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List of works by Hazel Dockrell

A Courageous Step Down the Road toward a New Tuberculosis Vaccine

scientific article published on 01 April 2009

A Feasibility Study for Diagnosis of Latent Tuberculosis Infection Using an IGRA Point-of-Care Platform in South Korea

scientific article published on 01 April 2019

A New Challenge for the Tuberculosis Vaccine Community? ⬇️

scientific article published on 01 April 2012

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts

scientific article published on 13 April 2018

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

scientific article

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

scientific article published on 17 September 2008

A longitudinal study of in vitro IFNγ production and cytotoxic T cell responses of tuberculosis patients in The Gambia

article

A postgenomic approach to identification of Mycobacterium leprae-specific peptides as T-cell reagents

scientific article

A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferon

scientific article published in September 1985

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

scholarly article

Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus

scientific article

Activation of liver macrophages in murine malaria is enhanced by vaccination

scientific article

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

scientific article published on 8 February 2018

An RFLP map for 2q33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy.

scientific article published on October 1993

Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.

scientific article

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa

scientific article

Another Step Down the Development Pipeline for the Novel Tuberculosis Vaccine MVA-85A

article

Antigen-coated latex particles as a model system for probing monocyte responses in leprosy

scientific article

Assay optimisation and technology transfer for multi-site immuno-monitoring in vaccine trials

scientific article published on 11 October 2017

B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis

scientific article

BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi

scientific article

BCG vaccination: a role for vitamin D?

scientific article

BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies

scientific article

Biomarkers for TB treatment response: challenges and future strategies

scientific article published on 22 July 2008

Blood-stage malaria in Biozzi high and low antibody responder mice: the importance of antibody and macrophages in immunity

scientific article published in March 1984

Broad heparin-binding haemagglutinin-specific cytokine and chemokine response in infants following Mycobacterium bovis BCG vaccination

scientific article published on August 2012

Building research capacity through international partnerships

scientific article published on December 2009

CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis

scientific article

Cell-mediated immune responses to mycobacterial antigens in patients with pulmonary tuberculosis and HIV infection.

scientific article published in October 1997

Cell-mediated immunity in the liver of mice vaccinated against malaria

scientific article published on December 1979

Cellular immune responses of leprosy contacts to fractionated Mycobacterium leprae antigens

scientific article

Changes in oxidative burst capacity during murine malaria and the effect of vaccination

scientific article published in October 1986

Characterization of human Mycobacterium bovis bacille Calmette-Guérin-reactive CD8+ T cells.

scientific article published on October 1999

Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity

scientific article

Clinical and histological discrepancies in diagnosis of ENL reactions classified by assessment of acute phase proteins SAA and CRP

scientific article published on 01 June 1995

Clinico-pathological features of erythema nodosum leprosum: A case-control study at ALERT hospital, Ethiopia

scientific article

Combination of cytokine responses indicative of latent TB and active TB in Malawian adults

scientific article

Comparison of IFN-gamma responses to mycobacterial antigens as markers of response to BCG vaccination

scientific article published on January 2008

Complement C1q expression in Erythema nodosum leprosum

scientific article published on 2 March 2018

Complex cytokine profiles induced by BCG vaccination in UK infants

scientific article published on 24 November 2009

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

scientific article published in PLoS ONE

Cytochemical identification of T and B cells in situ in mouse lymphoid tissue and lymph nodes from the rat, gerbil and cat.

scientific article published on July 1978

Cytokine production and lymphocyte proliferation in patients with Nocardia brasiliensis actinomycetoma

article

Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population

scientific article published on 01 June 2002

Cytokine responses and progression to active tuberculosis in HIV-1-infected Ugandans: a prospective study

scientific article published on November 2004

Decreased IFN- gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients

scientific article published on January 2002

Detection of high titres of Toxoplasma gondii antibodies in sera of patients with leprosy in Pakistan

scientific article published on 01 May 1992

Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study

scientific article (publication date: October 2013)

