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List of works by Gurdyal Besra

3-Ketosteroid 9alpha-hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis

scientific journal article

7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.

scientific article published on 12 February 2015

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

scientific article

A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection

scientific article published on 28 January 2008

A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

scientific article

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis

scientific article published on 5 March 2013

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

scientific journal article

A hybrid of the transhydrogenases from Rhodospirillum rubrum and Mycobacterium tuberculosis catalyses rapid hydride transfer but not the complete, proton-translocating reaction

scholarly article by Rosalind Wilson et al published March 2006 in BBA - Bioenergetics

A lipomannan variant with strong TLR-2-dependent pro-inflammatory activity in Saccharothrix aerocolonigenes

scientific article published on 14 June 2005

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe

scientific article published on 11 February 2015

A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection

scientific article

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids

scientific article

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

scientific article

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens

scientific article published on 09 January 2014

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.

scientific article

A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan

scientific article

A truncated lipoglycan from mycobacteria with altered immunological properties

scientific article

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

scientific article

Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis: STRUCTURAL AND MUTATIONAL ANALYSIS OF MANNOSYLTRANSFERASE CORYNEBACTERIUM GLUTAMICUM PimB'

scientific article

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

scientific article

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.

scientific article published on 6 September 2017

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

scientific article

Activation of the pro-drug ethionamide is regulated in mycobacteria

scientific journal article

Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected]

scientific article

Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis

scientific journal article

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

scientific article published on 11 February 2009

Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection

scientific article

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

scientific article published on 4 March 2008

Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole

scientific article published in June 2005

Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production

scientific article published on 29 February 2012

An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes

scientific article published on 15 December 2009

Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy

scientific article published on 13 February 2015

Ancient mycobacterial lipids: Key reference biomarkers in charting the evolution of tuberculosis

scientific article published on 12 February 2015

Antimycobacterial Activity and Mechanism of Action of NAS-91

scientific article

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.

scientific article published on 2 March 2018

Apolipoprotein-mediated pathways of lipid antigen presentation

scientific article

Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-d-arabinose metabolism

scientific article published on 04 August 2006

Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

article

Arabinogalactan and lipoarabinomannan biosynthesis: structure, biogenesis and their potential as drug targets.

scientific article published on January 2012

Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target

scientific article published on 26 April 2004

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis

scientific article published in 2023

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.

scientific article published on 15 February 2016

B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo

scholarly article

BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments

scientific article published on 20 June 2005

Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis

scientific article published on 20 January 2014

Biochemical and phenotypic characterisation of the <i>Mycobacterium smegmatis</i> transporter UspABC

scientific article published on 24 April 2021

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

scientific article

Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II

scientific journal article

Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase

scientific journal article

Biomolecular archaeology of ancient tuberculosis: response to “Deficiencies and challenges in the study of ancient tuberculosis DNA” by Wilbur et al. (2009)

article

Biosynthesis of Mycobacterial Lipoarabinomannan

scientific article published in Journal of Biological Chemistry

Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase

scientific article

Biosynthesis of the Linkage Region of the Mycobacterial Cell Wall

scientific article published in Journal of Biological Chemistry

Biosynthesis of the galactan component of the mycobacterial cell wall

scientific journal article

Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues

scientific journal article

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme

scientific article

CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection

scientific article

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

scientific article

CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor

scientific article

CD1d-restricted T cell activation by nonlipidic small molecules

scholarly article

Calreticulin controls the rate of assembly of CD1d molecules in the endoplasmic reticulum ⬇️

scientific article

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone

scientific article

Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization

scientific journal article

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis

scientific article published in May 2002

Characterization of the in vitro synthesized arabinan of mycobacterial cell walls

scientific article published on 01 June 1997

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.

scientific article published in January 2006

Characterization of the specific antigenicity of Mycobacterium fortuitum

scientific article published in July 1992

Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis.

scientific article

Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent

scientific article published on 4 August 2007

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.

scientific article

Combined natural killer T-cell based immunotherapy eradicates established tumors in mice

scientific article published on August 2007

Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae

scientific article published on May 2004

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome

scientific article published on 29 April 2013

Critical Role for CD1d-Restricted Invariant NKT Cells in Stimulating Intrahepatic CD8 T-Cell Responses to Liver Antigen

article

Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells

scientific article

Crystal Structure of Bovine CD1b3 with Endogenously Bound Ligands

scientific article

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines

scientific article

Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).

scientific article

Current status and future development of antitubercular chemotherapy

scientific article

Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis

scientific article published in October 2002

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

scientific article

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

scientific article published in Scientific Reports

Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis.

