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List of works by Ingrid Meulenbelt

A common mineralocorticoid receptor polymorphism (I180V) interacts with life events in relation to perfectionism in eating disorders: a pilot study

scientific article published on 14 September 2014

A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis

scientific article

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22

scientific journal article

A genome-wide association study of anorexia nervosa

scientific article

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.

scientific article published on 08 June 2009

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels

scientific article

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

article

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

scientific article

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone

scientific article published on 01 September 2018

Abdominal fat accumulation in adults born preterm exposed antenatally to maternal glucocorticoid treatment is dependent on glucocorticoid receptor gene variation

scientific article published on 10 August 2011

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice

scientific article

Allele-sharing statistics using information on family history

scientific article published on 12 August 2010

Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study

scientific article published on 29 November 2007

Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry.

scientific article

Annotating transcriptional effects of genetic variants in disease relevant tissue: Transcriptome-wide allelic imbalance in osteoarthritic cartilage

scientific article published on 23 February 2019

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

scientific article

Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis

scientific article published on 3 December 2010

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies

scientific article

Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes

scientific article published on 14 September 2008

Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites

scientific article published on 01 April 2005

Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip.

scientific article published in April 2004

Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation

scientific article published on 01 May 2005

Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting.

scientific article published on 22 November 2010

Association study of candidate genes for the progression of hand osteoarthritis.

scientific article published on 26 January 2013

Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: no replication found

scientific article

Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis.

scientific article published on 27 January 2016

Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years

scientific article published on 24 August 2010

Clinical burden of erosive hand osteoarthritis and its relationship to nodes

scientific article published on 21 April 2010

Clustering of hand osteoarthritis progression and its relationship to progression of osteoarthritis at the knee

scientific article published on 23 February 2013

Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study

scientific article published on 17 October 2006

Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis

scientific article

DNA Methylation in Osteoarthritis.

scientific article

Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat

scientific article published on 01 November 2000

Elucidating epigenetic regulation by identifying functional cis-acting long non-coding RNAs and their targets in osteoarthritic articular cartilage

scientific article published on 17 June 2020

Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.

scientific article published on May 2005

Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study.

scientific article published on 30 September 2004

Familial influence on tibiofemoral alignment

scientific article published on 06 April 2009

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

scientific article published on 19 September 2013

Genes expressed in blood link osteoarthritis with apoptotic pathways.

scientific article published on 17 July 2013

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.

scientific article

Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier

scientific article published on 28 April 2016

Genetic association analysis of RHOB and TXNDC3 in osteoarthritis

scientific article

Genetic influences on disordered eating behaviour are largely independent of body mass index.

scientific article published on 11 December 2007

Genetic linkage analysis of 14 candidate gene loci in a family with autosomal dominant osteoarthritis without dysplasia.

scientific article published in December 1997

Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders

scientific article published on 14 December 2012

Genetics of osteoarthritis: early developmental clues to an old disease

scientific article published in November 2008

Genome scanning by two-dimensional DNA typing: the use of repetitive DNA sequences for rapid mapping of genetic traits

scientific article published in February 1991

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

scholarly article

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

scientific article published on 30 August 2017

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

scientific article

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genotype-Based Score Test for Association Testing in Families

scientific article

Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine

scientific article published on 01 August 1999

High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes

scientific article published on 01 August 2006

Hip Ontogenesis: How Evolution, Genes, and Load History Shape Hip Morphotype and Cartilotype ⬇️

scientific article published on December 1, 2012

How does hip osteoarthritis differ from knee osteoarthritis?

scientific article published in 2022

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.

scientific article

IGF1 Promoter Polymorphism and Cranial Growth in Individuals Born Very Preterm

scientific article published on 31 March 2011

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

scientific article published on 06 August 2013

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

scientific article published on 11 March 2008

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study ⬇️

scientific article published on July 3, 2012

Illness perceptions in patients with osteoarthritis: change over time and association with disability

scientific article

Implementation of Functional Genomics for Bench-to-Bedside Transition in Osteoarthritis

scientific article published on August 2015

Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues

scientific article published on 04 April 2012

Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study

scientific article published on 01 May 2007

Innate immune response and implant loosening: Interferon gamma is inversely associated with early migration of total knee prostheses.