Development of a whole blood assay to measure T cell responses to leprosy: a new tool for immuno-epidemiological field studies of leprosy immunity

scientific article published on November 1994

Diabetes is associated with genotypically drug-resistant tuberculosis

scientific article published on 20 March 2020

Diagnosis of childhood tuberculosis and host RNA expression in Africa

scientific article published in May 2014

Diagnostic Potential of a PPE Protein Derived from Mycobacterium tuberculosis Beijing/K Strain

scientific article published on 01 September 2020

Diagnostic assays for leprosy based on T-cell epitopes.

scientific article

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

scientific article published on 4 May 2016

Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

scientific article

Differences in T-cell responses between Mycobacterium tuberculosis and Mycobacterium africanum-infected patients

scientific article published on 20 February 2014

Differential gene expression identifies novel markers of CD4+ and CD8+ T cell activation following stimulation by Mycobacterium tuberculosis

scientific article published on July 2004

Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity

scientific article

Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment

scientific article published on 4 June 2015

Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response

scientific article published on 7 August 2012

Dynamics of cytokine generation in patients with active pulmonary tuberculosis

scientific article

Effect of isoniazid preventive therapy on immune responses to mycobacterium tuberculosis: an open label randomised, controlled, exploratory study.

scientific article published on 22 October 2015

Endotoxin-induced serum factor kills malarial parasites in vitro.

scientific article published in July 1981

Enzyme differentiation of lymphocyte subpopulations in sections of human lymph nodes, tonsils and periodontal disease

scientific article published on April 1978

Evaluation of cell-mediated immune responses to two BCG vaccination regimes in young children in South Korea

article

Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

scientific article published on 13 June 2016

Evidence that the Mitsuda reaction to Mycobacterium leprae can be mediated by lymphocytes responsive to Mycobacterium tuberculosis.

scientific article published on June 1988

Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment

scientific article

Exogenous Re-infection by Multiple Exposures to Mycobacterium tuberculosis Contributes to Subsequent Development of Active Tuberculosis

scholarly article by Diane J. Ordway et al published 1 January 2005 in American Journal of Immunology

Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection

scientific article

Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK.

scientific article

Fixation for immunofluorescence and enzyme histochemistry on serial sections

scientific article

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis

scientific article published on 6 April 2018

From genome-based in silico predictions to ex vivo verification of leprosy diagnosis

scientific article published on 28 January 2009

Gamma delta T cell responses associated with the development of tuberculosis in health care workers

scientific article

Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults

scientific article

Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.

scientific article

Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania

scientific article

Global collaborations in leprosy research--the future is connected

scientific article published on 01 December 2008

High level expression of genes cloned in phage lambda gt11.

scientific article

Histochemical identification of T cells in oral lichen planus

scientific article published on July 1979

Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment

scientific article

Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia

scientific article published on December 2000

Human CD8+ CTL specific for the mycobacterial major secreted antigen 85A.

scientific article published on December 2000

Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen

scientific article

Human biomarkers: can they help us to develop a new tuberculosis vaccine?

scientific article published on 20 May 2016

Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis

scientific article published on January 1998

Identification of Specific Proteins and Peptides in Mycobacterium leprae Suitable for the Selective Diagnosis of Leprosy

scientific article published on 01 December 2005

Identification of immunological biomarkers which may differentiate latent tuberculosis from exposure to environmental nontuberculous mycobacteria in children

scientific article published on 27 November 2013

Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis

scientific article

Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy

scientific article published in 2012

IgG subclass antibody to Mycobacterium leprae 18,000 MW antigen is restricted to IgG1 and IgG3 in leprosy

scientific article published on 01 November 1994

Immune profiling of leprosy and tuberculosis patients to 15-mer peptides of Mycobacterium leprae and M. tuberculosis GroES in a BCG vaccinated area: implications for development of vaccine and diagnostic reagents

scientific article

Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: comparison with Glaxo-Evans 1077 BCG vaccine

scientific article published on 8 May 2006

Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa

scientific article published on 24 June 2009

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

scientific article

Impact of co-infections and BCG immunisation on immune responses among household contacts of tuberculosis patients in a Ugandan cohort.

