List of works - Thomas Arnesen

(Hyper)tension release by N-terminal acetylation

scientific article published on 28 May 2015

<i>NAA10</i> p.(D10G) and <i>NAA10</i> p.(L11R) Variants Hamper Formation of the NatA N-Terminal Acetyltransferase Complex

scientific article published on 26 November 2020

A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity

scientific article published on 30 September 2016

A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant

scientific article

A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly

scientific article published on 07 June 2019

A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy

scientific article published on 10 May 2018

A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)

scientific article

A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family

scientific article published on December 2006

A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates

scientific article

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

scientific article published on 21 October 2018

Actin's N-terminal acetyltransferase uncovered

scientific article published on 01 July 2018

An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity

scientific journal article

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects

scientific article

Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation

scientific article

Characterization of Evolutionarily Conserved NatC and NatA-N-Terminal Acetyltransferase Complexes

scientific article published on 06 March 2019

Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase

scientific article

Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases

scientific article published on 23 December 2020

Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population

scientific article published on 18 September 2017

Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex

scientific article

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

scientific article published on 13 March 2019

Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas.

scientific article published on 8 January 2014

Composition and biological significance of the human Nα-terminal acetyltransferases

scientific article

Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation

scientific journal article

DTNB-Based Quantification of In Vitro Enzymatic N-Terminal Acetyltransferase Activity

scientific article published on 01 January 2017

De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females

scientific article (publication date: May 2015)

Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization

scientific article

Depletion of the human Nα-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition

scientific article

Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors

scientific article

Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis

scientific article

Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice

scientific article published in 2024

Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency

scientific article published on 20 April 2016

Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms

scientific article

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases

scientific article

HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain

scientific article

HPLC-based quantification of in vitro N-terminal acetylation

scientific article published in January 2013

Holding it together: Naa60 at the Golgi

scientific article published in June 2015

Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity

scientific article

Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study

scientific article published on 6 February 2012

Identification and characterization of the human ARD1-NATH protein acetyltransferase complex

scientific article

Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30.

scientific article published on 13 December 2017

Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression

scientific article

In-gel N-acetylation for the quantification of the degree of protein in vivo N-terminal acetylation

scientific article published in January 2013

Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex

scientific article

Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha

scientific article

Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae.

scientific article published on 22 June 2018

Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil

scientific article

Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization

scientific article

Massively parallel sequencing identifies a previously unrecognized X-linked disorder resulting in lethality in male infants owing to amino-terminal acetyltransferase deficiency.

scientific article published on 19 September 2011

Mechanism of actin N-terminal acetylation

scientific article published on 08 April 2020

Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases

scientific article

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex

scientific article

Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane.

scientific article published on 14 February 2017

Molecular, cellular, and physiological significance of N-terminal acetylation.

scientific article published on 25 February 2015

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in

scientific article published on 27 August 2018

N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae

scientific article

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

scientific article published on 21 March 2020

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

scientific article

N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases

scientific article

N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects

scientific article

NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report.

scientific article published on 20 March 2018

NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment

scientific article

NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

scientific article published on 26 March 2018

Naa10 in development and disease.

scientific article published on 28 September 2015

Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion

scientific article

NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation

scientific article

Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway

scientific article published on 19 June 2013

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

scientific article published on 25 September 2020

Protein N-terminal acetylation: NAT 2007-2008 Symposia

scientific article

Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo

scientific article

Protein N-terminal acetyltransferases in cancer

scientific article

Protein N-terminal acetyltransferases: when the start matters

scientific article

Protein alpha-N-acetylation studied by N-terminomics

scientific article published on 02 August 2011

Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase

scientific article

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

scholarly article

Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases

scientific article

Spotlight on protein N-terminal acetylation

scientific article published on 27 July 2018

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.

scientific article published on 26 March 2018

Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation

scientific article

The N-terminal acetyltransferase Naa10 is essential for zebrafish development

scientific article published on 6 August 2015

The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation

scientific article

The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4

scientific article

The protein Nalpha-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells

scientific article

The protein acetyltransferase ARD1: a novel cancer drug target?

scientific article

The world of protein acetylation

scientific article

Towards a functional understanding of protein N-terminal acetylation

scientific article

Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies.

scientific article published on 9 April 2018

Using VAAST to Identify an X-linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency.

scientific article published in August 2011

Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency

scientific article

[14C]-Acetyl-Coenzyme A-Based In Vitro N-Terminal Acetylation Assay.

scientific article published in January 2017

List of works by Thomas Arnesen

(Hyper)tension release by N-terminal acetylation

<i>NAA10</i> p.(D10G) and <i>NAA10</i> p.(L11R) Variants Hamper Formation of the NatA N-Terminal Acetyltransferase Complex

A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity

A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant

A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly

A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy

A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1)

A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family

A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates

Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin

Actin's N-terminal acetyltransferase uncovered

An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects

Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation

Characterization of Evolutionarily Conserved NatC and NatA-N-Terminal Acetyltransferase Complexes

Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase

Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases

Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population

Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex

Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases

Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas.

Composition and biological significance of the human Nα-terminal acetyltransferases

Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation

DTNB-Based Quantification of In Vitro Enzymatic N-Terminal Acetyltransferase Activity

De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females

Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization

Depletion of the human Nα-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition

Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors

Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis

Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice

Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency

Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases

HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain

HPLC-based quantification of in vitro N-terminal acetylation

Holding it together: Naa60 at the Golgi

Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity

Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study

Identification and characterization of the human ARD1-NATH protein acetyltransferase complex

Identification of an alternatively spliced nuclear isoform of human N-terminal acetyltransferase Naa30.

Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression

In-gel N-acetylation for the quantification of the degree of protein in vivo N-terminal acetylation

Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex

Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha

Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae.

Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil

Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization

Massively parallel sequencing identifies a previously unrecognized X-linked disorder resulting in lethality in male infants owing to amino-terminal acetyltransferase deficiency.

Mechanism of actin N-terminal acetylation

Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex

Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane.

Molecular, cellular, and physiological significance of N-terminal acetylation.

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in

N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae

N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases

N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects

NAA10 dysfunction with normal NatA-complex activity in a girl with non-syndromic ID and a de novo NAA10 p.(V111G) variant - a case report.

NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment

NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

Naa10 in development and disease.

Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion

NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation

Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

Protein N-terminal acetylation: NAT 2007-2008 Symposia

Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo

Protein N-terminal acetyltransferases in cancer

Protein N-terminal acetyltransferases: when the start matters

Protein alpha-N-acetylation studied by N-terminomics

Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases

Spotlight on protein N-terminal acetylation

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.

Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation

The N-terminal acetyltransferase Naa10 is essential for zebrafish development