article

Pharos: Collating protein information to shed light on the druggable genome

scientific article

Potential of mean force between two hydrophobic solutes in water

scientific article

Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.

scientific article

Progress toward a universal biomedical data translator

publication published in 2022

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

scientific article

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

scientific article

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria

scientific article

Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens

scientific article

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

scientific article

Response to “Comment on ‘The Mechanism of Hydrophobic Solvation Depends on Solute Radius',J.Phys. Chem. B2000,104, 1326”

article

Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models

scientific article published on 26 November 2020

SAT-035 Small Molecule Allosteric Agonist of Relaxin Receptor Ml290 Demonstrates Antifibrotic Properties in Liver Fibrosis.

scientific article published on 30 April 2019

SMN Modulator ML372 Increases SMN Protein Abundance, Body Weight, Lifespan, and Rescues Motor Function in SMNΔ7 SMA Mice

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy

scientific article published on 5 April 2017

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor

scientific article

Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression

scientific article

Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models

scientific article published on 07 February 2020

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

scientific article published on 10 July 2009

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists

scientific article published on 11 February 2016

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening

scientific article

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

scientific article (publication date: 27 November 2013)

Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy

scientific article published on 01 July 2019

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

scientific article published on 06 March 2020

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

scientific article published on 13 June 2009

TCRD and Pharos 2021: mining the human proteome for disease biology

scientific article published on 06 November 2020

Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer

scientific article

Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome

scientific article published on July 2013

The Mechanism of Hydrophobic Solvation Depends on Solute Radius

The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

The NCATS Pharmaceutical Collection: a 10-year update

scientific article published on 01 October 2019

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

scientific article

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

scientific article published on October 2011

The pilot phase of the NIH Chemical Genomics Center

scientific article

The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases - recommendations of the IRDiRC Data Mining and Repurposing Task Force

scientific article published on 15 October 2019

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

scientific article

Unexplored therapeutic opportunities in the human genome

scientific article published on 23 March 2018

Unexplored therapeutic opportunities in the human genome.

scientific article published on 23 February 2018

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

scientific article

Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus

scientific article published on 27 March 2020

Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features

scientific article published on 04 October 2009

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

scientific article

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

scientific article published in Journal of Biological Chemistry

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