scientific article

Increased IL-4 production in response to virulent Mycobacterium tuberculosis in tuberculosis patients with advanced disease

scientific article published in January 2005

Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis

scientific article

Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions

scientific article

Induction of Th1 cytokine responses by mycobacterial antigens in leprosy

scientific article published on October 1996

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection

scientific article published on December 1998

Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.

scientific article published on 28 August 2013

Interferon-gamma and skin test responses of schoolchildren in southeast England to purified protein derivatives from Mycobacterium tuberculosis and other species of mycobacteria

scientific article published on November 2003

Interferon-gamma responses to ESAT-6 in tuberculosis patients early into and after anti-tuberculosis treatment

scientific article published on September 2005

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

scientific article published on 14 September 2015

Investigating the non-specific effects of BCG vaccination on the innate immune system in Ugandan neonates: study protocol for a randomised controlled trial

scientific article published on 11 April 2015

Isolation and Potential for Transmission of Mycobacterium bovis at Human-livestock-wildlife Interface of the Serengeti Ecosystem, Northern Tanzania

scientific article

Keep the faith--leprosy still needs new diagnostic tools and laboratory research

scientific article published on 01 December 2011

Killing of Plasmodium yoelii by enzyme-induced products of the oxidative burst ⬇️

scientific article published on February 1984

Killing of blood-stage murine malaria parasites by hydrogen peroxide.

scientific article published on January 1983

Killing of human malaria parasites by macrophage secretory products.

scientific article published on February 1984

Killing of the malarial parasite Plasmodium yoelii in vitro by cells of myeloid origin

scientific article published on 01 March 1982

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

scientific article published on 14 May 2007

Leprosy

scientific article published in 1995

Leprosy patients with lepromatous disease recognize cross-reactive T cell epitopes in the Mycobacterium leprae 10-kD antigen

scientific article published on 01 November 1998

Leprosy vaccines

scientific article published on May 1991

Long-lived memory B-cell responses following BCG vaccination

scientific article

Lymphocyte proliferative responses to chlamydial antigens in human chlamydial eye infections

scientific article published on October 1991

Macrophage functions in Biozzi mice

scientific article published on 01 July 1985

Macrophages as effector cells in immunity to malaria

scientific article

Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries

scientific article

Maternal BCG scar is associated with increased infant proinflammatory immune responses

scientific article

Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cure

scientific article

Molecular methods for distinguishing between relapse and reinfection in leprosy

scientific article published on 01 October 2008

Monocyte-derived macrophage cytokine responses induced by M. bovis BCG.

scientific article published on January 2000

Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection

Mycobacterial load affects adenosine deaminase 2 levels of tuberculous pleural effusion.

scientific article

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom

scientific article published on March 2004

Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.

scientific article

Mycobacterium tuberculosis-specific CD4+ T-cell response is increased, and Treg cells decreased, in anthelmintic-treated patients with latent TB.

scientific article published on 7 December 2015

New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells

scientific article published on 15 September 2017

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy

scientific article

One Health--'joining the dots'.

scientific article

PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment

scientific article

Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi.

scientific article published on 10 July 2001

Persistence of the immune response induced by BCG vaccination

scientific article

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

scientific article

Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy

scientific article published on March 2009

Possible transmission of Mycobacterium leprae in a group of UK leprosy contacts

scientific article

Post-immunization leucocytosis and its implications for the management of febrile infants.

scientific article published on 11 April 2018

Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae

scientific article

Presidential address: the role of research networks in tackling major challenges in international health

scientific article

Progress in research towards a world without leprosy. Report of a WHO meeting in Ethiopia, February 1998.

scientific article published in June 1998

Quantitation of IgM antibodies to the M. leprae synthetic disaccharide can predict early bacterial multiplication in leprosy

scientific article published on September 1990

Quantitative antibody ELISA for leprosy

scientific article published on December 1989

Real vaccines in the real world: tuberculosis vaccines move south

scientific article published on 01 August 2008

Recognition of Mycobacterium leprae recombinant 18,000 MW epitopes by IgG subclasses in leprosy

scientific article published on February 1995

Recognition of Mycobacterium leprae recombinant 18-kDa proteins in leprosy.