scientific article published on 24 July 2015

Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis

scientific article published on 20 November 2007

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

scientific article

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis.

scientific article

Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study

scientific article

Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study

scientific article published in October 1997

Isolation and mapping of human chromosome 21 cosmids using a probe for RTVL-H retrovirus-like elements.

scientific article published on March 1993

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches.

scientific article published on 26 September 2014

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations

scientific article published on 30 January 2009

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis

article

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

scientific article published on June 2009

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

scientific article published on 10 December 2010

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility

scientific article published on 19 August 2010

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

scientific article published on 23 July 2014

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

scientific article

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles

scientific article published on 27 October 2012

Molecular epidemiology, candidate genes versus genome-wide scans

scientific article published on October 2007

Mortality in osteoarthritis patients

scientific article published on 2 September 2014

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.

scientific article

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells

scientific article

New insights into osteoarthritis: early developmental features of an ageing-related disease.

scientific article published on September 2008

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

scientific article

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

scientific article published on 19 September 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Organisation of the human genome and our tools for identifying disease genes.

scientific article

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis

scientific article published on 01 May 2011

Osteoarthritis year 2011 in review: genetics.

scientific article published on 14 January 2012

Population haplotype analysis and evolutionary relations of the COL2A1 gene

scientific article published on 01 May 1996

RNA sequencing reveals interacting key determinants of osteoarthritis acting in subchondral bone and articular cartilage

scientific article published on 01 December 2020

Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis

scientific article

Radiographic progression of knee osteoarthritis is associated with MRI abnormalities in both the patellofemoral and tibiofemoral joint

scientific article

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

scientific article published on 6 November 2010

Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women

scientific article published on 5 June 2013

Relative efficiency of haplotype frequency estimation in sibships and nuclear families compared to unrelated individuals

scientific article published on 27 April 2007

Replication in genetic association studies: Comment on the editorial by Spector et al

scientific article published on 01 September 2006

Reply to “Human genetic studies on osteoarthritis from clinicians’ viewpoints”

scientific article published on 21 December 2011

Republished: Value of biomarkers in osteoarthritis: current status and perspectives

scientific article published on March 2014

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

scientific article published on 13 April 2014

Sex differences in sum scores may be hard to interpret: the importance of measurement invariance

scientific article published on 17 September 2009

Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA.

scientific article published on 16 June 2011

Systemic and local factors are involved in the evolution of erosions in hand osteoarthritis

scientific article published on 19 November 2010

The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth.

scientific article published on 11 September 2007

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males

scientific article published on 16 March 2013

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress

scientific article published on 30 December 2014

The first international workshop on the epigenetics of osteoarthritis

scientific article

The miRNA-mRNA interactome of murine induced pluripotent stem cell-derived chondrocytes in response to inflammatory cytokines

scientific article published on 07 August 2020

The role of epigenetics in osteoarthritis: current perspective

scientific article

The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA

scientific article published on 25 October 2008

The transcriptional landscape of age in human peripheral blood

scientific article

Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability

scientific article published on 02 February 2010

Time-efficient interleaved human (23)Na and (1)H data acquisition at 7 T.

scientific article

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage

scientific article published on May 2015

Translating genomics into mechanisms of disease: Osteoarthritis

scientific article published on December 2015

Translation of clinical problems in osteoarthritis into pathophysiological research goals

scientific article published on 26 May 2016

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

scientific article published on 2 April 2014

Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study

scientific article published on 3 August 2005

Validity of joint space width measurements in hand osteoarthritis

scientific article published on 5 September 2011

Validity, reliability, responsiveness and feasibility of four hand mobility measures in hand osteoarthritis

scientific article published on 14 December 2017

Value of biomarkers in osteoarthritis: current status and perspectives.

scientific article published on 29 July 2013

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