scientific article published on 10 September 2009

Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core

scientific article published on 21 July 2005

Deletion of manC in Corynebacterium glutamicum results in a phospho-myo-inositol mannoside- and lipoglycan-deficient mutant

scientific article published on 26 April 2012

Design, synthesis, and functional activity of labeled CD1d glycolipid agonists

scientific article

Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall

scientific article published on 28 September 2006

Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean

scientific article

Detection and strain typing of ancient Mycobacterium leprae from a medieval leprosy hospital.

scientific article

Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation

scientific article

Differential effects of Mycobacterium bovis--derived polar and apolar lipid fractions on bovine innate immune cells

scientific article published on 27 June 2012

Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+

scientific article

Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes

scientific article published on 9 October 2003

Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis

scientific article published on 10 April 2007

Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum

scientific article published on 6 August 2003

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan

scientific article published on 05 December 2016

Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis

scientific article published on 14 February 2013

Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells

scientific article

Endoplasmic reticulum glycoprotein quality control regulates CD1d assembly and CD1d-mediated antigen presentation

scientific article published on 24 April 2013

EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets

scientific journal article

EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator

scientific journal article

Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum

scientific article published in May 2005

Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease

scientific article published on 11 August 2020

Exploring the substrate specificity of a mycobacterial polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase

scientific article published in January 2008

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis

scientific journal article

Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

scientific article published in October 2007

Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.

scientific article

Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi.

scientific article published on January 1993

Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae

scientific article (publication date: 13 June 2013)

Glycolipid targets of CD1-mediated T-cell responses

scientific article

Glycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall

scientific article

Glycosylation of the phosphate binding protein, PstS, in Streptomyces coelicolor by a pathway that resembles protein O-mannosylation in eukaryotes

scientific article published on 10 November 2008

Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2

scientific article

Human CD4+ invariant NKT cells are involved in antibacterial immunity against Brucella suis through CD1d-dependent but CD4-independent mechanisms

scientific article published in April 2009

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

scientific article

IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines

article

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach

scientific article published in Scientific Reports

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol

scientific article published in August 2005

Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH

scientific article

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis

scientific article

Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such asCorynebacterium glutamicumandMycobacterium tuberculosis

scientific article published in Journal of Biological Chemistry

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis

scientific journal article

Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides

scientific article published on 4 March 2011

Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.

scientific article published on 28 April 2008

Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea

scientific article

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

scientific article

Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis

scientific article published on 29 May 2009

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

scientific article (publication date: 2010)

Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide

scientific article

Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis

scientific article (publication date: 2012)

Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis

scientific journal article

Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

scientific article

Identification of the apparent carrier in mycolic acid synthesis

scientific article

Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex

scientific article published in December 2007

Identification of the lipooligosaccharide biosynthetic gene cluster from Mycobacterium marinum

scientific article published on March 2007

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases

scientific article

In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system

scientific article published on 8 November 2002

Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death

scientific article published on 24 March 2009

Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv

scientific journal article

Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin

scientific article published on August 2009

Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity

scientific article

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

scientific article published on 25 August 2017

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

scientific article

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria

scientific article published on 24 March 2003

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection

scientific article

Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi

scientific article published on November 2011

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration

scientific article published on 15 April 2009

Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.

scientific article

Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

scientific article

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

scientific article

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

scientific article published on 30 October 2011

IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria

scientific article

Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis.

scientific article published on 7 May 2013

Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation

scientific article published on June 2009

Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis

scientific article

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester

scientific journal article

Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation

scientific article

Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction

scientific article published on 31 May 2011

Lipoarabinomannan biosynthesis in Corynebacterineae: the interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching

scientific article

LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum

scientific article published on 28 October 2005

Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones

scientific article

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b

scientific article

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.

scientific article published on 17 January 2018

MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii

scientific article published on 20 April 2015

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

scientific article published on 10 April 2017

Mannan chain length controls lipoglycans signaling via and binding to TLR2.

scientific article

Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity

scientific article published on 22 August 2013

Mechanism of thioamide drug action against tuberculosis and leprosy

scientific article

Metagenomic analysis of tuberculosis in a mummy.