scientific article published in September 1992

Recognition of mycobacterial antigens by sera from patients with leprosy

scientific article published on December 1988

Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB

scientific article

Relationship between IFN-gamma and skin test responsiveness to Mycobacterium tuberculosis PPD in healthy, non-BCG-vaccinated young adults in Northern Malawi

scientific article

Reply to Davies et al

scientific article published in 2007

Report on the first meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) consortium held at Armauer Hansen Research Institute, ALERT, Addis Ababa, Ethiopia on 24-27 October 2004.

scientific article

Report on the sixth meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) consortium held in Beijing, China on 23-25 August 2010

article

Role of CD8 T cells in mycobacterial infections

scientific article

Screening vaccine formulations for biological activity using fresh human whole blood

scientific article

Selective correlation of interferon-gamma, tumour necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor with immunoglobulin G1 and immunoglobulin G3 subclass antibody in leprosy

scientific article published on 01 October 1999

Sequence and immunological characterization of a serine-rich antigen from Mycobacterium leprae.

scientific article

Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania

scientific article

Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8+ T cells in vitro

scientific article published on March 1996

Strain-dependent variation in Mycobacterium bovis BCG-induced human T-cell activation and gamma interferon production in vitro

scientific article

T-cell recognition of the 18-kilodalton antigen of Mycobacterium leprae

scientific article

T-cell regulation in Erythema Nodosum Leprosum

scientific article published on 9 October 2017

T-independent macrophage changes in murine malaria

scientific article published in March 1983

TANDEM: understanding diabetes and tuberculosis

scientific article published on 24 March 2014

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

scientific article published on 4 October 2017

The Current Status of BCG Vaccination in Young Children in South Korea

scientific article

The Effects of Prednisolone Treatment on Cytokine Expression in Patients with Erythema Nodosum Leprosum Reactions

scientific article published on 9 February 2018

The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months.

scientific article published on 27 December 2005

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.

scientific article

The Use of Interferon Gamma Inducible Protein 10 as a Potential Biomarker in the Diagnosis of Latent Tuberculosis Infection in Uganda

scientific article published on 15 January 2016

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

article

The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection.

scientific article

The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette-Guérin immunization

scientific article published in June 2015

The importance of being nearest

scientific article published on 01 February 1984

The influence of previous exposure to environmental mycobacteria on the interferon-gamma response to bacille Calmette-Guérin vaccination in southern England and northern Malawi.

scientific article published on December 2006

The role of the liver in immunity to blood-stage murine malaria.

scientific article published in October 1980

Towards new TB vaccines: What are the challenges?

scientific article published on 9 March 2016

Tuberculosis vaccines: Opportunities and challenges

scientific article published on 17 January 2018

Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects

scientific article published on May 1999

Use of a whole blood assay to monitor the immune response to mycobacterial antigens in leprosy patients: a predictor for type 1 reaction onset?

scientific article published on September 1998

Use of polymerase chain reaction to assess efficacy of leprosy chemotherapy

scientific article published on July 1993

Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa

scientific article

Vaccinia expression of Mycobacterium tuberculosis-secreted proteins: tissue plasminogen activator signal sequence enhances expression and immunogenicity of M. tuberculosis Ag85.

scientific article published on November 2000

Variability between countries in cytokine responses to BCG vaccination: what impact might this have on protection?

scientific article published in February 2012

What Have We Learnt about BCG Vaccination in the Last 20 Years?

scientific article published on 13 September 2017

Whole Blood Profiling of Bacillus Calmette-Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation

scientific article

Whole blood assays for interferon-gamma: practicalities and potential for use as diagnostic tests in the field

scientific article

Whole blood cytokine assays--a new generation of diagnostic tests for tuberculosis?

scientific article published in June 1998

Working together toward vaccines and biomarkers in the real world

scientific article

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