scientific article published in July 2013

MmpL genes are associated with mycolic acid metabolism in mycobacteria and corynebacteria

scientific article

Modified mannose disaccharides as substrates and inhibitors of a polyprenol monophosphomannose-dependent alpha-(1-->6)-mannosyltransferase involved in mycobacterial lipoarabinomannan biosynthesis

scientific article published in February 2005

Modular approach to triazole-linked 1,6-α-D-oligomannosides to the discovery of inhibitors of Mycobacterium tuberculosis cell wall synthetase

scientific article published on October 2010

Modulation of CD1d-restricted NKT cell responses by CD4

article

Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides

scientific article

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation

scholarly article

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

scientific article published on 28 January 2008

Molecular interaction of CD1b with lipoglycan antigens

scientific article

Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.

scholarly article

Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51.

scientific article published on 19 September 2007

Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary

scientific article published on 13 February 2015

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

scientific article

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

scientific journal article

Mycobacterial arabinan biosynthesis: the use of synthetic arabinoside acceptors in the development of an arabinosyl transfer assay

article

Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response

scientific article

Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan ⬇️

scientific article

Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity

scientific article

Mycobacterium tuberculosis complex lipid virulence factors preserved in the 17,000-year-old skeleton of an extinct bison, Bison antiquus

scientific article

Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells

scientific article

Mycobacterium tuberculosisacyl carrier protein synthase adopts two different pH-dependent structural conformations

scientific article

Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step

scientific article published on 01 June 1997

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production

scientific article

Mycolic acid structure determines the fluidity of the mycobacterial cell wall

scientific article

Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillus

scientific article published on 02 July 2015

NK T cells provide lipid antigen-specific cognate help for B cells

scholarly article

NKT cell subsets mediate differential proatherogenic effects in ApoE-/- mice

scientific article published on 26 February 2009

NKT cells direct monocytes into a DC differentiation pathway

scientific article published on 20 February 2007

Natural killer T cells in adipose tissue prevent insulin resistance

scientific article

Natural killer T-cell autoreactivity leads to a specialized activation state

scientific article published on 08 September 2008

Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses

scientific article published on 4 October 2007

New CD1d agonists: synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

scientific article

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections

scientific article published on May 2008

New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: inhibition of antigen 85C mycolyltransferase activity and cytotoxicity

scientific article published on August 2006

New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria.

scientific article published in January 1994

Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix

scientific article

Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity.

scientific article published on 24 October 2015

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

scientific article published on 20 July 2009

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

scientific article published on September 2004

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

scientific article (publication date: 13 October 1998)

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses

scientific article published on 10 May 2019

Oligosaccharides as inhibitors of mycobacterial arabinosyltransferases. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues

scientific article published in February 2005

Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary

scientific article

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

scientific article published in October 2002

PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells

scientific article

Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules

scientific article

Phosphatidylinositol synthesis in mycobacteria

article

Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall

scientific article

Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation

scientific article published on 23 August 2018

Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases

scientific article

Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteria

scientific article

Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells

scientific article published on 31 January 2011

Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts

scientific article published on July 2004

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

scientific article

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

scientific article

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity

scientific article

Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d

scientific article published on 5 April 2007

Re-emergence of tuberculosis: strategies and treatment

scholarly article by Gurdyal Besra & Laurent Kremer published February 2002 in Expert Opinion on Investigational Drugs

Recognition of lyso-phospholipids by human natural killer T lymphocytes

scientific article

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.

scientific article published on 10 January 2013

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

scientific article

Regulation of CD1 antigen-presenting complex stability

scientific article

Regulation of cell wall synthesis and growth.

scientific article published on May 2007

Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation

scientific article published on 16 May 2011

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition

scientific article published on 14 March 2013

Role of lipid trimming and CD1 groove size in cellular antigen presentation

scientific article published on 22 June 2006

Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.

scientific article published on 03 August 2009

SAP expression in invariant NKT cells is required for cognate help to support B-cell responses

scientific article

Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules

scholarly article

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

scientific article

Saposins utilize two strategies for lipid transfer and CD1 antigen presentation

scientific article published on 13 February 2012

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway

scientific journal article

Sequence and analysis of a plasmid-encoded mercury resistance operon from Mycobacterium marinum identifies MerH, a new mercuric ion transporter

scientific article

Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei

scientific article (publication date: 22 February 2003)

Serum lipids regulate dendritic cell CD1 expression and function

scientific article published on 28 April 2008

Stereochemistry of 2,4-dimethyleicos-2-enoate from the pyruvylated glycolipid of Mycobacterium smegmatis

scientific article published on 01 December 1994

Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes

scientific article published on 01 March 2011

Stimulation of mycolic acid biosynthesis by incorporation of cis-tetracos-5-enoic acid in a cell-wall preparation from Mycobacterium smegmatis

scientific article published on 01 April 1993

Structural and functional features of Rhodococcus ruber lipoarabinomannan

scientific article published on June 2003

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

scientific article

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant

scientific article published on 18 April 2008

Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant

scientific article

Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum

scientific article published on 01 October 1995

Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells

scientific article

Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains

scientific article (publication date: 23 August 2002)

Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes

scientific article published on 07 March 2012

Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis

scientific article

Structure ofMycobacterium tuberculosismtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT)

scientific article

Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets.

scientific article published on November 2007

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

scientific article

Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activity ⬇️

scientific article published on December 1, 2001

Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity

scientific article published in December 2001

Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity

scientific article published on April 2002

Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice

scientific article

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis

article

Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000.

scientific article published on 22 April 2010

Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide

scientific article

Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides

scientific article published on June 2010

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.

scientific article

Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library

scientific article

Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis.

scientific article

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.

scientific article published on 18 May 2009

Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids

scientific article

Synthesis of a Versatile Building Block for the Preparation of 6-N-Derivatized α-Galactosyl Ceramides: Rapid Access to Biologically Active Glycolipids ⬇️

scientific article published on December 14, 2010

Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies

scientific article published on April 2010

Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis

scientific article

Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.

scientific article

Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis

scientific article

Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis

scientific article published in February 2004

Synthesis of methyl (Z)-tetracos-5-enoate and both enantiomers of ethyl (E)-6-methyltetracos-4-enoate: possible intermediates in the biosynthesis of mycolic acids in mycobacteria

scientific article published on 01 November 1993

Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis

scientific article

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation

scientific article published on 19 November 2010

Synthesis of α-Glucan in Mycobacteria Involves a Hetero-octameric Complex of Trehalose Synthase TreS and Maltokinase Pep2

scientific article

Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates

scientific article published on March 1998

Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase

scientific article

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

scientific article

Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity

scientific article published on 27 February 2020

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3

scientific article

The 5-Deoxy-5-methylthio-xylofuranose Residue in Mycobacterial Lipoarabinomannan. Absolute Stereochemistry, Linkage Position, Conformation, and Immunomodulatory Activity

scientific article published on 01 April 2006

The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module

scientific article

The M. tuberculosis antigen 85 complex and mycolyltransferase activity

scientific article published on 01 January 2002

The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development

scientific article

The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue

scientific article

The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition

scholarly article

The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid

scientific article published on 11 September 2012

The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129

scientific article

The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation

scientific journal article

The crystal structure of human CD1d with and without alpha-galactosylceramide

scientific article published on 10 July 2005

The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.

scientific article

The hydrolase LpqI primes mycobacterial peptidoglycan recycling.

scientific article published on 14 June 2019

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

scientific article published on 7 May 2007

The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction

scientific article published on 5 December 2007

The mechanism of splenic invariant NKT cell activation dictates localization in vivo

scientific article published on 19 June 2013

The methyl-branched fortifications of Mycobacterium tuberculosis

scientific article

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

scientific article published in 2024

The ppm operon is essential for acylation and glycosylation of lipoproteins in Corynebacterium glutamicum

scientific article

The role of hydrophobicity in tuberculosis evolution and pathogenicity

scientific article published on 2 May 2017

The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases

scientific article

The two carboxylases of Corynebacterium glutamicum essential for fatty acid and mycolic acid synthesis

scientific article

The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.

scientific article

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria

scientific article

Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis

scientific article

Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

scientific article published on 7 March 2012

Transposon mutagenesis of Mb0100 at the ppe1-nrp locus in Mycobacterium bovis disrupts phthiocerol dimycocerosate (PDIM) and glycosylphenol-PDIM biosynthesis, producing an avirulent strain with vaccine properties at least equal to those of M. bovis B

article by Grant S Hotter et al published April 2005 in Journal of Bacteriology

Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol

scientific article published on November 1996

Tsukamurella paurometabola lipoglycan, a new lipoarabinomannan variant with pro-inflammatory activity

scientific article

Tuberculosis chemotherapy: recent developments and future perspectives

scientific article published on January 2007

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis.

scientific article

Tuberculosis: a balanced diet of lipids and carbohydrates

scientific article published on August 2008

Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum

scientific article published in July 2005

Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis

scientific journal article

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in <i>Mycobacterium tuberculosis</i>

scientific article published on 15 December 2020

Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum

scientific article

Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis

scientific article (publication date: 26 December 2003)

Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells

scientific article published on January 1999

Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase

scientific journal article

V 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

scientific article

X-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)

scientific article

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

scientific article published on 3 March 2011

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents

scientific article

β-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy

scientific article published on 26 June 2013

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